Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease

Neuroscience Letters

Volumn 441, Issue 2, 2008, Pages 233-236

  Helisalmi, Seppo ^a   Tarvainen, Timo ^a   Vepsäläinen, Saila ^a   Koivisto, Anne Mari ^a,b   Hiltunen, Mikko ^a   Soininen, Hilkka ^a,b  

^a Unit of Neurology   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alzheimer's disease; Association; Case control; PPARG

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FINLAND; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; ONSET AGE; PPARG GENE; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

AGED; ALLELES; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; FEMALE; FINLAND; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR GAMMA;

EID: 46949088922     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.06.029     Document Type: Article

References (27)

1. Bertram L., McQueen M.B., Mullin K., Blacker D., and Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39 (2007) 17-23
2. Craft S., and Watson G.S. Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol. 3 (2004) 169-178
3. Doney A.S., Fischer B., Leese G., Morris A.D., and Palmer C.N. Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study. Arterioscl. Thromb. Vas. Biol. 24 (2004) 2403-2407
4. Erketin-Taner N. Genetics of Alzheimer's disease: a centennial review. Neurol. Clin. 25 (2007) 611-667
5. Franks P.W., Jablonski K.A., Delahanty L., Hanson R.L., Kahn S.E., Altshuler D., Knowler W.C., and Florez J.C. Diabetes Prevention Program Research Group, The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program. Diabetologia 50 (2007) 2451-2460
6. Hamada T., Kotani K., Tsuzaki K., Sano Y., Murata T., Tabata M., Sato S., and Sakane N. Association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene with small dense low-density lipoprotein in the general population. Metabolism 56 (2007) 1345-1349
7. Hamilton G., Proitsi P., Jehu L., Morgan A., Williams J., O'Donovan M.C., Owen M.J., Powell J.F., and Lovestone S. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. Am. J. Med. Genet. B: Neuropsych. Genet. 144 (2007) 508-516
8. Helwig U., Rubin D., Kiosz J., Schreiber S., Fölsch U.R., Nothnagel M., Döring F., and Schrezenmeir J. The minor allele of the PPARgamma2 Pro12Ala polymorphism is associated with lower postprandial TAG and insulin levels in non-obese healthy men. Br. J. Nutr. 97 (2007) 847-854
9. Heneka M.T., and Landreth G.E. PPARs in the brain. Biochim. Biophys. Acta 1771 (2007) 1031-1045
10. Heneka M.T., Landreth G.E., and Feinstein D.L. Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease. Ann. Neurol. 49 (2001) 276
11. in't Veld B.A., Hofman A., Launer L.J., van Duijn C.M., Stijnen T., Breteler M.M., and Stricker B.H. Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease. N. Engl. J. Med. 345 (2001) 1515-1521
12. Koivisto A.M., Helisalmi S., Pihlajamäki J., Hiltunen M., Koivisto K., Moilanen L., Kuusisto J., Helkala E.L., Hänninen T., Kervinen K., Kesäniemi Y.A., Laakso M., and Soininen H. Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population. Dement Geriatr. Cogn. Disord. 22 (2006) 449-453
13. Landreth G.E., and Heneka M.T. Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiol. Aging 22 (2001) 937-944
14. Lehtovirta M., Soininen H., Helisalmi S., Mannermaa A., Helkala E.L., Hartikainen P., Hänninen T., Ryynänen M., and Riekkinen P.J. Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism. Neurology 46 (1996) 413-419
15. Li H., Wetten S., Li L., St Jean P.L., Upmanyu R., Surh L., Hosford D., Barnes M.R., Briley J.D., Borrie M., Coletta N., Delisle R., Dhalla D., Ehm M.G., Feldman H.H., Fornazzari L., Gauthier S., Goodgame N., Guzman D., Hammond S., Hollingworth P., Hsiung G.Y., Johnson J., Kelly D.D., Keren R., Kertesz A., King K.S., Lovestone S., Loy-English I., Matthews P.M., Owen M.J., Plumpton M., Pryse-Phillips W., Prinjha R.K., Richardson J.C., Saunders A., Slater A.J., St George-Hyslop P.H., Stinnett S.W., Swartz J.E., Taylor R.L., Wherrett J., Williams J., Yarnall D.P., Gibson R.A., Irizarry M.C., Middleton L.T., and Roses A.D. Candidate single-nucleotide polymorphisms from a genomewide study of Alzheimer's disease. Arch. Neurol. 65 (2008) 45-53
16. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 34 (1984) 939-944
17. Meirhaeghe A., and Amouyel P. Impact of genetic variation of PPARgamma in humans. Mol. Genet. Metab. 83 (2004) 93-102
18. Ott A., Stolk R.P., van Harskamp F., Pols H.A., Hofman A., and Breteler M.M. Diabetes mellitus and the risk of dementia: the Rotterdam study. Neurology 53 (1999) 1937-1942
19. Pasquier F., Boulogne A., Leys D., and Fontaine P. Diabetes mellitus and dementia. Diabetes Metab. 32 (2006) 403-414
20. Purcell S., Cherney S.S., and Sham P.C. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19 (2003) 149-150
21. Reiman E.M., Webster J.A., Myers A.J., Hardy J., Dunckley T., Zismann V.L., Joshipura K.D., Pearson J.V., Hu-Lince D., Huentelman M.J., Craig D.W., Coon K.D., Liang W.S., Herbert R.H., Beach T., Rohrer K.C., Zhao A.S., Leung D., Bryden L., Marlowe L., Kaleem M., Mastroeni D., Grover A., Heward C.B., Ravid R., Rogers J., Hutton M.L., Melquist S., Petersen R.C., Alexander G.E., Caselli R.J., Kukull W., Papassotiropoulos A., and Stephan D.A. GAB2 alleles modify Alzheimer's risk in APOE ε4 carriers. Neuron 54 (2007) 713-720
22. Sastre M., Dewachter I., Rossner S., Bogdanovic N., Rosen E., Borghgraef P., Evert B.O., Dumitrescu-Ozimek L., Thal D.R., Landreth G., Walter J., Klockgether T., van Leuven F., and Heneka M.T. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 443-448
23. Sauder S., Kölsch H., Lütjohann D., Schulz A., von Bergmann M., Maier W., and Heun R. Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients. J. Neural. Transm. 112 (2005) 1381-1389
24. Scacchi R., Pinto A., Gambina G., Rosano A., and Corbo R.M. The peroxisome proliferator-activated receptor gamma (PPAR-γ2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians. Brain Res. 1139 (2007) 1-5
25. Stefanski A., Majkowska L., Ciechanowicz A., Frankow M., Safranow K., Parczewski M., Moleda P., and Pilarska K. Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes. J. Hum. Hypertens. 20 (2006) 684-692
26. Tsukamoto K., Watanabe T., Matsushima T., Kinoshita M., Kato H., Hashimoto Y., Kurokawa K., and Teramoto T. Determination by PCR_RFLP of APOE genotype in a Japanese population. J. Lab. Clin. Med. 121 (1993) 598-602
27. Yaffe K., Kanaya A.M., Lindquist K., Hsueh W.C., Cummings S.R., Beamer B., Newman A., Rosano C., Li R., and Harris T. Health ABC Study, PPAR-γ Pro12Ala genotype and risk of cognitive decline in elders. Neurobiol. Aging 29 (2008) 78-83