Emerging flaviviruses: The spread and resurgence of japanese encephalitis, west nile and dengue viruses

Nature Medicine

Volumn 10, Issue 12S, 2004, Pages S98-S109

  Mackenzie, John S ^a   Gubler, Duane J ^b   Petersen, Lyle R ^c  

^a CURTIN UNIVERSITY   (Australia)

^b Leahi Hospital   (United States)

^c NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; ALPHAN3 INTERFERON; DENGUE VACCINE; DNA VACCINE; IMMUNOGLOBULIN; INACTIVATED VIRUS VACCINE; JAPANESE ENCEPHALITIS VACCINE; LIVE VACCINE; SA 14 14 2 VACCINE; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS VACCINE; WEST NILE VACCINE;

ACTIVE IMMUNIZATION; CLINICAL FEATURE; CLINICAL TRIAL; DENGUE; DENGUE VIRUS; EPIDEMIC; EPIDEMIC ENCEPHALITIS; EPIDEMIOLOGICAL DATA; FINANCIAL MANAGEMENT; GENETIC VARIABILITY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; GOOD MANUFACTURING PRACTICE; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; JAPANESE ENCEPHALITIS VIRUS; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; MOSQUITO; NONHUMAN; PARASITE VECTOR; PRIORITY JOURNAL; PUBLIC HEALTH; REVIEW; VACCINATION REACTION; VACCINE PRODUCTION; VIRAL GENETICS; VIRUS ETIOLOGY; VIRUS INFECTION; VIRUS ISOLATION; VIRUS PATHOGENESIS; VIRUS STRAIN; VIRUS TRANSMISSION; WEST NILE FLAVIVIRUS;

AEDES; ANIMALS; DENGUE; DENGUE VIRUS; ENCEPHALITIS, JAPANESE; FLAVIVIRUS; FLAVIVIRUS INFECTIONS; HUMANS; PHYLOGENY; WEST NILE FEVER; WEST NILE VIRUS; WORLD HEALTH;

AVES; DENGUE VIRUS; DENGUE VIRUS GROUP; FLAVIVIRUS; JAPANESE ENCEPHALITIS VIRUS; MOSQUITO-BORNE VIRUSES; RNA VIRUSES; WEST NILE VIRUS;

EID: 10944252079     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1144     Document Type: Review

References (160)

1. Morse, S.S. Factors in the emergence of infectious diseases. Emerg. Infect. Dis. 1, 7-15 (1995).
2. Heinz, F.X. et al. Family Flaviviridae, in Virus Taxonomy. 7th Report of the International Committee on Taxonomy of Viruses (eds. van Regenmortel, M.H. et al.) 859-878 (Academic, San Diego, 2000).
3. Lindenbach, B.D. & Rice, C.M. Flaviviridae: The viruses and their replication, in Fields Virology 4th edn (eds. Knipe, D.M. & Howley, P.M.) 991-1042 (Lippincott Williams & Wilkins, Philadelphia, 2001).
4. Westaway, E.G. & Blok, J. Taxonomy and evolutionary relationships of flaviviruses, in Dengue and Dengue Hemorrhagic Fever (eds. Gubler, D.J. & Kuno, G.) 147-173 (CAB International, London, 1997).
5. Marin, M.S., Zanotto, P.M., Gritsun, T.S. & Gould, E.A. Phylogeny of TYU, SRE, and CFA virus: Different evolutionary rates in the genus Flavivirus. Virology 206, 1133-1139 (1995).
6. Zanotto, P.M., Gould, E.A., Gao, G.F., Harvey, P.H. & Holmes, E.C. Population dynamics of flaviviruses revealed by molecular phylogenetics. Proc. Natl. Acad. Sci. USA 93, 548-553 (1996).
7. Kuno, G., Chang, G.J., Tsuchiya, K.R., Karabatsos, N. & Cropp, C.B. Phylogeny of the genus Flavivirus. J. Virol. 72, 73-83 (1998).
