메뉴 건너뛰기




Volumn 6, Issue 5, 2004, Pages

p14ARF expression in invasive breast cancers and ductal carcinoma in situ- relationships to p53 and Hdm2

Author keywords

ARF protein; Ductal carcinoma in situ; Hdm2; HER 2; Immunohistochemistry

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; KI 67 ANTIGEN; PROTEIN MDM2; TRANSCRIPTION FACTOR TWIST; UBIQUITIN PROTEIN LIGASE E3; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN P14ARF; PROTEIN P53;

EID: 4644280243     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr912     Document Type: Article
Times cited : (18)

References (62)
  • 2
    • 0033037541 scopus 로고    scopus 로고
    • The INK4a/ARFlocus and its two gene products
    • Sharpless NE, DePinho RA: The INK4a/ARF locus and its two gene products. Curr Opin Genet Dev. 1999, 9: 22-30. 10.1016/S0959-437X(99)80004-5.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 22-30
    • Sharpless, N.E.1    DePinho, R.A.2
  • 4
    • 0343938848 scopus 로고    scopus 로고
    • Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function
    • Laín S, Xirodimas D, Lane DP: Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function. Exp Cell Res. 1999, 253: 315-324. 10.1006/excr.1999.4672.
    • (1999) Exp Cell Res , vol.253 , pp. 315-324
    • Laín, S.1    Xirodimas, D.2    Lane, D.P.3
  • 5
    • 0026694826 scopus 로고
    • Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion
    • Moll UM, Riou G, Levine AJ: Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA. 1992, 89: 7262-7266.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7262-7266
    • Moll, U.M.1    Riou, G.2    Levine, A.J.3
  • 6
    • 0032518917 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by human immunodeficiency virus rev protein
    • Roth J, Dobbelstein M, Freedman DA, Shenk T, Levine AJ: Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by human immunodeficiency virus rev protein. EMBO J. 1998, 17: 554-564. 10.1093/emboj/17.2.554.
    • (1998) EMBO J , vol.17 , pp. 554-564
    • Roth, J.1    Dobbelstein, M.2    Freedman, D.A.3    Shenk, T.4    Levine, A.J.5
  • 7
    • 0032980646 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
    • Tao W, Levine AJ: Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc Natl Acad Sci USA. 1999, 96: 3077-3080. 10.1073/pnas.96.6.3077.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3077-3080
    • Tao, W.1    Levine, A.J.2
  • 8
    • 0034642549 scopus 로고    scopus 로고
    • Nuclear exclusion of p53 in a subset of tumors requires MDM2 function
    • Lu W, Pochampally R, Chen L, Traidej M, Wang Y, Chen J: Nuclear exclusion of p53 in a subset of tumors requires MDM2 function. Oncogene. 2000, 19: 232-240. 10.1038/sj.onc.1203262.
    • (2000) Oncogene , vol.19 , pp. 232-240
    • Lu, W.1    Pochampally, R.2    Chen, L.3    Traidej, M.4    Wang, Y.5    Chen, J.6
  • 9
    • 0033521621 scopus 로고    scopus 로고
    • ARFwith Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
    • ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J. 1999, 18: 22-27. 10.1093/emboj/18.1.22.
    • (1999) EMBO J , vol.18 , pp. 22-27
    • Honda, R.1    Yasuda, H.2
  • 10
    • 0033993563 scopus 로고    scopus 로고
    • The ARF/p53 pathway
    • Sherr CJ, Weber JD: The ARF/p53 pathway. Curr Opin Genet Dev. 2000, 10: 94-99. 10.1016/S0959-437X(99)00038-6.
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 94-99
    • Sherr, C.J.1    Weber, J.D.2
  • 11
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARF-p53 pathway
    • Sherr CJ: Tumor surveillance via the ARF-p53 pathway. Genes Dev. 1998, 12: 2984-2991.
    • (1998) Genes Dev , vol.12 , pp. 2984-2991
    • Sherr, C.J.1
  • 12
    • 0033775870 scopus 로고    scopus 로고
    • p53 only ARF the story
    • Lloyd AC: p53 only ARF the story. Nat Cell Biol. 2000, 2: E48-E50. 10.1038/35004078.
    • (2000) Nat Cell Biol , vol.2 , pp. E48-E50
    • Lloyd, A.C.1
