Cord blood transplantation for adults

Vox Sanguinis

Volumn 91, Issue 3, 2006, Pages 195-205

  Brunstein, Claudio G ^a,b   Wagner, John E ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Division of Hematology   (United States)

Author keywords

Myeloablative transplantation; Non myeloablative transplantation; Umbilical cord blood

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOIMMUNITY; CHRONIC MYELOID LEUKEMIA; CORD BLOOD STEM CELL TRANSPLANTATION; GRAFT VERSUS HOST REACTION; HLA SYSTEM; HUMAN; INCIDENCE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SAFETY; SURVIVAL; T LYMPHOCYTE;

ADOLESCENT; ADULT; CORD BLOOD STEM CELL TRANSPLANTATION; DIRECTED TISSUE DONATION; GRAFT VS HOST DISEASE; HUMANS; MIDDLE AGED; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 33748421928     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2006.00823.x     Document Type: Review

References (62)

1. Confer DL: The National Marrow Donor Program. Meeting the needs of the medically underserved. Cancer 2001; 91:274-278
2. Anon: A Medical Professional's Guide to Unrelated Hematopoietic Cell Transplantation. Minneapolis, National Marrow Donor Program, 2005
3. Confer DL: Unrelated marrow donor registries. Curr Opin Hematol 1997; 4:408-412
4. Anon: Biennial Report of the National Bone Marrow Donor Registry. Minneapolis, MN, Health Resources and Services Administration, Healthcare System Bureau, Division of Transplantation, National Marrow Donor Program, 2004 (under contract #231-02-007)
5. Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A, Esperou H, Thierry D, Socie G, Lehn P: Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989; 321:1174-1178
6. Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin EC, Ciocci G, Carrier C, Stevens CE, Rubinstein P: Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 1996; 335:157-166
7. Wagner JE, Rosenthal J, Sweetman R, Shu XO, Davies SM, Ramsay NK, McGlave PB, Sender L, Cairo MS: Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood 1996; 88:795-802
8. Michel G, Rocha V, Chevret S, Arcese W, Chan KW, Filipovich A, Takahashi TA, Vowels M, Ortega J, Bordigoni P, Shaw PJ, Yaniv I, Machado A, Pimentel P, Fagioli F, Verdeguer A, Jouet JP, Diez B, Ferreira E, Pasquini R, Rosenthal J, Sievers E, Messina C, Iori AP, Garnier F, Ionescu I, Locatelli F, Gluckman E: Unrelated cord blood transplantation for childhood acute myeloid leukemia: a Eurocord Group analysis. Blood 2003; 102:4290-4297
9. Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C, Goldman A, Kersey J, Krivit W, MacMillan ML, Orchard PJ, Peters C, Weisdorf DJ, Ramsay NK, Davies SM: Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002; 100:1611-1618
10. Rocha V, Wagner JE Jr, Sobocinski KA, Klein JP, Zhang MJ, Horowitz MM, Gluckman E: Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. N Engl J Med 2000; 342:1846-1854
11. Gluckman E, Rocha V, Boyer-Chammard A, Locatelli F, Arcese W, Pasquini R, Ortega J, Souillet G, Ferreira E, Laporte JP, Fernandez M, Chastang C: Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 1997; 337:373-381
12. Rocha V, Cornish J, Sievers EL, Filipovich A, Locatelli F, Peters C, Remberger M, Michel G, Arcese W, Dallorso S, Tiedemann K, Busca A, Chan KW, Kato S, Ortega J, Vowels M, Zander A, Souillet G, Oakill A, Woolfrey A, Pay AL, Green A, Garnier F, Ionescu I, Wernet P, Sirchia G, Rubinstein P, Chevret S, Gluckman E: Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood 2001; 97:2962-2971
13. Grewal SS, Barker JN, Davies SM, Wagner JE: Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood? Blood 2003; 101:4233-4244
14. Barker JN, Krepski TP, DeFor TE, Davies SM, Wagner JE, Weisdorf DJ: Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biol Blood Marrow Transplant 2002; 8:257-260
15. Brunstein CG, Wagner JE: Umbilical cord blood transplantation and banking. Annu Rev Med 2006; 57:403-417
16. Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang MJ, Champlin RE, Stevens C, Barker JN, Gale RP, Lazarus HM, Marks DI, van Rood JJ, Scaradavou A, Horowitz MM: Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004; 351:2265-2275