8. Billoir, F. et al. Phylogeny of the genus Flavivirus using complete coding sequences of arthropod-borne viruses and viruses with no known vector. J. Gen. Virol. 81, 781-790 (2000).
9. Gaunt, M.W. et al. Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography. J. Gen. Virol. 82, 1867-1876 (2001).
10. Gould, E.A., de Lamballerie, X., Zanotto, P.M.A. & Holmes, E.C. Evolution, epidemiology, and dispersal of flaviviruses revealed by molecular phylogenies. Adv. Virus Res. 57, 71-103 (2001).
11. Gould, E.A., de Lamballerie, X., Zanotto, P.M.A & Holmes, E.C. Origins, evolution, and vector/host coadaptations within the genus Flavivirus. Adv. Virus Res. 59, 277-314 (2003).
12. Gould, E.A., Moss, S.R. & Turner, S.L. Evolution and dispersal of encephalitic flavivruses. Arch. Virol. Suppl. 18, 65-84 (2004).
13. Gould, E.A. Evolution of Japanese encephalitis serocomplex viruses. Curr. Top. Microbiol. Immunol. 267, 391-404 (2002).
14. Gritsun, T.S., Lashkevich, V.A. & Gould, E.A. Tick-borne encephalitis. Antiviral Res. 57, 129-146 (2003).
15. Porterfield, J.S. The basis of arbovirus classification. Med. Biol. 53, 400-405 (1975).
16. Calisher, C.A. et al. Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera. J. Gen. Virol. 70, 37-43 (1989).
17. Gubler, D.J. Dengue and dengue haemorrhagic fever: Its history and resurgence as a global public health problem, in Dengue and Dengue Hemorrhagic Fever (eds. Gubler, D.J. & Kuno, G.) 1-22 (CAB International, London, 1997).
18. Gubler, D.J. The global emergence/resurgence of arboviral diseases as public health problems. Arch. Med. Res. 33, 330-342 (2002).
19. Institute of Medicine. Emerging Infections: Microbial Threats to Health in the United States (eds. Lederberg, J., Shope, R.E. & Oaks, S.C.) (National Academy Press, Washington DC, 1992).
20. Institute of Medicine. Microbial Threats to Health in the United States: Emergence, Detection and Response (eds. Smolinski, M.S., Hamburg, M.S. & Lederberg, J.) (National Academy Press, Washington DC, 2003).
21. Mackenzie, J.S., Barrett, A.D.T. & Deubel, V. The Japanese encephalitis serological group of Flaviviruses: A brief introduction to the group. Curr. Top. Microbio. Immunol. 267, 1-10 (2002).
22. Solomon, T. & Vaughn, D.W. Pathogenesis and clinical features of Japanese encephalitis and West Nile virus infections. Curr. Top. Microbiol. Immunol. 267, 171-194 (2002).
23. Burke, D.S. & Leake, C.J. Japanese encephalitis, in The Arboviruses: Epidemiology and Ecology Vol. 3 (ed. Monath, T.P.) 63-92 (CRC, Boca Raton, Florida, 1988).
24. Solomon, T. & Winter, P.M. Neurovirulence and host factors in flavivirus encephali-tis-evidence from clinical epidemiology. Arch. Virol. Suppl. 18, 161-170 (2004).
25. Solomon, T. et al. Poliomyelitis-like illness due to Japanese encephalitis virus. Lancet 351, 1094-1097 (1998).
26. Scherer, W.F. Ecological studies of Japanese encephalitis in Japan. Parts I-IX. Am. J. Trop. Med. Hyg. 8, 644-722 (1959).
27. Buescher, E.L. & Scherer, W.F. Ecological studies of Japanese encephalitis virus in Japan. IX. Epidemiologic correlations and conclusions. Am. J. Trop. Med. Hyg. 8, 719-722 (1959).
28. Innis, B.L. Japanese encephalitis, in Exotic Viral Infections (ed. Porterfield, J. S.) 147-173 (Chapman & Hall, London, 1995).
29. Endy, T.P. & Nislak, A. Japanese encephalitis virus: Ecology and epidemiology. Curr. Top. Microbiol. Immunol. 267, 11-48 (2002).
