Metastatic tumours to the oral cavity - Pathogenesis and analysis of 673 cases

Oral Oncology

Volumn 44, Issue 8, 2008, Pages 743-752

  Hirshberg, Abraham ^a   Shnaiderman Shapiro, Anna ^a   Kaplan, Ilana ^b   Berger, Rannan ^c  

^a TEL AVIV UNIVERSITY   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

Author keywords

Metastases; Mouth metastases; Oral cancer; Oral metastases

Indexed keywords

ADULT; ANGIOGENESIS; APOPTOSIS; ARTICLE; BIOPSY; BONE METASTASIS; BONE PAIN; BONE SWELLING; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CLINICAL ASSESSMENT; COLORECTAL CANCER; FEMALE; GIANT CELL GRANULOMA; GINGIVA TUMOR; GYNECOLOGIC CANCER; HUMAN; INHIBITION KINETICS; JAW; KIDNEY CANCER; LIVER CANCER; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MANDIBLE CANCER; METASTASIS; MOUTH CANCER; PARESTHESIA; PATHOGENESIS; PRIMARY TUMOR; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PYOGENIC GRANULOMA; QUALITY OF LIFE; SEX RATIO; SOFT TISSUE METASTASIS;

ADULT; CARCINOMA; CASE-CONTROL STUDIES; COMBINED MODALITY THERAPY; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; JAW NEOPLASMS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; SEX FACTORS;

EID: 47249098443     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2007.09.012     Document Type: Article

References (150)

1. Hirshberg A., Leibovich P., and Buchner A. Metastases to the oral mucosa: analysis of 157 cases. J Oral Pathol Med 22 (1993) 385-390
2. Hirshberg A., Leibovich P., and Buchner A. Metastatic tumors to the jaws: analysis of 390 cases. J Oral Pathol Med 23 (1994) 337-341
3. Hirshberg A., and Buchner A. Metastatic tumours to the oral region. An overview. Oral Oncol Eur J Cancer 31B (1995) 355-360
4. Sahai E. Mechanisms of cancer cell invasion. Curr Opin Genet Dev 15 (2005) 87-96
5. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., et al. Cell migration: integrating signals from front to back. Science 302 (2003) 1704-1709
6. Patrick M., and Alain P. Metastasis: a question of life or death. Nat Rev Cancer 6 (2006) 449-458
7. Pantel K., and Brakenhoff R.H. Dissecting the metastatic cascade. Nat Rev Cancer 6 (2004) 448-456
8. Christofori G. New signals from the invasive front. Nature 441 (2006) 444-450
9. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
10. Gupta G.P., and Massague J. Cancer metastasis: building a framework. Cell 127 (2006) 679-695
11. Cavallaro U., and Christofori G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4 (2004) 118-132
12. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2 (2002) 442-454
13. Huber M.A., Kraut N., and Beug H. Molecular requirements for epithelial mesenchymal transition during tumor progression. Curr Opin Cell Biol 17 (2005) 548-558
14. Thompson E.W., and Newgreen D.F. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?. Cancer Res 65 (2005) 5991-5995
15. Friedl P., and Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3 (2003) 362-374
16. Guo W., and Giancotti F.G. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5 (2004) 816-826
17. Bhowmick N.A., and Moses H.L. Tumor-stroma interactions. Curr Opin Gen Dev 15 (2005) 97-101
18. Wyckoff J.B., Wang Y., Lin E.Y., Li J.F., Goswami S., Stanley E.R., et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67 (2007) 2649-2656
19. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29 (2002) 15-18
20. Folkman J., and Kalluri R. Cancer without disease. Nature 427 (2004) 787
