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Volumn 14, Issue 8, 2008, Pages 927-937

A Simplified Procedure for Hematopoietic Stem Cell Amplification Using a Serum-Free, Feeder Cell-Free Culture System

Author keywords

Fibroblast growth factor; Stem cells; Umbilical cord blood

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CELL CULTURE; CELL FREE SYSTEM; CELL HOMING; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; ENGRAFTMENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROCESS DESIGN; PROCESS DEVELOPMENT; STEM CELL EXPANSION;

EID: 47249129492     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2008.06.002     Document Type: Article
Times cited : (12)

References (48)
  • 1
    • 33846581509 scopus 로고    scopus 로고
    • Umbilical cord blood transplantation for myeloid malignancies
    • Brunstein C.G., Baker K.S., and Wagner J.E. Umbilical cord blood transplantation for myeloid malignancies. Curr Opin Hematol 14 (2007) 162-169
    • (2007) Curr Opin Hematol , vol.14 , pp. 162-169
    • Brunstein, C.G.1    Baker, K.S.2    Wagner, J.E.3
  • 2
    • 0024396816 scopus 로고
    • Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling
    • Gluckman E., Broxmeyer H.A., Auerbach A.D., et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 321 (1989) 1174-1178
    • (1989) N Engl J Med , vol.321 , pp. 1174-1178
    • Gluckman, E.1    Broxmeyer, H.A.2    Auerbach, A.D.3
  • 3
    • 29844452876 scopus 로고    scopus 로고
    • Clinical use of umbilical cord blood hematopoietic stem cells
    • Rocha V., and Gluckman E. Clinical use of umbilical cord blood hematopoietic stem cells. Biol Blood Marrow Transplant 12 Suppl 1 (2006) 34-41
    • (2006) Biol Blood Marrow Transplant , vol.12 , Issue.SUPPL. 1 , pp. 34-41
    • Rocha, V.1    Gluckman, E.2
  • 4
    • 20444398532 scopus 로고    scopus 로고
    • Cord blood immunology and stem cell transplantation
    • Bradley M.B., and Cairo M.S. Cord blood immunology and stem cell transplantation. Hum Immunol 66 (2005) 431-446
    • (2005) Hum Immunol , vol.66 , pp. 431-446
    • Bradley, M.B.1    Cairo, M.S.2
  • 5
    • 33748421928 scopus 로고    scopus 로고
    • Cord blood transplantation for adults
    • Brunstein C.G., and Wagner J.E. Cord blood transplantation for adults. Vox Sang 91 (2006) 195-205
    • (2006) Vox Sang , vol.91 , pp. 195-205
    • Brunstein, C.G.1    Wagner, J.E.2
  • 6
    • 0024415704 scopus 로고
    • Bone marrow donor registries: the relation between registry size and probability of finding complete and partial matches
    • Sonnenberg F.A., Eckman M.H., and Pauker S.G. Bone marrow donor registries: the relation between registry size and probability of finding complete and partial matches. Blood 74 (1989) 2569-2578
    • (1989) Blood , vol.74 , pp. 2569-2578
    • Sonnenberg, F.A.1    Eckman, M.H.2    Pauker, S.G.3
  • 7
    • 0028820426 scopus 로고
    • Impact of racial genetic polymorphism on the probability of finding an HLA-matched donor
    • Beatty P.G., Mori M., and Milford E. Impact of racial genetic polymorphism on the probability of finding an HLA-matched donor. Transplantation 60 (1995) 778-783
    • (1995) Transplantation , vol.60 , pp. 778-783
    • Beatty, P.G.1    Mori, M.2    Milford, E.3
  • 8
    • 47249124764 scopus 로고    scopus 로고
    • Verter. http://parentsguidecordblood.org.
    • Verter. http://parentsguidecordblood.org.