30. Vaughn, D.W. & Hoke, C.H. The epidemiology of Japanese encephalitis: Prospects for prevention. Epidemiol. Rev. 14, 197-221 (1992).
31. Umenai, T., Krzysko, R., Bektimerov, T.A. & Assaad, F.A. Japanese encephalitis current worldwide status. Bull. WHO 63, 625-631 (1985).
32. Igarashi, A. et al. Detection of West Nile and Japanese encephalitis viral genome sequences in cerebrospinal fluid from acute encephalitis cases in Karachi, Pakistan. Microbiol. Immunol. 38, 827-830 (1994).
33. Prasad, S.R. et al. An epidemic of encephalitis in Haryana: Serologic evidence of Japanese encephalitis in a few patients. Indian J. Pediatr. 30, 905-910 (1993).
34. Dhanda, V. et al. Virus isolation from wild-caught mosquitoes during an encephalitis outbreak in Kerala in 1996. Indian J. Med. Res. 106, 4-6 (1997).
35. Hanna, J.N. et al. An outbreak of Japanese encephalitis in the Torres Strait, Australia, 1995. Med. J. Aust. 165, 256-260 (1996).
36. Ritchie, S.A. et al. Isolation of Japanese encephalitis from Culex annulirostris in Australia. Am. J. Trop. Med. Hyg. 56, 80-84 (1997).
37. Mackenzie, J.S. et al. Emergence of Japanese encephalitis virus in the Australasian region, in Factors in the Emergence of Arbovirus Diseases (eds. Saluzzo, J.F. & Dodet, B.) 191-201 (Elsevier, Paris, 1997).
38. Hanna, J.N. et al. Japanese encephalitis in north Queensland, 1998. Med. J. Aust. 170, 533-536 (1999).
39. Kanamitsu, M. et al. Geographic distribution of arbovirus antibodies in indigenous human populations of the Indo-Australian archipelago. Am. J. Trop. Med. Hyg. 28, 351-363 (1979).
40. Marshall, I.D. Murray Valley and Kunjin encephalitis, in The Arboviruses: Epidemiology and Ecology Vol. 3 (ed. Monath, T.P.) 151-189 (CRC, Boca Raton, Florida, 1988).
41. Chen, W.R., Tesh, R.B. & Rico-Hesse, R. Genetic variation of Japanese encephalitis virus in nature. J. Gen. Virol. 71, 2915-2922 (1990).
42. Chen, W.R., Rico-Hesse, R. & Tesh, R.B. A new genotype of Japanese encephalitis virus from Indonesia. Am. J. Trop. Med. Hyg. 47, 61-69 (1992).
43. Ni, H. & Barrett, A.D.T. Nucleotide and deduced amino acid sequence of the structural protein genes of Japanese encephalitis viruses from different geographic locations. J. Gen. Virol. 76, 401-407 (1995).
44. Paranjpe, S. & Banerjee, K. Phylogenetic analysis of the envelope gene of Japanese encephalitis virus. Virus Res. 42, 107-117 (1996).
45. Williams, D.T., Wang, L.-F., Daniels, P.W. & Mackenzie, J.S. Molecular characterization of the first Australian isolate of Japanese encephalitis virus, the FU strain. J. Gen. Virol. 81, 2471-2480 (2000).
46. Uchil, P.D. & Satchidanandam, V. Phylogenetic analysis of Japanese encephalitis virus: Envelope gene based analysis reveals a fifth genotype, geographic clustering, and multiple introductions of the virus into the Indian subcontinent. Am. J. Trop. Med. Hyg. 65, 242-251 (2001).
47. Tsuchie, H. et al. Genotypes of Japanese encephalitis virus isolated in three states in Malaysia. Am. J. Trop. Med. Hyg. 56, 153-158 (1997).
48. Pyke, A.T. et al. The appearance of a second genotype of Japanese encephalitis virus isolated in the Australasian region. Am. J. Trop. Med. Hyg. 65, 747-753 (2001).