21. Reinmuth N., Parikh A.A., Ahmad S.A., et al. Biology of angiogenesis in tumors of the gastrointestinal tract. Microsc Res Tech 60 (2003) 199-207
22. Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9 (2003) 677-684
23. Rafii S., Lyden D., Benezra R., et al. Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy. Nat Rev Cancer 2 (2002) 826-835
24. Naumov G.N., Bender E., Zurakowski D., Kang S.Y., Sampson D., Flynn E., et al. A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. J Natl Cancer Inst 98 (2006) 316-325
25. Marches R., Scheuermann R., and Uhr J. Cancer dormancy from mice to man. Cell Cycle 5 (2006) 1772-1778
26. Aguirre-Ghiso J.A. The problem of cancer dormancy. Understanding the basic mechanisms and identifying therapeutic opportunities. Cell Cycle 5 (2006) 1740-1743
27. Pinkas J., Martin S.S., and Leder P. Bcl-2-mediated cell survival promotes metastasis of EpH4 βMEKDD mammary epithelial cells. Mol Cancer Res 2 (2004) 551-556
28. Loza-Coll M.A., Perera S., Shi W., and Filmus J. A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells. Oncogene 24 (2005) 1727-1737
29. Dunn G.P., Old L.J., and Schreiber R.D. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21 (2004) 137-148
30. Ziegler T., Silacci P., Harrison V.J., and Hayoz D. Nitric oxide synthase expression in endothelial cells exposed to mechanical forces. Hypertension 32 (1998) 351-355
31. Schuler M., and Green D.R. Transcription, apoptosis and p53: catch-22. Trends Genet 21 (2005) 182-187
32. Chambers A.F., Groom A.C., and MacDonald I.C. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2 (2002) 563-572
33. Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1 (1889) 571-573
34. Burger J.A., and Kipps T.J. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107 (2006) 1761-1767
35. Kucia M., Reca R., Miekus K., Wanzeck J., Wojakowski W., Janowska-Wieczorek A., et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 23 (2005) 879-894
36. Müller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410 (2001) 50-56
37. Brown D.M., and Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5 (2004) 365-374
38. Emami K.H., and Corey E. When prostate cancer meets bone: control by wnts. Cancer Lett 253 (2007) 170-179
39. Mundy G.R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2 (2002) 584-593
40. Logothetis C.J., and Lin S.H. Osteoblasts in prostate cancer metastasis to bone. Nat Rev Cancer 5 (2005) 21-28
41. Lynch C.C., Hikosaka A., Acuff H.B., et al. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell 7 (2005) 485-496
42. Yin J.J., Selander K., Chirgwin J.M., et al. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest 103 (1999) 197-206
43. Kang Y., Siegel P.M., Shu W., Drobnjak M., Kakonen S.M., Cordón-Cardo C., et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3 (2003) 537-549
44. Kang Y., He W., Tulley S., Gupta G.P., Serganova I., Chen C.R., et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA 102 39 (2005) 13909-13914
45. Staalsen N.H., and Nielsen J.S. Bronchogenic metastasis to the gingival. Oral Surge Oral Med Oral Pathol 74 (1992) 561-562
46. Lalikos J.F., Sotereanos G.C., Nawrocki J.S., and Tzakis A.G. Isolated mandibular metastasis of hepatocellular carcinoma. J Oral Maxillofac Surg 50 (1992) 754-759
47. Whitaker B., Robinson K., Hewan-Lowe K., and Budnick S. Thyroid metastasis of the oral soft tissues: case report of a diagnostic dilemma. J Oral Maxillofac Surg 51 (1993) 588-593
