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Volumn 133, Issue 6, 2008, Pages 1442-1450

Eicosanoid lipid mediators in fibrotic lung diseases: Ready for prime time?

Author keywords

Airway remodeling; Leukotrienes; Prostaglandins; Pulmonary fibrosis

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIOXIDANT; BLEOMYCIN; CHEMOKINE; CORTICOSTEROID; CYTOKINE; GLUTATHIONE; ICOSANOID; ILOPROST; LEUKOTRIENE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOXYGENASE INHIBITOR; LOSARTAN; MONTELUKAST; PHOSPHODIESTERASE INHIBITOR; PROSTACYCLIN DERIVATIVE; PROSTAGLANDIN; PROSTAGLANDIN E2; ZILEUTON;

EID: 46149094641     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.08-0306     Document Type: Article
Times cited : (62)

References (56)
  • 1
    • 0035895243 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    • Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001; 134:136-151
    • (2001) Ann Intern Med , vol.134 , pp. 136-151
    • Selman, M.1    King, T.E.2    Pardo, A.3
  • 2
    • 0037080547 scopus 로고    scopus 로고
    • American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias: This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001
    • American Thoracic Society, European Respiratory Society
    • American Thoracic Society, European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias: this joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002; 165:277-304
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 277-304
  • 3
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: Advances in eicosanoid biology
    • Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001; 294:1871-1875
    • (2001) Science , vol.294 , pp. 1871-1875
    • Funk, C.D.1
  • 4
    • 20444444296 scopus 로고    scopus 로고
    • Eicosanoids: Mediators and therapeutic targets in fibrotic lung disease
    • Charbeneau RP, Peters-Golden M. Eicosanoids: mediators and therapeutic targets in fibrotic lung disease. Clin Sci (Lond) 2005; 108:479-491
    • (2005) Clin Sci (Lond) , vol.108 , pp. 479-491
    • Charbeneau, R.P.1    Peters-Golden, M.2
  • 6
    • 36849042552 scopus 로고    scopus 로고
    • Leukotriene D4-induced, epithelial cell-derived transforming growth factor β1 in human bronchial smooth muscle cell proliferation
    • Bosse Y, Thompson C, McMahon S, et al. Leukotriene D4-induced, epithelial cell-derived transforming growth factor β1 in human bronchial smooth muscle cell proliferation. Clin Exp Allergy 2008; 38:113-121
    • (2008) Clin Exp Allergy , vol.38 , pp. 113-121
    • Bosse, Y.1    Thompson, C.2    McMahon, S.3
  • 7
    • 33646594755 scopus 로고    scopus 로고
    • Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells
    • Uzonyi B, Lotzer K, Jahn S, et al. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. Proc Natl Acad Sci U S A 2006; 103:6326-6331
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6326-6331
    • Uzonyi, B.1    Lotzer, K.2    Jahn, S.3
  • 8
    • 0023063940 scopus 로고
    • Leukotriene C4 binds to rat lung fibroblasts and stimulates collagen synthesis
    • Phan SH, McGarry BM, Loeffler KM, et al. Leukotriene C4 binds to rat lung fibroblasts and stimulates collagen synthesis. Adv Prostaglandin Thromboxane Res 1987; 17B:997-999
    • (1987) Adv Prostaglandin Thromboxane Res , vol.17 B , pp. 997-999
    • Phan, S.H.1    McGarry, B.M.2    Loeffler, K.M.3
  • 9
    • 38849161533 scopus 로고    scopus 로고
    • Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function
    • Vannella KM, McMillan TR, Charbeneau RP, et al. Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function. J Immunol 2007; 179:7883-7890
    • (2007) J Immunol , vol.179 , pp. 7883-7890
    • Vannella, K.M.1    McMillan, T.R.2    Charbeneau, R.P.3
  • 10
    • 0028809831 scopus 로고
    • Investigation of the inhibitory effects of PGE2 and selective EP agonists on chemotaxis of human neutrophils
    • Armstrong RA. Investigation of the inhibitory effects of PGE2 and selective EP agonists on chemotaxis of human neutrophils. Br J Pharmacol 1995; 116:2903-2908
    • (1995) Br J Pharmacol , vol.116 , pp. 2903-2908
    • Armstrong, R.A.1
  • 12
    • 0024325755 scopus 로고
    • The differential effect of prostaglandin E2 on transforming growth factor-β and insulin-induced collagen formation in lung fibroblasts
