Undiscovered role of endogenous thromboxane A2 in activation of cardiac sympathetic afferents during ischaemia

Journal of Physiology

Volumn 586, Issue 13, 2008, Pages 3287-3300

  Fu, Liang Wu ^a   Guo, Zhi Ling ^a   Longhurst, John C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; PROTEIN KINASE C; SULOTROBAN; THROMBOXANE A2; THROMBOXANE RECEPTOR; PHOSPHOLIPASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAT; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HEART INNERVATION; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART RIGHT VENTRICLE; IMMUNOHISTOCHEMISTRY; MALE; MECHANICAL STIMULATION; NERVE CONDUCTION; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY; SENSORY NERVE; SPINAL GANGLION; SYMPATHETIC NERVE; TISSUE DISTRIBUTION; ADULT; ANIMAL CELL; ANIMAL TISSUE; HEART NERVE; NERVE CONDUCTION VELOCITY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SENSORY NERVE CELL;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADRENERGIC FIBERS; AFFERENT PATHWAYS; ANIMALS; CATS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART; IMMUNOHISTOCHEMISTRY; MALE; MYOCARDIAL ISCHEMIA; PEPTIDE FRAGMENTS; PROTEIN KINASE C; RECEPTORS, THROMBOXANE; THROMBOXANE A2;

EID: 47249128130     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.148106     Document Type: Article

References (54)

