메뉴 건너뛰기




Volumn 53, Issue 10, 2004, Pages 2574-2580

A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; MANGANESE DERIVATIVE; MANGANESE SALEN CHLORIDE; NITRIC OXIDE; NITROGEN OXIDE; PEROXIDASE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SALEN MANGANESE DERIVATIVE; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

EID: 4644325195     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.10.2574     Document Type: Article
Times cited : (21)

References (50)
  • 1
    • 0026719297 scopus 로고
    • Free radicals as mediators of pancreatic islet beta-cell injury in autoimmune diabetes
    • Rabinovitch A: Free radicals as mediators of pancreatic islet beta-cell injury in autoimmune diabetes. J Lab Clin Med 119:455-456, 1992
    • (1992) J Lab Clin Med , vol.119 , pp. 455-456
    • Rabinovitch, A.1
  • 2
    • 0027413011 scopus 로고
    • Lazaroid antioxidant reduces incidence of diabetes and insulitis in nonobese diabetic mice
    • Rabinovitch A, Suarez WL, Power RF: Lazaroid antioxidant reduces incidence of diabetes and insulitis in nonobese diabetic mice. J Lab Clin Med 121:603-607, 1993
    • (1993) J Lab Clin Med , vol.121 , pp. 603-607
    • Rabinovitch, A.1    Suarez, W.L.2    Power, R.F.3
  • 3
    • 0027489210 scopus 로고
    • Nitric oxide production in islets from nonobese diabetic mice: Aminoguanidine-sensitive and -resistant stages in the immunological diabetic process
    • Corbett JA, Mikhael A, Shimizu J, Frederick K, Misko TP, McDaniel ML, Kanagawa O, Unanue ER: Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc Natl Acad Sci U S A 90:8992-8995, 1993
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8992-8995
    • Corbett, J.A.1    Mikhael, A.2    Shimizu, J.3    Frederick, K.4    Misko, T.P.5    McDaniel, M.L.6    Kanagawa, O.7    Unanue, E.R.8
  • 4
    • 0027301777 scopus 로고
    • Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: Prevention by dexamethasone
    • Corbett JA, Wang JL, Misko TP, Zhao W, Hickey WF, McDaniel ML: Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone. Autoimmunity 15:145-153, 1993
    • (1993) Autoimmunity , vol.15 , pp. 145-153
    • Corbett, J.A.1    Wang, J.L.2    Misko, T.P.3    Zhao, W.4    Hickey, W.F.5    McDaniel, M.L.6
  • 5
    • 0030987135 scopus 로고    scopus 로고
    • Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β-cells
    • Suarez-Pinzon WL, Szabo C, Rabinovitch A: Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β-cells. Diabetes 46:907-911, 1997
    • (1997) Diabetes , vol.46 , pp. 907-911
    • Suarez-Pinzon, W.L.1    Szabo, C.2    Rabinovitch, A.3
  • 7
    • 0032791152 scopus 로고    scopus 로고
    • Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells
    • Tiedge M, Lortz S, Munday R, Lenzen S: Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells. Diabetologia 42:849-855, 1999
    • (1999) Diabetologia , vol.42 , pp. 849-855
    • Tiedge, M.1    Lortz, S.2    Munday, R.3    Lenzen, S.4
  • 8
    • 0034949349 scopus 로고    scopus 로고
    • An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice
    • Suarez-Pinzon WL, Mabley JG, Strynadka K, Power RF, Szabo C, Rabinovitch A: An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice. J Autoimmun 16:449-455, 2001
    • (2001) J Autoimmun , vol.16 , pp. 449-455
    • Suarez-Pinzon, W.L.1    Mabley, J.G.2    Strynadka, K.3    Power, R.F.4    Szabo, C.5    Rabinovitch, A.6
  • 9
    • 0019783833 scopus 로고
    • Superoxide dismutase is a prophylactic against alloxan diabetes
    • Grankvist K, Marklund S, Taljedal IB: Superoxide dismutase is a prophylactic against alloxan diabetes. Nature 294:158-160, 1981
    • (1981) Nature , vol.294 , pp. 158-160
    • Grankvist, K.1    Marklund, S.2    Taljedal, I.B.3
  • 10
    • 0031669435 scopus 로고    scopus 로고
    • Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species
    • Tiedge M, Lortz S, Munday R, Lenzen S: Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species. Diabetes 47:1578-1585, 1998
    • (1998) Diabetes , vol.47 , pp. 1578-1585
    • Tiedge, M.1    Lortz, S.2    Munday, R.3    Lenzen, S.4
  • 11
    • 0027390271 scopus 로고
    • Inhibition of superoxide-generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromans)
