Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of the breast

Applied Immunohistochemistry and Molecular Morphology

Volumn 11, Issue 1, 2003, Pages 1-8

  Reis Filho, Jorge S ^a,c   Milanezi, Fernanda ^a   Paredes, Joana ^a   Silva, Paula ^a,b   Pereira, Emílio M ^d   Maeda, Sueli A ^d   De Carvalho, Leda V ^d   Schmitt, Fernando C ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

^c UNIVERSITY OF MINHO   (Portugal)

^d Laboratory of Clinical Pathology Salomão and Zoppi   (Brazil)

Author keywords

Breast; Carcinosarcoma; Immunohistochemistry; Matrix producing carcinoma; Metaplastic carcinoma; Myoepithelium; Spindle cell carcinoma

Indexed keywords

ACTIN; BIOTIN; CADHERIN; CYTOKERATIN; CYTOKERATIN 14; MASPIN; MOLECULAR MARKER; P CADHERIN; PEROXIDASE; PROTEIN P63; PROTEIN S 100; STREPTAVIDIN; UNCLASSIFIED DRUG; VIMENTIN;

ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ARTICLE; BREAST CARCINOMA; BREAST EPITHELIUM; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOGENESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; METAPLASIA; MYOEPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STEM CELL;

EID: 0037347755     PISSN: 15412016     EISSN: None     Source Type: Journal    
DOI: 10.1097/00129039-200303000-00001     Document Type: Article

References (37)

1. Tavassoli FA. Classification of metaplastic carcinomas of the breast. Pathol Annu 1992;27(pt 2):89-119.
2. Gobbi H, Simpson JF, Borowsky A, et al. Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer 1999;85:2170-82.
3. Sneige N, Yaziji H. Mandavilli SR, et al. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol 2001; 25:1009-16.
4. Chhieng C, Cranor M, Lesser ME, et al. Metaplastic carcinoma of the breast with osteocartilaginous heterologous elements. Am J Surg Pathol 1998;22:188-94.
5. Oberman HA. Metaplastic carcinoma of the breast. A clinicopathologic study of 29 patients. Am J Surg Pathol 1987;11:918-29.
6. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. I. Matrix-producing carcinoma. Hum Pathol 1989;20:628-35.
7. Wargotz ES, Deos PH, Norris HJ. Metaplastic carcinomas of the breast. II. Spindle cell carcinoma. Hum Pathol 1989;20:732-40.
8. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. III. Carcinosarcoma. Cancer 1989;64:1490-9.
9. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. IV. Squamous cell carcinoma of ductal origin. Cancer 1990;65:272-6.
10. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. V. Metaplastic carcinoma with osteoclastic giant cells. Hum Pathol 1990;21:1142-50.
11. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
12. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
13. Hendrix MJ. De-mystifying the mechanism(s) of maspin. Nat Med 2000;6:374-6.
14. Maass N, Teffner M, Rösel F, et al. Decline in the expression of the serine proteinase inhibitor maspin is associated with tumour progression in ductal carcinomas of the breast. J Pathol 2001;195:321-6.
15. Lele SM, Graves K, Gatalica Z. Immunohistochemical detection of maspin is a useful adjunct in distinguishing radial sclerosing lesion from tubular carcinoma of the breast. Appl Immunohistochem Molecul Morphol 2000;8:32-6.
16. Reis Filho JS, Milanezi F, Silva P, et al. Maspin expression in myoepithelial tumours of the breast. Pathol Res Pract 2001;197:817-21.
17. Reis-Filho JS, Schmidtt FC. Taking advantage of basic research: p63 is a reliable myoepithelial and stem cell marker. Adv Anat Pathol 2002;9:280-9.
18. Barbareschi M, Pecciarini L, Cangi MG, et al. p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Am J Surg Pathol 2001;25:1054-60.
19. Paredes J, Milanezi F, Viegas L, et al. P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast. Virchows Arch 2002;440:16-21.
20. Gamallo C, Moreno-Bueno G, Sarrio D, et al. The prognostic significance of P-cadherin in infiltrating ductal breast carcinoma. Mod Pathol 2001;14:650-4.
21. Madhavan M, Srinivas P, Abraham E, et al. Cadherins as predictive markers of nodal metastasis in breast cancer. Mod Pathol 2001;14:423-7.
22. Palacios J, Benito N, Pizarro A, et al. Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features. Am J Pathol 1995;46:605-12.
23. Han AC, Soler AP, Knudsen KA, et al. Distinct cadherin profiles in special variant carcinomas and other tumors of the breast. Hum Pathol 1999;30:1035-9.
24. Peralta Soler A, Knudsen KA, Salazar H, et al. P-cadherin expression in breast carcinoma indicates poor survival. Cancer 1999;86:1263-72.
25. Reis-Filho JS, Milanezi F, Schmitt FC. Maspin is expressed in the nuclei of breast myoepithelial cells. J Pathol 2002;197:272-3.
26. Zhuang Z, Lininger RA, Man YG, et al. Identical clonality of both components of mammary carcinosarcoma with differential loss of heterozygosity. Mod Pathol 1997;10:354-62.
27. Thompson L, Chang B, Barsky SH. Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis. Am J Surg Pathol 1996;20:277-85.
28. Wang X, Mori I, Tang W, et al. Metaplastic carcinoma of the breast: p53 analysis identified the same point mutation in the three histologic components. Mod Pathol 2001;14:1183-6.
29. Hamperl H. The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. Curr Top Pathol 1970; 53:161-220.
30. Foote FW, Stewart FW. A histologic classification of carcinoma of the breast. Am J Cancer 1940;40:74-9.
31. Hamperl H. Über die Myothelien (myo-epithelialen Element) der Brustdrüse. Virchows Arch Path Anat 1939;305:171-215.
32. Harb JM, Komorowski RA, Vitali CM. Metaplastic breast carcinoma invading chest wall. Ultrastruct Pathol 1995;19:439-43.
33. Raju GC, Wee A. Spindle cell carcinoma of the breast. Histopathology 1990;16:497-9.
34. Simpson RH, Cope N, Skalova A, et al. Malignant adenomyoepithelioma of the breast with mixed osteogenic, spindle cell, and carcinomatous differentiation. Am J Surg Pathol 1998;22:631-6.
35. Chu PG, Lyda MH, Weiss LM. Cytokeratin 14 expression in epithelial neoplasms: a survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumors. Histopathology 2001;39:9-16.
36. Loose JH, Patchefsky AS, Hollander IJ, et al. Adenomyoepithelioma of the breast. A spectrum of biologic behavior. Am J Surg Pathol 1992;16:868-76.
37. Sapino A, Papotti M, Sanfilippo B, et al. Tumor types derived from epithelial and myoepithelial cell lines of R3230AC rat mammary carcinoma. Cancer Res 1992;52:1553-60.