1. Ahlgren SC & Levine JD (1994). Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat. J Neurophysiol 72, 684-692.
2. Aizawa H & Hirose T (1988). A possible mechanism of airway hyperresponsiveness induced by prostaglandin F2 α and thromboxane A2. Prosaglandins Leukot Essent Fatty Acids 33, 185-189.
3. Arita H, Nakano T & Hanasaki K (1989). Thromboxane A2: Its generation and role in platelet activation. Prog Lipid Res 28, 273-301.
4. Baker D, Coleridge H, Coleridge J & Nerdrum T (1980). Search for a cardiac nociceptor: Stimulation by bradykinin of sympathetic afferent nerve endings in the heart of the cat. J Physiol 306, 519-536.
5. Bevan S (1996). Intracellular messengers and signal transduction in nociceptors. In Neurobiology of Nociceptors, ed. Belmonte C & Cervero F, pp. 298-324. OUP, Oxford, New York.
6. Blackman SC, Dawson G, Antonakis K & Le Breton GC (1998). The identification and characterization of oligodendrocyte thromboxane A2 receptors. J Biol Chem 273, 475-483.
7. Borg C, Lim CT, Yeomans DC, Dieter JP, Komiotis D, Anderson EG & Le Breton GC (1994). Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies. J Biol Chem 269, 6109-6116.
8. Carrithers JA, Liu F, Shirer HW & Orr JA (1994). Mechanisms for techypneic response to the thromboxane A2 memetic U-46,619 in rabbits. Am J Physiol Regul Integr Comp Physiol 266, R321-R327.
9. Coleman RA, Smith WL & Narumiya S (1994). International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46, 205-229.
10. Fitzgerald DJ, Roy L, Catella F & Fitzgerald GA (1986). Platelet activation in unstable coronary disease. N Engl J Med 315, 983-989.
11. Folts JD (1994). Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 54, 365-370.
12. Folts JD, Crowell EB Jr & Rowe GG (1976). Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 54, 365-370.
13. Foreman R (1999). Mechanisms of cardiac pain. Annu Rev Physiol 61, 143-167.
14. Fu L-W & Longhurst JC (2002a). Activated platelets contribute to stimulation of cardiac afferents during ischaemia in cats: Role of 5-HT 3 receptors. J Physiol 544, 897-912.
15. Fu L-W & Longhurst JC (2002b). Role of activated platelets in excitation of cardiac afferents during myocardial ischemia in cats. Am J Physiol Heart Circ Physiol 282, H100-H109.
16. Fu L-W & Longhurst JC (2002c). Thromboxane A2 stimulates ischemically sensitive cardiac afferents. FASEB J 16, A830.
17. Fu L-W & Longhurst JC (2005). Interactions between histamine and bradykinin in stimulation of ischaemically sensitive cardiac afferents in felines. J Physiol 565, 1007-1017.
18. Fu L-W, Schunack W & Longhurst JC (2005). Histamine contributes to ischemia-related activation of cardiac spinal afferents: Role of H 1 receptors and PKC. J Neurophysiol 93, 713-722.
19. Furci L, Fitzgerald DJ & Fitzgerald GA (1991). Heterogeneity of prostaglandin H2/thromboxane A2 receptors: Distinct subtypes mediate vascular smooth muscle contraction and platelet aggregation. J Pharmacol Exp Ther 258, 74-81.
20. Gao H, Welch WJ, DiBona GF & Wilcox CS (1997). Sympathetic nervous system and hypertension during prolonged TxA2/PGH2 receptor activation in rats. Am J Physiol Heart Circ Physiol 273, H734-H739.
21. Guo Z-L, Fu L-W, Symons J & Longhurst JC (1998). Signal transduction in activation of ischemically sensitive abdominal visceral afferents: role of PKC. Am J Physiol Heart Circ Physiol 275, H1024-H1031.
22. Guo Z-L, Symons JD & Longhurst JC (1999). Activation of visceral afferents by bradykinin and ischemia: Independent roles of PKC and prostaglandins. Am J Physiol Heart Circ Physiol 276, H1884-H1891.
23. Hirsh P, Hillis L, Campbell W, Firth B & Willerson J (1981). Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. N Engl J Med 304, 685-691.
24. Hsu KS & Han WM (1996). Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice. Br J Pharmacol 118, 2220-2227.
25. 2 synthesis. Eur J Pharmacol 107, 259-262.
26. 2 mimetic, U46,619, on pulmonary vagal afferents in the cat. Respir Physiol 87, 383-396.
27. 2. Brain Res 744, 175-178.
28. Kuo DC, Oravitz JJ & DeGroat WC (1984). Tracing of afferent and efferent pathways in the left inferior cardiac nerve of the cat using retrograde and transganglionic transport of horseradish peroxidase. Brain Res 321, 111-118.
29. Lewy RI, Wiener L, Walinsky P, Lefer AM, Silver MJ & Smith JB (1980). Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature. Circulation 61, 1165-1171.
30. Malliani A (1990). Cardiocardiac excitatory reflexes during myocardial ischemia. Basic Res Cardiol 85, 243-252.
31. Malliani A, Lombardi F & Pagani M (1981). Functions of afferents in cardiovascular sympathetic nerves. J Auton Nerv Syst 3, 231-236.
32. Mehta J, Mehta P, Feldman R & Horalek C (1984 a). Thromboxane release in coronary artery disease: Spontaneous versus pacing-induced angina. Am Heart J 107, 286-292.
33. Mehta J, Nichols WW & Goldman R (1984b). Prostacyclin release following endoperoxide analogue infusion in the intact dog. Am J Physiol Regul Integr Comp Physiol 246, R205-R210.
34. Meller ST & Gebhart GF (1992). A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain. Neuroscience 48, 501-524.
35. 2 receptors in Schwann cells. J Neurochem 78, 446-456.
36. Nichols WW, Mehta JL, Thompson L & Donnelly WH (1988). Synergistic effects of LTC4 and TxA2 on coronary flow and myocardial function. Am J Physiol Heart Circ Physiol 255, H153-H159.
37. Nossaman BD, McMahon TJ, Ragheb MS, Ibrahim IN, Babycos CR, Hood JS & Kadowitz PJ (1992). Blockade of thromboxane/endoperoxide receptor-mediated responses in the pulmonary vascular bed of the cat by sulotroban. Eur J Pharmacol 213, 1-7.
38. oude Egbrink MG, Tangelder GJ, Slaaf DW & Reneman RS (1993). Different roles of prostaglandins in thromboembolic processes in arterioles and venules in vivo. Thromb Haemost 70, 826-833.
39. Pan H-L, Longhurst JC, Eisenach JC & Chen S-R (1999). Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats. J Physiol 518, 857-866.
40. Parratt JR & Cokerm S (1981). The significance of prostaglandin and thromboxane release in acute myocardial ischemia. In Prostaglandins and Thromboxanes: Proceedings of the Third International Symposium on Prostaglandins and Thromboxanes in the Cardiovascular System, ed. Förster W, pp. 21-25. Pergamon Press, New York.
41. Patterson LM, Zheng H, Ward SM & Berhoud H-R (2003). Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract. Cell Tissue Res 311, 277-287.
42. Phan A, Fu L-W & Longhurst JC (2002). Thromboxane A2 contributes to cardiac-cardiovascular presser reflexes during myocardial ischemia. FASEB J 16, A833.
43. Pickar JG (1998). The thromboxane A2 mimetic U-46619 inhibits somatomotor activity via a vagal reflex from the lung. Am J Physiol Regul Integr Comp Physiol 275, R706-R712.
44. Qin C, Chandler M, Miller K & Foreman R (2003). Chemical activation of cardiac receptors affects activity of superficial and deeper T3-T4 spinal neurons in rats. Brain Res 959, 77-85.
45. Shams H & Scheid P (1990). Effects of thromboxane on respiration and pulmonary circulation in the cat: Role of vagus nerve. J Appl Physiol 68, 2042-2046.
46. Stegmeier K, Pill J, Muller-Beckmann B, Schmidt FH, Witte EC, Wolff HP & Patscheke H (1984). The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. Thromb Res 35, 379-395.
47. Sun SY, Wang W & Schultz HD (2001). Activation of cardiac afferents by arachidonic acid: Relative contributions of metabolic pathways. Am J Physiol Heart Circ Physiol 281, H93-H104.
48. Taiwo YO & Levine JD (1991). Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neuroscience 44, 131-135.
49. Tjen-A-Looi SC, Fu L-W & Longhurst JC (2002). Xanthine oxidase, but not neutrophils, contribute to activation of cardiac sympathetic afferents during myocardial ischaemia in cats. J Physiol 543, 327-336.
50. Uchida Y & Murao S (1974). Excitation of afferent cardiac sympathetic nerve fibers during coronary occlusion. Am J Physiol 226, 1094-1099.
51. 2 mimetic evokes a bradycardia mediated by stimulation of cardiac vagal afferent nerves. Am J Physiol Heart Circ Physiol 282, H482-H490.
52. 2 receptor mRNA in rabbit nodose ganglion neurons. Neurosci Lett 386, 121-126.
53. White JC (1957). Cardiac pain: Anatomic pathway and physiologic mechanisms. Circulation 16, 644-655.
54. Zahner MR, Li D-P, Chen S-R & Pan H-L (2003). Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol 551, 515-523.