    • Fine A, Poliks CF, Donahue LP, et al. The differential effect of prostaglandin E2 on transforming growth factor-β and insulin-induced collagen formation in lung fibroblasts. J Biol Chem 1989; 264:16988-16991
    • (1989) J Biol Chem , vol.264 , pp. 16988-16991
    • Fine, A.1    Poliks, C.F.2    Donahue, L.P.3
  • 13
    • 13244258341 scopus 로고    scopus 로고
    • Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity
    • White ES, Atrasz RG, Dickie EG, et al. Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity. Am J Respir Cell Mol Biol 2005; 32:135-141
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 135-141
    • White, E.S.1    Atrasz, R.G.2    Dickie, E.G.3
  • 14
    • 0018832895 scopus 로고
    • Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen
    • Baum BJ, Moss J, Breul SD, et al. Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen. J Biol Chem 1980; 255:2843-2847
    • (1980) J Biol Chem , vol.255 , pp. 2843-2847
    • Baum, B.J.1    Moss, J.2    Breul, S.D.3
  • 15
    • 0031709737 scopus 로고    scopus 로고
    • Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alphal, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts
    • Choung J, Taylor L, Thomas K, et al. Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alphal, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts. J Cell Biochem 1998; 71: 254-263
    • (1998) J Cell Biochem , vol.71 , pp. 254-263
    • Choung, J.1    Taylor, L.2    Thomas, K.3
  • 16
    • 0033007542 scopus 로고    scopus 로고
    • Glucocorticoids augment fibroblast-mediated contraction of collagen gels by inhibition of endogenous PGE production
    • Skold CM, Liu XD, Zhu YK, et al. Glucocorticoids augment fibroblast-mediated contraction of collagen gels by inhibition of endogenous PGE production. Proc Assoc Am Physicians 1999; 111:249-258
    • (1999) Proc Assoc Am Physicians , vol.111 , pp. 249-258
    • Skold, C.M.1    Liu, X.D.2    Zhu, Y.K.3
  • 17
    • 34547647436 scopus 로고    scopus 로고
    • PGE(2) inhibition of TGF-betal-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling
    • Thomas PE, Peters-Golden M, White ES, et al. PGE(2) inhibition of TGF-betal-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling. Am J Physiol Lung Cell Mol Physiol 2007; 293:L417-L428
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Thomas, P.E.1    Peters-Golden, M.2    White, E.S.3
  • 18
    • 33845358419 scopus 로고    scopus 로고
    • Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: Interaction with hepatocyte growth factor
    • Zhang A, Wang MH, Dong Z, et al. Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: interaction with hepatocyte growth factor. Am J Physiol Renal Physiol 2006; 291:F1323-F1331
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Zhang, A.1    Wang, M.H.2    Dong, Z.3
  • 19
    • 0037080719 scopus 로고    scopus 로고
    • Protection from pulmonary fibrosis in leukotriene-deficient mice
    • Peters-Golden M, Bailie M, Marshall T, et al. Protection from pulmonary fibrosis in leukotriene-deficient mice. Am J Respir Crit Care Med 2002; 165:229-235
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 229-235
    • Peters-Golden, M.1    Bailie, M.2    Marshall, T.3
  • 20
    • 1542327670 scopus 로고    scopus 로고
    • Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis
    • Beller TC, Friend DS, Maekawa A, et al. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc Natl Acad Sci U S A 2004; 101:3047-3052
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3047-3052
    • Beller, T.C.1    Friend, D.S.2    Maekawa, A.3
  • 21
    • 33845484030 scopus 로고    scopus 로고
    • Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury
    • Failla M, Genovese T, Mazzon E, et al. Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury. Respir Res 2006; 7:137
    • (2006) Respir Res , vol.7 , pp. 137
    • Failla, M.1    Genovese, T.2    Mazzon, E.3
  • 22
    • 7244227766 scopus 로고    scopus 로고
    • Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production
    • Hodges RJ, Jenkins RG, Wheeler-Jones CP, et al. Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production. Am J Pathol 2004; 165:1663-1676
    • (2004) Am J Pathol , vol.165 , pp. 1663-1676
    • Hodges, R.J.1    Jenkins, R.G.2    Wheeler-Jones, C.P.3
  • 23
    • 0034292434 scopus 로고    scopus 로고
    • GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism
