Cytokine profile in canine immune-mediated polyarthritis and osteoarthritis

Veterinary and Comparative Orthopaedics and Traumatology

Volumn 18, Issue 2, 2005, Pages 67-72

  Hegemann, N ^c   Wondimu, A ^b   Kohn, B ^c   Brunnberg, L ^c   Schmidt, M F G ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b WISTAR INSTITUTE   (United States)

^c NONE

Author keywords

Cytokine profile; Dog; Immune mediated polyarthritis; Osteoarthritis

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIOASSAY; BLOOD; COMPARATIVE STUDY; CYTOTOXICITY TEST; DOG; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE THERAPY; IMMUNE SYSTEM; KNEE CRUCIATE LIGAMENT; LIGAMENT RUPTURE; LYMPHOCYTE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; POLYARTHRITIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIAL FLUID; TH2 CELL; ANIMAL; ANIMAL DISEASE; ANTERIOR CRUCIATE LIGAMENT; ARTHRITIS; BIOSYNTHESIS; DOG DISEASE; GENE EXPRESSION; IMMUNOLOGY; LYMPHOCYTE COUNT; METABOLISM; METHODOLOGY; RUPTURE;

CANIS FAMILIARIS;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; ARTHRITIS; CYTOKINES; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION; LYMPHOCYTE COUNT; MALE; OSTEOARTHRITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RUPTURE, SPONTANEOUS; SYNOVIAL FLUID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 20444437670     PISSN: 09320814     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1632931     Document Type: Article

References (26)

1. Bennett D. Immune based erosive inflammatory joint disease of the dog. Canine rheumatoid arthritis. J Small Anim Pract 1987; 28: 799-820.
2. Berner B, Akca D, Jung T et al. Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry. J Rheumatol 2000; 27: 1128-35.
3. Brunnberg L. Diagnosing lameness in dogs. Oxford: Blackwell Science 2001.
4. Cameron M, Buchgraber A, Passler H et al. The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations. Am J Sports Med 1997; 25: 751-4.
5. Carter SD, Bell SC, Bari AS et al. Immune complexes and rheumatoid factors in canine arthritides. Ann Rheum Dis 1989; 48: 986-91.
6. Carter SD, Barnes A, Gilmore WH. Canine rheumatoid arthritis and inflammatory cytokines. Vet Immunol Immunopathol 1999; 69: 201-14.
7. Feldmann M. Development of anti-TNF-α therapy of rheumatoid arthritis. Nat Rev Immunol 2002; 2: 364-71.
8. Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002; 39: 237-46.
9. Galloway RH, Lester SJ. Histopathological evaluation of canine stifle joint synovial membrane collected at the time of repair of cranial cruciate ligament rupture. J Am Anim Hosp Assoc 1995; 31: 289-94.
10. Gerli R, Lunardi C, Pizalis C. Unmasking the antiinflammatory cytokine response in rheumatoid synovitis. Rheumatol 2002; 41: 1341-5.
11. Goldring SR. Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology. 2003; 42 (S2): 11-6.
12. Gracie JA, Forsey RJ, Chan WL et al. A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 1999; 104: 1393-401.
13. Hay CW, Chu Q, Budsberg SC et al. Synovial fluid interleukin 6, tumor necrosis factor, and nitric oxide values in dogs with osteoarthritis secondary to cranial cruciate ligament rupture. Am J Vet Res 1997; 58: 1027-32.
14. Hewicker-Trautwein M, Carter SD, Bennett D et al. Immunocytochemical demonstration of lymphocyte subsets and MHC class II antigen expression in synovial membranes from dogs with rheumatoid arthritis and degenerative joint disease. Vet Immunol Immunopathol 1999; 67: 341-57.
15. Kohn B, Garner M, Lübke S et al. Polyarthritis following vaccination in four dogs. Vet Comp Orthop Traumatol 2003; 16: 6-10.
16. Kohn B. Canine immune-mediated polyarthritis. In: Proceedings. WSAVA, Bangkok, 2003; 440-3.
17. May C, Hughes DE, Carter SD et al. Lymphocyte populations in the synovial membranes of dogs with rheumatoid arthritis. Vet Immunol Immunopathol 1992; 31: 289-300.
18. Nash MA, Lenzi R, Platsoucas CD et al. RT-PCR quantitation of cytokine responses in vivo from specimens containing small numbers of cells during bioimmunotherapy. J Immunol Methods 1998; 219: 169-79.
19. Rottman JB, Tompkins WA, Tompkins MB. A reverse transcription- quantitative competitive polymerase chain reaction (RT-qcPCR) technique to measure cytokine gene expression in domestic mammals. Vet Pathol 1996; 33: 242-8.
20. Schumacher HR, Newton C, Halliwell RE. Synovial pathologic changes in spontaneous canine rheumatoid-like arthritis. Arthritis Rheum 1980; 23: 412-23.
21. St Clair EW. Interleukin-10: therapeutic prospects in rheumatoid arthritis. Curr Dir Autoimmun 2000; 2: 126-49.
22. Van den Berg WB. Arguments for interleukin 1 as a target in chronic arthritis. Ann Rheum Dis 2000; 59 (S1): 81-4
23. Van den Berg WB. Anti-cytokine therapy in chronic destructive arthritis. Arthritis Res 2001; 3(1): 18-26.
24. Venn G, Nietfeld JJ, Duits AJ et al. Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis. Arthritis Rheum 1993; 36(6): 819-26.
25. Vervoordeldonk MJ, Tak PP. Cytokines in rheumatoid arthritis. Curr Rheumatol Rep 2002; 4(3): 208-17.
26. Yuan GH, Masuko-Hongo K, Kato T et al. Immunologic intervention in the pathogenesis of osteoarthritis. Arthritis Rheum2003; 48(3): 602-11.