  • 14
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARFnetwork in tumour suppression
    • Sherr CJ: The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol. 2001, 2: 731-737. 10.1038/35096061.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 731-737
    • Sherr, C.J.1
  • 15
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4atumour suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle DE, Zindy F, Ashmun RA, Sherr CJ: Alternative reading frames of the INK4a tumour suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 1995, 83: 993-100. 10.1016/0092-8674(95)90214-7.
    • (1995) Cell , vol.83 , pp. 100-993
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 16
  • 18
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4alocus mediated by the alternative reading frame product p19ARF
    • Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ: Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 1997, 91: 649-659. 10.1016/S0092-8674(00)80452-3.
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3    Quelle, D.E.4    Downing, J.R.5    Ashmun, R.A.6    Grosveld, G.7    Sherr, C.J.8
  • 22
    • 0034724446 scopus 로고    scopus 로고
    • Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
    • Khan SH, Moritsugu J, Wahl GM: Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Proc Natl Acad Sci USA. 2000, 97: 3266-3271. 10.1073/pnas.050560997.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3266-3271
    • Khan, S.H.1    Moritsugu, J.2    Wahl, G.M.3
  • 23
    • 0037468575 scopus 로고    scopus 로고
    • p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
    • Eymin B, Leduc C, Coll JL, Brambilla E, Gazzeri S: p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice. Oncogene. 2003, 22: 1822-1835. 10.1038/sj.onc.1206303.
    • (2003) Oncogene , vol.22 , pp. 1822-1835
    • Eymin, B.1    Leduc, C.2    Coll, J.L.3    Brambilla, E.4    Gazzeri, S.5
  • 26
    • 0034660460 scopus 로고    scopus 로고
    • Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization
    • Rizos H, Darmanian AP, Mann GJ, Kefford RF: Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization. Oncogene. 2000, 19: 2978-2985. 10.1038/sj.onc.1203629.
    • (2000) Oncogene , vol.19 , pp. 2978-2985
    • Rizos, H.1    Darmanian, A.P.2    Mann, G.J.3    Kefford, R.F.4
  • 28
    • 0035899468 scopus 로고    scopus 로고
    • Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
    • Xirodimas D, Saville MK, Edling C, Lane DP, Laín S: Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene. 2001, 20: 4972-4983. 10.1038/sj.onc.1204656.
    • (2001) Oncogene , vol.20 , pp. 4972-4983
    • Xirodimas, D.1    Saville, M.K.2    Edling, C.3    Lane, D.P.4    Laín, S.5
  • 30
    • 0037082509 scopus 로고    scopus 로고
    • ARFnuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppressor pathways
    • ARF nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppressor pathways. Blood. 2002, 99: 1411-1418. 10.1182/blood.V99.4.1411.
    • (2002) Blood , vol.99 , pp. 1411-1418
    • Sanchez-Aguilera, A.1    Sanchez-Beato, M.2    Garcia, J.F.3    Prieto, I.4    Pollan, M.5    Piris, M.A.6
  • 32
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via IK4a/ARF
    • Jacobs JJL, Scheijen B, Voncken J-W, Kieboom K, Berns A, van Lohuizen M: Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via IK4a/ARF. Genes Dev. 1999, 13: 2678-2690. 10.1101/gad.13.20.2678.
    • (1999) Genes Dev , vol.13 , pp. 2678-2690
    • Jacobs, J.J.L.1    Scheijen, B.2    Voncken, J.-W.3    Kieboom, K.4    Berns, A.5    van Lohuizen, M.6
  • 33
  • 35
    • 0033772613 scopus 로고    scopus 로고
    • Immunohistochemical inactivation of p14ARF concomitant with MDM2 overexpression inversely correlates with p53 overexpression in oral squamous cell carcinoma