  • 9
    • 0035874535 scopus 로고    scopus 로고
    • Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis
    • Barker J.N., Davies S.M., DeFor T., et al. Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood 97 (2001) 2957-2961
    • (2001) Blood , vol.97 , pp. 2957-2961
    • Barker, J.N.1    Davies, S.M.2    DeFor, T.3
  • 10
    • 34249899377 scopus 로고    scopus 로고
    • Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study
    • Eapen M., Rubinstein P., Zhang M.J., et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 369 (2007) 1947-1954
    • (2007) Lancet , vol.369 , pp. 1947-1954
    • Eapen, M.1    Rubinstein, P.2    Zhang, M.J.3
  • 11
    • 9244256765 scopus 로고    scopus 로고
    • Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    • Laughlin M.J., Eapen M., Rubinstein P., et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 351 (2004) 2265-2275
    • (2004) N Engl J Med , vol.351 , pp. 2265-2275
    • Laughlin, M.J.1    Eapen, M.2    Rubinstein, P.3
  • 12
    • 9244219607 scopus 로고    scopus 로고
    • Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia
    • Rocha V., Labopin M., Sanz G., et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 351 (2004) 2276-2285
    • (2004) N Engl J Med , vol.351 , pp. 2276-2285
    • Rocha, V.1    Labopin, M.2    Sanz, G.3
  • 13
    • 0035874490 scopus 로고    scopus 로고
    • Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
    • Rocha V., Cornish J., Sievers E.L., et al. Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood 97 (2001) 2962-2971
    • (2001) Blood , vol.97 , pp. 2962-2971
    • Rocha, V.1    Cornish, J.2    Sievers, E.L.3
  • 14
    • 0036721158 scopus 로고    scopus 로고
    • Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
    • Wagner J.E., Barker J.N., DeFor T.E., et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 100 (2002) 1611-1618
    • (2002) Blood , vol.100 , pp. 1611-1618
    • Wagner, J.E.1    Barker, J.N.2    DeFor, T.E.3
  • 15
    • 0036284776 scopus 로고    scopus 로고
    • Ex vivo expanded cord blood cells provide rapid engraftment in fetal sheep but lack long-term engrafting potential
    • McNiece I.K., Almeida-Porada G., Shpall E.J., and Zanjani E. Ex vivo expanded cord blood cells provide rapid engraftment in fetal sheep but lack long-term engrafting potential. Exp Hematol 30 (2002) 612-616
    • (2002) Exp Hematol , vol.30 , pp. 612-616
    • McNiece, I.K.1    Almeida-Porada, G.2    Shpall, E.J.3    Zanjani, E.4
  • 17
    • 0030979306 scopus 로고    scopus 로고
    • Potential and distribution of transplanted hematopoietic stem cells in a nonablated mouse model
    • Nilsson S.K., Dooner M.S., Tiarks C.Y., et al. Potential and distribution of transplanted hematopoietic stem cells in a nonablated mouse model. Blood 89 (1997) 4013-4020
    • (1997) Blood , vol.89 , pp. 4013-4020
    • Nilsson, S.K.1    Dooner, M.S.2    Tiarks, C.Y.3
  • 18
    • 0030051967 scopus 로고    scopus 로고
    • Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts
    • Peters S.O., Kittler E.L., Ramshaw H.S., and Quesenberry P.J. Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts. Blood 87 (1996) 30-37
    • (1996) Blood , vol.87 , pp. 30-37
    • Peters, S.O.1    Kittler, E.L.2    Ramshaw, H.S.3    Quesenberry, P.J.4
  • 19
    • 0033152360 scopus 로고    scopus 로고
    • Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells
    • Piacibello W., Sanavio F., Severino A., et al. Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells. Blood 93 (1999) 3736-3749
    • (1999) Blood , vol.93 , pp. 3736-3749
