Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii

Molecular and Biochemical Parasitology

Volumn 76, Issue 1-2, 1996, Pages 23-29

  Denton, Helen ^a   Brown, Samantha M A ^a   Roberts, Craig W ^b   Alexander, James ^b   McDonald, Vincent ^c   Thong, Kam Wah ^d   Coombs, Graham H ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

anaerobiosis; Cryptosporidium parvum; Eimeria tenella; pyrophosphate dependent phosphofructokinase; pyruvate kinase; Toxoplasma gondii

Indexed keywords

6 PHOSPHOFRUCTOKINASE; PYRUVATE KINASE;

ANAEROBIC GROWTH; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYPTOSPORIDIUM PARVUM; EIMERIA TENELLA; ENZYME ACTIVITY; GLYCOLYSIS; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII;

EID: 0029862742     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(95)02527-8     Document Type: Article

References (24)

1. Wang, C.C. (1982) Biochemistry and physiology of coccidia. In: The Biology of the Coccidia (Long, P.L., eds.), pp. 167-228. University Park Press, Baltimore.
2. Current, W.L. (1989) Crypotosporidium spp. In: Parasitic Infections in the Immunocompromised Host (Walzer, P.W. and Genta, R.M., eds), pp. 251-341. Marcel Delska Inc., NY/Basel.
3. Fulton, J.D. and Spooner, D.F. (1960) Metabolic studies on T. gondii. Exp. Parasitol. 9, 293-301.
4. 1H-NMR spectroscopic study of aerobic glucose metabolism in Toxoplasma gondii harvested from the peritoneal exudate of experimentally infected mice. Physiol. Chem. Phys. 14, 381-384.
5. Peng, Z.-Y. and Mansour, T.E. (1992) Purification and properties of pyrophosphate-dependent phosphofructokinase from Toxoplasma gondii. Mol. Biochem. Parasitol. 54, 223-230 .
6. Denton, H., Thong, K-W. and Coombs, G.H. (1994) Eimeria tenella contains a pyrophosphate-dependent phosphofructokinase and a pyruvate kinase with unusual allosteric regulators. FEMS Microbiol. Lett. 115, 87-92.
7. Reeves, R.E., South, D.J., Blytt, H.J. and Warren, L.G. (1974) Pyrophosphate:D-fructose 6-phosphate 1-phosphotransferase: a new enzyme with the glycolytic function of 6-phosphofructokinase. J. Biol. Chem. 249, 7737-7741.
8. Mertens, E. (1990) Occurrence of pyrophosphatase:fructose 6-phosphate 1-phosphotransferase in Giardia trophozoites. Mol. Biochem. Parasitol. 40, 147-150.
9. Mertens, E., De Jonckheere, J. and Van Schaftingen, E. (1993) Pyrophosphate-dependent phosphofructokinase from the amoeba Naegleria fowleri, an AMP-sensitive enzyme. Biochem. J. 292, 793-803.
10. Mertens, E., Van Schaftingen, E. and Muller, M. (1989) Presence of a fructose 2,6-bisphosphate-insensitive pyrophosphate:fructose 6-phosphate phosphotransferase in the anaerobic protozoa Tritrichomonas foetus, Trichomonas vaginalis and Isotricha prostoma. Mol. Biochem. Parasitol. 37, 183-190.
11. Mertens, E. (1991) Pyrophosphate-dependent phosphofructokinase, an anaerobic glycolytic enzyme. FEBS Lett. 285, 1-5.
12. Fothergill-Gilmore, L. A. and Michels, P.A.M. (1993) Evolution of glycolysis. Progr. Biophys. Mol. Biol. 59, 105-235.
13. Mertens, E. (1993) ATP versus pyrophosphate: Glycolysis revisited in parasitic protists. Parasitol. Today 9, 122-126.
14. Reeves, R.E. (1968) A new enzyme with the glycolytic function of pyruvate kinase. J. Biol. Chem. 213, 3202-3204.
15. Wood, H.G., O'Brien, W.E. and Michaels, G. (1985) Properties of carboxytransphosphorylase; pyruvate phosphate dikinase; pyrophosphate-phosphofructokinase and pyrophosphate-acetate kinase and their roles in the metabolism of inorganic pyrophosphate. Adv. Enzymol. 45, 85-155.
16. Roberts, C.W. and Alexander, J. (1992) Studies on a murine model of congenital toxoplasmosis: vertical transmission only occurs in BALB/c mice infected for the first time during pregnancy. Parasitology. 104, 19-23.
17. Iseki, M. (1986) Two species of Cryptosporidium naturally infecting house rats, Rattus norvegicus. Jpn. J. Parasitol. 35, 521-526.
18. McDonald, V., Stables, R., Warhurst, D.C., Barer, M.R., Blewett, D.A., Chapman, H.D., Connolly, G.M., Chiodini, P.L. and McAdam, K.P.W.J. (1990) In vitro cultivation of Cryptosporidiutn parvum and screening of anticryptosporidial drugs. Antimicrob. Agents Chemotherapy 34, 1498-1500.
19. Ogunkolade, B.W., Robinson, H.A., McDonald, V., Webster, K. and Evans, D.A. (1993) Isoenzyme variation within the genus Cryptosporidium. Parasitol. Res. 79, 385-388.
20. Chifflet, S., Torriglia, A., Chiesa, R. and Tolosa, S. (1988) A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases. Anal. Biochem. 168, 1-4.
21. Searle, S.M.J. and Muller, M. (1991) Inorganic pyrophosphatase of Trichomonas vaginalis. Mol. Biochem. Parasitol. 44, 91-96.
22. McLaughlin, J., Lindmark, D.G. and Muller, M. (1978) Inorganic pyrophosphatase and nucleoside diphosphatase in the parasitic protozoon, Entamoeba histolytica. Biochem. Biophys. Res. Commun. 82, 913-920.
23. Peng, Z-Y., Mansour, J.M., Araujo, F., Ju, J-Y., McKenna, C.E. and Mansour, T.E. (1995) Some phosphonic acid analogs as inhibitors of pyrophosphate-dependent phosphofructokinase, a novel target in Toxoplasma gondii. Biochem. Pharmacol. 49, 105-113.
24. Mertens, E., Van Schaftingen, E. and Muller, M., (1992) Pyruvate kinase from Trichomonas vaginalis, an allosteric enzyme stimulated by ribose-5-phosphate and glycerate-3-phosphate. Mol. Biochem. Parasitol. 54, 13-20.