Human embryonic stem cells may display higher resistance to genotoxic stress as compared to primary explanted somatic cells

Stem Cells and Development

Volumn 17, Issue 3, 2008, Pages 599-607

  Vinoth, Kumar Jayaseelan ^a   Heng, Boon Chin ^a   Poonepalli, Anuradha ^b   Banerjee, Birendranath ^b   Balakrishnan, Lakshmidevi ^b   Lu, Kai ^a   Hande, M Prakash ^b   Cao, Tong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

MITOMYCIN C; PEPTIDE NUCLEIC ACID;

ARTICLE; CELL CULTURE; CELL FUNCTION; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA DAMAGE; EMBRYONIC STEM CELL; EXPLANT; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTOXICITY; HUMAN; HUMAN CELL; LUNG FIBROBLAST; METAPHASE; PRIORITY JOURNAL; SOMATIC CELL; TELOMERE;

ANIMALS; CELLS, CULTURED; CHROMOSOME BREAKAGE; DNA DAMAGE; DRUG RESISTANCE; EMBRYONIC STEM CELLS; FIBROBLASTS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; METAPHASE; MICE; MITOMYCIN; PEPTIDE NUCLEIC ACIDS; TELOMERE;

ANIMALIA;

EID: 46749142543     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2007.0088     Document Type: Article

References (36)

