메뉴 건너뛰기




Volumn 116, Issue 15, 2003, Pages 3227-3238

Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1 and EGF-dependent signalling pathways

Author keywords

Cell shape; EGF; IGF 1; MAP kinase; PI 3 kinase; Wound epithelialization

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RHO FACTOR; SOMATOMEDIN C;

EID: 0041629643     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00610     Document Type: Review
Times cited : (198)

References (70)
  • 1
    • 0024395197 scopus 로고
    • Fibronectin inhibits the terminal differentiation of human keratinocytes
    • Adams, J. C. and Watt, F. M. (1989). Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature 340, 307-309.
    • (1989) Nature , vol.340 , pp. 307-309
    • Adams, J.C.1    Watt, F.M.2
  • 2
    • 0023624729 scopus 로고
    • Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-alpha and epidermal growth factor
    • Barrandon, Y. and Green, H. (1987). Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor. Cell 50, 1131-1137.
    • (1987) Cell , vol.50 , pp. 1131-1137
    • Barrandon, Y.1    Green, H.2
  • 3
    • 0030722189 scopus 로고    scopus 로고
    • Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases
    • Bennett, A. M. and Tonks, N. K. (1997). Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science 278, 1288-1291.
    • (1997) Science , vol.278 , pp. 1288-1291
    • Bennett, A.M.1    Tonks, N.K.2
  • 4
    • 0030809751 scopus 로고    scopus 로고
    • Insulin stimulates haptotactic migration of human epidermal keratinocytes through activation of NF-ΚB transcription factor
    • Benoliel, A. M., Kahn-Perles, B., Imbert, J. and Verrando, P. (1997). Insulin stimulates haptotactic migration of human epidermal keratinocytes through activation of NF-ΚB transcription factor. J. Cell Sci. 110, 2089-2097.
    • (1997) J. Cell Sci. , vol.110 , pp. 2089-2097
    • Benoliel, A.M.1    Kahn-Perles, B.2    Imbert, J.3    Verrando, P.4
  • 5
    • 0021750054 scopus 로고
    • Inositol trisphosphate, a novel second messenger in cellular signal transduction
    • Berridge, M. J. and Irvine, R. F. (1984). Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312, 315-321.
    • (1984) Nature , vol.312 , pp. 315-321
    • Berridge, M.J.1    Irvine, R.F.2
  • 6
    • 0034028713 scopus 로고    scopus 로고
    • Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers
    • Blakytny, R., Jude, E. B., Martin Gibson, J., Boulton, A. J. and Ferguson, M. W. (2000). Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. J. Pathol. 190, 589-594.
    • (2000) J. Pathol. , vol.190 , pp. 589-594
    • Blakytny, R.1    Jude, E.B.2    Martin Gibson, J.3    Boulton, A.J.4    Ferguson, M.W.5
  • 7
    • 0030901145 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo
    • Brooks, P. C., Klemke, R. L., Schon, S., Lewis, J. M., Schwartz, M. A. and Cheresh, D. A. (1997). Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J. Clin. Invest. 99, 1390-1398.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1390-1398
    • Brooks, P.C.1    Klemke, R.L.2    Schon, S.3    Lewis, J.M.4    Schwartz, M.A.5    Cheresh, D.A.6
  • 9
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering, B. M. and Coffer, P. J. (1995). Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376, 599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 10
    • 0030866897 scopus 로고    scopus 로고
    • Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
    • Canagarajah, B. J., Khokhlatchev, A., Cobb, M. H. and Goldsmith, E. J. (1997). Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell 90, 859-869.