    • Thomas PD, Mao GD, Rabinovitch A, Poznansky MJ: Inhibition of superoxide-generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromans). Biochem Pharmacol 45: 241-251, 1993
    • (1993) Biochem Pharmacol , vol.45 , pp. 241-251
    • Thomas, P.D.1    Mao, G.D.2    Rabinovitch, A.3    Poznansky, M.J.4
  • 12
    • 0028180612 scopus 로고
    • Large amount of (apo)ferritin in the pancreatic insulin cell and its stimulation by glucose
    • MacDonald MJ, Cook JD, Epstein ML, Flowers CH: Large amount of (apo)ferritin in the pancreatic insulin cell and its stimulation by glucose. FASEB J 8:777-781, 1994
    • (1994) FASEB J , vol.8 , pp. 777-781
    • MacDonald, M.J.1    Cook, J.D.2    Epstein, M.L.3    Flowers, C.H.4
  • 13
    • 0025138642 scopus 로고
    • Ultrastructural changes in the pancreas of carbonyl iron-fed rats
    • Iancu TC, Ward RJ, Peters TJ: Ultrastructural changes in the pancreas of carbonyl iron-fed rats. J Pediatr Gastroenterol Nutr 10:95-101, 1990
    • (1990) J Pediatr Gastroenterol Nutr , vol.10 , pp. 95-101
    • Iancu, T.C.1    Ward, R.J.2    Peters, T.J.3
  • 14
    • 0028198779 scopus 로고
    • The Fenton oxidation mechanism: Reactivities of biologically relevant substrates with two oxidizing intermediates differ from those predicted for the hydroxyl radical
    • Wink DA, Nims RW, Saavedra JE, Utermahlen WE Jr, Ford PC: The Fenton oxidation mechanism: reactivities of biologically relevant substrates with two oxidizing intermediates differ from those predicted for the hydroxyl radical. Proc Natl Acad Sci U S A 91:6604-6608, 1994
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6604-6608
    • Wink, D.A.1    Nims, R.W.2    Saavedra, J.E.3    Utermahlen Jr., W.E.4    Ford, P.C.5
  • 15
    • 0027184205 scopus 로고
    • Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: Comparison with enzymatically formed nitric oxide from L-arginine
    • Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, Byrns RE: Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci U S A 90:8103-8107, 1993
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8103-8107
    • Ignarro, L.J.1    Fukuto, J.M.2    Griscavage, J.M.3    Rogers, N.E.4    Byrns, R.E.5
  • 16
    • 0019852821 scopus 로고
    • CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
    • Grankvist K, Marklund SL, Taljedal IB: CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J 199:393-398, 1981
    • (1981) Biochem J , vol.199 , pp. 393-398
    • Grankvist, K.1    Marklund, S.L.2    Taljedal, I.B.3
  • 17
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S, Drinkgern J, Tiedge M: Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 20:463-466, 1996
    • (1996) Free Radic Biol Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 19
    • 0030798658 scopus 로고    scopus 로고
    • Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic β-cells against oxidative stress
    • Kubisch HM, Wang J, Bray TM, Phillips JP: Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic β-cells against oxidative stress. Diabetes 46:1563-1566, 1997
    • (1997) Diabetes , vol.46 , pp. 1563-1566
    • Kubisch, H.M.1    Wang, J.2    Bray, T.M.3    Phillips, J.P.4
  • 21
    • 0032080663 scopus 로고    scopus 로고
    • Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta-induced cytotoxicity and reduces nitric oxide production
    • Hohmeier HE, Thigpen A, Tran VV, Davis R, Newgard CB: Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta-induced cytotoxicity and reduces nitric oxide production. J Clin Invest 101:1811-1820, 1998
    • (1998) J Clin Invest , vol.101 , pp. 1811-1820
    • Hohmeier, H.E.1    Thigpen, A.2    Tran, V.V.3    Davis, R.4    Newgard, C.B.5
  • 22
    • 0037315583 scopus 로고    scopus 로고
    • Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes
    • Bertera S, Crawford ML, Alexander AM, Papworth GD, Watkins SC, Robbins PD, Trucco M: Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes 52:387-393, 2003
    • (2003) Diabetes , vol.52 , pp. 387-393
    • Bertera, S.1    Crawford, M.L.2    Alexander, A.M.3    Papworth, G.D.4    Watkins, S.C.5    Robbins, P.D.6    Trucco, M.7
  • 24
    • 0026439698 scopus 로고