49. Ma, S.-P. et al. Short report: A major genotype of Japanese encephalitis virus currently circulating in Japan. Am. J. Trop. Med. Hyg. 69, 151-154 (2003).
50. Nga, P.T. et al. Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: Implications for frequent introductions of JEV from Southeast Asia to East Asia. J. Gen. Virol. 85, 1625-1631 (2004).
51. Yang, D.K. et al. Molecular characterisation of full-length genome of Japanese encephalitis virus (KV1899) isolated from pigs in Korea. J. Vet. Sci. 5, 197-205 (2004).
52. Twiddy, S.S. & Holmes, E.C. The extent of homologous recombination in members of the genus Flavivirus. J. Gen. Virol. 84, 429-440 (2003).
53. Yun, S.-I. et al. Molecular characterization of the full-length genome of the Japanese encephalitis virus strain K87P39. Virus Res. 96, 129-140 (2003).
54. Tsai, T.F. Factors in the changing epidemiology of Japanese encephalitis and West Nile fever. in Factors in the Emergence of Arbovirus Diseases (eds. Saluzzo, J.F. & Dodet, B.) 179-189 (Elsevier, Paris, 1997).
55. Mackenzie, J.S. et al. Japanese encephalitis as an emerging virus: The emergence and spread of Japanese encephalitis virus in Australasia. Curr. Top. Microbiol. Immunol. 267, 49-73 (2002).
56. Ritchie, S.A. & Rochester, W. Wind-blown mosquitoes and introduction of Japanese encephalitis into Australia. Emerg. Infect. Dis. 7, 900-903 (2001).
57. Mackenzie, J.S., Lindsay, M.D. & Daniels, P.W. The effect of climate on the incidence of vector-borne viral diseases: The potential value of seasonal forecasting, in Applications of Seasonal Climate Forecasting in Agriculture and Natural Ecosystems-The Australian [Experience (eds. Hammer, G., Nicholls, N. & Mitchell, C.) 429-452 (Kluwer Academic Publishers, The Netherlands, 2000).
58. Min, J.-G. & Mei, X. Progress in studies on the overwintering of the mosquito Culex tritaeniorhynchus. Southeast Asian J. Trop. Med. Publ. Hlth. 27, 810-817 (1996).
59. Ming, J.-G. et al. Autumn southward ‘return’ migration of the mosquito Culex tritaeniorhynchus in China. Med. Vet. Entomol. 7, 323-327 (1993).
60. Asahina, S. & Noguchi, K. Long distance flight of Culex tritaeniorynchus. Jpn. J. Sanit. Zool. 19, 110-112 (1968).
61. Innis, B.L. Japanese encephalitis, in Exotic Viral Infections (ed. Porterfield, J.S.) 147-174 (Chapman & Hall, London, 1995).
62. Solomon, T. et al. Origin and evolution of Japanese encephalitis virus in Southeast Asia. J. Virol. 77, 3091-3098 (2003).
63. Monath, T.P. Japanese encephalitis vaccines: Current vaccines and future prospects. Curr. Top. Microbiol. Immunol. 267, 105-138 (2002).
64. Chang, G.J., Kuno, G., Purdy, D.E. & Davis, B.S. Recent advancement in flavivirus vaccine development. Expert Rev. Vaccines 3, 199-220 (2004).
65. Bistra, M.B. et al. Efficacy of a single-dose SA14-14-2 vaccine against Japanese encephalitis: A case control study. Lancet 358, 791-795 (2001).
66. Monath, T.P. et al. Clinical proof of principle for ChimeriVax: Recombinant live, attenuated vaccines against flavivirus infections. Vaccine 20, 1004-1018 (2002).
67. Beasley, D.W.C. et al. Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax-JE experimental vaccine. Vaccine22, 3722-3726 (2004).
68. Smithburn, K.C., Hughes, T.P., Burke, A.W. & Paul, J.H. A neurotropic virus isolated from the blood of a native of Uganda. Am. J. Trop. Med. 20, 471-492 (1940).
