메뉴 건너뛰기




Volumn 50, Issue 8, 2006, Pages 917-923

Acetyl-l-carnitine protects striatal neurons against in vitro ischemia: The role of endogenous acetylcholine

Author keywords

Electrophysiology; Field potentials; Ischemia; Mitochondrial metabolism; Neuroprotection; Striatum

Indexed keywords

ACETYLCHOLINE; GLUCOSE; HEMICHOLINIUM 3; LEVACECARNINE; METHOCTRAMINE; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M2 RECEPTOR ANTAGONIST; MUSCARINIC RECEPTOR BLOCKING AGENT; NITROGEN; OXYGEN; PIRENZEPINE; SCOPOLAMINE;

EID: 33646899542     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.01.002     Document Type: Article
Times cited : (28)

References (49)
  • 2
    • 0028347621 scopus 로고
    • Effect of acetyl-l-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat - study by 13P- and 1H-NMR spectroscopy
    • Aureli T., Miccheli A., Di Cocco M.E., Ghirardi O., Giuliani A., Ramacci M.T., and Conti F. Effect of acetyl-l-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat - study by 13P- and 1H-NMR spectroscopy. Brain Res. 643 (1994) 92-99
    • (1994) Brain Res. , vol.643 , pp. 92-99
    • Aureli, T.1    Miccheli, A.2    Di Cocco, M.E.3    Ghirardi, O.4    Giuliani, A.5    Ramacci, M.T.6    Conti, F.7
  • 3
    • 0030817765 scopus 로고    scopus 로고
    • Post-ischemic recovery of acetylcholine release in vitro: influence of different excitatory amino acid receptor subtype antagonists
    • Badini I., Beani L., Bianchi C., Marzola G., and Siniscalchi A. Post-ischemic recovery of acetylcholine release in vitro: influence of different excitatory amino acid receptor subtype antagonists. Neurochem. Int. 31 (1997) 817-824
    • (1997) Neurochem. Int. , vol.31 , pp. 817-824
    • Badini, I.1    Beani, L.2    Bianchi, C.3    Marzola, G.4    Siniscalchi, A.5
  • 4
    • 0026584524 scopus 로고
    • Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    • Beal M.F. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?. Ann. Neurol. 31 (1992) 119-130
    • (1992) Ann. Neurol. , vol.31 , pp. 119-130
    • Beal, M.F.1
  • 5
    • 0030472579 scopus 로고    scopus 로고
    • Presynaptic depression of excitatory synaptic inputs to rat hypoglossal motoneurons by muscarinic M2 receptors
    • Bellingham M.C., and Berger A.J. Presynaptic depression of excitatory synaptic inputs to rat hypoglossal motoneurons by muscarinic M2 receptors. J. Neurophysiol. 76 (1996) 3758-3770
    • (1996) J. Neurophysiol. , vol.76 , pp. 3758-3770
    • Bellingham, M.C.1    Berger, A.J.2
  • 8
    • 0029135256 scopus 로고
    • On the mechanisms underlying hypoxia-induced membrane depolarization in striatal neurons
    • Calabresi P., Pisani A., Mercuri N.B., and Bernardi G. On the mechanisms underlying hypoxia-induced membrane depolarization in striatal neurons. Brain 118 (1995) 1027-1038
    • (1995) Brain , vol.118 , pp. 1027-1038
    • Calabresi, P.1    Pisani, A.2    Mercuri, N.B.3    Bernardi, G.4
  • 9
    • 0031978837 scopus 로고    scopus 로고
    • Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease
    • Calabresi P., Centonze D., Pisani A., Sancesario G., Gubellini P., Marfia G.A., and Bernardi G. Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease. Ann. Neurol. 43 (1998) 586-597
    • (1998) Ann. Neurol. , vol.43 , pp. 586-597
    • Calabresi, P.1    Centonze, D.2    Pisani, A.3    Sancesario, G.4    Gubellini, P.5    Marfia, G.A.6    Bernardi, G.7
  • 10
    • 0034649379 scopus 로고    scopus 로고
    • Cellular factors controlling neuronal vulnerability in the brain: a lesson from the striatum
    • Calabresi P., Centonze D., and Bernardi G. Cellular factors controlling neuronal vulnerability in the brain: a lesson from the striatum. Neurology 55 (2000) 1249-1255
    • (2000) Neurology , vol.55 , pp. 1249-1255
    • Calabresi, P.1    Centonze, D.2    Bernardi, G.3
  • 13
    • 0036212150 scopus 로고    scopus 로고
    • Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability
    • Calabresi P., Saulle E., Centonze D., Pisani A., Marfia G.A., and Bernardi G. Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability. Brain 125 (2002) 844-860
    • (2002) Brain , vol.125 , pp. 844-860
