Opioid and melanocortin receptors: Do they have overlapping pharmacophores?

Biopolymers - Peptide Science Section

Volumn 90, Issue 3, 2008, Pages 433-438

  Lee, Yeon Sun ^a   Agnes, Richard S ^a   Cain, James P ^a   Kulkarni, Vinod ^a   Cai, Minying ^a   Salibay, Christine ^a   Ciano, Kathy ^a   Petrov, Ravil ^a   Mayorov, Alexander ^a   Vagner, Josef ^a   Trivedi, Dev ^a   Davis, Peg ^b   Ma, Shou Wu ^b   Lai, Josephine ^b   Porreca, Frank ^b   Vardanyan, Ruben ^a   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Anti opioid effect; Antinociception; Dmt Tic; Fentanyl; Melanocortin receptor; Multi target drug; Opioid receptor; Overlapping pharmacophores; Side effect

Indexed keywords

ARSENIC COMPOUNDS; CARBOXYLIC ACIDS; CHLORINE COMPOUNDS; LIGANDS; ORGANIC ACIDS; PHARMACODYNAMICS; TEMPERATURE INDICATING CAMERAS; TITANIUM CARBIDE;

ANTI-OPIOID EFFECT; ANTINOCICEPTION; BINDING ASSAYS; BIOLOGICAL ACTIVITIES; DMT-TIC; FENTANYL; MELANOCORTIN; MELANOCORTIN RECEPTOR; MULTI-TARGET DRUG; OPIOID RECEPTOR; OVERLAPPING PHARMACOPHORES; PHARMACOPHORE; PHARMACOPHORES; SIDE EFFECT; SMALL MOLECULES; TETRAHYDROISOQUINOLINE;

SEMICONDUCTOR COUNTERS;

DELTA OPIATE RECEPTOR; FENTANYL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HORMONE RECEPTOR STIMULATING AGENT; LIGAND; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR AGONIST; MELANOCORTIN 5 RECEPTOR; MELANOCORTIN RECEPTOR; OPIATE RECEPTOR; UNCLASSIFIED DRUG; CYCLIC AMP;

ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CHIMERA; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TARGETING; IC 50; PHARMACOPHORE; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; BINDING COMPETITION; CELL LINE; CYTOLOGY; DRUG POTENTIATION; HUMAN; KIDNEY; METABOLISM; RADIOASSAY;

BINDING, COMPETITIVE; CELL LINE; CYCLIC AMP; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; LIGANDS; RADIOLIGAND ASSAY; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTORS, OPIOID, DELTA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 46749141403     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20814     Document Type: Article

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