69. Petersen, L.R. & Roehrig, J.T. West Nile virus: A reemerging global pathogen. Emerg. Infect. Dis. 7, 611-614 (2001).
70. Murgue, B., Zeller, H. & Deubel, V. The ecology and epidemiology of West Nile virus in Africa, Europe and Asia. Curr. Top. Microbiol. Immunol. 267, 196-221 (2002).
71. Hall, R.A., Broom, A.K., Smith, D.W. & Mackenzie, J.S. The ecology and epidemiology of Kunjin virus. Curr. Top. Microbiol. Immunol. 261, 253-269 (2002).
72. Jia, X.Y. et al. Genetic analysis of the West Nile New York 1999 encephalitis virus. Lancet 354, 1971-1972 (1999).
73. Lanciotti, R.S. et al. Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern US. Science 286, 2333-2337 (1999).
74. Lanciotti, R.S. et al. Complete genome sequences and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe, and the Middle East. Virology 298, 96-105 (2002).
75. Berthet, F.X. et al. Extensive nucleotide changes and deletions within the envelope glycoprotein gene of Euro-African West Nile viruses. J. Gen. Virol. 78, 2293-2297 (1997).
76. Scherret, J.H., Mackenzie, J.S., Hall, R.A., Deubel, V. & Gould, E.A. Phylogeny and molecular epidemiology of West Nile and Kunjin viruses. Curr. Top. Microbiol. Immunol. 267, 373-390 (2002).
77. Burt, F.J. et al. Phylogenetic relationships of southern African West Nile virus isolates. Emerg. Infect. Dis. 8, 820-826 (2002).
78. Lvov, D.K. et al. West Nile virus and other zoonotic viruses in Russia: Examples of emerging and reemerging situations. Arch. Virol. Suppl. 18, 85-96 (2004).
79. Charrel, R.N. et al. Evolutionary relationship between Old World West Nile virus strains. Evidence for viral gene flow between Africa, the Middle East, and Europe. Virology 315, 381-388 (2003).
80. Beasley, D.W. et al. Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype. Virology 296, 17-23 (2002).
81. Komar, N. et al. Experimental infection of North American birds with the New York 1999 strain of West Nile virus. Emerg. Infect. Dis. 9, 311-322 (2003).
82. Malkinson, M. & Banet, C. The role of birds in the ecology of West Nile virus in Europe and Africa. Curr. Top. Microbiol. Immunol. 267, 309-322 (2002).
83. McLean, R.G., Ubico, S.R., Bourne, D. & Komar, N. West Nile virus in livestock and wildlife. Curr. Top. Microbiol. Immunol. 267, 272-308 (2002).
84. Rappole, J.H. et al. Migratory birds and West Nile virus. J. Appl. Microbiol. 94, 47S-58S (2003).
85. Solomon, T. Flavivirus encephalitis. N. Engl. J. Med. 351, 370-378 (2004).
86. Hubalek, Z. & Halouzka, J. West Nile fever-a reemerging mosquito-borne viral disease in Europe. Emerg. Infect. Dis. 5, 643-650 (1999).
87. Lillibridge, K.M. et al. The 2002 introduction of West Nile virus into Harris County, Texas, an area historically endemic for St. Louis encephalitis. Am. J. Trop. Med. Hyg. 70, 676-681 (2004).
88. Iwamoto, M. et al. Transmission of West Nile virus from an organ donor to four transplant recipients. N. Engl. J. Med. 348, 2196-2203 (2003).
89. Pealer, L.N. et al. Transmission of West Nile virus through blood transfusion in the United States in 2002. N. Engl. J. Med. 349, 1236-1245 (2003).
90. Intrauterine West Nile virus infection-New York, 2002. MMWR Morb. Mortal. Wkly. Rep. 51, 1135-1136 (2002).
91. Possible West Nile virus transmission to an infant through breast-feeding- Michigan, 2002. MMWR Morb. Mortal. Wkly. Rep. 51, 877-878 (2002).
92. West Nile virus infection among turkey breeder farm workers-Wisconsin, 2002. MMWRMorb. Mortal. Wkly. Rep. 52, 1017-1019 (2003).
