A novel GDP-dependent pyruvate kinase isozyme from Toxoplasma gondii localizes to both the apicoplast and the mitochondrion

Journal of Biological Chemistry

Volumn 283, Issue 20, 2008, Pages 14041-14052

  Saito, Tomoya ^a   Nishi, Manami ^b   Lim, Muoy I ^b   Wu, Bo ^b   Maeda, Takuya ^a   Hashimoto, Hisayuki ^a   Takeuchi, Tsutomu ^a   Roos, David S ^b,c   Asai, Takashi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Ellison Medical Foundation

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; AMINO ACIDS; ANTIBODIES; FLUORESCENCE; GLUCOSE; ORGANIC ACIDS; PORT TERMINALS;

AMINO ACID SEQUENCES; APICOPLAST; CATALYTIC ACTIVITIES; CONSERVED REGIONS; CYTOSOLIC; DIPHOSPHATE; ENZYMATIC CHARACTERIZATIONS; FLUORESCENT PROTEINS; HIGH PH; IMMUNOFLUORESCENCE ASSAYS; PHYLOGENETIC ANALYSES; PYRUVATE KINASES; REGULATORY EFFECTS; SUBSTRATE BINDINGS; TOXOPLASMA GONDII; TRANSLATION PRODUCTS;

FRUCTOSE;

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; FRUCTOSE 1,6 BISPHOSPHATE; FRUCTOSE 2,6 BISPHOSPHATE; GLUCOSE 6 PHOSPHATASE; GUANOSINE DIPHOSPHATE; ISOENZYME; MITOCHONDRIAL ENZYME; POTASSIUM ION; PROTOZOAL PROTEIN; PYRUVATE KINASE; RECOMBINANT ENZYME; RIBOSE 5 PHOSPHATE; ISOPROTEIN; RECOMBINANT PROTEIN;

APICOPLAST; ARTICLE; CYTOSOL; ENZYME LOCALIZATION; ENZYME MECHANISM; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF; SEQUENCE HOMOLOGY; TOXOPLASMA GONDII; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; KINETICS; METABOLISM; MOLECULAR GENETICS; PHYLOGENY; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS; TOXOPLASMA;

EUKARYOTA; PROTEOBACTERIA; TOXOPLASMA GONDII;

AMINO ACID SEQUENCE; ANIMALS; GUANOSINE DIPHOSPHATE; KINETICS; MITOCHONDRIA; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHYLOGENY; PROTEIN BINDING; PROTEIN ISOFORMS; PYRUVATE KINASE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TOXOPLASMA;

EID: 46649104129     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709015200     Document Type: Article

References (73)

