Rational vector design for efficient non-viral gene delivery: Challenges facing the use of plasmid DNA

Molecular Biotechnology

Volumn 39, Issue 2, 2008, Pages 97-104

  Mairhofer, Juergen ^a   Grabherr, Reingard ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

Antibiotic resistance gene; Bacterial minimal vector; DNA structure; DNA vaccines; Gene delivery; Gene therapy; Non viral; Plasmid DNA; Plasmid size; Transient protein expression; Vector design

Indexed keywords

ANTIBIOTICS; BACTERIOLOGY; BIOMARKERS; DNA; GENE TRANSFER; GENES; GENETIC ENGINEERING; NUCLEIC ACIDS; ORGANIC ACIDS; VACCINES;

ANTIBIOTIC RESISTANCE GENE; BACTERIAL MINIMAL VECTOR; DNA STRUCTURE; DNA VACCINES; GENE DELIVERY; GENE THERAPY; NON-VIRAL; PLASMID DNA; PLASMID SIZE;

VECTORS;

BACTERIAL DNA; BETA LACTAM ANTIBIOTIC; KANAMYCIN; MINICIRCLE DNA; PLASMID DNA; RECOMBINANT DNA;

ALLERGIC REACTION; ANAPHYLAXIS; ANTIBIOTIC RESISTANCE; CONFERENCE PAPER; DNA STRUCTURE; DNA SUPERCOILING; DNA VECTOR; DRUG DESIGN; DRUG POTENCY; DRUG QUALITY; DRUG SAFETY; GENE SILENCING; GENETIC STABILITY; HUMAN; INFECTION; NEPHROTOXICITY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; OTOTOXICITY; PROTEIN EXPRESSION; TITRIMETRY; BACTERIAL GENE; BIOSYNTHESIS; GENE DOSAGE; GENE TRANSFER; GENE VECTOR; GENETIC MARKER; OPERATOR GENE; PLASMID; REGULATORY RNA SEQUENCE; REVIEW; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE;

BACTERIA (MICROORGANISMS);

DNA, RECOMBINANT; DNA, SUPERHELICAL; GENE DOSAGE; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENES, BACTERIAL; GENETIC MARKERS; GENETIC VECTORS; OPERATOR REGIONS (GENETICS); PLASMIDS; RNA 3' POLYADENYLATION SIGNALS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 46349094993     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-008-9046-7     Document Type: Conference Paper

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