17. Rubinstein P, Stevens CE: Placental blood for bone marrow replacement: the New York Blood Center's program and clinical results. Bailliere's Best Pract Res Clin Haematol 2000; 13:565-584
18. Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, Gerson SL, Lazarus HM, Cairo M, Stevens CE, Rubinstein P, Kurtzberg J: Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001; 344:1815-1822
19. Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A, Jacobsen N, Ruutu T, de Lima M, Finke J, Frassoni F, Gluckman E: Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004; 351:2276-2285
20. Rocha V, Arcese WGS, Laporte JP, Takahashi TA, Fernandez M, Granena A, Chevret S, Gluckman E: Prognostic factors of outcome after unrelated cord blood transplant (UCBT) in adults with hematologic malignancies. Blood 2000; 96:587a
21. Sanz GF, Saavedra S, Planelles D, Senent L, Cervera J, Barragan E, Jimenez C, Larrea L, Martin G, Martinez J, Jarque I, Moscardo F, Plume G, Andreu R, Regadera AI, Garcia I, Molla S, Solves P, de La Rubia J, Bolufer P, Benlloch L, Soler MA, Marty ML, Sanz MA: Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 2001; 98:2332-2338
22. Long GD, Laughlin M, Madan B, Kurtzberg J, Gasparetto C, Morris A, Rizzieri D, Smith C, Vredenburgh J, Halperin EC, Broadwater G, Niedzwiecki D, Chao NJ: Unrelated umbilical cord blood transplantation in adult patients. Biol Blood Marrow Transplant 2003; 9:772-780
23. Cornetta K, Laughlin M, Carter S, Wall D, Weinthal J, Delaney C, Wagner J, Sweetman R, McCarthy P, Chao N: Umbilical cord blood transplantation in adults: results of the prospective cord blood transplantation (COBLT). Biol Blood Marrow Transplant 2005; 11:149-160
24. Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, Migliaccio AR, Berkowitz RL, Cabbad M, Dobrila NL, Taylor PE, Rosenfield RE, Stevens CE: Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998; 339:1565-1577
25. Barker J, Scaradavou A, Steven CE, Rubinstein A: Analysis of 608 umbilical cord blood (UCB) transplants: HLA-match is a critical determinant of transplant-related mortality (TRM) in the post-engraftment period even in the absence of acute graftvs-host disease (aGVHD). Blood 2005; 106:92a
26. Rocha V, Aversa F, Labopin M, Sanz G, Ciceri F, Arcese W, Bunjes D, Rowe JM, Di Bartolomeo P, Frassoni F, Martelli MF, Gluckman E: Outcomes of unrelated cord blood and haploidentical stem cell transplantation in adults with acute leukaemia. Blood 2005; 106:92a
27. Takahashi S, Ooi J, Tomonari A, Konuma T, Fukuno K, Tsukada N, Monna-Ooiwa M, Yamaguchi T, Tojo A, Asano S: Clinical outcomes of cord blood transplantation from unrelated donors comparable with marrow or blood transplantation from related donors in adults: a single institute analysis. Blood 2005; 106:93a
28. Takahashi S, Iseki T, Ooi J, Tomonari A, Takasugi K, Shimohakamada Y, Yamada T, Uchimaru K, Tojo A, Shirafuji N, Kodo H, Tani K, Takahashi T, Yamaguchi T, Asano S: Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood 2004; 104:3813-3820
29. Barker JN, Weisdorf DJ, Wagner JE: Creation of a double chimera after the transplantation of umbilical-cord blood from two partially matched unrelated donors. N Engl J Med 2001; 344:1870-1871
30. Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, McGlave PB, Miller JS, Verfaillie CM, Wagner JE: Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105:1343-1347
31. Kai S, Misawa M, Iseki T, Takahashi S, Kishi K, Hiraoka A, Kato S, Hara H: Double-unit cord blood transplantation in Japan. Blood 2004; 104:5166a
32. De Lima M, St John LS, Wieder ED, Lee MS, McMannis J, Karandish S, Giralt S, Beran M, Couriel D, Korbling M, Bibawi S, Champlin R, Komanduri KV: Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units. Br J Haematol 2002; 119:773-776