    • (1997) Cell , vol.90 , pp. 859-869
    • Canagarajah, B.J.1    Khokhlatchev, A.2    Cobb, M.H.3    Goldsmith, E.J.4
  • 11
    • 0026659868 scopus 로고
    • Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells
    • Carter, A. N. and Downes, C. P. (1992). Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. J. Biol. Chem. 267, 14563-14567.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14563-14567
    • Carter, A.N.1    Downes, C.P.2
  • 12
    • 0028089832 scopus 로고
    • Epidermal growth factor receptor-mediated cell motility: Phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
    • Chen, P., Xie, H., Sekar, M. C., Gupta, K. and Wells, A. (1994). Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement. J. Cell Biol. 127, 847-857.
    • (1994) J. Cell Biol. , vol.127 , pp. 847-857
    • Chen, P.1    Xie, H.2    Sekar, M.C.3    Gupta, K.4    Wells, A.5
  • 14
    • 0032825266 scopus 로고    scopus 로고
    • Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
    • Cheresh, D. A., Leng, J. and Klemke, R. L. (1999). Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J. Cell Biol. 146, 1107-1116.
    • (1999) J. Cell Biol. , vol.146 , pp. 1107-1116
    • Cheresh, D.A.1    Leng, J.2    Klemke, R.L.3
  • 15
    • 0018607228 scopus 로고
    • Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors
    • Chinkers, M., McKanna, J. A. and Cohen, S. (1979). Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors. J. Cell Biol. 83, 260-265.
    • (1979) J. Cell Biol. , vol.83 , pp. 260-265
    • Chinkers, M.1    McKanna, J.A.2    Cohen, S.3
  • 16
    • 0001895889 scopus 로고
    • The stimulation of epidermal keratinization by a protein isolated from the submaxillary gland of the mouse
    • Cohen, S. and Elliott, G. A. (1963). The stimulation of epidermal keratinization by a protein isolated from the submaxillary gland of the mouse. J. Invest. Dermatol. 40, 1-5.
    • (1963) J. Invest. Dermatol. , vol.40 , pp. 1-5
    • Cohen, S.1    Elliott, G.A.2
  • 17
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley, S., Paterson, H., Kemp, P. and Marshall, C. J. (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 18
    • 0034677631 scopus 로고    scopus 로고
    • PIP2 and PIP3: Complex roles at the cell surface
    • Czech, M. P. (2000). PIP2 and PIP3: complex roles at the cell surface. Cell 100, 603-606.
    • (2000) Cell , vol.100 , pp. 603-606
    • Czech, M.P.1
  • 19
    • 0029807471 scopus 로고    scopus 로고
    • Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-Src and v-Ha-Ras, in Sf9 and mammalian cells
    • Datta, K., Bellacosa, A., Chan, T. O. and Tsichlis, P. N. (1996). Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-Src and v-Ha-Ras, in Sf9 and mammalian cells. J. Biol. Chem. 271, 30835-30839.
    • (1996) J. Biol. Chem. , vol.271 , pp. 30835-30839
    • Datta, K.1    Bellacosa, A.2    Chan, T.O.3    Tsichlis, P.N.4
  • 20
  • 21
    • 0023037089 scopus 로고
    • Transforming growth factor-alpha: Structure and biological activities
    • Derynck, R. (1986). Transforming growth factor-alpha: structure and biological activities. J. Cell. Biochem. 32, 293-304.
    • (1986) J. Cell. Biochem. , vol.32 , pp. 293-304
    • Derynck, R.1
  • 22
    • 0033573049 scopus 로고    scopus 로고
    • Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signalling cascades
    • Fan, H. and Derynck, R. (1999). Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signalling cascades. EMBO J. 18, 6962-6972.
    • (1999) EMBO J. , vol.18 , pp. 6962-6972
    • Fan, H.1    Derynck, R.2
  • 23
    • 0034644115 scopus 로고    scopus 로고
    • Signalling pathways and cell mechanics involved in wound closure by epithelial cell sheets
    • Fenteany, G., Janmey, P. A. and Stossel, T. P. (2000). Signalling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr. Biol. 10, 831-838.
