The thromboxane A2 mimetic U-46619 inhibits somatomotor activity via a vagal reflex from the lung

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 275, Issue 3 44-3, 1998, Pages

  Pickar, Joel G ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Vagus nerve; Viscerosomatic reflex

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; THROMBOXANE RECEPTOR STIMULATING AGENT; THROMBOXANE A2;

ANIMAL EXPERIMENT; AORTA; ARTICLE; CAT; CONTROLLED STUDY; HEART RIGHT ATRIUM; ILLNESS BEHAVIOR; KNEE; MOTOR ACTIVITY; NONHUMAN; PERICARDIUM; PRIORITY JOURNAL; TENDON REFLEX; VAGOTOMY; VAGUS NERVE; VAGUS REFLEX; ANIMAL; BLOOD PRESSURE; DRUG EFFECT; INNERVATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG; PHYSIOLOGY; REFLEX;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; BLOOD PRESSURE; CATS; INJECTIONS, INTRAVENOUS; KNEE; LUNG; MOTOR ACTIVITY; REFLEX; THROMBOXANE A2; VAGOTOMY; VAGUS NERVE;

EID: 0031711384     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.275.3.r706     Document Type: Article

References (15)

1. Bell, L. B., K. P. O'Hagan, and P. S. Clifford. Cardiac but not pulmonary receptors mediate depressor response to IV phenyl biguanide in conscious rabbits. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R1050-R1057, 1993.
2. Bluthe, R., V. Walter, P. Parnet, S. Laye, J. Lestage, D. Verrier, S. Poole, B. E. Stenning, K. W. Kelley, and R. Dantzer. Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C. R. Acad. Sci. III 317: 499-503, 1994.
3. Brigham, K. L., and B. Meyrick. Endotoxin and lung injury. Am. Rev. Respir. Dis. 133: 913-927, 1986.
4. 2 mimetic U-46619 induces systemic and pulmonary hypertension and delayed tachypnea in the goat. J. Appl. Physiol. 77: 1466-1473, 1994.
5. 2 mimetic U-46619 in rabbits. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R321-R327, 1994.
6. Coast, J. R., G. S. Thompson, Jr., and S. S. Cassidy. Inhibition of skeletal muscle activity by lung expansion in the dog. J. Appl. Physiol. 62: 2058-2065, 1987.
7. 2 on some isolated smooth muscle preparations. Br. J. Pharmacol. 73: 773-778, 1981.
8. Coleridge, H. M., J. C. G. Coleridge, and F. Rosenthal. Prolonged inactivation of cortical pyramidal tract neurones in cats by distension of the carotid sinus. J. Physiol. (Lond.) 256: 635-649, 1976.
9. Coleridge, J. C. G., and H. M. Coleridge. Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99: 1-110, 1984.
10. Dawes, G. S., and J. H. Comroe, Jr. Chemoreflexes from the heart and lungs. Physiol. Rev. 34: 167-201, 1954.
11. Deshpande, S. S., and M. S. Devanadan. Reflex inhibition of monosynaptic reflexes by stimulation of type J pulmonary endings. J. Physiol. (Lond.) 206: 345-357, 1970.
12. DiCarlo, S. E., H. L. Collins, and C.-Y. Chen. Vagal afferents reflexly inhibit exercise in conscious rats. Med. Sci. Sports Exerc. 26: 459-462, 1994.
13. Ginzel, K. H. Muscle relaxation by drugs which stimulate sensory nerve endings. I. The effect of veratrum alkaloids, phenyldiguanide and 5-hydroxytryptamine. Neuropharmacology 12: 133-148, 1973.
14. Ginzel, K. H. The importance of sensory nerve endings as sites of drug action. Naunyn Schmiedebergs Arch. Pharmacol. 288: 29-56, 1975.
15. Ginzel, K. H., and E. Eldred. Relief of decerebrate rigidity by viscero-somatic reflex action. Proc. West. Pharmacol. Soc. 12: 41-44, 1969.