33. Fanning L, Hamza N, Tary-Lehman M, Jorascak J, Koc O, Lazarus H, Cooper B, Gerson S, Rubinstein P, Stevens C, Laughlin M: High rate of graft failure after infusion of multiple (3-5) umbilical cord blood (UCB) units in adults with hematologic disorders. Role of HLA disparity and UCB graft T cell-cross immune reactivation. Blood 2003; 195a
34. Yoo KH, Kang HJ, Lee SH, Jung HL, Sung KW, Koo HH, Shin HY, HSA: Double unit cord blood transplantation in children with acute leukemia. Blood 2005; 106:578a
35. Wiktor-Jedrzejczak W, Rokicka M, Urbanowska E, Torosjan T, Gronkowska A, Graczyk-Pol E, Tomaszewska A, Paluszewska M, Tormanowska M, Krol M, Krol M, Jolkowska J, Witt M: Simultaneous transplantation of three cord blood units in adults with high risk acute leukemia. Blood 2005; 106:451b
36. Brunstein CG, Barker JN, DeFor T, French K, Weisdorf DJ, Wagner JE: Non-myeloabaltive (NMA) umbilical cord blood transplantation (UCBT): promising disease-free survival 95 consecutive patients. Blood 2005; 106:166a
37. Ballen K, Spitzer TR, Yeap B, McAfee S, Dey BR, Attar E, Alyea E, Cutler C, Ho V, Lee S, Soiffer R, Antin JH: Excellent disease-free survival after double cord blood transplantation using a reduced intensity chemotherapy only conditioning regimen in a diverse adult population. Blood 2005; 106:579a
38. Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Miller JS, Wagner JE: Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood 2003; 102:1915-1919
39. Ooi J, Iseki T, Takahashi S, Tomonari A, Takasugi K, Shimohakamada Y, Yamada T, Ishii K, Ohno N, Nagamura F, Uchimaru K, Tojo A, Asano S: Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia. Blood 2004; 103:489-491
40. Verneris MR, Brunstein C, DeFor TE, Barker J, Weisdorf DJ, Blazar BR, Miller JS, Wagner JE: Risk of relapse (REL) after umbilical cord blood transplantation (UCBT) in patients with acute leukemia: marked reduction in recipients of two units. Blood 2005; 106:93a
41. Jaffe ES, Harris NL, Vardiman JW: Tumors of Haematopoietic, Lymphoid Tissues. World Health Organization, Classification of Tumours. Lyon, International Agency for Research on Cancer, 2001
42. Dominietto A, Lamparelli T, Raiola AM, Van Lint MT, Gualandi F, Berisso G, Bregante S, Di Grazia C, Soracco M, Pitto A, Frassoni F, Bacigalupo A: Transplant-related mortality and long-term graft function are significantly influenced by cell dose in patients undergoing allogeneic marrow transplantation. Blood 2002; 100:3930-3934
43. Canals C, Martino R, Sureda A, Altes A, Briones J, Subira M, Ancin I, Martin-Henao G, Brunet S, Sierra J: Strategies to reduce transplant-related mortality after allogeneic stem cell transplantation in elderly patients. Comparison of reduced-intensity conditioning and unmanipulated peripheral blood stem cells vs a myeloablative regimen and CD34+ cell selection. Exp Hematol 2003; 31:1039-1043
44. di Grazia C, Raiola AM, Van Lint MT, Lamparelli T, Gualandi F, Berisso G, Bregante S, Dominietto A, Mordini N, Bruno B, Frassoni F, Bacigalupo A: Conventional hematopoietic stem cell transplants from identical or alternative donors are feasible in recipients relapsing after an autograft. Haematologica 2001; 86:646-651
45. Ringden O, Labopin M, Gorin NC, Meloni G, Blaise D, Reiffers J, Carlson K, Fouillard L, Frassoni F: The dismal outcome in patients with acute leukaemia who relapse after an autograft is improved if a second autograft or a matched allograft is performed. Acute Leukaemia Working Party European Group for Blood Marrow Transplantation (EBMT). Bone Marrow Transplant 2000; 25:1053-1058
46. Radich JP, Gooley T, Sanders JE, Anasetti C, Chauncey T, Appelbaum FR: Second allogeneic transplantation after failure of first autologous transplantation. Biol Blood Marrow Transplant 2000; 6:272-279
47. Storb R, Yu C, Wagner JL, Deeg HJ, Nash RA, Kiem HP, Leisenring W, Shulman H: Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation. Blood 1997; 89:3048-3054
48. Lambert JF, Colvin GA, Zhong S, Wang H, D'Hondt L, Abedi M, Frimberger AE, Stewart FM, Quesenberry PJ: H2-mismatched transplantation with repetitive cell infusions and CD40 ligand antibody infusions without myeloablation. Br J Haematol 2002; 119:155-163