93. Possible dialysis-related West Nile virus transmission-Georgia, 2003. MMWR Morb. Mortal. Wkly. Rep, 53, 738-739 (2004).
94. Petersen, L.R. & Marfin, A.A. West Nile virus: A primer for the clinician. Ann. Intern. Med. 137, 173-179 (2002).
95. Watson, J.T. et al. Clinical characteristics and functional outcomes of West Nile fever. Ann. Intern. Med. 141, 360-365 (2004).
96. Sejvar, J.J. et al. Neurologic manifestations and outcome of West Nile virus infection. J. Am. Med. Assoc. 290, 511-515 (2003).
97. O’Leary, D.R. et al. The epidemic of West Nile virus in the United States, 2002. Vector Borne Zoonotic Dis. 4, 61-70 (2004).
98. Sejvar, J.J. et al. Acute flaccid paralysis and West Nile virus infection. Emerg. Infect. Dis. 9, 788-793 (2003).
99. Guarner, J. et al. Clinicopathologic study and laboratory diagnosis of 23 cases with West Nile virus encephalomyelitis. Hum. Pathol. 35, 983-990 (2004).
100. Southam, C.M. & Moore, A.E. Induced virus infections in man by the Egypt isolates of West Nile virus. Am. J. Trop. Med. Hyg. 3, 19-50 (1954).
101. Kleinschmidt-DeMasters, B.K. et al. Naturally acquired West Nile virus encephalomyelitis in transplant recipients: Clinical, laboratory, diagnostic, and neu- ropathological features. Arch. Neurol. 61, 1210-1220 (2004).
102. Perelygin, A.A. et al. Positional cloning of the murine flavivirus resistance gene. Proc. Natl. Acad. Sci. USA 99, 9322-9327 (2002).
103. Diamond, M.S. et al. B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. J. Virol. 77, 2578-2586 (2003).
104. Wang, T. et al. IFN-y-producing yS T cells help control murine West Nile virus infection. J. Immunol. 171, 2524-2531 (2003).
105. Shrestha, B. & Diamond, M.S. Role of CD8+ T cells in control of West Nile virus infection. J. Virol. 78, 8312-8321 (2004).
106. Gea-Banacloche, J. et al. West Nile virus: Pathogenesis and therapeutic options. Ann. Intern. Med. 140, 545-553 (2004).
107. Solomon, T. et al. Interferon a-2a in Japanese encephalitis: A randomised double- blind placebo-controlled trial. Lancet 361, 821-826 (2003).
108. Granwehr, B.P. et al. West Nile virus: Where are we now? Lancet Infect. Dis. 4, 547-556 (2004).
109. Kimura, R. & Hotta, S. On the inoculation of dengue virus into mice. (In Japanese). Nippon Igaku3379, 629-633 (1944).
110. Sabin, A.B. Research on dengue during World War II. Am. J. Trop. Med. Hyg. 1, 30-50 (1952).
111. Hammon, W.M. et al. New hemorrhagic fevers of children in the Philippines and Thailand. Trans. Assoc. Am. Physicians73, 140-155 (1960).
112. Twiddy, S.S., Holmes, E.C. & Rambaut, A. Inferring the rate and time-scale of dengue virus evolution. Mol. Biol. Evol. 20, 122-129 (2003).
113. Holmes, E.C. & Twiddy, S.S. The origin, emergence and evolutionary genetics of dengue virus. Inf. Genetics Evol. 3, 19-28 (2003).
114. Rico-Hesse, R. Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology 174, 479-493 (1990).
115. Lewis, J.A. et al. Phylogenetic relationships of dengue-2 viruses. Virology 197, 216-224 (1993).
116. Rosen, L. The emperor’s new clothes revisited, a reflection on the pathogenesis of dengue hemorrhagic fever. Am. J. Trop. Med. Hyg. 26, 337-343 (1997).
117. Gubler, D.J., Reed, D., Rosen, L. & Hitchcock, J.D., Jr. Epidemiologic, clinical, and virologic observations on dengue in the Kingdom of Tonga. Am. J. Trop. Med. Hyg. 27, 581-589 (1978).