48. Sproat C.P., Brown A.E., and Lindley R.P. Oral metastasis in malignant pleural mesothelioma. Br J Oral Mxillofac Surg 31 (1993) 316-317
49. Doval D.C., Naresh K.N., Sabitha K.S., Vijaykumar M., Bapsy P.P., Anantha N., et al. Carcinoma of the urinary bladder metastatic to the oral cavity. Indian J Cancer 31 (1994) 8-11
50. Piattelli A., and Tamborrino F. Soft palate metastasis from a small cell carcinoma of the lung. Acta Stomatol Belg 92 (1995) 31-33
51. Lee B.Y., Guerra V.J., Cagir B., Herz B.L., and Zamurovic D. Pulmonary blastoma presenting as a solitary lip metastasis: case report and review of the literature. J Spinal Cord Med 18 (1995) 203-207
52. Alandez F., Llanes F., Herrera J.I., Carasol M., and Bascones A. Metastatic lung carcinoma involving the periodontium. J Periodontol 66 (1995) 896-898
53. Takinami S., Yahata H., Kanoshima A., Yamasaki M., Funaoka K., Nakamura E., et al. Hepatocellular carcinoma metastatic to the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79 (1995) 649-654
54. Florio S.J., and Hurd T.C. Gastric carcinoma metastatic to the hard palate. J Oral Maxillofac Surg 53 (1995) 1097-1098
55. Sesenna E., Tullio A., and Piazza P. Treatment of craniofacial metastasis of a renal adenocarcinoma. J Oral Maxillofac Surg 53 (1995) 187-193
56. Aydogan B.L., Myers J.N., Myers E.N., and Kirkwood J. Malignant melanoma metastatic to the tonsil. Laryngoscope 106 (1996) 313-316
57. Llanes F., Sanz-Ortega J., Suarez B., and Sanz-Esponera J. Hepatocellular carcinomas diagnosed following metastasis to the oral cavity. Report of 2 cases. J Periodontol 67 (1996) 717-719
58. Aguirre A., Rinaggio J., and Diaz-Ordaz E. Lingual metastasis of renal cell carcinoma. J Oral Maxillofac Surg 54 (1996) 344-346
59. Guvenc M.G., Ada M., Acroglu E., and Pamukcu M. Tonsillar metastasis of primary signet-ring cell carcinoma of the cecum. Auris Nasus Larynx 33 (2006) 85-88
60. Dayal P.K., Patil S., Suvarna P., and Srinivasan S.V. Maxillary metastasis of osteosarcoma. Indian J Dent Res 8 (1997) 86-89
61. Ide F., Shimoyama T., Haga H., and Horie N. Basaloid squamous cell carcinoma of the esophagus metastatic to the gingiva. Oral Surge Oral Med Oral Pathol Oral Radiol Endod 83 (1997) 584-587
62. Ahsar A., Khateery S.M., and Kovacs A. Mandibular metastatic hepatocellular carcinoma: a case involving severe postbiopsy hemorrhage. J Oral Maxillofac Surg 55 (1997) 547-552
63. Yushimura Y., Matsuda S., and Naitoh S. Hepatocellular carcinoma metastatic to the mandibular ramus and condyle. J Oral Maxillofac Surg 55 (1997) 297-306
64. Santamaria J., Gracia A., Gil J., and Barbier L. Metastasis of malignant melanoma to the region of an impacted mandibular third molar: a case report. J Oral Maxillofac Surg 55 (1997) 1003-1006
65. Srivasan S.V., Pal K.M., Dayal P.K., Bastian T.S., and Patil S. Metastatic malignant melanoma of maxillary gingival. A case report. Indian J Dent Res 8 (1997) 119-122
66. Koyama T., Hasimoto K., Yamaguchi K., and Fukuda H. Esophageal carcinoma metastatic centrally to the mandible: a case report with implication of cell proliferating marker KI 67. J Oral Mxillofacial Surg 55 (1997) 640-645
67. Chin A., Liang T.S., and Borislow A.J. Initial presentation of hepatocellular carcinoma as a mandibular mass: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86 (1998) 457-460
68. Selden H.S., Manhoff D.T., Hatges N.A., and Michel R.C. Metastatic carcinoma to the mandible that mimicked pulpal/periodontal disease. J Endod 24 (1998) 267-270
