Variation in Galr1 expression determines susceptibility to excitotoxin-induced cell death in mice

Genes, Brain and Behavior

Volumn 7, Issue 5, 2008, Pages 587-598

  Kong, S ^a   Lorenzana, A ^a   Deng, Q ^a   McNeill, T H ^a   Schauwecker, P E ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

C57BL 6J; Candidate genes; Cell death; Congenic mice; FVB NJ; Hippocampus; Quantitative trait locus; Seizure

Indexed keywords

EXCITOTOXIN;

ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOMICS; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ANIMALS; BASE SEQUENCE; CELL DEATH; EPILEPSY; EXCITATORY AMINO ACID AGONISTS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOMICS; HAPLOTYPES; HIPPOCAMPUS; KAINIC ACID; MALE; MICE; MICE, CONGENIC; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; NERVE TISSUE PROTEINS; NEUROTOXINS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, GALANIN, TYPE 1; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS;

MUS;

EID: 47249101505     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2008.00395.x     Document Type: Article

References (47)

1. Ben-Ari, Y. (1990) Galanin and glibenclamide modulate the anoxic release of glutamate in rat CA3 hippocampal neurons. Eur J Neurosci 2, 62 68.
2. Ben-Ari, Y., Tremblay, E., Berger, M. Nitecka, L. (1984) Kainic acid seizure syndrome and binding sites in developing rats. Brain Res 316, 284 288.
3. Bose, R. Wrana, J.L. (2006) Regulation of Par6 by extracellular signals. Curr Opin Cell Biol 18, 206 212.
4. Dieffenbach, C.W., Lowe, T.M. Dveksler, G.S. (1993) General concepts for PCR primer design. PCR Methods Appl 3, S30 37.
5. Donarum, E.A., Stephan, D.A., Larkin, K., Murphy, E.J., Gupta, M., Senepharnsiri, H., Switzer, R.C., Pearl, P.L., Snead, O.C., Jakobs, C. Gibson, K.M. (2006) Expression profiling reveals multiple myelin alterations in murine succinate semialdehyde dehydrogenase deficiency. J Inherit Metab Dis 29, 143 156.
6. Franklin, K.B.J. Paxinos, G. (1997) The Mouse Brain in Stereotaxic Coordinates. Academic Press, New York.
7. Fujikawa, D.G. (1995) Neuroprotective effect of ketamine administered after status epilepticus onset. Epilepsia 36, 186 195.
8. Fujikawa, D.G. (1996) The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus. Brain Res 725, 11 12.
9. Fujikawa, D.G., Daniels, A.H. Kim, J.S. (1994) The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. Epilepsy Res 17, 207 219.
10. Haberman, R.P., Samulski, R.J. McCown, T.J. (2003) Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression. Nat Med 9, 1076 1080.
11. Jacoby, A.S., Hort, Y.J., Constantinescu, G., Shine, J. Iismaa, T.P. (2002) Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity. Mol Brain Res 107, 195 200.
12. Lorenzana, A., Chancer, Z. Schauwecker, P.E. (2007) A QTL on chromosome 18 is a critical determinant of excitotoxic cell death susceptibility. Eur J Neurosci 25, 1998 2008.
13. Mathis, C., Hindelang, C., LeMeur, M. Borrelli, E. (2000) A transgenic mouse model for inducible and reversible dysmyelination. J Neurosci 20, 7698 7705.
14. Mathisen, P.M., Pease, S., Garvey, J., Hood, L. Readhead, C. (1993) Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. Proc Natl Acad Sci U S A 90, 10125 10129.
15. Mazarati, A. Lu, X. (2005) Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors. Neuropeptides 39, 277 280.
16. Mazarati, A.M., Hohmann, J.G., Bacon, A., Liu, H., Sankar, R., Steiner, R.A., Wynick, D. Wasterlain, C.G. (2000) Modulation of hippocampal excitability and seizures by galanin. J Neurosci 20, 6276 6281.
17. Mazarati, A., Lu, X., Shinmei, S., Badie-Mahdavi, H. Bartfai, T. (2004) Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GALR1) knockout mice. Neuroscience 128, 431 441.
18. Mazarati, A., Lundström, O., Sollenberg, U., Shin, D., Langel, Ü. Sankar, R. (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J Pharm Exp Ther 318, 700 708.
19. McColl, C.D., Jacoby, A.S., Shine, J., Iismaa, T.P. Bekkers, J.M. (2006) Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus. Neuropharmacology 50, 209 218.
20. McKhann, G.M., Wenzel, H.J., Robbins, C.A., Sosunov, A.A. Schwartzkroin, P.A. (2003) Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology. Neuroscience 122, 551 561.