118. Lanciotti, R.S., Lewis, J.G., Gubler, D.J. & Trent, D.W. Molecular evolution and epidemiology of dengue-3 viruses. J. Gen. Virol. 75, 65-75 (1994).
119. Rico-Hesse, R. et al. Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology 230, 244-251 (1997).
120. Leitmeyer, K.C. et al. Dengue virus structural differences that correlate with patho- genesis. J. Virol. 73, 4738-4747 (1999).
121. Messer, W.B. et al. Emergence and global spread of a dengue serotype 3, subtype III virus. Emerg. Infect. Dis. 9, 800-809 (2003).
122. Gubler, D.J. et al. Virological surveillance for dengue haemorrhagic fever in Indonesia using the mosquito inoculation technique. Bull. WHO 57, 931-936 (1979).
123. Bennett, S.N. et al. Selection-driven evolution of emergent dengue virus. Mol. Biol. Evol. 10, 1650-1658 (2003).
124. Holmes, E.C., Worobey, M. & Rambaut, A. Phylogenetic evidence for recombination in dengue virus. Mol. Biol. Evol. 16, 405-409 (1999).
125. Tolou, H. et al. Evidence for recombination in natural populations of dengue virus type 1 based on the analysis of complete genome sequences. J. Gen. Virol. 82, 1283-1290 (2001).
126. Uzcategui, N.Y. et al. The molecular epidemiology of dengue type 2 virus in Venezuela: Evidence for in situ virus evolution and recombination. J. Gen. Virol. 82, 2945-2953 (2001).
127. Holmes, E.C. & Burch, S.S. The causes and consequences of genetic variation in dengue virus. Trends Microbiol. 8, 74-77 (2000).
128. Gubler, D.J. Dengue and dengue hemorrhagic fever. Clin. Microbiol. Rev. 11, 480-496 (1998).
129. Gubler, D.J. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 10, 100-103 (2002).
130. World Health Organization. Dengue Haemorrhagic Fever, Diagnosis, Treatment, Prevention and Control Edn. 2 (World Health Organization, Geneva, 1997).
131. Kurane, I. & Ennis, F.A. Immunopathogenesis of dengue virus infections, in Dengue and Dengue Hemorrhagic Fever (eds. Gubler, D.J. & Kuno, G.) 273-290 (CAB International, London, 1997)
132. Innis, B.L. Dengue and dengue hemorrhagic fever, in Exotic Viral Infections (ed. Porterfield, J.S.) 103-145 (Chapman & Hall, London, 1995).
133. Kuno, G. Serodiagnosis of flaviviral infections and vaccinations in humans. Adv. Virus Res. 61, 3-65 (2004).
134. Halstead, S.B., Rojanasuphot, S. & Sangkawibha, N. Original antigenic sin in dengue. Am. J. Trop. Med. Hyg. 32, 154-156 (1983).
135. Guzman, M.G. & Kouri, G. Dengue diagnosis, advances and challenges. Int. J. Infect. Dis. 8, 69-80 (2004).
136. Halstead, S.B. The XXth century dengue pandemic: Need for surveillance and research. Rapp. Trimest. Stat. Sanit. Mond. 45, 292-298 (1992).
137. Gubler, D.J. & Clark, G.G. Dengue/dengue hemorrhagic fever: The emergence of a global health problem. Emerg. Infect. Dis. 1, 55-57 (1995).
138. World Health Organization. Strengthening implementation of the global strategy for dengue fever/dengue haemorrhagic fever prevention and control. Report of the Informal Consultation, 18-20 October 1999 (World Health Organization, Geneva, 2000).
139. Gubler, D.J. Aedes aegypti and Aedes aegypti-borne disease control in the 1990s: Top down or bottom up. Am. J. Trop. Med. Hyg. 40, 571-578 (1989).
140. Kinney, R.M. & Huang, C.Y.H. Development of new vaccines against dengue fever and Japanese encephalitis. Intervirology 44, 176-197 (2001).