49. Corradini P, Zallio F, Mariotti J, Farina L, Bregni M, Valagussa P, Ciceri F, Bacigalupo A, Dodero A, Lucesole M, Patriarca F, Rambaldi A, Scime R, Locasciulli A, Bandini G, Gianni AM, Tarella C, Olivieri A: Effect of age and previous autologous transplantation on nonrelapse mortality and survival in patients treated with reduced-intensity conditioning and allografting for advanced hematologic malignancies. J Clin Oncol 2005; 23:6690-6698
50. Aoudjhane M, Labopin M, Gorin NC, Shimoni A, Ruutu T, Kolb HJ, Frassoni F, Boiron JM, Yin JL, Finke J, Shouten H, Blaise D, Falda M, Fauser AA, Esteve J, Polge E, Slavin S, Niederwieser D, Nagler A, Rocha V: Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia. a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT). Leukemia 2005; 19:2304-2312
51. Tauro S, Craddock C, Peggs K, Begum G, Mahendra P, Cook G, Marsh J, Milligan D, Goldstone A, Hunter A, Khwaja A, Chopra R, Littlewood T, Peniket A, Parker A, Jackson G, Hale G, Cook M, Russell N, Mackinnon S: Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia. J Clin Oncol 2005; 23:9387-9393
52. Slavin S, Nagler A, Naparstek E: Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 1998; 91:756-763
53. Giralt S, Thall PF, Khouri I, Wang X, Braunschweig I, Ippolitti C, Claxton D, Donato M, Bruton J, Cohen A, Davis M, Andersson BS, Anderlini P, Gajewski J, Kornblau S, Andreeff M, Przepiorka D, Ueno NT, Molldrem J, Champlin R: Melphalan and purine analog-containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation. Blood 2001; 97:631-637
54. Del Toro G, Bradley MB, Satwani P, Morris E, van de Ven C, Cheung Y-K, Yamashiro D, Garvin J, Bhatia M, Roman E, Schwartz J, Militano O, Cooney E, Wolownik K, Hawks R, Foley S, Cairo MS: Reduced intensity (RI) allogeneic cord blood hematopoietic cell transplantation (Allo CBHCT) in pediatric patients with malignant and non-malignant diseases. Blood 2005; 106:479b
55. Koh LP, Chao NJ: Umbilical cord blood transplantation in adults using myeloablative and nonmyeloablative preparative regimens. Biol Blood Marrow Transplant 2004; 10:1-22
56. McSweeney PA, Bearman SI, Jones RB, Nieto Y, Cagnoni PJ, McNiece I, Slat-Vasquez V, Ward W: Nonmyeloblative hematopoietic cell transplants using cord blood. Blood 2001; 98:666a
57. Miyakoshi S, Yuji K, Kami M, Kusumi E, Kishi Y, Kobayashi K, Murashige N, Hamaki T, Kim SW, Ueyama J, Mori S, Morinaga S, Muto Y, Masuo S, Kanemaru M, Hayashi T, Takaue Y, Taniguchi S: Successful engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with advanced hematological diseases. Clin Cancer Res 2004; 10:3586-3592
58. Morii T, Amano I, Tanaka H, Takahashi T, Kimura H: Reduced-intensity unrelated cord blood transplantation (RICBT) in adult patients with high-risk hematological malignancies. Blood 2005; 106:444b
59. Rio B, Belhocine R, Renaud M, François S, Gluckman E, Blaise D, Rocha V: Reduced intensity conditioning regimen for unrelated cord blood transplantation in adults. A Multicentric Phase I-II Trial. Blood 2005; 106:1018a
60. Barker JN, Weisdorf DJ, Defor TE, Brunstein CG, Wagner JE: Umbilical cord blood (UCB) transplantation after non-myeloablative (NMA) conditioning for advanced follicular lymphoma, mantle cell lymphoma and chronic lymphocytic leukemia: low transplant-related mortality and high progression-free survival. Blood 2005; 106:813a
61. Majhail NS, Weisdorf DJ, Wagner JE, Defor TE, Brunstein CG, Burns LJ: Comparable results of umbilical cord blood and HLA matched sibling donor hematopoietic stem cell transplant after reduced-intensity preparative regimen for advanced hodgkin's lymphoma. Blood 2006; 107:3804-3807
62. Brunstein CG, Weisdorf DJ, DeFor T, Tolar J, Wagner JE: Increased risk of Epstein-Barr virus associated lymphoprolipherative disorder (EBV-PTLD) after anti-thymocyte globulin (ATG) non-myeloablative (NMA) conditioning for umbilical cord blood transplantation (UCBT). Blood 2006 (in press)