21. McLin, J.P. Steward, O. (2006) Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains. Eur J Neurosci 24, 2191 2202.
22. Minakuchi, M., Kakazu, N., Gorrin-Rivas, M.J., Abe, T., Copeland, T.D., Ueda, K. Adachi, Y. (2001) Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET. Eur J Biochem 268, 1340 1351.
23. Nadler, J.V. Cuthbertson, G.J. (1980) Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways. Brain Res 195, 47 56.
24. Nadler, J.V. Evenson, D.A. (1983) Use of excitatory amino acids to make axon-sparing lesions of hypothalamus. Methods Enzymol 103, 393 400.
25. Nadler, J.V., Perry, B.W., Gentry, C. Cotman, C.W. (1980) Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J Comp Neurol 192, 333 359.
26. Notredame, C., Higgins, D.G. Heringa, J. (2000) T-Coffee: a novel method for fast and accurate multiple sequence alignment. J Mol Biol 302, 205 217.
27. Noveroske, J.K., Hardy, R., Dapper, J.D., Vogel, H. Justice, M.J. (2005) A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination. Mamm Genome 16, 672 682.
28. Ohgane, J., Wakayama, T., Senda, S., Yamazaki, Y., Inoue, K., Ogura, A., Marh, J., Tanaka, S., Yanagimachi, R. Shiota, K. (2004) The Sall3 locus is an epigenetic hotspot of aberrant DNA methylation associated with placentomegaly of cloned mice. Genes Cells 9, 253 260.
29. Parrish, M., Ott, T., Lance-Jones, C., Schuetz, G., Schwaeger-Nickolenko, A. Monaghan, A.P. (2004) Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality. Mol Cell Biol 24, 7102 7112.
30. Racine, R.J. (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32, 281 294.
31. Rozen, S. Skaletsky, H. (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132, 365 386.
32. Sato, K., Suematsu, A., Nakashima, T., Takemoto-Kumura, S., Aoki, K., Morishita, Y., Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., Kodama, T., Chatila, T.A., Bito, H. Takayanagi, H. (2007) Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med 12, 1410 1416.
33. Schauwecker, P.E. (2003) Genetic basis of kainate-induced excitotoxicity in mice: phenotypic modulation of seizure-induced cell death. Epilepsy Res 55, 201 210.
34. Schauwecker, P.E. Steward, O. (1997) Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc Natl Acad Sci U S A 94, 4103 4108.
35. Schauwecker, P.E., Ramirez, J.J. Steward, O. (2000) Genetic dissection of the signals that induce synaptic reorganization. Exp Neurol 161, 139 152.
36. Schauwecker, P.E., Williams, R.W. Santos, J.B. (2004) Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis. J Comp Neurol 477, 96 107.
37. Schmued, L.C. Hopkins, K.J. (2000) Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874, 123 130.
38. Shuttleworth, C.W. Connor, J.A. (2001) Strain-dependent differences in calcium signaling predict excitotoxicity in murine hippocampal neurons. J Neurosci 21, 4225 4236.
39. Sidman, R.L., Angevine, J.B. Taber Pierce, E. (1971) Atlas of the Mouse Brain and Spinal Cord. Harvard University Press, Cambridge, MA.
40. Sousa, N., Madeira, M.D. Paula-Barbosa, M.M. (1998) Effects of corticosterone treatment and rehabilitation on the hippocampal formation of neonatal and adult rats. An unbiased stereological study. Brain Res 794, 199 210.
41. Sperk, G., Lassmann, H., Baran, H., Kish, S.J., Seitelberger, F. Hornykiewicz, O. (1983) Neurochemical and histopathological changes. Neuroscience 10, 1301 1315.
42. Varon, R., Gooding, R., Steglich, C. et al (2003) Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome. Nat Genet 35, 185 189.
43. West, M.J., Slomianka, L. Gundersen, H.J. (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231, 482 497.
44. Yoshimura, T., Arimura, N. Kaibuchi, K. (2006) Signaling networks in neuronal polarization. J Neurosci 26, 10626 10630.
45. Zhao, Q., Shao, J., Chen, W. Li, Y.P. (2007) Osteoclast differentiation and gene regulation. Front Biosci 12, 2519 2529.
46. Zini, S., Roisin, M.P., Armengaud, C. Ben-Ari, Y. (1993a) Effect of potassium channel modulators on the release of glutamate induced by ischaemic-like conditions in rat hippocampal slices. Neurosci Lett 153, 202 205.
47. Zini, S., Roisin, M.P., Langel, U., Bartfai, T. Ben-Ari, Y. (1993b) Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus. Eur J Pharmacol 245, 1 7.