69. Tomita T., Inouye T., Shinden S., and Mukai M. Paliative radiotherapy for lingual metastasis of renal cell carcinoma. Auris Nasus Larynx 25 (1998) 209-214
70. Galen D.M. Mandibular metastasis of endometrial carcinoma diagnosed via dental radiograph. JADA 129 (1998) 1595-1598
71. Erdag T., Bilgen C., and Ceryan K. Metastatic thyroid carcinoma of the mandible. Rev Laryngo Otol Rhynol 119 (1998) 31-34
72. Fields R.T., Byrd D.L., and Preskitt J.T. Malignant pheochromocytoma with mandibular metastasis. J Oral Maxillofac Surg 56 (1998) 979-984
73. Piattelli A., Fioroni M., and Rubini C. Gingival metastasis from a prostate adenocarcinoma. J Periodontol 70 (1999) 441-444
74. Bhattacharyya I., Williamson A., Cohen D.M., and Bever J.L. Metastatic neuroblastoma with ganglionuromtous differentiation and mandibular involvement. Oral Surge Oral Med Oral Pathol Oral Radiol Endod 88 (1999) 582-586
75. Piattelli A., Fioroni M., and Rubini C. Tongue metastasis from a malignant diffuse mesothelioma of the pleura: report of a case. J Oral Maxillofac Surg 57 (1999) 861-863
76. Suzuki K., Yoshida H., Onizawa K., and Onobori M. Metastatic osteosarcoma to the mandibular gingiva: a case report. J Oral Mxillofac Surg 57 (1999) 864-868
77. Piattelli A., Fioroni M., and Rubini C. Gingival metastasis from a medullary thyroid carcinoma: case report. J Periodontol 71 (2000) 112-116
78. Maiorano E., Piattelli A., and Favia G. Hepatocellular carcinoma metastatic to the oral mucosa: report of a case with multiple gingival localizations. J Periodontol 71 (2000) 641-645
79. Cardona F., Bagan J.V., and Perez A. Mandibular metastasis of bladder transitional cell carcinoma. J Oral Maxillofac Surg 58 (2000) 1154-1158
80. Wakashugi S., Kageshita T., and Ono T. Metastatic melanoma to the palatine tonsil with a favorable prognosis. Br J Dermatol 145 (2001) 327-329
81. DeCourten A., Irie C., Samson J., and Lombardi T. Metastatic transitional cell carcinoma of the urinary bladder presenting as a mandibular gingival swelling. J Periodontol 72 (2001) 688-690
82. Poulopoulos A.K., Antoniades K., and Kiziridou A. Bilateral metastatic breast angiosarcoma to the mandibular gingiva: case report. Oral Oncol 37 (2001) 199-201
83. Scipio J.E., Murti P.R., Al-Bayaty H.F., Matthews R., and Scully C. Metastasis of breast carcinoma to mandibular gingiva. Oral Oncol 37 (2001) 393-396
84. Tomikawa M., Higuchi Y., Saku M., Takeshita M., Yohsida K., and Sugimachi K. Carcinoma of the colon metastatic to the lower gingiva. Dig Surg 18 (2001) 333-335
85. Vural E., and Hanna E. Metastatic follicular thyroid carcinoma to the mandible: a case report and review of literature. Am J Otolaryngol 19 (1998) 198-202
86. Dosortez D.E., Orr J.W., Salenius S.A., and Orr P.F. Mandibular metastasis in a patient with endometrial cancer. Gynecol Oncol 72 (1999) 243-245
87. Nakamura T., Ishimaru J.I., Mizui T., Kobayashi A., Iwata H., and Shimokawa K. Osteosarcoma metastatic to the mandible: a case report. Oral Pathol Oral Radiol Endod 91 (2001) 452-454
88. Morris P.R., Prstojevich S.J., and Hedayati P. Male breast cancer with maxillofacial metastasis: case report. J Oral Maxillofacial Surg 59 (2001) 578-580
89. Medina B.R., Martinez E., Torres A.V., and Trujillo S.M. J Oral Maxillofac Surg 59 (2001) 467-471
