Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs

Neuroscience Letters

Volumn 378, Issue 2, 2005, Pages 82-87

  Rosenthal, Robert E ^a   Bogaert, Yolanda E ^b   Fiskum, Gary ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Acetyl L carnitine; Brain injury; Cardiac arrest; Cerebral ischemia; Dogs; Metabolism

Indexed keywords

LEVACECARNINE;

ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE SEVERITY; DOG; FRONTAL CORTEX; HEART ARREST; HUMAN; LACTATE BLOOD LEVEL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL;

EID: 14844339380     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.12.011     Document Type: Article

References (36)

1. T. Aureli, A. Miccheli, M.E. Di Cocco, O. Ghirardi, A. Giuliani, M.T. Ramacci, and F. Conti Effect of acetyl-l-carnitine on recovery of brain phosphorous metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat-study by 13P and 1H-NMR spectroscopy Brain Res. 643 1994 92 99
2. S.A. Bernard, T.W. Gray, M.D. Buist, B.M. Jones, W. Silvester, G. Gutteridge, and K. Smith Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia N. Engl. J. Med. 346 2002 557 563
3. N. Bircher, and P. Safar Cerebral preservation during cardiopulmonary resuscitation Crit. Care Med. 13 1985 185 190
4. A.L. Bleyaert, E.M. Nemoto, P. Safar, S.M. Stezoski, J.J. Mickell, J. Moossy, and G.R. Rao Thiopental amelioration of brain damage after global ischemia in monkeys Anesthesiology 49 1978 390 398
5. Y.E. Bogaert, R.E. Rosenthal, and G. Fiskum Post-ischemic inhibition of cerebral cortex pyruvate dehydrogenase Free Radic. Biol. Med. 16 1994 811 820
6. Y.E. Bogaert, K.F.R. Sheu, P.R. Hof, A.M. Brown, J.P. Blass, R.E. Rosenthal, and G. Fiskum Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation Exp. Neurol. 161 2000 115 126
7. Brain Resuscitation Clinical Trial I Study Group, Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest, N. Engl. J. Med. 314 (1986) 397-403.
8. Brain Resuscitation Clinical Trial II study Group, A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest, N. Engl. J. Med. 324 (1991) 1225-1231.
9. E. Candelario-Jalil, A. Gonzalez-Falcon, M. Garcia-Cabreara, O.S. Leon, and B.L. Fiebich Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat Brain Res. 1007 2004 98 108
10. J.L. Farber Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis Lab. Invest. 47 1982 114 123
11. G. Fiskum Mitochondrial damage during cerebral ischemia Ann. Emerg. Med. 14 1985 810 815
12. G. Forloni, N. Angeretti, and S. Smiroldo Neuroprotective activity of acetyl-l-carnitine: studies in vitro J. Neurosci. Res. 37 1994 92 96
13. T. Fukuchi, Y. Katayama, T. Kamiya, A. McKee, F. Kashiwagi, and A. Terashi The effect of duration of cerebral ischemia on brain pyruvate dehydrogenase activity, energy metabolites, and blood flow during reperfusion in gerbil brain Brain Res. 792 1998 59 65
14. A. Gasparetto, G.G. Corbucci, R.A. DeBlasi, M. Antonelli, E. Bagiella, S. D'Iddio, and C. Trevisani Influence of acetyl-l-carnitine infusion on hemodynamic parameters and survival of circulatory-shock patients Int. J. Clin. Pharmacol. Res. 11 1991 83 92
15. P.J. Hoehner, T.J.J. Blanck, R.E. Rosenthal, and G. Fiskum Acetyl-l-carnitine prevents the increase in 3HPN200-110 binding during early reperfusion following global cerebral ischemia in dogs J. Cereb. Blood Flow Metab. 13 Suppl. 1 1993 S649
16. P.J. Hoehner, T.J.J. Blanck, R. Roy, R.E. Rosenthal, and G. Fiskum Alteration of voltage dependent calcium channels (VDCC) in the canine brain during cardiac arrest and reperfusion J. Cereb. Blood Flow Metab. 12 1992 418 424