    • Calabresi, P.1    Saulle, E.2    Centonze, D.3    Pisani, A.4    Marfia, G.A.5    Bernardi, G.6
  • 14
    • 0037327231 scopus 로고    scopus 로고
    • Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studies
    • Calabresi P., Centonze D., Cupini L.M., Costa C., Pisani F., and Bernardi G. Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studies. Neurobiol. Dis. 12 (2003) 82-88
    • (2003) Neurobiol. Dis. , vol.12 , pp. 82-88
    • Calabresi, P.1    Centonze, D.2    Cupini, L.M.3    Costa, C.4    Pisani, F.5    Bernardi, G.6
  • 16
    • 0041663734 scopus 로고    scopus 로고
    • Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: an electrophysiological study
    • Calabresi P., Marti M., Picconi B., Saulle E., Costa C., Centonze D., Pisani F., and Bernardi G. Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: an electrophysiological study. Exp. Neurol. 182 (2003) 461-469
    • (2003) Exp. Neurol. , vol.182 , pp. 461-469
    • Calabresi, P.1    Marti, M.2    Picconi, B.3    Saulle, E.4    Costa, C.5    Centonze, D.6    Pisani, F.7    Bernardi, G.8
  • 17
    • 0032875579 scopus 로고    scopus 로고
    • Attenuation by acetyl-l-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion
    • Calvani M., and Arrigoni-Martelli E. Attenuation by acetyl-l-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int. J. Tissue React. 21 (1999) 1-6
    • (1999) Int. J. Tissue React. , vol.21 , pp. 1-6
    • Calvani, M.1    Arrigoni-Martelli, E.2
  • 18
    • 0034845855 scopus 로고    scopus 로고
    • Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia
    • Centonze D., Saulle E., Pisani A., Bernardi G., and Calabresi P. Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia. Brain 124 (2001) 1855-1865
    • (2001) Brain , vol.124 , pp. 1855-1865
    • Centonze, D.1    Saulle, E.2    Pisani, A.3    Bernardi, G.4    Calabresi, P.5
  • 19
    • 0842289182 scopus 로고    scopus 로고
    • Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia
    • Costa C., Leone G., Saulle E., Pisani F., Bernardi G., and Calabresi P. Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia. Stroke 35 (2004) 596-600
    • (2004) Stroke , vol.35 , pp. 596-600
    • Costa, C.1    Leone, G.2    Saulle, E.3    Pisani, F.4    Bernardi, G.5    Calabresi, P.6
  • 20
    • 0024500456 scopus 로고
    • Effect of aging and acetyl-l-carnitine on energetic and cholinergic metabolism in rat brain regions
    • Curti D., Dagani F., Galmozzi M.R., and Marzatico F. Effect of aging and acetyl-l-carnitine on energetic and cholinergic metabolism in rat brain regions. Mech. Ageing Dev. 47 (1989) 39-45
    • (1989) Mech. Ageing Dev. , vol.47 , pp. 39-45
    • Curti, D.1    Dagani, F.2    Galmozzi, M.R.3    Marzatico, F.4
  • 21
    • 0036591533 scopus 로고    scopus 로고
    • Acetyl-l-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels
    • Dhitavat S., Ortiz D., Shea T.B., and Rivera E.R. Acetyl-l-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels. Neurochem. Res. 27 (2002) 501-505
    • (2002) Neurochem. Res. , vol.27 , pp. 501-505
    • Dhitavat, S.1    Ortiz, D.2    Shea, T.B.3    Rivera, E.R.4
  • 22
    • 0019796481 scopus 로고
    • Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices
    • Dolezal V., and Tucek S. Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J. Neurochem. 36 (1981) 1323-1330
    • (1981) J. Neurochem. , vol.36 , pp. 1323-1330
    • Dolezal, V.1    Tucek, S.2
  • 23
    • 4043086952 scopus 로고    scopus 로고
    • Mitochondria in health and disease: perspectives on a new mitochondrial biology
    • Duchen M.R. Mitochondria in health and disease: perspectives on a new mitochondrial biology. Mol. Aspects Med. 25 (2004) 365-451
    • (2004) Mol. Aspects Med. , vol.25 , pp. 365-451
    • Duchen, M.R.1
  • 24
    • 0023747172 scopus 로고
    • Systemic acetyl-l-carnitine elevates nigral levels of glutathione and GABA
    • Fariello R.G., Ferraro T.N., Golden G.T., and DeMattei M. Systemic acetyl-l-carnitine elevates nigral levels of glutathione and GABA. Life Sci. 43 (1988) 289-292
    • (1988) Life Sci. , vol.43 , pp. 289-292
    • Fariello, R.G.1    Ferraro, T.N.2    Golden, G.T.3    DeMattei, M.4
  • 27
    • 0029992108 scopus 로고    scopus 로고