90. Ahmad S., Roberts G.J., Lucas V.S., Barrett A.W., and Hakness W. Metastatic infiltration of the dental pulp by medulloblastoma. J Oral Pathol Med 31 (2002) 244-245
91. Meneghini F., Castellani A., Camelin N., and Zanetti U. Metastatic chordoma to the mandibular condyle: an anterior surgical approach. J Oral Maxillofac Surg 60 (2002) 1489-1493
92. Yoshii T., Muraoka S., Sano N., Furudoi S., and Komori T. Large cell carcinoma of the lung metastatic to the mandibular gingiva. J Periodontol 73 (2002) 571-574
93. Ogutcen-Toller M., Metin M., and Yildiz L. Metastatic breast carcinoma mimicking periodontal disease on radiographs. J Clin Periodontol 29 (2002) 269-271
94. Carnelio S., Pai K., Rao N., Solomon M., and Ahasan A. Metastatic osteosarcoma to the maxilla: a case report and a review of the literature. Quintessence Int 33 (2002) 397-399
95. Yanagi Y., Asaumi J., Hisatomi M., Konouchi H., Wakasa T., and Kishi K. Mandibular metastasis presenting as the initial manifestation of malignant pheochromocytoma. Eur J Radiol 44 (2002) 5-9
96. Neff B.A., Pribitkin E.A., and Willcox Jr. T.O. Hepatocellular cancer metastatic to the zygoma: primary resection and immediate reconstruction. Ear Nose Throat J 81 (2002) 57-58
97. Fukuda M., Miyata M., Okabe K., and Sakashita H. A case series of 9 tumors metastatic to the oral and maxillofacial region. J Oral Maxillofac Surg 60 (2002) 942-944
98. Garci{dotless}́a-Reija M.F., Matilla J.M., De Paz A., Sánchez-Cuéllar A., and Verrier A. Unusual metastasis to the mandibular alveolus of a malignant pleural mesothelioma. Otolaryngol Head Neck Surg 126 (2002) 435-437
99. Willard C.C., Weber C.R., and Buche W. Metastatic esophageal adenocarcinoma inwolving the maxilla. J Ora Maxillofac Surg 60 (2002) 1496-1499
100. Okada H., Kamino Y., Shimo M., Kitamura E., Katoh T., Nishimura H., et al. Metastatic hepatocellular carcinoma of the maxillary sinus: a rare autopsy case without lung metastasis and a review. Int J Oral Maxillofac Surg 32 (2003) 97-100
101. Ramon Ramirez J., Seoane J., Montero J., Esparza Gomez G.C., and Cerero R. Isolated gingival metastasis from hepatocellular carcinoma mimicking a pyogenic granuloma. J Clin Periodontol 30 (2003) 926-929
102. Ostrosky A., Mareso E.A., Klurfan F.J., and Gonzalez M.J. Mandibular metastasis of follicular thyroid carcinoma. Case report. Med Oral 8 (2003) 224-227
103. Alves F.A., Lopes M.A., Ikeda M.K., Kowalski L.P., and Almeida O.P. Oral metastasis of telangiectatic osteosarcoma. Oral Dis 9 (2003) 104-106
104. Colella G., Capone R., and Cappabianca S. Mandibular metastasis from papillary thyroid carcinoma - a case report. Tumori 89 (2003) 452-454
105. van der Waal R.I., Buter J., and van der Waal I. Oral metastases: report of 24 cases. Br J Oral Maxillofac Surg 41 (2003) 3-6
106. Jimenez Y. Oral metastasis in esophagus cancer. Med Oral 9 2 (2004) 182
107. Terakado N., Shintani S., Nakashiro K., and Hamakawa H. Malignant pleural mesothelioma metastasis to the mandible. Int J Oral Maxillofac Surg 33 (2004) 798-800
108. Pires F.R., Sagarra R., Correa M.E., Pereira C.M., Vargas P.A., and Lopes M.A. Oral metastasis of a hepatocellular carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97 (2004) 359-368
109. Kao S.Y., Tu H.F., Chang K.W., Chang C.S., Yang A.H., and Li W.Y. Epithelioid sarcoma metastasis to the gingivae: a case report. Int J Oral Maxillofac Surg 33 (2004) 205-208