    • (2000) Curr. Biol. , vol.10 , pp. 831-838
    • Fenteany, G.1    Janmey, P.A.2    Stossel, T.P.3
  • 24
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R. and Tsichlis, P. N. (1995). The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 25
    • 0034723310 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signalling pathway
    • Glading, A., Chang, P., Lauffenburger, D. A. and Wells, A. (2000). Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signalling pathway. J. Biol. Chem. 275, 2390-2398.
    • (2000) J. Biol. Chem. , vol.275 , pp. 2390-2398
    • Glading, A.1    Chang, P.2    Lauffenburger, D.A.3    Wells, A.4
  • 26
    • 0025028911 scopus 로고
    • Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells
    • Gotoh, Y., Nishida, E., Yamashita, T., Hoshi, M., Kawakami, M. and Sakai, H. (1990). Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells. Eur. J. Biochem. 193, 661-669.
    • (1990) Eur. J. Biochem. , vol.193 , pp. 661-669
    • Gotoh, Y.1    Nishida, E.2    Yamashita, T.3    Hoshi, M.4    Kawakami, M.5    Sakai, H.6
  • 27
    • 0034883588 scopus 로고    scopus 로고
    • A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis
    • Haase, I., Hobbs, R. M., Romero, M. R., Broad, S. and Watt, F. M. (2001). A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. J. Clin. Invest. 108, 527-536.
    • (2001) J. Clin. Invest. , vol.108 , pp. 527-536
    • Haase, I.1    Hobbs, R.M.2    Romero, M.R.3    Broad, S.4    Watt, F.M.5
  • 28
    • 0023235340 scopus 로고
    • Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus
    • Han, V. K., D'Ercole, A. J. and Lund, P. K. (1987). Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus. Science 236, 193-197.
    • (1987) Science , vol.236 , pp. 193-197
    • Han, V.K.1    D'Ercole, A.J.2    Lund, P.K.3
  • 29
    • 0028947261 scopus 로고
    • A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila
    • Harden, N., Loh, H. Y., Chia, W. and Lim, L. (1995). A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila. Development 121, 903-914.
    • (1995) Development , vol.121 , pp. 903-914
    • Harden, N.1    Loh, H.Y.2    Chia, W.3    Lim, L.4
  • 30
    • 0034635434 scopus 로고    scopus 로고
    • Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
    • Hill, K., Welti, S., Yu, J., Murray, J. T., Yip, S. C., Condeelis, J. S., Segall, J. E. and Backer, J. M. (2000). Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells. J. Biol. Chem. 275, 3741-3744.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3741-3744
    • Hill, K.1    Welti, S.2    Yu, J.3    Murray, J.T.4    Yip, S.C.5    Condeelis, J.S.6    Segall, J.E.7    Backer, J.M.8
  • 31
    • 0029932093 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: Correlation of increased expression with epidermal hyperplasia
    • Hodak, E., Gottlieb, A. B., Anzilotti, M. and Krueger, J. G. (1996). The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: correlation of increased expression with epidermal hyperplasia. J. Invest. Dermatol. 106, 564-570.
    • (1996) J. Invest. Dermatol. , vol.106 , pp. 564-570
    • Hodak, E.1    Gottlieb, A.B.2    Anzilotti, M.3    Krueger, J.G.4
  • 32
    • 0030956320 scopus 로고    scopus 로고
    • Signalling through intercellular adhesion molecule 1 (ICAM-1) in a B cell lymphoma line. The activation of Lyn tyrosine kinase and the mitogen-activated protein kinase pathway
    • Holland, J. and Owens, T. (1997). Signalling through intercellular adhesion molecule 1 (ICAM-1) in a B cell lymphoma line. The activation of Lyn tyrosine kinase and the mitogen-activated protein kinase pathway. J. Biol. Chem. 272, 9108-9112.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9108-9112
    • Holland, J.1    Owens, T.2
  • 35
    • 0031459917 scopus 로고    scopus 로고
    • Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
    • Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J. and Parise, L. V. (1997). Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390, 632-636.