    • Moore BB, Coffey MJ, Christensen P, et al. GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. J Immunol 2000; 165:4032-4039
    • (2000) J Immunol , vol.165 , pp. 4032-4039
    • Moore, B.B.1    Coffey, M.J.2    Christensen, P.3
  • 24
    • 33644750037 scopus 로고    scopus 로고
    • Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice
    • Murakami S, Nagaya N, Itoh T, et al. Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 2006; 290:L59-L65
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Murakami, S.1    Nagaya, N.2    Itoh, T.3
  • 25
    • 0025985547 scopus 로고
    • Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E
    • Borok Z, Gillissen A, Buhl R, et al. Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E. Am Rev Respir Dis 1991; 144:1080-1084
    • (1991) Am Rev Respir Dis , vol.144 , pp. 1080-1084
    • Borok, Z.1    Gillissen, A.2    Buhl, R.3
  • 26
    • 0028924146 scopus 로고
    • Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2
    • Wilborn J, Crofford LJ, Burdick MD, et al. Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J Clin Invest 1995; 95:1861-1868
    • (1995) J Clin Invest , vol.95 , pp. 1861-1868
    • Wilborn, J.1    Crofford, L.J.2    Burdick, M.D.3
  • 27
    • 0034038206 scopus 로고    scopus 로고
    • Different expression of TNF-alpha receptors and prostaglandin E(2) production in normal and fibrotic lung fibroblasts: Potential implications for the evolution of the inflammatory process
    • Vancheri C, Sortino MA, Tomaselli V, et al. Different expression of TNF-alpha receptors and prostaglandin E(2) production in normal and fibrotic lung fibroblasts: potential implications for the evolution of the inflammatory process. Am J Respir Cell Mol Biol 2000; 22:628-634
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 628-634
    • Vancheri, C.1    Sortino, M.A.2    Tomaselli, V.3
  • 28
    • 0035070056 scopus 로고    scopus 로고
    • Cyclooxygenase-2 deficiency results in a loss of the antiproliferative response to transforming growth factor-β in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice
    • Keerthisingam CB, Jenkins RG, Harrison NK, et al. Cyclooxygenase-2 deficiency results in a loss of the antiproliferative response to transforming growth factor-β in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. Am J Pathol 2001; 158:1411-1422
    • (2001) Am J Pathol , vol.158 , pp. 1411-1422
    • Keerthisingam, C.B.1    Jenkins, R.G.2    Harrison, N.K.3
  • 29
    • 0024474984 scopus 로고
    • Leukotrienes, LTC4 and LTB4, in bronchoalveolar lavage in bronchial asthma and other respiratory diseases
    • Wardlaw AJ, Hay H, Cromwell O, et al. Leukotrienes, LTC4 and LTB4, in bronchoalveolar lavage in bronchial asthma and other respiratory diseases. J Allergy Clin Immunol 1989; 84:19-26
    • (1989) J Allergy Clin Immunol , vol.84 , pp. 19-26
    • Wardlaw, A.J.1    Hay, H.2    Cromwell, O.3
  • 30
    • 0030005712 scopus 로고    scopus 로고
    • Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis
    • Wilborn J, Bailie M, Coffey M, et al. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest 1996; 97:1827-1836
    • (1996) J Clin Invest , vol.97 , pp. 1827-1836
    • Wilborn, J.1    Bailie, M.2    Coffey, M.3
  • 31
    • 0037309390 scopus 로고    scopus 로고
    • Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2
    • Moore BB, Peters-Golden M, Christensen PJ, et al. Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2. Am J Physiol Lung Cell Mol Physiol 2003; 284:L342-L349
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Moore, B.B.1    Peters-Golden, M.2    Christensen, P.J.3
  • 32
    • 0037834817 scopus 로고    scopus 로고
    • Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: Implications for fibroproliferation
    • Charbeneau RP, Christensen PJ, Chrisman CJ, et al. Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation. Am J Physiol Lung Cell Mol Physiol 2003; 284:L1103-L1111
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Charbeneau, R.P.1    Christensen, P.J.2    Chrisman, C.J.3
  • 33
    • 0242636991 scopus 로고    scopus 로고
    • Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis
    • Marchand-Adam S, Marchal J, Cohen M, et al. Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2003; 168: 1156-1161
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1156-1161
    • Marchand-Adam, S.1    Marchal, J.2    Cohen, M.3
  • 34
    • 0027213308 scopus 로고
