Intake of whole grains and vegetables determines the plasma enterolactone concentration of Danish women

Journal of Nutrition

Volumn 134, Issue 10, 2004, Pages 2691-2697

  Johnsen, Nina F ^a,b   Hausner, Helene ^a,b   Olsen, Anja ^a   Tetens, Inge ^b   Christensen, Jane ^a   Knudsen, Knud Erik Bach ^c   Overvad, Kim ^d   Tjønneland, Anne ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d AALBORG UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Intestinal microflora; Lignans; Whole grains

Indexed keywords

ENTEROLACTONE; LIGNAN;

ADULT; ARTICLE; BEVERAGE; BODY MASS; BREAST CANCER; CABBAGE; CEREAL; CIGARETTE SMOKING; COFFEE; DEFECATION; DENMARK; DIET; DIETARY FIBER; FAT INTAKE; FEMALE; FLUOROIMMUNOASSAY; FOOD INTAKE; FRUIT; GRAIN; HEART DISEASE; HUMAN; INTESTINE FLORA; LIFESTYLE; MAJOR CLINICAL STUDY; POSTMENOPAUSE; POTATO; PREVALENCE; PROSPECTIVE STUDY; QUESTIONNAIRE; VEGETABLE;

BRASSICA OLERACEA VAR. CAPITATA; MAMMALIA; SOLANUM TUBEROSUM;

EID: 4744361085     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.10.2691     Document Type: Article

References (43)