    • Sano T, Hikino T, Xue Q, Saito T, Kashiwabara K, Oyama T, Nakajima T: Immunohistochemical inactivation of p14ARF concomitant with MDM2 overexpression inversely correlates with p53 overexpression in oral squamous cell carcinoma. Pathology Int. 2000, 50: 709-716. 10.1046/j.1440-1827.2000.01109.x.
    • (2000) Pathology Int , vol.50 , pp. 709-716
    • Sano, T.1    Hikino, T.2    Xue, Q.3    Saito, T.4    Kashiwabara, K.5    Oyama, T.6    Nakajima, T.7
  • 36
    • 0034746793 scopus 로고    scopus 로고
    • Immunohistochemical detection of the alternate INK4a-encoded tumor suppressor protein p14ARF in archival human cancers and cell lines using commercial antibodies: correlation with p16INK4a expression
    • Geradts J, Wilentz RE, Roberts H: Immunohistochemical detection of the alternate INK4a-encoded tumor suppressor protein p14ARF in archival human cancers and cell lines using commercial antibodies: correlation with p16INK4a expression. Mod Pathol. 2001, 14: 1162-1168. 10.1038/modpathol.3880452.
    • (2001) Mod Pathol , vol.14 , pp. 1162-1168
    • Geradts, J.1    Wilentz, R.E.2    Roberts, H.3
  • 37
    • 0036792617 scopus 로고    scopus 로고
    • INK4aexpression
    • INK4a expression. Mod Pathol. 2002, 15: 1106-1107. 10.1097/01.MP.0000030090.45666.DB. (letter)
    • (2002) Mod Pathol , vol.15 , pp. 1106-1107
    • Vestey, S.1    Winters, Z.E.2
  • 41
    • 0029021632 scopus 로고
    • Prognostic classification of breast ductal carcinoma in situ
    • Silverstein MJ, Poller DN, Waisman JR: Prognostic classification of breast ductal carcinoma in situ. Lancet. 1995, 345: 1154-1157. 10.1016/S0140-6736(95)90982-6.
    • (1995) Lancet , vol.345 , pp. 1154-1157
    • Silverstein, M.J.1    Poller, D.N.2    Waisman, J.R.3
  • 42
    • 85010806132 scopus 로고
    • Sheffield, UK: NHSBSP Publications
    • National Breast Screening Programme: Pathology Reporting in Breast Cancer Screening. 1995, Sheffield, UK: NHSBSP Publications, 2
    • (1995) , vol.2
  • 43
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer: the value of histological grade in breast cancer: experience from a large study with long-term follow-up
    • Elston CW, Ellis IO: Pathological prognostic factors in breast cancer: the value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991, 19: 403-410.
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 44
    • 0033874943 scopus 로고    scopus 로고
    • Immunohistochemical detection of steroid receptors in breast cancer: a working protocol. UK Receptor Group, UK NEQAS, The Scottish Breast Cancer Pathology Group, and The Receptor and Biomarker Study Group of the EORTC
    • Leake R, Barnes D, Pinder S, Ellis I, Anderson L, Anderson T, Adamson R, Rhodes T, Miller K, Walker R: Immunohistochemical detection of steroid receptors in breast cancer: a working protocol. UK Receptor Group, UK NEQAS, The Scottish Breast Cancer Pathology Group, and The Receptor and Biomarker Study Group of the EORTC. J Clin Pathol. 2000, 53: 634-635. 10.1136/jcp.53.8.634.
    • (2000) J Clin Pathol , vol.53 , pp. 634-635
    • Leake, R.1    Barnes, D.2    Pinder, S.3    Ellis, I.4    Anderson, L.5    Anderson, T.6    Adamson, R.7    Rhodes, T.8    Miller, K.9    Walker, R.10
  • 45
    • 1342301548 scopus 로고    scopus 로고
    • COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ
    • Boland GP, Butt IS, Prasad R, Knox WF, Bundred NJ: COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. Br J Cancer. 2004, 90: 423-429. 10.1038/sj.bjc.6601534.
    • (2004) Br J Cancer , vol.90 , pp. 423-429
    • Boland, G.P.1    Butt, I.S.2    Prasad, R.3    Knox, W.F.4    Bundred, N.J.5
  • 46
    • 0036717202 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formalin-fixed and paraffin-processed cell lines and breast tumours: a comparative study involving results from laboratories in 21 countries