1. Dubey, J. P. (1993) in Parasitic Protozoa (Kreier, J. P., ed) pp. 5-56, Academic Press, San Diego
2. Fulton, J. D., and Spooner, D. F. (1960) Exp. Parasitol. 9, 293-301
3. Boyer, P. D. (1962) in The Enzymes (Boyer, P. D., Lardy, H., and Myrback, K., eds) 2nd Ed., pp. 95-113, Academic Press, New York
4. Valentini, G., Chiarelli, L., Fortin, R., Speranza, M. L., Galizzi, A., and Mattevi, A. (2000) J. Biol. Chem. 275, 18145-18152
5. Waygood, E. B., and Sanwal, B. D. (1974) J. Biol. Chem. 249, 265-274
6. Waygood, E. B., Rayman, M. K., and Sanwal, B. D. (1975) Can. J. Biochem. 53, 444-454
7. Plaxton, W. C. (1996) Annu. Rev. Plant Physiol. Plant Mol. Biol. 47, 185-214
8. Saito, T., Maeda, T., Nakazawa, M., Takeuchi, T., Nozaki, T., and Asai, T. (2002) Int. J. Parasitol. 32, 961-967
9. Peng, Z. Y., and Mansour, T. E. (1992) Mol. Biochem. Parasitol. 54, 223-230
10. Denton, H., Roberts, C. W., Alexander, J., Thong, K. W., and Coombs, G. H. (1996) FEMS Microbiol. Lett. 137, 103-108
11. Maeda, T., Saito, T., Oguchi, Y., Nakazawa, M., Takeuchi, T., and Asai, T. (2003) Parasitol. Res. 89, 259-265
12. Bahl, A., Brunk, B., Crabtree, J., Fraunholz, M. J., Gajria, B., Grant, G. R., Ginsburg, H., Gupta, D., Kissinger, J. C., Labo, P., Li, L., Mailman, M. D., Milgram, A. J., Pearson, D. S., Roos, D. S., Schug, J., Stoeckert, C. J., Jr., and Whetzel, P. (2003) Nucleic Acids Res. 31, 212-215
13. Hoffman, S. L., Subramanian, G. M., Collins, F. H., and Venter, J. C. (2002) Nature 415, 702-709
14. Roos, D. S., Donald, R. G., Morrissette, N. S., and Moulton, A. L. (1994) Methods Cell Biol. 45, 27-63
15. Asai, T., and Suzuki, Y. (1990) FEMS Microbiol. Lett. 60, 89-92
16. Nishi, M. (2006) Cell-cycle Regulation of Organelle Biogenesis and Apicoplast Protein Trafficking in Toxoplasma gondii. Ph.D. thesis, University of Pennsylvania
17. Waller, R. F., Keeling, P. J., Donald, R. G., Striepen, B., Handman, E., Lang-Unnasch, N., Cowman, A. F., Besra, G. S., Roos, D. S., and McFadden, G. I. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12352-12357
18. Kissinger, J. C., Gajria, B., Li, L., Paulsen, I. T., and Roos, D. S. (2003) Nucleic Acids Res. 31, 234-236
19. Hulo, N., Bairoch, A., Bulliard, V., Cerutti, L., De Castro, E., Langendijk-Genevaux, P. S., Pagni, M., and Sigrist, C. J. (2006) Nucleic Acids Res. 34, D227-D230
20. Emanuelsson, O., Nielsen, H., Brunak, S., and von Heijne, G. (2000) J. Mol. Biol. 300, 1005-1016
21. Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997) Protein Eng. 10, 1-6
22. Bendtsen, J. D., Nielsen, H., von Heijne, G., and Brunak, S. (2004) J. Mol. Biol. 340, 783-795
23. Emanuelsson, O., Nielsen, H., and von Heijne, G. (1999) Protein Sci. 8, 978-984
24. Kyte, J., and Doolittle, R. F. (1982) J. Mol. Biol. 157, 105-132
25. Chen, F., Mackey, A. J., Stoeckert, C. J., Jr., and Roos, D. S. (2006) Nucleic Acids Res. 34, D363-D368
26. Li, L., Stoeckert, C. J., Jr., and Roos, D. S. (2003) Genome Res. 13, 2178-2189
27. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) Nucleic Acids Res. 25, 4876-4882
28. Felsenstein, J. (1989) Cladistics 5, 164-166
29. Schmidt, H. A., Strimmer, K., Vingron, M., and von Haeseler, A. (2002) Bioinformatics (Oxf.) 18, 502-504
30. Huelsenbeck, J. P., and Ronquist, F. (2001) Bioinformatics (Oxf.) 17, 754-755
31. Ronquist, F., and Huelsenbeck, J. P. (2003) Bioinformatics (Oxf.) 19, 1572-1574
32. Kahn, A., and Marie, J. (1982) Methods Enzymol. 90, 131-140
33. Sibley, L. D., Niesman, I. R., Asai, T., and Takeuchi, T. (1994) Exp. Parasitol. 79, 301-311
34. van Dooren, G. G., Stimmler, L. M., and McFadden, G. I. (2006) FEMS Microbiol. Rev. 30, 596-630
35. Muirhead, H., Clayden, D. A., Barford, D., Lorimer, C. G., Fothergill-Gilmore, L. A., Schiltz, E., and Schmitt, W. (1986) EMBO J. 5, 475-481
36. Mattevi, A., Valentini, G., Rizzi, M., Speranza, M. L., Bolognesi, M., and Coda, A. (1995) Structure (Lond.) 3, 729-741
37. Rigden, D. J., Phillips, S. E., Michels, P. A., and Fothergill-Gilmore, L. A. (1999) J. Mol. Biol. 291, 615-635
38. Laughlin, L. T., and Reed, G. H. (1997) Arch. Biochem. Biophys. 348, 262-267
39. Jurica, M. S., Mesecar, A., Heath, P. J., Shi, W., Nowak, T., and Stoddard, B. L. (1998) Structure (Lond.) 6, 195-210
40. Oria-Hernandez, J., Riveros-Rosas, H., and Ramirez-Silva, L. (2006) J. Biol. Chem. 281, 30717-30724