1. Adlercreutz, H., Heikkinen, R., Woods, M., Fotsis, T., Dwyer, J. T. & Goldin, B. R. (1982) Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet 11: 1295-1298.
2. Ingram, D., Sanders, K., Kolybaba, M. & Lopez, D. (1997) Case-control study of phyto-oestrogens and breast cancer. Lancet 350: 990-994.
3. Pietinen, P., Stumpf, K., Männistö, S., Ktaja, V., Uusitupa, M. & Adlercreutz, H. (2001) Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol. Biomark. Prev. 10: 339-344.
4. McCann, S. E., Moysich, K. B., Freudenheim, J. L., Ambrosone, C. B. & Shields, P. G. (2002) The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women. J. Nutr. 132: 3036-3041.
5. Davies, M. J., Bowey, E. A., Adlercreutz, H., Rowland, I. R. & Rumsby, P. C. (1999) Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane-treated rats. Carcinogenesis 20: 927-931.
6. Mutanen, M., Pajari, A.-M. & Oikarinen, S. I. (2000) Beef induces and rye bran prevents the formation of intestinal polyps in ApcMin mice: relation to β-catenin and PKC isozymes. Carcinogenesis 21: 1167-1173.
7. Vaharanta, M., Voutilainen, S., Lakka, T. A., van der Lee, M., Adlercreutz, H. & Salonen, J. T. (1999) Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet 354: 2112-2115.
8. Saarinen, N. M., Smeds, A., Mäkelä, S. I., Ämmä lä, J., Hakala, K., Pihlava, J.-M., Ryhänen, E.-L., Sjöholm, R. & Santti, R. (2002) Structural determinants of plant lignans for the formation of enterolactone in vivo. J. Chromatogr. B 777: 311-319.
9. Mazur, W. (1998) Phytoestrogen content in foods. Baillieres Clin. Endocrinol. Metab. 12: 729-742.
10. Mazur, W. & Adlercreutz, H. (1998) Natural and anthropogenic environmental oestrogens: the scientific basis for risk assessment. Pure Appl. Chem. 70: 1759-1776.
11. Axelson, M. & Setchell, K.D.R. (1981) The excretion of lignans in rats-evidence for an intestinal bacterial source for this new group of compounds. FEBS Lett. 123: 337-342.
12. Stitch, S. R., Toumba, J. K., Groen, M. B., Funke, C. W., Leemhuis, J., Vink, J. & Woods, G. F. (1980) Excretion, isolation and structure of a phenolic constituent of female urine. Nature (Lond.) 287: 738-740.
13. Nesbitt, P. D., Lam, Y. & Thompson, L. U. (1999) Human metabolism of mammalian lignan precursors in raw and processed flaxseed. Am. J. Clin. Nutr. 69: 549-555.
14. Rowland, I. R., Wiseman, H., Sanders, T.A.B., Adlercreutz, H. & Bowey, E. A. (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet in equol production by the gut microflora. Nutr. Cancer 36: 27-32.
15. Adlercreutz, H. (2002) Phyto-oestrogens and cancer. Lancet 3: 364-373.
16. Kilkkinen, A., Stumpf, K., Pietinen, P., Valsta, L. M., Tapanainen, H. & Adlercreutz, H. (2001) Determinants of serum enterolactone concentration. Am. J. Clin. Nutr. 73: 1094-1100.
17. Horner, N. K., Kristal, A. R., Prunty, J., Skor, H. E., Potter, J. D. & Lampe, J. W. (2002) Dietary determinants of plasma enterolactone. Cancer Epidemiol. Biomark. Prev. 11: 121-126.
18. Overvad, K., Tjønneland, A., Haraldsdóttir, J., Bang, S., Ewertz, M. & Jensen, O. M. (1991) Development of a semiquantitative food frequency questionnaire to assess food, energy and nutrient intake in Denmark. Int. J. Epidemiol. 20: 900-905.
19. Tjønneland, A., Overvad, K., Haraldsdóttir, J., Bang, S., Ewertz, M. & Jensen, O. M. (1991) Validation of a semi-quantitative food frequency questionnaire developed in Denmark. Int. J. Epidemiol. 20: 906-912.
20. Tjønneland, A., Haraldsdóttir, J., Overvad, K., Stripp, C., Ewertz, M. & Jensen, O. M. (1992) Influence of individually estimated portion size data on the validity of a semi-quantitative food frequency questionnaire. Int. J. Epidemiol. 21: 770-777.
21. Haraldsdóttir, J., Tjønneland, A. & Overvad, K. (1994) Validity of individual portion size estimates in a food frequency questionnaire. Int. J. Epidemiol. 23: 786-796.
22. Lauritsen, J. (1998) Foodcalc 1.3 [Online], http://foodcalc.dk [accessed January 4, 2004].
23. Probert, C.S.J., Emmett, P. M. & Heaton, K. W. (1995) Some determinants of whole-gut transit time: a population-based study. Q. J. Med. 88: 311-315.
24. Adlercreutz, H., Wang, G. J., Lapcik, O., Hampl, R., Wähä lä, K., Mäkelä, T., Lusa, K., Talme, M. & Mikola, H. (1998) Time-resolved fluoroimmunoassay for plasma enterolactone. Anal. Biochem. 265: 208-215.
25. Stumpf, K., Uehara, M., Nurmi, T. & Adlercreutz, H. (2000) Changes in the time-resolved fluoroimmunoassay of plasma enterolactone. Anal. Biochem. 284: 153-157.
26. McBurney, M. I. & Thompson, L. U. (1990) Fermentative characteristics of cereal brans and vegetable fibres. Nutr. Cancer 13: 271-280.
27. Kitts, D. D., Yuan, Y. V., Wijewickreme, A. N. & Thompson, L. U. (1999) Antioxidant activity of the flaxseed lignan secoisolariciresinol diglucoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol. Cell. Biochem. 202: 91-100.
28. Prasad, K. (2000) Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone. Int. J. Angiol. 9: 220-25.
29. Niemeyer, H. B. & Metzler, M. (2003) Differences in the antioxidant activity of plant and mammalian lignans. J. Food Eng. 56: 255-256.
30. Geisler, J., Omsjø, I. H., Helle, S. I., Silsand, T. & Lønning, P. E. (1999) Plasma oestrogen fractions in postmenopausal women receiving hormone replacement therapy: influence of route of administration and cigarette smoking. J. Endocrinol. 162: 265-270.
31. Bylund, A., Zhang, J. X., Bergh, A., Damber, J. E., Widmark, A., Johansson, A., Adlercreutz, H., Aman, P., Shepherd, M. J. & Hallmans, G. (2000) Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate 42: 304-314.
32. Hausner, H., Johnsen, N. F., Hallund, J. & Tetens, I. (2004) A single measurement is inadequate to estimate enterolactone levels in Danish postmenopausal women due to large intraindividual variations. J. Nutr. 134: 1197-1200.
33. Kirkman, L. M., Lampe, J. W., Chambell, D. R., Martini, M. C. & Slavin, J. L. (1995) Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutr. Cancer 24: 1-12.
34. Hutchins, A. M., Lampe, J. W., Martini, M. C., Campbell, D. R. & Slavin, J. L. (1995) Vegetables, fruits, and legumes: effect on urinary isoflavonoid phytoestrogen and lignan excretion. J. Am. Diet. Assoc. 95: 769-774.
35. Juntunen, K. S., Mazur, W. M., Liukkonen, K. H., Uehara, M., Poutanen, K. S., Adlercreutz, H.C.T. & Mykkänen, H. M. (2000) Consumption of whole-meal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white bread in healthy Finnish men and women. Br. J. Nutr. 84: 839-846.
36. Hutchins, A. M., Martini, M. C., Olson, B. A., Thomas, W. & Slavin, J. L. (2000) Flaxseed influences urinary lignan excretion in a dose-dependent manner in postmenopausal women. Cancer Epidemiol. Biomark. Prev. 9:1113-1118.
37. Jacobs, D. R., Pereira, M. A., Stumpf, K., Pins, J. J. & Adlercreutz, H. (2002) Whole grain food intake elevates serum enterolactone. Br. J. Nutr. 88: 111-116.
38. McIntosh, G. H., Noakes, M., Royle, P. J. & Foster, P. R. (2003) Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men. Am. J. Clin. Nutr. 77: 967-974.
39. Danish Dietary Habits 2000-2001 (Danish) [Online]. The Danish Veterinary and Food Administration, http://www.foedevaredirektoratet.dk/fdir/publications/ 2002010/rapport.pdf [accessed January 4, 2004].
40. Nutrition Report 2000 (Finnish) [Online]. National Public Health Institute. http://www.ktl.fi/ravitsemus/2000ravi.ik.pdf [accessed January 4, 2004].
41. Thompson, L. U., Rickard, S. E., Cheung, F., Kenaschuk, E. O. & Obermeyer, W. R. (1997) Variability in anticancer lignan levels in flaxseed. Nutr. Cancer 27: 26-30.
42. Heinonen, S., Nurmi, T., Liukkonen, K., Poutanen, K., Wähälä, K., Deyama, T., Nishibe, S. & Adlercreutz, H. (2001) In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. J. Agric. Food Chem. 49: 3178-3186.
43. Medicinal Products Statistics 1998-2002 (Danish) [Online]. Danish Medicines Agency. http://www.produktresume.dk/docushare/dscgi/ds.py/View/ Collection-145 (Table 2.J. 2) [accessed December 16, 2003].