110. Jayasooriya P.R., Gunarathna I.A.N.S., Attygalla A.M., and Tilakaratne W.M. Metastatic renal cell carcinoma presenting as a clear cell tumor in the head and neck region. Oral Oncology Extra 40 (2004) 50-53
111. Irani S., Moshref M., and Lofti A. Metastasis of gastric adenocarcinoma to the mandible. Oral Oncol Extra 40 (2004) 85-87
112. Junquera L., Rodri{dotless}́guez-Recio C., Torre A., Sánchez-Mayoral J., and Fresno M.F. Hepatocallular carcinoma metastatic to the mandible. A case report involving severe hemorrhage. Med Oral 9 (2004) 345-349
113. Shimoyama S., Seto Y., Aoki F., Ogawa T., Toma T., Endo H., et al. Gastric cancer with metastasis to the gingiva. J Gastroenterol Hepatol 19 (2004) 831-835
114. Mason A.C., Azari K.K., Farkas L.M., Duvvuri U., and Myers E.N. Metastatic adenocarcinoma of the colon presenting as a mass in the mandible. Head Neck 27 (2005) 729-732
115. Sanchez-Jimenez J., Acebal-Blanco F., Arevalo-Arevalo R.E., and Molina-Martinez M. Metastatic tumours in upper maxillary bone of esophageal adenocarcinoma. A case report. Med Oral Patol Oral Cir Bucal 10 (2005) 252-257
116. Taguchi A., Suei Y., Ogawa I., Naito K., Nagasaki T., Lee K., et al. Metastatic retinoblastoma of the maxilla and mandible. Dentomaxillofac Radiol 34 (2005) 126-131
117. Pereira C.M., de Abreu Alves F., Corrêa M.E., Lima C.S., and de Almeida O.P. Mouth metastasis of peripheral primitive neuroectodermal tumor. Oral Dis 11 (2005) 44-45
118. Colombo P., Tondulli L., Masci G., Muzza A., Rimassa L., Petrella D., et al. Oral ulcer as an exclusive sign of gastric cancer: report of a rare case. BMC Cancer 19 5 (2005) 117
119. Siriwardena B.S.M.S., Tilakaratne W.M., and Rajapska R.M.S.K. Metastatic transitional cell carcinoma of the urinary bladder to the mandible. Oral Oncol Extra 41 (2005) 22-24
120. Huang C.J., Chang Y.L., Yang M.C., Hsueh C., and Yu C.T. Lung cancer metastatic to the maxillary gingival-a case report and literature review. Oral Oncol Extra 41 (2005) 118-120
121. Poulopoulos A.K., Vahtsevanos K., and Kiziridu A. Metastatic carcinoma if the urinary bladder presenting as a submental swelling. Oral Oncol Extra 41 (2005) 114-117
122. Rajappa S., Loya A.C., Rao R.D., Rao S.I., Surath A., and Srihari U. Metastasis to oral cavity - a report of two cases and review of literature. Indian J Med Pediatric Oncol 26 (2005) 43-46
123. Alvarez-Alvarez C., Iglesias-Rodri{dotless}́guez B., Pazo-Irazu S., and Delgado-Sánchez-Gracián C. Colonic adenocarcinoma with metastasis to the gingiva. Med Oral Patol Oral Cir Bucal 11 (2006) E85-E87
124. Yasar F., Oz G., Dolanmaz D., and Akgunlu F. Mandibular metastasis in a patient with pulmonary adenocarcinoma. Dentomaxillofac Radiol 35 (2006) 383-385
125. Jia J., Chen X.M., Sun Z.J., and Zhang W.F. Mandibular metastasis of nephroblastoma: a rare case. Int J Oral Maxillofac Surg 35 (2006) 1160-1161
126. Kesting M.R., Loeffelbein D.J., Holzle F., Wolff K.D., and Ebsen M. Male breast cancer metastasis presenting as submandibular swelling. Auris Nasus Larynx 33 (2006) 483-485
127. Morita N., Yabuta T., Todo K., and Taenaka Y. A metastatic haemangiopericytoma of the floor of the mouth. Int J Oral Maxillofac Surg 35 (2006) 563-565
128. Chen Y.K., Chen C.H., and Lin L.M. Soft-tissue metastasis of osteosarcoma to the submental vestibule. Int J Oral Maxillofac Surg 35 (2006) 1068-1071
129. Kulamarva G., Wilbourn M., Anand R., Mourouzis C., Spedding A.V., and Brennan P.A. Metastasising chordoma to the mandible from a rare vertebral site: the first reported case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104 (2007) 240-242
