Synovial MMP-3 and TIMP-1 levels and their correlation with cytokine expression in canine rheumatoid arthritis

Veterinary Immunology and Immunopathology

Volumn 91, Issue 3-4, 2003, Pages 199-204

  Hegemann, Nina ^a   Wondimu, Assefa ^a   Ullrich, Kirsten ^a   Schmidt, Michael F G ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Canine; Cytokines; Marker; MMP 3; Rheumatoid arthritis; TIMP 1

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 6; MESSENGER RNA; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTHROPATHY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOG DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; KNEE CRUCIATE LIGAMENT; LIGAMENT RUPTURE; MALE; NONHUMAN; OSTEOARTHRITIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RNA ANALYSIS; SYNOVIAL FLUID;

ANIMALS; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CYTOKINES; DOG DISEASES; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; MALE; MATRIX METALLOPROTEINASE 3; RNA, MESSENGER; SYNOVIAL FLUID; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

CANIS FAMILIARIS;

EID: 0037429189     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(03)00005-9     Document Type: Article

References (15)

1. Carter S.D., Barnes A., Gilmore W.H. Canine rheumatoid arthritis and inflammatory cytokines. Vet. Immunol. Immunopathol. 69:1999;201-214.
2. Cook J.L., Anderson C.C., Kreeger J.M., Tomlinson J.L. Effects of human recombinant interleukin-1beta on canine articular chondrocytes in three-dimensional culture. Am. J. Vet. Res. 61:2000;766-770.
3. Gunther M., Haubeck H.D., van de Leur E., Blaser J., Bender S., Gutgemann I., Fischer D.C., Tschesche H., Greiling H., Heinrich P.C. Transforming growth factor beta 1 regulates tissue inhibitor of metalloproteinases-1 expression in differentiated human articular chondrocytes. Arthritis Rheum. 37(3):1994;395-405.
4. Hegemann N., Kohn B., Brunnberg L., Schmidt M.F.G. Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders. Osteoarthritis Cartilage. 10(9):2002;714-721.
5. MacNaul K.L., Chartrain N., Lark M., Tocci M.J., Hutchinson N.I. Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression. J. Biol. Chem. 265(28):1990;17238-17245.
6. Martel-Pelletier J., McCollum R., Fujimoto N., Obata K., Cloutier J.M., Pelletier J.P. Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. Lab. Invest. 70(6):1994;807-815.
7. Martel-Pelletier J., Welsch D.J., Pelletier J.P. Metalloproteases and inhibitors in arthritic diseases. Best. Pract. Res. Clin. Rheumatol. 15(5):2001;805-829.
8. Nash M.A., Lenzi R., Platsoucas C.D., Freedman R.S. RT-PCR quantitation of cytokine responses in vivo from specimens containing small numbers of cells during bioimmunotherapy. J. Immunol. Meth. 219:1998;169-179.
9. Peeva E., Fishman A.D., Goddard G., Wadler S., Barland P. Rheumatoid arthritis exacerbation caused by exogenous interleukin-12. Arthritis Rheum. 43(2):2000;461-463.
10. Person J.M., Quintin-Colonna F., Boulois H.J. Les poly-arthrites immunologiques du chien: Bilan de 2436 examenes serologiques effectues par le laboratoire d'immunopathologie de l'Ecole Nationale Veterinaire d'Alfort entre 1978 et 1986. Recl. Med. Vet. Ec. Alfort. 167:1991;1141-1149.
11. Ribbens C., Andre B., Kaye O., Kaiser M.J., Bonnet V., Jasper J.M., de Grote D., Franchimont N., Malaise M.G. Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not. Rheumatology. 29:2000;1357-1365.
12. Rottman J.B., Tompkins W.A., Tompkins M.B. A reverse transcription-quantitative competitive polymerase chain reaction (RT-qcPCR) technique to measure cytokine gene expression in domestic mammals. Vet. Pathol. 33:1996;242-248.
13. Tamura T., Kosaka N., Ishiwa J., Sato T., Nagase H., Ito A. Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. Osteoarthritis Cartilage. 9:2001;257-263.
14. van Beuningen H.M., Glansbeek H.L., van der Kraan P.M., van den Berg W.B. Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections. Osteoarthritis Cartilage. 8:2000;25-33.
15. Vervoordeldonk M.J., Tak P.P. Cytokines in rheumatoid arthritis. Curr. Rheumatol. Rep. 4(3):2002;208-217.