    • Piacibello, W.1    Sanavio, F.2    Severino, A.3
  • 20
    • 32844456680 scopus 로고    scopus 로고
    • Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells
    • Robinson S.N., Ng J., Niu T., et al. Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant 37 (2006) 359-366
    • (2006) Bone Marrow Transplant , vol.37 , pp. 359-366
    • Robinson, S.N.1    Ng, J.2    Niu, T.3
  • 22
    • 34548127716 scopus 로고    scopus 로고
    • Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess
    • Madlambayan G.J., Rogers I., Purpura K.A., et al. Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess. Biol Blood Marrow Transplant 12 (2006) 1020-1030
    • (2006) Biol Blood Marrow Transplant , vol.12 , pp. 1020-1030
    • Madlambayan, G.J.1    Rogers, I.2    Purpura, K.A.3
  • 23
    • 27144518462 scopus 로고    scopus 로고
    • Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells
    • Delaney C., Varnum-Finney B., Aoyama K., et al. Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood 106 (2005) 2693-2699
    • (2005) Blood , vol.106 , pp. 2693-2699
    • Delaney, C.1    Varnum-Finney, B.2    Aoyama, K.3
  • 24
    • 0027185511 scopus 로고
    • Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells
    • Fleming W.H., Alpern E.J., Uchida N., et al. Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. J Cell Biol 122 (1993) 897-902
    • (1993) J Cell Biol , vol.122 , pp. 897-902
    • Fleming, W.H.1    Alpern, E.J.2    Uchida, N.3
  • 25
    • 0030689031 scopus 로고    scopus 로고
    • Synchronized cell-cycle induction of engrafting long-term repopulating stem cells
    • Nilsson S.K., Dooner M.S., and Quesenberry P.J. Synchronized cell-cycle induction of engrafting long-term repopulating stem cells. Blood 90 (1997) 4646-4650
    • (1997) Blood , vol.90 , pp. 4646-4650
    • Nilsson, S.K.1    Dooner, M.S.2    Quesenberry, P.J.3
  • 26
    • 34247487449 scopus 로고    scopus 로고
    • Identification and analysis of in vitro cultured CD45-positive cells capable of multi-lineage differentiation
    • Rogers I., Yamanaka N., Bielecki R., et al. Identification and analysis of in vitro cultured CD45-positive cells capable of multi-lineage differentiation. Exp Cell Res 313 (2007) 1839-1852
    • (2007) Exp Cell Res , vol.313 , pp. 1839-1852
    • Rogers, I.1    Yamanaka, N.2    Bielecki, R.3
  • 27
    • 26244436798 scopus 로고    scopus 로고
    • Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion
    • Madlambayan G.J., Rogers I., Kirouac D.C., et al. Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Exp Hematol 33 (2005) 1229-1239
    • (2005) Exp Hematol , vol.33 , pp. 1229-1239
    • Madlambayan, G.J.1    Rogers, I.2    Kirouac, D.C.3
  • 28
    • 0019468220 scopus 로고
    • Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis
    • Taswell C. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J Immunol 126 (1981) 1614-1619
    • (1981) J Immunol , vol.126 , pp. 1614-1619
    • Taswell, C.1
  • 29
    • 0030916733 scopus 로고    scopus 로고
    • Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay
    • Wang J.C., Doedens M., and Dick J.E. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 89 (1997) 3919-3924
    • (1997) Blood , vol.89 , pp. 3919-3924
    • Wang, J.C.1    Doedens, M.2    Dick, J.E.3
  • 30
    • 4544271598 scopus 로고    scopus 로고
    • Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells
    • McNiece I., Harrington J., Turney J., et al. Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy 6 (2004) 311-317
    • (2004) Cytotherapy , vol.6 , pp. 311-317
    • McNiece, I.1    Harrington, J.2    Turney, J.3
  • 31
