A bridging water anchors the tethered 5-(3-aminopropyl)-2′- deoxyuridine amine in the DNA major groove proximate to the N+2 C·G base pair: Implications for formation of interstrand 5′-GNC-3′ cross-links by nitrogen mustards

Biochemistry

Volumn 47, Issue 27, 2008, Pages 7147-7157

  Wang, Feng ^a   Li, Feng ^b   Ganguly, Manjori ^c   Marky, Luis A ^c   Gold, Barry ^c,d   Egli, Martin ^b   Stone, Michael P ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; NITROGEN; NITROGEN COMPOUNDS; ORGANIC ACIDS; ORGANIC COMPOUNDS;

AMINOPROPYL; BASE PAIRS; DEOXYURIDINE; DODECAMERS; NITROGEN MUSTARDS; SITE SPECIFIC;

NUCLEIC ACIDS;

5 (3 AMINOPROPYL) 2' DEOXYURIDINE; AMINE; AZIRIDINE DERIVATIVE; CHLORMETHINE; CURVED DNA; DEOXY 7 DEAZAGUANOSINE; DEOXYGUANOSINE DERIVATIVE; DEOXYURIDINE DERIVATIVE; DNA; MAGNESIUM ION; MELPHALAN; WATER;

ARTICLE; BASE PAIRING; BINDING SITE; DNA CONFORMATION; DNA CROSS LINKING; DNA HELIX; DRUG MECHANISM; ELECTRICITY; MOLECULAR INTERACTION; PRIORITY JOURNAL; THERMODYNAMICS;

BASE PAIRING; BASE SEQUENCE; CALORIMETRY; CATIONS; CROSS-LINKING REAGENTS; CRYSTALLIZATION; DEOXYGUANINE NUCLEOTIDES; DEOXYURIDINE; DNA; ELECTROSTATICS; MOLECULAR SEQUENCE DATA; NITROGEN MUSTARD COMPOUNDS; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; THERMODYNAMICS; TRANSITION TEMPERATURE; WATER;

BRASSICACEAE;

EID: 46849112412     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800375m     Document Type: Article

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