    • (1997) Nature , vol.390 , pp. 632-636
    • Keely, P.J.1    Westwick, J.K.2    Whitehead, I.P.3    Der, C.J.4    Parise, L.V.5
  • 38
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu, J. P., Baker, J., Perkins, A. S., Robertson, E. J. and Efstratiadis, A. (1993). Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75, 59-72.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 39
    • 0024239024 scopus 로고
    • Construction and use of a safe and efficient amphotropic packaging cell line
    • Markowitz, D., Goff, S. and Bank, A. (1988a). Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167, 400-406.
    • (1988) Virology , vol.167 , pp. 400-406
    • Markowitz, D.1    Goff, S.2    Bank, A.3
  • 40
    • 0023871422 scopus 로고
    • A safe packaging line for gene transfer: Separating viral genes on two different plasmids
    • Markowitz, D., Goff, S. and Bank, A. (1988b). A safe packaging line for gene transfer: separating viral genes on two different plasmids. J. Virol. 62, 1120-1124.
    • (1988) J. Virol. , vol.62 , pp. 1120-1124
    • Markowitz, D.1    Goff, S.2    Bank, A.3
  • 41
    • 0030934532 scopus 로고    scopus 로고
    • Wound healing - Aiming for perfect skin regeneration
    • Martin, P. (1997). Wound healing - aiming for perfect skin regeneration. Science 276, 75-81.
    • (1997) Science , vol.276 , pp. 75-81
    • Martin, P.1
  • 42
    • 0033548181 scopus 로고    scopus 로고
    • Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration
    • McCawley, L. J., Li, S., Wattenberg, E. V. and Hudson, L. G. (1999). Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration. J. Biol. Chem. 274, 4347-4353.
    • (1999) J. Biol. Chem. , vol.274 , pp. 4347-4353
    • McCawley, L.J.1    Li, S.2    Wattenberg, E.V.3    Hudson, L.G.4
  • 43
    • 0027176804 scopus 로고
    • Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown
    • McNamee, H. P., Ingber, D. E. and Schwartz, M. A. (1993). Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J. Cell Biol. 121, 673-678.
    • (1993) J. Cell Biol. , vol.121 , pp. 673-678
    • McNamee, H.P.1    Ingber, D.E.2    Schwartz, M.A.3
  • 44
    • 0030453194 scopus 로고    scopus 로고
    • Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
    • Miyamoto, S., Teramoto, H., Gutkind, J. S. and Yamada, K. M. (1996). Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135, 1633-1642.
    • (1996) J. Cell Biol. , vol.135 , pp. 1633-1642
    • Miyamoto, S.1    Teramoto, H.2    Gutkind, J.S.3    Yamada, K.M.4
  • 45
    • 0003121411 scopus 로고    scopus 로고
    • Epidermal growth factor and transforming growth factor-alpha
    • (ed. R. A. F. Clark), New York: Plenum Press
    • Nanney, L. B. and King, L. E. J. (1996). Epidermal growth factor and transforming growth factor-alpha. In The Molecular and Cellular Biology of Wound Repair (ed. R. A. F. Clark), pp. 171-194. New York: Plenum Press.
    • (1996) The Molecular and Cellular Biology of Wound Repair , pp. 171-194
    • Nanney, L.B.1    King, L.E.J.2
  • 46
    • 0033549558 scopus 로고    scopus 로고
    • Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner
    • Nguyen, D. H., Catling, A. D., Webb, D. J., Sankovic, M., Walker, L. A., Somlyo, A. V., Weber, M. J. and Gonias, S. L. (1999). Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J. Cell Biol. 146, 149-164.