141. Halstead, S.B. & Deen, J. The future of dengue vaccines. Lancet360, 1243-1245 (2002).
142. Bhamarapravati, N. & Yoksan, S. Live attenuated tetravalent dengue vaccine. Vaccine 18 Suppl. 2, 44-47 (2000).
143. Sun, W. et al. Vaccination of human volunteers with monovalent and tetravalent live-attenuated dengue vaccine candidates. Am. J. Trop. Med. Hyg. 69 Suppl. 6, 24-31 (2003).
144. Whitehead, S.S. et al. A live attenuated dengue virus type 1 vaccine candidate with a 30-nucleotide deletion in the 3’untranslated region is highly attenuated and immuno- genetic in monkeys. J. Virol. 77, 1653-1657 (2003).
145. Guirakhoo, F. et al. Construction, safety and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine. J. Virol. 75, 7290-7304 (2001).
146. Huang, C.Y.H. et al. Chimeric dengue type 2 (vaccine strain PDK-53)/Dengue type 1 virus as a potential candidate Dengue type 1 virus vaccine. J. Virol. 74, 3020-3028 (2000).
147. Whitehead, S.S. et al. Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice and rhesus monkeys. Vaccine 21, 4307-4316 (2003).
148. Konishi, E., Yamaoka, M., Kurane, I. & Mason, P.W. A DNA vaccine expressing dengue type 2 premembrane and envelope genes induces neutralizing antibody and memory B cells in mice. Vaccine 18, 1133-1139 (2000).
149. Men, R. et al. Immunization of rhesus monkeys with a recombinant of modified vaccine virus Ankara expressing a truncated envelope glycoprotein of dengue type 2 virus induced resistance to dengue type 2 virus challenge. Vaccine 18, 3113-3122 (2000).
150. Accelerating the Development and Introduction of a Dengue Vaccine for Poor Children. Hosted by: Children’s Hospital No. 1 and Pasteur Institute of Ho Chi Minh City, December 5-8, 2001 (Ho Chi Minh City, Vietnam, 2001).
151. Lounibos, L.P. Invasions by insect vectors of human disease. Annu. Rev. Entomol. 47, 233-266 (2002).
152. van den Hurk, A.F. et al. Japanese encephalitis on Badu Island, Australia: The first isolation of Japanese encephalitis virus from Culex gelidus in the Australasian region and the role of mosquito host feeding patterns in virus transmission cycles. Trans. R. Soc. Trop. Med. Hyg. 95, 595-600 (2001).
153. Mackenzie, J.S. & Broom, A.K. Old river irrigation area: The effect of dam construction and irrigation on the incidence of Murray Valley encephalitis virus, in Water Resources-Health, Environment and Development (ed. Kay, B.H.) 108-122 (Spon, London, 1998).
154. Weissenbock, H. et al. Emergence of Usutu virus, an African mosquito-borne fla- vivirus of the Japanese encephalitis virus group, central Europe. Emerg. Infect. Dis. 8, 652-656 (2002).
155. Weissenbock, H. et al. Usutu virus activity in Austria, 2001-2002. Microbes Infect. 5, 1132-1136 (2003).
156. Buckley, A. et al. Serological evidence of West Nile virus, Usutu virus and Sindbis virus infection of birds in the UK. J. Gen. Virol. 84, 2807-2817 (2003).
157. Robertson, S.E. et al. Yellow fever. A decade of reemergence. J. Am. Med. Assoc. 276, 1157-1162 (1996).
158. Sanders, E.J. et al. First recorded outbreak of yellow fever in Kenya, 1992-1993. I. Epidemiologic investigations. Am. J. Trop. Med. Hyg. 59, 644-649 (1998).
159. Monath, T.P. Yellow fever: An update. Lancet Infect. Dis. 1, 11-20 (2001).
160. Monath, T.P. Yellow fever, in The Arboviruses: Epidemiology and Ecology Vol. 5 (ed. Monath, T.P.) 139-231 (CRC Press, Boca Raton, 1989).