    • Bioenergetics and glutamate excitotoxicity
    • Greene J.G., and Greenamyre J.T. Bioenergetics and glutamate excitotoxicity. Prog. Neurobiol. 48 (1996) 613-634
    • (1996) Prog. Neurobiol. , vol.48 , pp. 613-634
    • Greene, J.G.1    Greenamyre, J.T.2
  • 29
    • 0029044195 scopus 로고
    • Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?
    • Hunter A.J., Green A.R., and Cross A.J. Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?. Trends Pharmacol. Sci. 16 (1995) 123-128
    • (1995) Trends Pharmacol. Sci. , vol.16 , pp. 123-128
    • Hunter, A.J.1    Green, A.R.2    Cross, A.J.3
  • 30
    • 0024971871 scopus 로고
    • Acetyl-l-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats
    • Imperato A., Ramacci M.T., and Angelucci L. Acetyl-l-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats. Neurosci. Lett. 107 (1989) 251-255
    • (1989) Neurosci. Lett. , vol.107 , pp. 251-255
    • Imperato, A.1    Ramacci, M.T.2    Angelucci, L.3
  • 31
    • 0031007270 scopus 로고    scopus 로고
    • Effects of MK-801 and pentobarbital on cholinergic terminal damage and delayed neuronal death in the ischemic gerbil hippocampus
    • Ishimaru H., Takahashi A., Ikarashi Y., and Maruyama Y. Effects of MK-801 and pentobarbital on cholinergic terminal damage and delayed neuronal death in the ischemic gerbil hippocampus. Brain Res. Bull. 43 (1997) 81-85
    • (1997) Brain Res. Bull. , vol.43 , pp. 81-85
    • Ishimaru, H.1    Takahashi, A.2    Ikarashi, Y.3    Maruyama, Y.4
  • 32
    • 0030029959 scopus 로고    scopus 로고
    • The disruption of spatial cognition and changes in brain amino acid, monoamine and acetylcholine in rats with transient cerebral ischemia
    • Iwasaki K., Kitamura Y., Ohgami Y., Mishima K., and Fujiwara M. The disruption of spatial cognition and changes in brain amino acid, monoamine and acetylcholine in rats with transient cerebral ischemia. Brain Res. 709 (1996) 163-172
    • (1996) Brain Res. , vol.709 , pp. 163-172
    • Iwasaki, K.1    Kitamura, Y.2    Ohgami, Y.3    Mishima, K.4    Fujiwara, M.5
  • 33
    • 0026048763 scopus 로고
    • Activity of l-carnitine and l-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo
    • Janiri L., Falcone M., Persico A., and Tempesta E. Activity of l-carnitine and l-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo. J. Neural Transm. Gen. Sect. 86 (1991) 135-146
    • (1991) J. Neural Transm. Gen. Sect. , vol.86 , pp. 135-146
    • Janiri, L.1    Falcone, M.2    Persico, A.3    Tempesta, E.4
  • 34
    • 3342967838 scopus 로고    scopus 로고
    • Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage
    • Kristian T. Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage. Cell Calcium 36 (2004) 221-233
    • (2004) Cell Calcium , vol.36 , pp. 221-233
    • Kristian, T.1
  • 35
    • 0033600277 scopus 로고    scopus 로고
    • The changing landscape of ischaemic brain injury mechanisms
    • Lee J.M., Zipfel G.J., and Choi D.W. The changing landscape of ischaemic brain injury mechanisms. Nature 399 (1999) A7-A14
    • (1999) Nature , vol.399
    • Lee, J.M.1    Zipfel, G.J.2    Choi, D.W.3
  • 36
    • 0036082631 scopus 로고    scopus 로고
    • Presynaptic muscarinic M(2)-receptor-mediated inhibition of N-type Ca(2+) channels in cultured sphenopalatine ganglion: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation
    • Liu J., Evans M.S., and Lee T.J. Presynaptic muscarinic M(2)-receptor-mediated inhibition of N-type Ca(2+) channels in cultured sphenopalatine ganglion: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation. J. Pharmacol. Exp. Ther. 302 (2002) 397-405
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 397-405
    • Liu, J.1    Evans, M.S.2    Lee, T.J.3
  • 37
    • 0037133319 scopus 로고    scopus 로고
    • Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l-carnitine and/or R-alpha-lipoic acid
    • Liu J., Killilea D.W., and Ames B.N. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l-carnitine and/or R-alpha-lipoic acid. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 1876-1881
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 1876-1881
    • Liu, J.1    Killilea, D.W.2    Ames, B.N.3
  • 38
    • 0030908696 scopus 로고    scopus 로고