    • Rhodes A, Jasani B, Anderson E, Dodson AR, Balaton AJ: Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formalin-fixed and paraffin-processed cell lines and breast tumours: a comparative study involving results from laboratories in 21 countries. Am J Clin Pathol. 2002, 118: 408-417. 10.1309/97WN-W6UX-XJWT-02H2.
    • (2002) Am J Clin Pathol , vol.118 , pp. 408-417
    • Rhodes, A.1    Jasani, B.2    Anderson, E.3    Dodson, A.R.4    Balaton, A.J.5
  • 48
    • 0031728614 scopus 로고    scopus 로고
    • An immunochemical analysis of mdm2 expression in human breast cancer and the identification of a growth-regulated cross-reacting species p170
    • O'Neill M, Campbell SJ, Save V, Thompson AM, Hall PA: An immunochemical analysis of mdm2 expression in human breast cancer and the identification of a growth-regulated cross-reacting species p170. J Pathol. 1998, 186: 254-261. 10.1002/(SICI)1096-9896(1998110)186:3<254::AID-PATH185>3.3.CO;2-L.
    • (1998) J Pathol , vol.186 , pp. 254-261
    • O'Neill, M.1    Campbell, S.J.2    Save, V.3    Thompson, A.M.4    Hall, P.A.5
  • 50
    • 0024536892 scopus 로고
    • Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods
    • Kinsel LB, Szabo E, Greene GL, Konrath J, Leight GS, McCarty KS: Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods. Cancer Res. 1989, 49: 1052-1056.
    • (1989) Cancer Res , vol.49 , pp. 1052-1056
    • Kinsel, L.B.1    Szabo, E.2    Greene, G.L.3    Konrath, J.4    Leight, G.S.5    McCarty, K.S.6
  • 52
    • 0346485798 scopus 로고    scopus 로고
    • WAF1/CIP1expression is correlated with HER-2/neuin breast cancer and is an independent predictor of prognosis
    • WAF1/CIP1 expression is correlated with HER-2/neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Res. 2003, 5: R242-R249. 10.1186/bcr654.
    • (2003) Breast Cancer Res , vol.5 , pp. R242-R249
    • Winters, Z.E.1    Leek, R.D.2    Bradburn, M.J.3    Norbury, C.J.4    Harris, A.L.5
  • 53
    • 1842326156 scopus 로고    scopus 로고
    • Genetic changes in intraductal breast cancer detected by comparative genomic hybridization
    • Kuukasjarvi T, Tanner M, Pennanen S, Karhu R, Kallioniemi O-P, Isola J: Genetic changes in intraductal breast cancer detected by comparative genomic hybridization. Am J Pathol. 1997, 150: 1465-1471.
    • (1997) Am J Pathol , vol.150 , pp. 1465-1471
    • Kuukasjarvi, T.1    Tanner, M.2    Pennanen, S.3    Karhu, R.4    Kallioniemi, O.-P.5    Isola, J.6
  • 54
    • 0033119769 scopus 로고    scopus 로고
    • Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer
    • Roylance R, Gorman P, Harris W, Liebmann R, Barnes D, Hanby A, Sheer D: Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer. Cancer Res. 1999, 59: 1433-1436.
    • (1999) Cancer Res , vol.59 , pp. 1433-1436
    • Roylance, R.1    Gorman, P.2    Harris, W.3    Liebmann, R.4    Barnes, D.5    Hanby, A.6    Sheer, D.7
  • 56
    • 0001837570 scopus 로고    scopus 로고
    • Functions of the MDM2 oncoprotein
    • Freedman DA, Wu L, Levine AJ: Functions of the MDM2 oncoprotein. Cell Mol Life Sci. 1999, 55: 96-107. 10.1007/s000180050273.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 96-107
    • Freedman, D.A.1    Wu, L.2    Levine, A.J.3
  • 59
    • 0033771948 scopus 로고    scopus 로고
    • Identification of a cryptic nucleolar-localization signal in MDM2
    • Lohrum MAE, Ashcroft M, Kubbutat MHG, Vousden KH: Identification of a cryptic nucleolar-localization signal in MDM2. Nat Cell Biol. 2000, 2: 179-181. 10.1038/35004057.
    • (2000) Nat Cell Biol , vol.2 , pp. 179-181
    • Lohrum, M.A.E.1    Ashcroft, M.2    Kubbutat, M.H.G.3    Vousden, K.H.4
  • 60
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neuinduces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung M-C: HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol. 2001, 3: 973-982. 10.1038/ncb1101-973.
    • (2001) Nat Cell Biol , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.-C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.