130. Park J.Y., Kim H.S., Zo J.I., Lee S., and Choi S.W. Initial presentation of lung sarcomatoid carcinoma as a metastatic lesion in the mandibular gingiva. J Periodontol 77 (2006) 734-737
131. Teshigawara K., Kakizaki S., Sohara N., Hashida T., Tomizawa Y., Sato K., et al. Solitary mandibular metastasis as an initial manifestation of hepatocellular carcinoma. Acta Med Okayama 60 (2006) 243-247
132. Scolozzi P., Marret N., Bouzourene H., Luthi F., Bauer J., Jaques B., et al. Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma. J Oral Pathol Med 35 (2006) 579-581
133. Jaguar G.C., Prado J.D., Soares F., Alves F.A., and Osorio C.A.T. Gingival metastasis from a non small cell undifferentiated carcinoma of the lung mimicking pyogenic granuloma. Oral Oncol Extra 42 (2006) 36-39
134. Jia J., Zhang W.F., Liu B., and Zhao Y. Pathological fracture of condyle from metastatic breast adenocarcinoma. Oral Oncol Extra 42 (2006) 98-100
135. Sari M., Serin G.M., Inanli S., and Kaya H. Condylar metastasis involving TMJ and TMJ dislocation presenting as initial manifestation of squamos lung cancer. Oral Oncology Extra 42 (2006) 224-226
136. Spinelli G.P., Caprio G., Toma F., Barberi S., Miele E., Bhoghi F., et al. Metastatic infiltration of adenocarcinoma of he rectum in hard palate. Report of case and literature review. Oral Oncology Extra 42 (2006) 206-209
137. Kohli M., and Schaefer R. Managemet of solitary palatal metastasis from renal cell carcinoma. Nat Clin Prac Urol 3 (2006) 392-396
138. D'silva N., Summerline D.J., Cordell K.G., Abdelsayed R.A., Tomish C.E., Hanks C.T., et al. Metastatic tumors in the jaws. Aretrospective study of 114 cases. JADA 137 (2006) 1667-1672
139. Hirshberg A., leibovich P., Horowitz I., and Buchner A. Metastatic tumors to post-extraction site. J Oral Maxillofac Surg 51 (1993) 1334-1337
140. Batson O.V. The function of the vertebral veins and their role in the spread of metastases. Ann Surg 112 (1940) 138-149
141. Cummings J., Hacking N., Fairhurst J., Ackery D., and Jenkins J.D. Distribution of bony metastases in prostatic carcinoma. Br J Urol 66 (1990) 411-414
142. Cotta C.V., Konoplev S., Medeiros L.J., Carlos E., and Bueso-Ramos C.E. Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment. Ann Diag Pathol 10 (2006) 169-192
143. Hashimoto N., Kwrihara K., Yamasaki H., Ohba S., Sakai H., and Yoshida S. Pathological characteristics of metastatic carcinoma in the human mandible. J Oral Pathol Med 16 (1987) 362-367
144. Jemal A., Siegel R., Ward E., Murray T., Xu J., and Thun M.J. Cancer statistics, 2007. Cancer J Clin 57 (2007) 43-66
145. Rodan G.A. The development and function of the skeleton and bone metastases. Cancer 97 Suppl 3 (2003) 726-732
146. Aggarwal B.B., Shishodia S., Sandur S.K., Pandey M.K., and Sethi G. Inflammation and cancer: how hot is the link?. Biochem Pharmacol 72 (2006) 1605-1621
147. Mantovani A. Cancer: inflammation by remote control. Nature 435 (2005) 752-753
148. Sabino M.A.C., and Mantyh P.W. Pathophysiology of bone cancer. J Support Oncol 3 (2005) 15-24
149. Laurencet F.M., Anchisi S., Tullen E., and Dietrich P.Y. Mental neuropathy: report of five cases and review of the literature. Crit Rev Oncol Hematol 34 (2000) 71-79
150. Chorost M.I., Lee M.C., Yeoh C.B., Molina M., and Ghosh B.C. Unknown primary. J Surg Oncol 87 (2004) 191-203