17. Hypothermia after Cardiac Arrest Study Group, Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest, N. Engl. J. Med. 346 (2002) 549-556.
18. A. Inano, Y. Sai, H. Nikaido, N. Hasimoto, M. Asano, A. Tsuji, and I. Tamai Acetyl-l-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2 Biopharm. Drug Dispos. 24 2003 357 365
19. T. Ishii, Y. Shimpo, Y. Matsuoka, and K. Kinoshita Anti-apoptotic effect of acetyl-l-carnitine and l-carnitine in primary cultured neurons Jpn. J. Pharmacol. 83 2000 119 124
20. H. Kuratsune, Y. Watanabe, K. Yamaguti, G. Jacobsson, M. Takahashi, T. Machii, H. Onoe, K. Onoe, K. Matsumura, S. Valind, T. Kitani, and B. Langstron High uptake of [2-11C] acetyl-l-carnitine into the brain: a PET study Biochem. Biophys. Res. Commun. 231 1997 488 493
21. Y. Liu, R.E. Rosenthal, P. Starke-Reed, and G. Fiskum Inhibition of post-cardiac arrest brain protein oxidation by acetyl-l-carnitine Free Radic. Biol. Med. 15 1993 667 670
22. M.M. Lolic, G. Fiskum, and R.E. Rosenthal Neuroprotective effects of acetyl-l-carnitine after stroke in rats Ann. Emerg. Med. 29 1997 758 765
23. R.O. Roine, M. Kaste, A. Kinnunen, P. Nikki, and S. Kajaste Nimodipine after resuscitation from out-of-hospital ventricular fibrillation: a placebo-controlled, double blind, randomized trial J. Am. Med. Assoc. 264 1990 3171 3177
24. R.E. Rosenthal, F. Hamud, G. Fiskum, P.J. Varghese, and S. Sharpe Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine J. Cereb. Blood Flow Metab. 7 1987 752 758
25. R.E. Rosenthal, R. Silbergleit, P. Hof, Y. Haywood, and G. Fiskum Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest Stroke 34 2003 1311 1316
26. R.E. Rosenthal, R. Williams, Y.E. Bogaert, P.R. Getson, and G. Fiskum Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-l-carnitine Stroke 23 1992 1312 1318
27. A. Sakamoto, S.T. Ohnishi, T. Ohnishi, and R. Ogawa Relationship between free radical production and lipid peroxidation during ischemia-reperfusion injury in the rat brain Brain Res. 554 1991 86 192
28. P.D. Schellinger, and S. Warach Therapeutic time window of thrombolytic therapy following stroke Curr. Atheroscler. Rep. 6 2004 288 294
29. A. Shuaib, T. Waquaar, T. Wishart, R. Kanthan, and W. Howlett Acetyl-l-carnitine attenuates neuronal damage in gerbils with transient forebrain ischemia only when given before the insult Neurochem. Res. 20 1995 1021 1025
30. T. Tabatabaie, J.D. Potts, and R.A. Floyd Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase Arch. Biochem. Biophys. 336 1990 290 296
31. P. Vaagenes, R. Cantadore, P. Safar, J. Moossy, G. Rao, W. Diven, H. Alexander, and W. Stezoski Amelioration of brain damage by lidoflazine after prolonged ventricular fibrillation cardiac arrest in dogs Crit. Care Med. 12 1985 846 855
32. J. Van Reempts, and M. Borgers Ischemic brain injury and cell calcium: morphologic and therapeutic aspects Ann. Emerg. Med. 13 1985 736 742
33. E. Zaidan, K.F.R. Sheu, and N.R. Sims The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats J. Neurochem. 70 1998 233 241
34. E. Zaidan, and N.R. Sims Reduced activity of the pyruvate dehydrogenase complex but not cytochorme c oxidase is associated with neuronal loss in the striatum following short-term forebrain ischemia Brain Res. 772 1997 23 28
35. E. Zaidan, and N.R. Sims Selective reductions in the activity of the PDH complex in mitochondria isolated from brain subregions following rorebrain ischemia in rats J. Cereb. Blood Flow Metab. 13 1993 98 104
36. I. Zini, A. Tomasi, R. Grimaldi, V. Vannini, and L.F. Agnati Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis Neurosci. Lett. 138 1992 279 282