    • Combination therapy with an antioxidant and a corticosteroid prevents autoimmune diabetes in NOD mice
    • Rabinovitch A, Suarez WL, Power RF: Combination therapy with an antioxidant and a corticosteroid prevents autoimmune diabetes in NOD mice. Life Sci 51:1937-1943, 1992
    • (1992) Life Sci , vol.51 , pp. 1937-1943
    • Rabinovitch, A.1    Suarez, W.L.2    Power, R.F.3
  • 26
    • 0035889960 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase initiates relapsing remitting experimental autoimmune encephalomyelitis in rats, yet nitric oxide appears to be essential for clinical expression of disease
    • O'Brien NC, Charlton B, Cowden WB, Willenborg DO: Inhibition of nitric oxide synthase initiates relapsing remitting experimental autoimmune encephalomyelitis in rats, yet nitric oxide appears to be essential for clinical expression of disease. J Immunol 167:5904-5912, 2001
    • (2001) J Immunol , vol.167 , pp. 5904-5912
    • O'Brien, N.C.1    Charlton, B.2    Cowden, W.B.3    Willenborg, D.O.4
  • 28
    • 0037103792 scopus 로고    scopus 로고
    • Oxidation of nitric oxide by oxomanganese-salen complexes: A new mechanism for cellular protection by superoxide dismutase/catalase mimetics
    • Sharpe MA, Ollosson R, Stewart VC, Clark JB: Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics. Biochem J 366:97-107, 2002
    • (2002) Biochem J , vol.366 , pp. 97-107
    • Sharpe, M.A.1    Ollosson, R.2    Stewart, V.C.3    Clark, J.B.4
  • 29
    • 0031562673 scopus 로고    scopus 로고
    • Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites
    • Malfroy B, Doctrow SR, Orr PL, Tocco G, Fedoseyeva EV, Benichou G: Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites. Cell Immunol 177:62-68, 1997
    • (1997) Cell Immunol , vol.177 , pp. 62-68
    • Malfroy, B.1    Doctrow, S.R.2    Orr, P.L.3    Tocco, G.4    Fedoseyeva, E.V.5    Benichou, G.6
  • 30
    • 4644360896 scopus 로고    scopus 로고
    • Prolongation of skin and heart allograft survival by synthetic catalytic scavengers of reactive oxygen species
    • Tocco G, Illigens B, Iwamoto Y, Akiyama Y, Benichou GA: Prolongation of skin and heart allograft survival by synthetic catalytic scavengers of reactive oxygen species. Hum Immunol 64:S51, 2003
    • (2003) Hum Immunol , vol.64
    • Tocco, G.1    Illigens, B.2    Iwamoto, Y.3    Akiyama, Y.4    Benichou, G.A.5
  • 32
    • 0002296980 scopus 로고    scopus 로고
    • Salen-manganese complexes: Combined superoxide dismutase/ catalase mimics with broad pharmacological efficacy
    • Doctrow SR, Huffman K, Marcus CB, Musleh W, Bruce A, Baudry M, Malfroy B: Salen-manganese complexes: combined superoxide dismutase/ catalase mimics with broad pharmacological efficacy. Adv Pharmacol 38:247-269, 1997
    • (1997) Adv Pharmacol , vol.38 , pp. 247-269
    • Doctrow, S.R.1    Huffman, K.2    Marcus, C.B.3    Musleh, W.4    Bruce, A.5    Baudry, M.6    Malfroy, B.7
  • 34
    • 0026500329 scopus 로고
    • Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide
    • Hogg N, Darley-Usmar VM, Wilson MT, Moncada S: Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J 281:419-424, 1992
    • (1992) Biochem J , vol.281 , pp. 419-424
    • Hogg, N.1    Darley-Usmar, V.M.2    Wilson, M.T.3    Moncada, S.4
  • 35
    • 0027451972 scopus 로고
    • Cytotoxicity of nitric oxide in Fu5 rat hepatoma cells: Evidence for co-operative action with hydrogen peroxide
    • Ioannidis I, de Groot H: Cytotoxicity of nitric oxide in Fu5 rat hepatoma cells: evidence for co-operative action with hydrogen peroxide. Biochem J 296:341-345, 1993
    • (1993) Biochem J , vol.296 , pp. 341-345
    • Ioannidis, I.1    De Groot, H.2
  • 36
    • 0028925540 scopus 로고
    • Nitric oxide (NO) donor molecules: Effect of NO release rate on vascular smooth muscle cell proliferation in vitro
    • Mooradian DL, Hutsell TC, Keefer LK: Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro. J Cardiovasc Pharmacol 25:674-678, 1995
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 674-678
    • Mooradian, D.L.1    Hutsell, T.C.2    Keefer, L.K.3
  • 37
    • 0842321318 scopus 로고    scopus 로고
    • Does peroxynitrite involve in the elevation of cellular glutathione induced by sodium nitroprusside (SNP) in RAW 264.7 cells?
