Xanthine oxidase, but not neutrophils, contributes to activation of cardiac sympathetic afferents during myocardial ischaemia in cats

Journal of Physiology

Volumn 543, Issue 1, 2002, Pages 327-336

  Tjen A Looi, Stephanie C ^a   Fu, Liang Wu ^a   Longhurst, John C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERROUS GLUCONATE; HYDROXYL RADICAL; IRON; OXIPURINOL; POLYCLONAL ANTIBODY; PURINE; REACTIVE OXYGEN METABOLITE; SEROTONIN; SEROTONIN RECEPTOR; TROPISETRON; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR; MYELOPEROXIDASE; SEROTONIN 3 RECEPTOR; ANTIBODY; ENZYME INHIBITOR; INDOLE DERIVATIVE; PEROXIDASE; SEROTONIN ANTAGONIST;

ADRENERGIC STIMULATION; ANGINA PECTORIS; ANIMAL EXPERIMENT; CARDIOVASCULAR REFLEX; CARDIOVASCULAR RESPONSE; CAT; CONTROLLED STUDY; FEMALE; HEART INNERVATION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE; HYPOTHESIS; MALE; NERVE CELL MEMBRANE POTENTIAL; NEUTROPHIL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SENSORY NERVE CELL; SYMPATHETIC INNERVATION; THROMBOCYTE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME INHIBITION; MUSCLE SPINDLE AFFERENT NERVE; NERVE ENDING; NEUTROPHIL COUNT; RABBIT; RECEPTOR BLOCKING; SENSORY NERVE; SEROTONIN RELEASE; THROMBOCYTE COUNT; ACTION POTENTIAL; ADRENERGIC NERVE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HEART MUSCLE; IMMUNOLOGY; LEUKOCYTE COUNT; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; ULTRASTRUCTURE;

ACTION POTENTIALS; ADRENERGIC FIBERS; ANIMAL; ANTIBODIES; CATS; ENZYME INHIBITORS; FEMALE; INDOLES; LEUKOCYTE COUNT; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NEURONS, AFFERENT; NEUTROPHILS; OXYPURINOL; PEROXIDASE; SEROTONIN ANTAGONISTS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; XANTHINE OXIDASE; ANIMALS;

EID: 0037101931     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2001.013482     Document Type: Review

References (61)

1. Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocking agent by inhibition of neutrophil activity without reduction of neutrophil migration
2. Search for a cardiac nociceptor: Stimulation by bradykinin of sympathetic afferent nerve endings in the heart of the cat
3. Nafazatrom-induced salvage of ischemic myocardium in anesthesized dogs is mediated through inhibition of neutrophil function
4. Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils
5. Cardiac prostaglandin release during myocardial ischemia induced by atrial pacing in patients with coronary heart disease
6. Bilateral upper thoracic sympathectomy in angina pectoris: Results in 52 cases
7. Excitation of afferent cardiac sympathetic nerve fibres during myocardial ischaemia
8. Activation of cardiac sympathetic afferents: Effects of exogenous adenosine and adenosine analogues
9. Production of polyclonal antibodies against proteins and peptides
10. Oxygen-free radicals at myocardial level: Effects of ischemia and reperfusion
11. Histopathologic evolution of myocardial infarction
12. C5a-induced myocardial ischaemia: Role for CD 18-dependent PMN localization and PMN-platelet interactions
13. Activation of ischemically sensitive cardiac afferents by serotonin through 5-HT3 receptors
14. Activated platelets stimulate cardiac afferents through a 5-HT receptor mechanism
15. Adenosine activates cardiac sympathetic afferent fibers and potentiates the excitation induced by coronary occlusion
16. Direct measurement of myocardial free radical generation in an in vivo model: Effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase
17. Direct measurement of myocardial free radical generation in an in vivo model: Effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase
18. Action of uric acid, allopurinol and oxypurinol on the myeloperoxidase-derived oxidant hypochlorous acid
19. Role of free radicals and catalytic metal ions in human disease. An overview
20. Changes in hemodynamics and bradykinin concentration in coronary sinus blood in experimental coronary artery occlusion
21. The phlogistic role of C3 leukotactic fragments in myocardial infarcts in rats
22. Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease
23. 2 and hydroxyl radicals
24. Cardiac-cardiovascular reflexes induced by hydrogen peroxide in cats
25. Polysensory response characteristics of dorsal root ganglion neurones that may serve sensory functions during myocardial ischaemia
26. Ventricular sensory neurons in canine dorsal root ganglia: Effects of adenosine and substance P
27. Structure changes in myocardium during acute ischemia
28. Total ischemia in dog hearts, in vitro. 1. Comparison of high energy phosphate production, utilization, and depletion, and of adenine nucleotide catabolism in total ischemia in vitro vs. severe ischemia in vivo
29. Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion
30. Changes in bradykinin level in coronary sinus blood after the experimental occlusion of a coronary artery
31. Characterization of free radical generation by xanthine oxidase. Evidence for hydroxyl radical generation
32. Increased concentration of leukotriene B4 but not thromboxane B2 in intestinal lymph of cats during brief ischemia
33. Both neutrophils (PMNs) and xanthine oxidase (XO) contribute to activation of cardiac sympathetic afferents in cats
34. Complement localization in ischemic baboon myocardium
35. Spinal sympathetic cardio-cardiac reflexes
36. The speed of healing myocardial infarction: A study of the pathologic anatomy in seventy-two cases
37. A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain
38. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
39. Cardiac chemical reflex control of preload in conscious dogs
40. Circulatory responses to stimulation of medullated and non-medullated afferents in the cardiac nerve in the cat
41. Hydroxyl radical production during myocardial ischemia and reperfusion in cats
42. Analysis of the pressor sympathetic reflex produced by intracoronary injections of bradykinin in conscious dogs
43. Cardiac nociceptors and ischemia: Role of sympathetic afferents in cat
44. Anterior transthoracic upper dorsal sympathectomy
45. Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats
46. Lack of a role of adenosine in activation of ischermically sensitive cardiac sympathetic afferents
47. Xanthine oxidase: Biochemistry, distribution and physiology
48. Pressor reflexes produced by stimulation of afferent fibers in the cardiac sympathetic nerves of the cat
49. Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose
50. Reduction ofthe extent of ischemic myocardial injury by neutrophil depletion in the dog
51. Selective accumulation of the first component of complement and leukocytes in ischemic canine heart muscle: A possible initiator of an extra myocardial mechanism of ischemic injury
52. Free radicals and myocardial ischemia and reperfusion injury
53. An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by Prostaglandins and myocardial ischemia
54. Reflex sympathoexcitation by cardiac sympathetic afferents during myocardial ischemia. Role ofadenosine
55. Evaluation of the role of xanthine oxidase in myocardial reperfusion injury
56. Interactions between cardiac sympathetic and cardiac vagal afferents in the nucleus tractus solitarius
57. Endogenous bradykinin activates ischemically sensitive cardiac visceral afferents through kinin B2-receptors
58. Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia
59. In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury
60. Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart
61. Measurement and characterization of free radical generation in reoxygenated human endothelial cells