    • 33846104293 scopus 로고    scopus 로고
    • Murine embryonic stem cells
    • Nagy A., and Vintersten K. Murine embryonic stem cells. Methods Enzymol 418 (2006) 3-21
    • (2006) Methods Enzymol , vol.418 , pp. 3-21
    • Nagy, A.1    Vintersten, K.2
  • 32
    • 0030788152 scopus 로고    scopus 로고
    • Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture
    • Bhatia M., Bonnet D., Kapp U., et al. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med 186 (1997) 619-624
    • (1997) J Exp Med , vol.186 , pp. 619-624
    • Bhatia, M.1    Bonnet, D.2    Kapp, U.3
  • 33
    • 0028818775 scopus 로고
    • A functional comparison of CD34+ CD38- cells in cord blood and bone marrow
    • Hao Q.L., Shah A.J., Thiemann F.T., et al. A functional comparison of CD34+ CD38- cells in cord blood and bone marrow. Blood 86 (1995) 3745-3753
    • (1995) Blood , vol.86 , pp. 3745-3753
    • Hao, Q.L.1    Shah, A.J.2    Thiemann, F.T.3
  • 34
    • 0031260589 scopus 로고    scopus 로고
    • Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion
    • Iscove N.N., and Nawa K. Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion. Curr Biol 7 (1997) 805-808
    • (1997) Curr Biol , vol.7 , pp. 805-808
    • Iscove, N.N.1    Nawa, K.2
  • 35
    • 0029995686 scopus 로고    scopus 로고
    • Cycle initiation and colony formation in culture by murine marrow cells with long-term reconstituting potential in vivo
    • Trevisan M., Yan X.Q., and Iscove N.N. Cycle initiation and colony formation in culture by murine marrow cells with long-term reconstituting potential in vivo. Blood 88 (1996) 4149-4158
    • (1996) Blood , vol.88 , pp. 4149-4158
    • Trevisan, M.1    Yan, X.Q.2    Iscove, N.N.3
  • 36
    • 0035807964 scopus 로고    scopus 로고
    • Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells
    • Christensen J.L., and Weissman I.L. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci USA 98 (2001) 14541-14546
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14541-14546
    • Christensen, J.L.1    Weissman, I.L.2
  • 37
    • 33845874383 scopus 로고    scopus 로고
    • Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
    • Edling C.E., Pedersen M., Carlsson L., et al. Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation. Br J Haematol 136 (2007) 260-268
    • (2007) Br J Haematol , vol.136 , pp. 260-268
    • Edling, C.E.1    Pedersen, M.2    Carlsson, L.3
  • 38
    • 0027401968 scopus 로고
    • Expansion of hemopoietic activity in long-term culture of human bone marrow by c-kit ligand (stem cell factor)
    • Firkin F., Dunlop J., and Bertoncello I. Expansion of hemopoietic activity in long-term culture of human bone marrow by c-kit ligand (stem cell factor). Growth Factors 8 (1993) 135-140
    • (1993) Growth Factors , vol.8 , pp. 135-140
    • Firkin, F.1    Dunlop, J.2    Bertoncello, I.3
  • 39
    • 33244483382 scopus 로고    scopus 로고
    • Differential regulation of cell growth and gene expression by FGF-2 and FGF-4 in pituitary lactotroph GH4 cells
    • Jackson T.A., Koterwas D.M., and Bradford A.P. Differential regulation of cell growth and gene expression by FGF-2 and FGF-4 in pituitary lactotroph GH4 cells. Mol Cell Endocrinol 247 (2006) 183-191
    • (2006) Mol Cell Endocrinol , vol.247 , pp. 183-191
    • Jackson, T.A.1    Koterwas, D.M.2    Bradford, A.P.3
  • 40
    • 33847224527 scopus 로고    scopus 로고
    • Mechanism of insulin-like growth factor I-mediated proliferation of adult neural progenitor cells: role of Akt