1. Piersma AH. (2006). Alternative methods for developmental toxicity testing. Basic Clin Pharmacol Toxicol 98:427-431.
2. Segner H. (2004). Cytotoxicity assays with fish cells as an alternative to the acute lethality test with fish. Altern Lab Anim 32:375-382.
3. Mersch-Sundermann V, S Knasmuller, XJ WuF Darroudi and F Kassie. (2004). Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 198:329-340.
4. Knasmuller S, V Mersch-Sundermann, S Kevekordes, F Darroudi, WW Huber, C Hoelzl, J Bichler and BJ Majer. (2004). Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 198:315-328.
5. Morel F, S Langouet, K Maheo and A Guillouzo. (1997). The use of primary hepatocyte cultures for the evaluation of chemoprotective agents. Cell Biol Toxicol 13: 323-329.
6. Hilliard C, R Hill, M Armstrong, C Fleckenstein, J Crowley, E Freeland, D Duffy and SM Galloway. (2007). Chromosome aberrations in Chinese hamster and human cells: A comparison using compounds with various genotoxicity profiles. Mutat Res 13 Mutat Res 616:103-118.
7. Balluch M. (2006). Animals have a right to life. ALTEX 23:281-293.
8. Luy J. (2006). The question of a right to life in animal ethics. ALTEX 23:279-280.
9. Rohwedel J, K Guan, C Hegert and AM Wobus. (2001). Embryonic stem cells as an in vitro model for mutagenicity, cytotoxicity and embryotoxicity studies: present state and future prospects. Toxicol In Vitro 15:741-753.
10. Thomson JA, J Itskovitz-Eldor, SS Shapiro, MA Waknitz, JJ Swiergiel, VS Marshall and JM Jones. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
11. Reubinoff BE, MF Pera, CY Fong, A Trounson and A Bongso. (2000). Embryonic stem cell. Nature Biotechnol 18:399-404.
12. Cowan CA, I Klimanskaya, J McMahon, J Atienza, J Witmyer, JP Zucker, S Wang, CC Morton, AP McMahon, D Powers and DA Melton. (2004). Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med 350:1353-1356.
13. Caisander G, H Park, K Frej, J Lindqvist, C Bergh, K Lundin and C Hanson. (2006). Chromosomal integrity maintained in five human embryonic stem cell lines after prolonged in vitro culture. Chromosome Res 14:131-137.
14. Buzzard JJ, NM Gough, JM Crook and A Colman. (2004). Karyotype of human ES cells during extended culture. Nature Biotechnol 22:381-382.
15. Genschow E, G Scholz, NA Brown, AH Piersma,M Brady,N Clemann, H Huuskonen, F Paillard, S Bremer and H Spielmann. (1999). Development of prediction models for three in vitro embryotoxicity tests which are evaluated in an ECVAM validation study. ALTEX 16:73-83.
16. Walmsley RM. (2005). Genotoxicity screening: the slow march to the future. Expert Opin Drug Metab Toxicol 1:261-268.
17. Cimino MC. (2006). Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes. Environ Mol Mutagen 47:362-390.
18. Iyer VN and W Szybalski. (1964). Mitomycins and Porfiromycin: Chemical mechanism of activation and crosslinking of DNA. Science 145:55-58.
19. Organization for Economic Cooperation and Development (OECD). 2 rue Andre Pascal, F-75775 Paris Cedex 16, France. (1997). Mammalian Bone Marrow Chromosomal Aberration Test. OECD 475 Accessible online at the following website address: http://www.oecd.org/dataoecd/18/11/1948450.pdf (last accessed on May 8, 2008).
20. Hande MP, E Samper, P Lansdorp and MA Blasco. (1999). Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol 144:589 OECD 475-601.
21. Speicher MR, SG Ballard and DC Ward. (1996). Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nature Genet 12:368-375.
22. Ware CB, AM Nelson and CA Blau. (2006). A comparison of NIH-approved human ESC lines. Stem Cells 24:2677-2684.
23. Satoh T, M Hatanaka, K Yamamoto, M Kuro-o and T Sofuni. (2002). Application of mFISH for the analysis of chemically-induced chromosomal aberrations: a model for the formation of triradial chromosomes. Mutat Res 504:57-65.
24. Chung HW, SJ Kang and SY Kim. (2002). A combination of the micronucleus assay and a FISH technique for evaluation of the genotoxicity of 1,2,4-benzenetriol. Mutat Res 516:49-56.
25. Bender MA, RJ Preston, RC Leonard, BE Pyatt, PC Gooch and MD Shelby. (1988). Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. Mutat Res 204:421-433.
26. Murg MN, M Schuler and DA Eastmond. (1999). Persistence of chromosomal alterations affecting the 1cen-q12 region in a human lymphoblastoid cell line exposed to diepoxybutane and MMC. Mutat Res 446:193-203.
27. Hande, MP, TV Azizova, LE Burak, VF Khokhryakov, CR Geard and DJ Brenner. (2005). Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH study. Genes Chromosomes Cancer 44:1-9.
28. Brogger A and J Johansen. (1972). A model for the production of chromosome damage by MMC. Chromosoma 38:95-104.
29. Natarajan AT and W Schmid. (1971). Differential response of constitutive and facultative heterochromatin in the manifestation of mitomycin induced chromosome aberrations in Chinese hamster cells in vitro. Chromosoma 33:48-62.
30. Bradner WT. (2001). MMC: a clinical update. Cancer Treat Rev 27:35-50.
31. Player A, Y Wang, B Bhattacharya, M Rao, RK Puri and ES Kawasaki. (2006). Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines. Stem Cells Dev 15:315-323.
32. Wu H, J Xu, ZP Pang, W Ge, KJ Kim, B Blanchi, C Chen, TC Südhof and YE Sun. (2007). Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci USA 104:13821-1386.
33. Chen MF, CT Lin, WC Chen, CT Yang, CC Chen, SK Liao, JM Liu, CH Lu, and KD Lee. (2006). The sensitivity of human mesenchymal stem cells to ionizing radiation. Int J Radiat Oncol Biol Phys 66:244-253.
34. DiBiase SJ, ZC Zeng, R Chen, T Hyslop, WJ Curran Jr and F Iliakis G. (2000). DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res 60:1245-1253.
35. Saretzki G, L Armstrong, A Leake, M Lako and T von Z Zglinicki. (2004). Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. Stem Cells 22:962-971.
36. Shum L, CM Coleman, Y Hatakeyama and RS Tuan. (2003). Morphogenesis and dysmorphogenesis of the appendicular skeleton. Birth Defects Res C Embryo Today 69:102-122.