Is intraneuronal amyloid β-peptide accumulation the trigger of Alzheimer's disease pathophysiology?

Journal of Alzheimer's Disease

Volumn 6, Issue 4, 2004, Pages 433-434

  Moreiraa, Paula I ^a,b   Liu, Quan ^a   Honda, Kazuhiro ^a   Smith, Mark A ^a   Santos, Maria S ^b   Oliveira, Catarina R ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; COPPER; HYDROGEN PEROXIDE; LIPOFUSCIN; OXIDIZING AGENT;

ALZHEIMER DISEASE; CEREBROSPINAL FLUID; FEEDBACK SYSTEM; GOLGI COMPLEX; HUMAN; LYSOSOME; MOUSE; NONHUMAN; NOTE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SENILE PLAQUE; TRANSGENIC MOUSE;

EID: 4644312270     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/jad-2004-6411     Document Type: Note

References (14)

1. E.M. Lopez, K.F.S. Bell, A. Ribeiro-da-Silva and A.C. Cuello, Early changes in neurons of the hippocampus and neocortex in transgenic rats expressing intracellular human Aβ, J. Alzheimers Dis, in press.
2. Q.X. Li, C. Maynard, R. Cappai, C.A. McLean, R.A. Cherny, T. Lynch, J.G. Culvenor, J. Trevaskis, J.E. Tanner, K.A. Bailey, C. Czech, A. Bush, K. Beyreuther and C.L. Masters, Intracellular accumulation of detergent-soluble amyloidogenic Aβ fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice, J. Neurochem. 72 (1999), 2479-2487.
3. G.K. Gouras, J. Tsai, J. Naslund, B. Vincent, M. Edgar, F. Checler, J.P. Greenfield, V. Haroutunian, J.D. Buxbaum, H. Xu, P. Greengard and N.R. Relkin, Intraneuronal Aβ42 accumulation in human brain, Am. J. Pathol. 156 (2000), 15-20.
4. R.H. Takahashi, T.A. Milner, F. Li, E.E. Nam, M.A. Edgar, H. Yamaguchi, M.F. Beal, H. Xu, P. Greengard and G.K. Gouras, Intraneuronal Alzheimer Aβ accumulates in multivesicular bodies and is associated with synaptic pathology, Am. J. Pathol. 161 (2002), 1869-1879.
5. S. Oddo, A. Caccamo, J.D. Shepherd, M.P. Murphy, T.E. Golde, Kayed, R. Metherate, M.P. Mattson, Y. Akbari and F.M. LaFerla, Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction, Neuron 39 (2003), 409-421.
6. A.L. Phinney, M.E. Calhoun, D.P. Wolfer, H.P. Lipp, H. Zheng and M. Jucker, No hippocampal neuron or synaptic bouton loss in learning-impaired aged β-amyloid precursor protein-null mice, Neuroscience 90 (1999), 1207-1216.
7. J. Naslund, V. Haroutunian, R. Mohs, K.-L. Davis, P. Davies, P. Greengard and J.-D. Buxbaum, Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline, JAMA 283 (2000), 1571-1577.
8. C.S. Atwood, M.E. Obrenovich, T. Liu, H. Chian, G. Perry, M.A. Smith and R.N. Martins, Amyloid-β: a chameleon walking in two worlds: a review of the throphic and toxic properties of amyloid-β, Brain Res. Rev. 43 (2003), 1-16.
9. A.I. Bush, Metals and neuroscience, Curr. Opin. Chem. Biol. 4 (2000), 184-191.
10. M.A. Smith, A. Nunomura, X. Zhu, A. Takeda and G. Perry, Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease, Antioxid. Redox Signal 2 (2000), 413-420.
11. A. Nunomura, G. Perry, K. Hirai, G. Aliev, A. Takeda, S. Chiba and M.A. Smith, Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome, Ann. N. Y. Acad. Sci. 893 (1999), 362-364.
12. A. Nunomura, G. Perry, M.A. Pappolla, R.P. Friedland, K. Hirai, S. Chiba and M.A. Smith, Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome, J. Neuropathol. Exp. Neurol. 60 (2001), 759-767.
13. A. Nunomura, G. Perry, G. Aliev, K. Hirai, A. Takeda, E. K. Balraj, P.K. Jones, H. Ghanbari, T. Wataya, S. Shimohama, S. Chiba, C.S. Atwood, R.B. Petersen and M.A. Smith, Oxidative damage is the earliest event in Alzheimer disease, J. Neuropathol. Exp. Neurol. 60 (2001), 759-767.
14. M.P. Cuajungco, L.E. Goldstein, A. Nunomura, M.A. Smith, J.T. Lim, C.S. Atwood, X. Huang, Y.M. Farrag, G. Perry and A.I. Bush, Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc, J. Biol. Chem. 275 (2000), 19439-19442.