    • Neuroprotective effects of acetyl-l-carnitine after stroke in rats
    • Lolic M.M., Fiskum G., and Rosenthal R.E. Neuroprotective effects of acetyl-l-carnitine after stroke in rats. Ann. Emerg. Med. 29 (1997) 758-765
    • (1997) Ann. Emerg. Med. , vol.29 , pp. 758-765
    • Lolic, M.M.1    Fiskum, G.2    Rosenthal, R.E.3
  • 39
    • 0029831493 scopus 로고    scopus 로고
    • Update on the mechanism of action of antiepileptic drugs
    • Meldrum B.S. Update on the mechanism of action of antiepileptic drugs. Epilepsia 37 (1996) S4-S11
    • (1996) Epilepsia , vol.37
    • Meldrum, B.S.1
  • 40
    • 0033496016 scopus 로고    scopus 로고
    • Excitotoxins in neuronal apoptosis and necrosis
    • Nicotera P., and Lipton S.A. Excitotoxins in neuronal apoptosis and necrosis. J. Cereb. Blood Flow Metab. 19 (1999) 583-591
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 583-591
    • Nicotera, P.1    Lipton, S.A.2
  • 41
    • 0023133949 scopus 로고
    • Effect of l-acetyl carnitine HCl on rat steady-state visual evoked potentials. Comparison with l-carnitine
    • Onofrj M., Bodis-Wollner I., and Calvani M. Effect of l-acetyl carnitine HCl on rat steady-state visual evoked potentials. Comparison with l-carnitine. Drugs Exp. Clin. Res. 13 (1987) 5-13
    • (1987) Drugs Exp. Clin. Res. , vol.13 , pp. 5-13
    • Onofrj, M.1    Bodis-Wollner, I.2    Calvani, M.3
  • 42
    • 0028025440 scopus 로고
    • Effect of aging and acetyl-l-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria
    • Paradies G., Ruggiero F.M., Petrosillo G., Gadaleta M.N., and Quagliariello E. Effect of aging and acetyl-l-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria. FEBS Lett. 350 (1994) 213-215
    • (1994) FEBS Lett. , vol.350 , pp. 213-215
    • Paradies, G.1    Ruggiero, F.M.2    Petrosillo, G.3    Gadaleta, M.N.4    Quagliariello, E.5
  • 43
    • 0032723242 scopus 로고    scopus 로고
    • In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling
    • Rapoport S.I. In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling. Neurochem. Res. 24 (1999) 1403-1415
    • (1999) Neurochem. Res. , vol.24 , pp. 1403-1415
    • Rapoport, S.I.1
  • 44
    • 0026667916 scopus 로고
    • Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-l-carnitine
    • Rosenthal R.E., Williams R., Bogaert Y.E., Getson P.R., and Fiskum G. Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-l-carnitine. Stroke 23 (1992) 1312-1317
    • (1992) Stroke , vol.23 , pp. 1312-1317
    • Rosenthal, R.E.1    Williams, R.2    Bogaert, Y.E.3    Getson, P.R.4    Fiskum, G.5
  • 45
    • 0028874731 scopus 로고
    • Acetyl-l-carnitine attenuates neuronal damage in gerbils with transient forebrain ischemia only when given before the insult
    • Shuaib A., Waqaar T., Wishart T., Kanthan R., and Howlett W. Acetyl-l-carnitine attenuates neuronal damage in gerbils with transient forebrain ischemia only when given before the insult. Neurochem. Res. 20 (1995) 1021-1025
    • (1995) Neurochem. Res. , vol.20 , pp. 1021-1025
    • Shuaib, A.1    Waqaar, T.2    Wishart, T.3    Kanthan, R.4    Howlett, W.5
  • 46
    • 0020423164 scopus 로고
    • The distribution and role of carnitine in the mammalian brain
    • Shug A.L., Schmidt M.J., Golden G.T., and Fariello R.G. The distribution and role of carnitine in the mammalian brain. Life Sci. 31 (1982) 2869-2874
    • (1982) Life Sci. , vol.31 , pp. 2869-2874
    • Shug, A.L.1    Schmidt, M.J.2    Golden, G.T.3    Fariello, R.G.4
  • 48
    • 0025967410 scopus 로고
    • Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain
    • Sugita S., Uchimura N., Jiang Z.G., and North R.A. Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 2608-2611
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 2608-2611
    • Sugita, S.1    Uchimura, N.2    Jiang, Z.G.3    North, R.A.4
  • 49
    • 0025284835 scopus 로고
    • Acetyl-l-carnitine as a precursor of acetylcholine
    • White H.L., and Scates P.W. Acetyl-l-carnitine as a precursor of acetylcholine. Neurochem. Res. 15 (1990) 597-601
    • (1990) Neurochem. Res. , vol.15 , pp. 597-601
    • White, H.L.1    Scates, P.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.