41. Krogh, A., and Nielsen, H. (1998) in Proceedings of the Sixth International Conference on Intelligent Systems for Molecular Biology (ISMB 6), Menlo Park, June 28-July 1, 1998, pp. 122-130, AAAI Press, Menlo Park, CA
42. Saavedra, E., Olivos, A., Encalada, R., and Moreno-Sanchez, R. (2004) Exp. Parasitol. 106, 11-21
43. Hattori, J., Baum, B. R., McHugh, S. G., Blakeley, S. D., Dennis, D. T., and Miki, B. L. (1995) Biochem. Syst. Ecol. 23, 773-780
44. Dhanasekaran, S., Chandra, N. R., Chandrasekhar Sagar, B. K., Rangarajan, P. N., and Padmanaban, G. (2004) J. Biol. Chem. 279, 6934-6942
45. Esposito, S., Carfagna, S., Massaro, G., Vona, V., and Di Martino Rigano, V. (2001) Planta 212, 627-634
46. Jault, J. M., Di Pietro, A., Falson, P., and Gautheron, D. C. (1991) J. Biol. Chem. 266, 8073-8078
47. Olejnik, K., Murcha, M. W., Whelan, J., and Kraszewska, E. (2007) FEBS J. 274, 4877-4885
48. Plowman, K. M., and Krall, A. R. (1965) Biochemistry 4, 2809-2814
49. Abbe, K., and Yamada, T. (1982) J. Bacteriol. 149, 299-305
50. Crow, V. L., and Pritchard, G. G. (1982) Methods Enzymol. 90, 165-170
51. Munoz, M. E., and Ponce, E. (2003) Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 135, 197-218
52. van Schaftingen, E., Vandercammen, A., Detheux, M., and Davies, D. R. (1992) Adv. Enzyme Regul. 32, 133-148
53. Denton, H., Brown, S. M., Roberts, C. W., Alexander, J., McDonald, V., Thong, K. W., and Coombs, G. H. (1996) Mol. Biochem. Parasitol. 76, 23-29
54. Kapoor, R., and Venkitasubramanian, T. A. (1981) Biochem. J. 193, 435-440
55. Larsen, T. M., Laughlin, L. T., Holden, H. M., Rayment, I., and Reed, G. H. (1994) Biochemistry 33, 6301-6309
56. Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R. W., Carlton, J. M., Pain, A., Nelson, K. E., Bowman, S., Paulsen, I. T., James, K., Eisen, J. A., Rutherford, K., Salzberg, S. L., Craig, A., Kyes, S., Chan, M. S., Nene, V., Shallom, S. J., Suh, B., Peterson, J., Angiuoli, S., Pertea, M., Allen, J., Selengut, J., Haft, D., Mather, M. W., Vaidya, A. B., Martin, D. M., Fairlamb, A. H., Fraunholz, M. J., Roos, D. S., Ralph, S. A., McFadden, G. I., Cummings, L. M., Subramanian, G. M., Mungall, C., Venter, J. C., Carucci, D. J., Hoffman, S. L., Newbold, C., Davis, R. W., Fraser, C. M., and Barrell, B. (2002) Nature 419, 498-511
57. Peeters, N., and Small, I. (2001) Biochim. Biophys. Acta 1541, 54-63
58. Roos, D. S., Crawford, M. J., Donald, R. G., Kissinger, J. C., Klimczak, L. J., and Striepen, B. (1999) Curr. Opin. Microbiol. 2, 426-432
59. Pino, P., Foth, B. J., Kwok, L. Y., Sheiner, L., Schepers, R., Soldati, T., and Soldati-Favre, D. (2007) Plos Pathog. 3, e115
60. Ireland, R. J., Luca, V. D., and Dennis, D. T. (1979) Plant Physiol. 63, 903-907
61. Ireland, R. J., Luca, V. D., and Dennis, D. T. (1980) Plant Physiol. 65, 1188-1193
62. Simcox, P. D., and Dennis, D. T. (1978) Plant Physiol. 61, 871-877
63. Foth, B. J., Stimmler, L. M., Handman, E., Crabb, B. S., Hodder, A. N., and McFadden, G. I. (2005) Mol. Microbiol. 55, 39-53
64. Crawford, M. J., Thomsen-Zieger, N., Ray, M., Schachtner, J., Roos, D. S., and Seeber, F. (2006) EMBO J. 25, 3214-3222
65. Jelenska, J., Crawford, M. J., Harb, O. S., Zuther, E., Haselkorn, R., Roos, D. S., and Gornicki, P. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2723-2728
66. Mazumdar, J., Wilson, E. H., Masek, K., Hunter, C. A., and Striepen, B. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 13192-13197
67. Wiesner, J., and Seeber, F. (2005) Expert Opin. Ther. Targets 9, 23-44
68. Ralph, S. A., Van Dooren, G. G., Waller, R. F., Crawford, M. J., Fraunholz, M. J., Foth, B. J., Tonkin, C. J., Roos, D. S., and McFadden, G. I. (2004) Nat. Rev. Microbiol. 2, 203-216
69. Goodman, C. D., and McFadden, G. I. (2007) Curr. Drug Targets 8, 15-30
70. Wilson, R. J., Denny, P. W., Preiser, P. R., Rangachari, K., Roberts, K., Roy, A., Whyte, A., Strath, M., Moore, D. J., Moore, P. W., and Williamson, D. H. (1996) J. Mol. Biol. 261, 155-172
71. Coombs, G. H., Denton, H., Brown, S. M., and Thong, K. W. (1997) Adv. Parasitol. 39, 141-226
72. Melo, E. J., Attias, M., and De Souza, W. (2000) J. Struct. Biol. 130, 27-33
73. Vercesi, A. E., Rodrigues, C. O., Uyemura, S. A., Zhong, L., and Moreno, S. N. (1998) J. Biol. Chem. 273, 31040-31047