    • (1999) J. Cell Biol. , vol.146 , pp. 149-164
    • Nguyen, D.H.1    Catling, A.D.2    Webb, D.J.3    Sankovic, M.4    Walker, L.A.5    Somlyo, A.V.6    Weber, M.J.7    Gonias, S.L.8
  • 47
    • 0028961293 scopus 로고
    • Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes, C. D. and Hall, A. (1995). Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 48
    • 0033594123 scopus 로고    scopus 로고
    • Rho GTPases control polarity, protrusion, and adhesion during cell movement
    • Nobes, C. D. and Hall, A. (1999). Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144, 1235-1244.
    • (1999) J. Cell Biol. , vol.144 , pp. 1235-1244
    • Nobes, C.D.1    Hall, A.2
  • 49
    • 0028837170 scopus 로고
    • Activation of the small GTP-binding proteins Rho and Rac by growth factor receptors
    • Nobes, C. D., Hawkins, P., Stephens, L. and Hall, A. (1995). Activation of the small GTP-binding proteins Rho and Rac by growth factor receptors. J. Cell Sci. 108, 225-233.
    • (1995) J. Cell Sci. , vol.108 , pp. 225-233
    • Nobes, C.D.1    Hawkins, P.2    Stephens, L.3    Hall, A.4
  • 50
    • 0027265532 scopus 로고
    • Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products
    • Peppelenbosch, M. P., Tertoolen, L. G., Hage, W. J. and de Laat, S. W. (1993). Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products. Cell 74, 565-575.
    • (1993) Cell , vol.74 , pp. 565-575
    • Peppelenbosch, M.P.1    Tertoolen, L.G.2    Hage, W.J.3    de Laat, S.W.4
  • 51
    • 0028363982 scopus 로고
    • Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro
    • Philpott, M. P., Sanders, D. A. and Kealey, T. (1994). Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro. J. Invest. Dermatol. 102, 857-861.
    • (1994) J. Invest. Dermatol. , vol.102 , pp. 857-861
    • Philpott, M.P.1    Sanders, D.A.2    Kealey, T.3
  • 52
    • 0023795580 scopus 로고
    • Wound macrophages express TGF-alpha, and other growth factors in vivo: Analysis by mRNA phenotyping
    • Rappolee, D. A., Mark, D., Banda, M. J. and Werb, Z. (1988). Wound macrophages express TGF-alpha, and other growth factors in vivo: analysis by mRNA phenotyping. Science 241, 708-712.
    • (1988) Science , vol.241 , pp. 708-712
    • Rappolee, D.A.1    Mark, D.2    Banda, M.J.3    Werb, Z.4
  • 53
    • 0030293886 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
    • Reif, K., Nobes, C. D., Thomas, G., Hall, A. and Cantrell, D. A. (1996). Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6, 1445-1455.
    • (1996) Curr. Biol. , vol.6 , pp. 1445-1455
    • Reif, K.1    Nobes, C.D.2    Thomas, G.3    Hall, A.4    Cantrell, D.A.5
  • 54
    • 0026778133 scopus 로고
    • The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley, A. J. and Hall, A. (1992). The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 55
    • 0026654125 scopus 로고
    • The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
    • Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992). The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 57
    • 0031434673 scopus 로고    scopus 로고
    • The role of IGF-I in human skin and its appendages: Morphogen as well as mitogen?
    • Rudman, S. M., Philpott, M. P., Thomas, G. A. and Kealey, T. (1997). The role of IGF-I in human skin and its appendages: morphogen as well as mitogen? J. Invest. Dermatol. 109, 770-777.
    • (1997) J. Invest. Dermatol. , vol.109 , pp. 770-777
    • Rudman, S.M.1    Philpott, M.P.2    Thomas, G.A.3    Kealey, T.4
  • 58
    • 0027426128 scopus 로고
    • Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells
    • Saklatvala, J., Rawlinson, L. M., Marshall, C. J. and Kracht, M. (1993). Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells. FEBS Lett. 334, 189-192.