    • Kurozumi R, Tokuzumi S, Kojima S: Does peroxynitrite involve in the elevation of cellular glutathione induced by sodium nitroprusside (SNP) in RAW 264.7 cells? Biol Pharm Bull 26:1070-1075, 2003
    • (2003) Biol Pharm Bull , vol.26 , pp. 1070-1075
    • Kurozumi, R.1    Tokuzumi, S.2    Kojima, S.3
  • 40
    • 0028633557 scopus 로고
    • Cytokines, nitric oxide and insulin secreting cells
    • Cunningham JM, Green IC: Cytokines, nitric oxide and insulin secreting cells. Growth Regul 4:173-180, 1994
    • (1994) Growth Regul , vol.4 , pp. 173-180
    • Cunningham, J.M.1    Green, I.C.2
  • 41
    • 0032171420 scopus 로고    scopus 로고
    • Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
    • Wink DA, Mitchell JB: Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free Radic Biol Med 25:434-456, 1998
    • (1998) Free Radic Biol Med , vol.25 , pp. 434-456
    • Wink, D.A.1    Mitchell, J.B.2
  • 42
    • 0030787471 scopus 로고    scopus 로고
    • Extensive peroxynitrite activity during progressive stages of central nervous system inflammation
    • van der Veen RC, Hinton DR, Incardonna F, Hofman FM: Extensive peroxynitrite activity during progressive stages of central nervous system inflammation. J Neuroimmunol 77:1-7, 1997
    • (1997) J Neuroimmunol , vol.77 , pp. 1-7
    • Van Der Veen, R.C.1    Hinton, D.R.2    Incardonna, F.3    Hofman, F.M.4
  • 43
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 87:1620-1624, 1990
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 45
    • 0030573997 scopus 로고    scopus 로고
    • Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death
    • Delaney CA, Tyrberg B, Bouwens L, Vaghef H, Hellman B, Eizirik DL: Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death. FEBS Lett 394:300-306, 1996
    • (1996) FEBS Lett , vol.394 , pp. 300-306
    • Delaney, C.A.1    Tyrberg, B.2    Bouwens, L.3    Vaghef, H.4    Hellman, B.5    Eizirik, D.L.6
  • 46
    • 0000892477 scopus 로고    scopus 로고
    • In vivo aspects of nitric oxide (NO) chemistry: Does peroxynitrite (-OONO) play a major role in cytotoxicity?
    • Fukuto JM, Ignarro L: In vivo aspects of nitric oxide (NO) chemistry: does peroxynitrite (-OONO) play a major role in cytotoxicity? Accounts of Chemical Research 30:149-152, 1997
    • (1997) Accounts of Chemical Research , vol.30 , pp. 149-152
    • Fukuto, J.M.1    Ignarro, L.2
  • 47
    • 0344643456 scopus 로고    scopus 로고
    • Peroxynitrite-induced cytotoxicity: Mechanism and opportunities for intervention
    • Virag L, Szabo E, Gergely P, Szabo C: Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol Lett 140-141:113-124, 2003
    • (2003) Toxicol Lett , vol.140-141 , pp. 113-124
    • Virag, L.1    Szabo, E.2    Gergely, P.3    Szabo, C.4
  • 48
    • 0034937590 scopus 로고    scopus 로고
    • Cytotoxicity related to oxidative and nitrosative stress by nitric oxide
    • Wink DA, Miranda KM, Espey MG: Cytotoxicity related to oxidative and nitrosative stress by nitric oxide. Exp Biol Med (Maywood) 226:621-623, 2001
    • (2001) Exp Biol Med (Maywood) , vol.226 , pp. 621-623
    • Wink, D.A.1    Miranda, K.M.2    Espey, M.G.3
  • 49
    • 0035172901 scopus 로고    scopus 로고
    • Cysteine-Zn2+ complexes: Unique molecular switches for inducible nitric oxide synthase-derived NO
    • Kroncke KD: Cysteine-Zn2+ complexes: unique molecular switches for inducible nitric oxide synthase-derived NO. FASEB J 15:2503-2507, 2001
    • (2001) FASEB J , vol.15 , pp. 2503-2507
    • Kroncke, K.D.1
  • 50
    • 0031567576 scopus 로고    scopus 로고
    • What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
    • Halliwell B: What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo? FEBS Lett 411:157-160, 1997
    • (1997) FEBS Lett , vol.411 , pp. 157-160
    • Halliwell, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.