    • Kalluri H.S., Vemuganti R., and Dempsey R.J. Mechanism of insulin-like growth factor I-mediated proliferation of adult neural progenitor cells: role of Akt. Eur J Neurosci 25 (2007) 1041-1048
    • (2007) Eur J Neurosci , vol.25 , pp. 1041-1048
    • Kalluri, H.S.1    Vemuganti, R.2    Dempsey, R.J.3
  • 41
    • 0033179208 scopus 로고    scopus 로고
    • Basic fibroblast growth factor is expressed by CD19/CD11c-positive cells in hairy cell leukemia
    • Gruber G., Schwarzmeier J.D., Shehata M., et al. Basic fibroblast growth factor is expressed by CD19/CD11c-positive cells in hairy cell leukemia. Blood 94 (1999) 1077-1085
    • (1999) Blood , vol.94 , pp. 1077-1085
    • Gruber, G.1    Schwarzmeier, J.D.2    Shehata, M.3
  • 42
    • 0033561090 scopus 로고    scopus 로고
    • Optimal proliferation of a hematopoietic progenitor cell line requires either costimulation with stem cell factor or increase of receptor expression that can be replaced by overexpression of Bcl-2
    • Huang H.M., Li J.C., Hsieh Y.C., et al. Optimal proliferation of a hematopoietic progenitor cell line requires either costimulation with stem cell factor or increase of receptor expression that can be replaced by overexpression of Bcl-2. Blood 93 (1999) 2569-2577
    • (1999) Blood , vol.93 , pp. 2569-2577
    • Huang, H.M.1    Li, J.C.2    Hsieh, Y.C.3
  • 43
    • 33644547703 scopus 로고    scopus 로고
    • An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival
    • Yang W., Klaman L.D., Chen B., et al. An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev Cell 10 (2006) 317-327
    • (2006) Dev Cell , vol.10 , pp. 317-327
    • Yang, W.1    Klaman, L.D.2    Chen, B.3
  • 44
    • 0028859541 scopus 로고
    • Bax-deficient mice with lymphoid hyperplasia and male germ cell death
    • Knudson C.M., Tung K.S., Tourtellotte W.G., et al. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270 (1995) 96-99
    • (1995) Science , vol.270 , pp. 96-99
    • Knudson, C.M.1    Tung, K.S.2    Tourtellotte, W.G.3
  • 45
    • 0032961234 scopus 로고    scopus 로고
    • Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency
    • Perez G.I., Robles R., Knudson C.M., et al. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat Genet 21 (1999) 200-203
    • (1999) Nat Genet , vol.21 , pp. 200-203
    • Perez, G.I.1    Robles, R.2    Knudson, C.M.3
  • 46
    • 0348148880 scopus 로고    scopus 로고
    • Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    • Opferman J.T., Letai A., Beard C., et al. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426 (2003) 671-676
    • (2003) Nature , vol.426 , pp. 671-676
    • Opferman, J.T.1    Letai, A.2    Beard, C.3
  • 47
    • 0033964863 scopus 로고    scopus 로고
    • Expansion of human cord blood CD34 (+) CD38 (-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC phenotype and function
    • Dorrell C., Gan O.I., Pereira D.S., et al. Expansion of human cord blood CD34 (+) CD38 (-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC phenotype and function. Blood 95 1 (2000) 102-110
    • (2000) Blood , vol.95 , Issue.1 , pp. 102-110
    • Dorrell, C.1    Gan, O.I.2    Pereira, D.S.3
  • 48
    • 0035556126 scopus 로고    scopus 로고
    • Human UC-blood banking: impact of blood volume, cell separation and cryopreservation on leukocyte and CD34(+) cell recovery
    • Rogers I., Sutherland, Holt D., et al. Human UC-blood banking: impact of blood volume, cell separation and cryopreservation on leukocyte and CD34(+) cell recovery. Cytotherapy 3 (2001) 269-276
    • (2001) Cytotherapy , vol.3 , pp. 269-276
    • Rogers, I.1    Sutherland2    Holt, D.3


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