Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis

Journal of Immunology

Volumn 167, Issue 5, 2001, Pages 2791-2797

  Sogabe, H ^a   Nangaku, M ^a   Ishibashi, Y ^a   Wada, T ^a   Fujita, T ^a   Sun, X ^a   Miwa, T ^a   Madaio, M P ^a   Song, W C ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT; DECAY ACCELERATING FACTOR; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; M PROTEIN; NITROGEN; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; HISTOPATHOLOGY; IMMUNE COMPLEX NEPHRITIS; IMMUNOPATHOGENESIS; KIDNEY FUNCTION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; UREA NITROGEN BLOOD LEVEL;

EID: 0035451680     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.5.2791     Document Type: Article

References (56)

1. Physiology and pathophysiology of complement: Progress and trends
2. The regulators of complement activation (RCA) gene cluster
3. Membrane complement regulatory proteins: Insight from animal studies and relevance to human diseases
4. Decay-accelerating factor: Biochemistry, molecular biology, and function
5. Complement regulatory proteins in glomerular diseases
6. The evolution of mouse and human complement C3-binding proteins: Divergence of form but conservation of function
7. Mouse Crry/p65: Characterization of monoclonal antibodies and the tissue distribution of a functional homologue of human MCP and DAF
8. Molecular cloning of the rat complement regulatory protein, 512 antigen
9. A novel membrane glycoprotein capable of inhibiting membrane attack by homologous complement
10. CD59, an Ly-6-like protein expressed in human lymphoid-cells, regulates the action of the complement membrane attack complex on homologous cells
11. Paroxysmal nocturnal hemoglobinuria
12. Affected erythrocytes of patients with paroxysmal nocturnal haemoglobinuria are deficient in the complement regulatory protein decay-accelerating factor
13. Amelioration of lytic abnormalities of paroxysmal nocturnal hemoglobinuria with decay-accelerating factor
14. Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids
15. Expression of decay accelerating factor mRNA and complement C3 mRNA in human diseased kidney
16. Complement activation induces the expression of decay-accelerating factor on human mesangial cells
17. Decay accelerating factor regulates complement activation on glomerular epithelial cells
18. Identification of human erythrocyte blood group antigens on decay-accelerating factor (DAF) and an erythrocyte phenotype negative for DAF
19. Molecular cloning and characterization of decay-accelerating factor deficiency in Cromer blood group Inab phenotype
20. Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria
21. Mouse decay-accelerating factor, selective and tissue-specific induction by estrogen of the gene encoding the glycosylphosphatidyl-inositol-anchored form
22. Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting
23. Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes: Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms
24. Molecular cloning of murine decay-accelerating factor by immunoscreening
25. Characterization of GPI-DAF and TM-DAF expression in wild-type and GPI-DAF gene knockout mice using polyclonal and monoclonal antibodies with dual or single specificity
26. Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): Preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1
27. Molecular cloning of a murine homologue of membrane cofactor protein (CD46): Preferential expression in testicular germ cells
28. Antiglomerular basement membrane nephritis in the mouse: Study on the role of complement in the heterologous phase
29. Experimental glomerulonephritis in mice as a model for immunopharmacological studies
30. Molecular mechanisms of experimental glomerulonephritis: An overview
31. The role of the complement system in renal injury
32. Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice
33. Anti-glomerular basement membrane antibody-induced experimental glomerulonephritis: Evidence for dose-dependent, direct antibody and complement-induced, cell-independent injury
34. Role of leukocytes in metabolic and functional derangements of experimental glomerulonephritis
35. Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor
36. Transgenic mice overexpressing the complement inhibitor City as a soluble protein are protected from antibody-induced glomerular injury
37. Expression of a soluble complement inhibitor protects transgenic mice from antibody-induced acute renal failure
38. Sex-limited protein: In vitro and in vivo functions
39. Knocking out mouse CD59 using a PCR derived gene targeting vector
40. Overexpression of Crry protects mesangial cells from complement-mediated injury
41. Immune complex glomerulonephritis in C4- and C3-deficient mice
42. Development of glomerular lesions in experimental long-term diabetes in the rat
43. Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats
44. Contribution of renal secreted complement C3 to the circulating pool in humans
45. Different mediator systems in biphasic heterologous phase of anti-GBM nephritis in mice
46. Morphology of hDAF (CD55) transgenic pig kidneys following ex-vivo hemoperfusion with human blood
47. Role of CD59 in experimental glomerulonephritis in rats
48. CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats
49. Tubulointerstitial injury induced in rats by a monoclonal antibody that inhibits function of a membrane inhibitor of complement
50. A direct comparison of complement inhibitory capacities of the GPI- and transmembrane forms of mouse DAF to mouse Crry and human rsCR1
51. Anti-GBM nephritis in the mouse: Role of granulocytes in the heterologous phase
52. Complement membrane attack complex (C5b-9) mediates interstitial disease in experimental nephrotic syndrome
53. Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes
54. Resistance of Fc receptor-deficient mice to fatal glomerulonephritis
55. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis