Acetyl-cholinesterase inhibition by extracts and isolated flavones from Linaria reflexa Desf. (Scrophulariaceae)

Natural Product Communications

Volumn 2, Issue 7, 2007, Pages 759-763

  Loizzo, Monica Rosa ^a   Tundis, Rosa ^a   Menichini, Federica ^a   Bonesi, Marco ^a   Statti, Giancarlo Antonio ^a   Deguin, Brigitte ^b   Tillequin, François ^b   Menichini, Francesco ^a   Houghton, Peter J ^c  

^a UNIVERSITY OF CALABRIA   (Italy)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Acetyl cholinesterase (AChE); Ellman's method; Flavones; Linaria reflexa Desf.; Scrophulariaceae

Indexed keywords

EID: 47349091831     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0700200711     Document Type: Article

References (28)

1. Geldmacher DS, Whitehouse PJ. (1997) Differential diagnosis of Alzheimer's disease. Neurology, 48, S2-S9.
2. Selkoe DJ. (1996) Amyloid beta-protein and genetics of Alzheimer's disease. Journal of Biological Chemistry, 27, 18295-18298.
3. Lue LF, Kuo YM, Roher AE. (1999) Soluble amyloid beta peptide concentration as a predictor of synaptic changes in Alzheimer's disease. American Journal of Pathology, 155, 853-862.
4. Francis PT, Palmer AM, Snape M, Wilcock GK. (1999) The cholinergic hypothesis of Alzheimer's disease: A review of progress. Journal of Neurology, Neurosurgery, and Psichiatry, 66, 137-147.
5. Wright CF, Geula C, Mcsulam MM. (1993) Neurological Cholinesterase in the normal brain and in Alzheimer's disease: Relation to plaques, tangles, and patterns of selective vulnerability. Annals of Neurology, 34, 373-384.
6. Davies P, Maloney AJ. (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet, 2, 1457-1459.
7. Weinstock M. (1999) Selectivity of Cholinesterase inhibition: Clinical implication for the treatment of Alzheimer's Disease. CNS Drugs, 12, 303-307.
8. Rubey RN. (2003) The Cholinesterase inhibitors. Journal of Psychiatric Practice, 9, 422-430.
9. Small GW, Rabins PV, Barry PP, Buckholtz NS, DeKosky ST, Ferris SH, Finkel SI, Gwyther LP, Khachaturian ZS, Lebowitz BD, McRae TD, Morris JC, Oakley F, Schneider LS, Streim JE, Sunderland T, Teri LA, Tune LE. (1997) Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. Journal of the American Medical Association, 278, 1363-1371.
10. Houghton PJ, Ren Y, Howes MJ. (2006) Acetylcholinesterase inhibitors from plants and fungi. Natural Product Reports, 23, 181-199.
11. Kim HK, Kim M, Kim S, Kim M, Chung JH. (2004) Effects of green tea polyphenol on cognitive and acetylcholinesterase activities. Bioscience, Biotechnology and Biochemistry, 68, 1977-1979.
12. Oinonen PP, Jokela JK, Hatakka AI, Vuorela PM. (2006) Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis. Fitoterapia, 77, 429-434.
13. Pignatti, S. (1982) Flora D'ltalia; Edagricole (ed): Bologna, Italy, pp 542-543.
14. Ercil D, Sakar MK, Del Olmo E, San Feliciano A. (2004) Chemical constituents of Linaria aucheri. Turkish Journal of Chemistry, 28, 133-139.
15. Tundis R, Deguin B, Loizzo MR, Bonesi M, Statti GA, Tillequin F, Menichini F. (2005) Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. Bioorganic & Medicinal Chemistry Letters, 15, 4757-4760.
16. Ramassamy C. (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. European Journal of Pharmacology, 545, 51-64.
17. Rhee IK, van de Meent M, Ingkaninan K, Verpoorte R. (2001) Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining. Journal of Chromatography A, 915, 217-223.
18. Rhee IK, van Rijn RH, Verpoorte R. (2003) Qualitative determination of false-positive effects in the acetylcholinesterase assay using thin layer chromatography. Phytochemical Analysis, 14, 127-131.
19. Ren Y, Houghton PJ, Hider RCH (2006) Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer's disease. Journal Pharmacy and Pharmacology, 58, 989-996.
20. Heo HJ, Kim MJ, Lee JM, Choi SJ, Cho HY, Hong B, Kim HK, Kim E, Shin DH. (2004) Naringenin from Citrus junos has an inhibitory effect on acetylcholinesterase and a mitigating effect on amnesia. Dementia and Geriatric Cognitive Disorders, 17, 151-157.
21. Hasan A, Khan KM, Sher M, Maharvi GM, Nawaz SA, Choudhary MI, Atta-ur-Rahman, Supuran CT. (2005) Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones. Journal of Enzyme Inhibition and Medicinal Chemistry, 20, 41-47.
22. Clifford MN. (2004) Diet-derived phenols in plasma and tissues and their implications for health. Planta Medico, 70, 1103-1114.
23. Ames BN, Shigenaga MK and Hagen TM. (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences USA, 90, 7915-7922.
24. Benzi, G. and Moretti A. (1995) Are reactive oxygen species involved in Alzheimer's Disease? Neurobiology of Aging, 16, 661-674.
25. Rice-Evans C. (2004) Flavonoids and isoflavones: absorption, metabolism, and bioactivity. Free Radical Biology & Medicine, 36, 827-828.
26. Youdim KA. (2004) Flavonoids and the Brain: interactions at the Blood Brain Barrier and their physiological effects on the central nervous system. Free Radical Biology & Medicine, 37, 1683-1693.
27. Wagner H, Bladt S. (1996) Plant Drug Analysis, Springer, Germany.
28. Perry NS, Houghton PJ, Theobald A, Jenner P, Perry EK. (2000) In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease. Journal of Pharmacy and Pharmacology, 52, 895-902.