Effect of acetyl-L-carnitine on hyperactivity and spatial memory deficits of rats exposed to neonatal anoxia

Neuroscience Letters

Volumn 223, Issue 3, 1997, Pages 201-205

  Dell'Anna, Elisabetta ^a   Iuvone, Laura ^b   Calzolari, Stefano ^c   Geloso, Maria Concetta ^b  

^a UNIVERSITY OF UDINE   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c Child Neuropsychiatry Unit   (Italy)

Author keywords

acetyl L carnitine; attention deficit hyperactivity disorder; hyperactivity; neuroprotection; perinatal asphyxia; spatial memory

Indexed keywords

ACETYLCARNITINE; LEVACECARNINE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MAZE TEST; MEMORY; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCARNITINE; ANIMALS; ANIMALS, NEWBORN; ANOXIA; HYPERKINESIS; MAZE LEARNING; MEMORY; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; SPACE PERCEPTION;

EID: 0031039215     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)13411-5     Document Type: Article

References (25)

1. Amiel-Tison C., Ellison P. Birth asphyxia in the fullterm newborn: early assessment and outcome. Dev. Med. Child Neurol. 28:1986;671-682.
2. Angelucci L., Ramacci M.T., Taglialatela G., Hulsebosh C., Morgan B., Werrbach-Perez K., Perez-Polo R. Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine. J. Neurosci. Res. 20:1988;491-496.
3. 1H-NMR spectroscopy. Brain Res. 643:1994;92-99.
4. Barks J.D.E., Silverstein F.S. Excitatory amino acids contribute to the pathogenesis of perinatal hypoxic-ischemic injury. Brain Pathol. 2:1992;235-243.
5. Blokland A., Raaijmakers W., van der Staay J.F., Jolles J. Differential effect of acetyl-L-carnitine on open field behavior in young and old rats. Physiol. Behav. 47:1990;783-785.
6. Curti D., Dagani F., Galmozzi M.R., Marzatico F. Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. Mech. Aging Dev. 47:1989;39-45.
7. Dell'Anna M.E., Calzolari S., Molinari M., Iuvone L., Calimici R. Neonatal anoxia induces transitory hyperactivity, permanent spatial memory deficits and CA1 cell density reduction in developing rats. Behav. Brain Res. 45:1991;125-134.
8. Dell'Anna M.E., Luthman J., Lindqvist E., Olson L. Development of monoamine systems after neonatal anoxia in rats. Brain Res. Bull. 32:1993;159-170.
9. Dell'Anna M.E., Geloso M.C., Draisci G., Luthman J. Transient changes in fos and GFAp immunoreactivity precede neuronal cell loss in the rat hippocampus following neonatal anoxia. Exp. Neurol. 131:1995;144-156.
10. Dell'Anna E., Geloso M.C., Magarelli M., Molinari M. Development of gamma-aminobutyric acid (GABA) and calcium binding proteins immunoreactivity in the rat hippocampus following neonatal anoxia. Neurosci. Lett. 211:1996;93-96.
11. Filloux F.M., Adair J., Narang N. The temporal evolution of striatal dopamine receptor binding and mRNA expression following hypoxia-ischemia in the neonatal rat. Dev. Brain Res. 94:1996;81-91.
12. Forloni G., Angeretti N., Smiroldo S. Neuroprotective activity of acetyl-L-carnitine: studies in vitro. J. Neurosci. Res. 37:1994;92-96.
13. Hershkowitz M., Grimm V., Speiser Z. The effects of postnatal anoxia on behavior and on muscarinic and beta-adrenergic receptors in the hippocampus of the developing rats. Dev. Brain Res. 7:1983;147-155.
14. Hill A., Volpe J.J. Seizures, hypoxic-ischemic injury and intraventricular hemorrhage in the newborn. Ann. Neurol. 10:1981;109-121.
15. Imperato A., Ramacci M.T., Angelucci L. Acetyl-L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats. Neurosci. Lett. 107:1989;251-255.
16. Kohjimoto Y., Ogawa T., Matsumoto M., Shirakawa K., Kuwaki T., Yasuda H., Anami K., Fuji T., Satoh H., Ono T. Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats. Jpn. J. Pharmacol. 48:1988;365-371.
17. Lipton S.A., Kater S.B. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends Neurosci. 12:1989;265-270.
18. Morris A.J., Carey E.M. Postnatal changes in the concentration of carnitine and acetylcarnitine in the rat brain. Dev. Brain Res. 8:1983;381-384.
19. Pascale A., Milano S., Corsico N., Lucchi L., Battaini F., Arrigoni Martelli E., Trabucchi M., Govoni S. Protein kinase C activation and antiamnesic effect of acetyl-L-carnitine: in vitro and in vivo studies. Eur. J. Pharmacol. 265:1994;1-7.
20. Pettegrew J.W., Klunk W.E., Kanagasabai P., Kanfler J.N., McClure R.J. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiol. Aging. 16:1995;1-4.
21. Shaffer, S.Q., Shaffer, D., O'Connor, P.A. and Stockman, C.J., Hard thought on neurological 'soft signs'. In M. Rutter (Ed.), Developmental Neuropsychiatry, Guilford Press, New York, 1983, pp. 133-143.
22. Siliprandi N., Siliprandi D., Ciman M. Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine. Biochem. J. 96:1965;777-782.
23. Spagnoli A., Lucca U., Menasce G., Bandera L., Cizza G., Forloni G., Tettamanti M.et al. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology. 41:1991;1726-1732.
24. Szatkowski M., Attwell D. Triggering and execution of neuronal death in brain ischemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 17:1994;359-365.
25. Valerio C., Clementi G., Spadaro F., D'Agata V., Raffaele R., Grassi M., Lauria N., Drago F. The effects of acetyl-L-carnitine on experimental models of learning and memory deficits in the old rat. Funct. Neurol. 4:1989;387-390.