    • (1993) FEBS Lett. , vol.334 , pp. 189-192
    • Saklatvala, J.1    Rawlinson, L.M.2    Marshall, C.J.3    Kracht, M.4
  • 59
    • 0030972462 scopus 로고    scopus 로고
    • Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in Madin-Darby canine kidney-C7 cells
    • Schramek, H., Feifel, E., Healy, E. and Pollack, V. (1997). Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in Madin-Darby canine kidney-C7 cells. J. Biol. Chem. 272, 11426-11433.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11426-11433
    • Schramek, H.1    Feifel, E.2    Healy, E.3    Pollack, V.4
  • 60
  • 61
    • 0026088781 scopus 로고
    • Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated 'MAP' kinase
    • Takishima, K., Griswold-Prenner, I., Ingebritsen, T. and Rosner, M. R. (1991). Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated 'MAP' kinase. Proc. Natl. Acad. Sci. USA 88, 2520-2524.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2520-2524
    • Takishima, K.1    Griswold-Prenner, I.2    Ingebritsen, T.3    Rosner, M.R.4
  • 63
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • Toker, A. and Cantley, L. C. (1997). Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673-676.
    • (1997) Nature , vol.387 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 64
    • 0034708482 scopus 로고    scopus 로고
    • Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
    • Toker, A. and Newton, A. C. (2000). Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J. Biol. Chem. 275, 8271-8274.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8271-8274
    • Toker, A.1    Newton, A.C.2
  • 65
    • 0035936807 scopus 로고    scopus 로고
    • Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin
    • Vasioukhin, V., Bauer, C., Degenstein, L., Wise, B. and Fuchs, E. (2001). Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104, 605-617.
    • (2001) Cell , vol.104 , pp. 605-617
    • Vasioukhin, V.1    Bauer, C.2    Degenstein, L.3    Wise, B.4    Fuchs, E.5
  • 66
    • 0025876488 scopus 로고
    • Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation
    • Vassar, R. and Fuchs, E. (1991). Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev. 5, 714-727.
    • (1991) Genes Dev. , vol.5 , pp. 714-727
    • Vassar, R.1    Fuchs, E.2
  • 67
    • 0002653135 scopus 로고    scopus 로고
    • Cultivation of human epidermal keratinocytes with a 3T3 feeder layer
    • (ed. J. E. Celis), London: Academic Press
    • Watt, F. M. (1998). Cultivation of human epidermal keratinocytes with a 3T3 feeder layer. In Cell Biology: A Laboratory Handbook, Vol. 1 (ed. J. E. Celis), pp. 113-118. London: Academic Press.
    • (1998) Cell Biology: A Laboratory Handbook , vol.1 , pp. 113-118
    • Watt, F.M.1
  • 68
    • 0027375277 scopus 로고
    • Activation of phosphatidylinositol-3-kinase by platelet-derived growth factor and insulin-like growth factor-1 is inhibited by a transmembrane phosphotyrosine phosphatase
    • Way, B. A. and Mooney, R. A. (1993). Activation of phosphatidylinositol-3-kinase by platelet-derived growth factor and insulin-like growth factor-1 is inhibited by a transmembrane phosphotyrosine phosphatase. J. Biol. Chem. 268, 26409-26415.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26409-26415
    • Way, B.A.1    Mooney, R.A.2
  • 69
    • 0030460336 scopus 로고    scopus 로고
    • Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes
    • Zhu, A. J. and Watt, F. M. (1996). Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. J. Cell Sci. 109, 3013-3023.
    • (1996) J. Cell Sci. , vol.109 , pp. 3013-3023
    • Zhu, A.J.1    Watt, F.M.2
  • 70
    • 0033535838 scopus 로고    scopus 로고
    • Signalling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro
    • Zhu, A. J., Haase, I. and Watt, F. M. (1999). Signalling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. Proc. Natl. Acad. Sci. USA 96, 6728-6733.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6728-6733
    • Zhu, A.J.1    Haase, I.2    Watt, F.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.