    • Transforming growth factor β upregulates 5-lipoxygenase activity during myeloid cell maturation
    • Steinhilber D, Radmark O, Samuelsson B. Transforming growth factor β upregulates 5-lipoxygenase activity during myeloid cell maturation. Proc Natl Acad Sci U S A 1993; 90:5984-5988
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5984-5988
    • Steinhilber, D.1    Radmark, O.2    Samuelsson, B.3
  • 35
    • 33746215177 scopus 로고    scopus 로고
    • Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling
    • Shim YM, Zhu Z, Zheng T, et al. Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling. J Immunol 2006; 177:1918-1924
    • (2006) J Immunol , vol.177 , pp. 1918-1924
    • Shim, Y.M.1    Zhu, Z.2    Zheng, T.3
  • 36
    • 0033849141 scopus 로고    scopus 로고
    • Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice
    • Peebles RS Jr, Dworski R, Collins RD, et al. Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice. Am J Respir Crit Care Med 2000; 162:676-681
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 676-681
    • Peebles Jr, R.S.1    Dworski, R.2    Collins, R.D.3
  • 37
    • 0032133454 scopus 로고    scopus 로고
    • Comparison of the regulations by Th2-type cytokines of the arachidonic-acid metabolic pathway in human alveolar macrophages and monocytes
    • Endo T, Ogushi F, Kawano T, et al. Comparison of the regulations by Th2-type cytokines of the arachidonic-acid metabolic pathway in human alveolar macrophages and monocytes. Am J Respir Cell Mol Biol 1998; 19:300-307
    • (1998) Am J Respir Cell Mol Biol , vol.19 , pp. 300-307
    • Endo, T.1    Ogushi, F.2    Kawano, T.3
  • 38
    • 0038404961 scopus 로고    scopus 로고
    • CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4
    • Espinosa K, Bosse Y, Stankova J, et al. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J Allergy Clin Immunol 2003; 111:1032-1040
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1032-1040
    • Espinosa, K.1    Bosse, Y.2    Stankova, J.3
  • 39
    • 34547589208 scopus 로고    scopus 로고
    • Antioxidant status after iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis
    • Balbir-Gurman A, Braun-Moscovici Y, Livshitz V, et al. Antioxidant status after iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis. Clin Rheumatol 2007; 26:1517-1521
    • (2007) Clin Rheumatol , vol.26 , pp. 1517-1521
    • Balbir-Gurman, A.1    Braun-Moscovici, Y.2    Livshitz, V.3
  • 40
    • 0029416956 scopus 로고
    • Prostaglandin E2 regulates production of plasminogen activator isoenzymes, urokinase receptor, and plasminogen activator inhibitor-1 in primary cultures of rat calvarial osteoblasts
    • Allan EH, Martin TJ, Prostaglandin E2 regulates production of plasminogen activator isoenzymes, urokinase receptor, and plasminogen activator inhibitor-1 in primary cultures of rat calvarial osteoblasts. J Cell Physiol 1995; 165:521-529
    • (1995) J Cell Physiol , vol.165 , pp. 521-529
    • Allan, E.H.1    Martin, T.J.2
  • 41
    • 1942518857 scopus 로고    scopus 로고
    • cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts
    • Liu X, Ostrom RS, Insel PA. cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. Am J Physiol Cell Physiol 2004; 286:C1089-C1099
    • (2004) Am J Physiol Cell Physiol , vol.286
    • Liu, X.1    Ostrom, R.S.2    Insel, P.A.3
  • 42
    • 0037783488 scopus 로고    scopus 로고
    • Elevated levels of leukotriene B4 and leukotriene E4 in bronchoalveolar lavage fluid from patients with scleroderma lung disease
    • Kowal-Bielecka O, Distler O, Kowal K, et al. Elevated levels of leukotriene B4 and leukotriene E4 in bronchoalveolar lavage fluid from patients with scleroderma lung disease. Arthritis Rheum 2003; 48:1639-1646
    • (2003) Arthritis Rheum , vol.48 , pp. 1639-1646
    • Kowal-Bielecka, O.1    Distler, O.2    Kowal, K.3
  • 43
    • 0023994058 scopus 로고
    • Increased levels of leukotriene C4 in bronchoalveolar lavage from patients with pigeon breeder's disease
    • Selman M, Barquin N, Sansores R, et al. Increased levels of leukotriene C4 in bronchoalveolar lavage from patients with pigeon breeder's disease. Arch Invest Med (Mex) 1988; 19:127-131
    • (1988) Arch Invest Med (Mex) , vol.19 , pp. 127-131
    • Selman, M.1    Barquin, N.2    Sansores, R.3
  • 44
    • 0024336630 scopus 로고
    • Alveolar macrophages from patients with asbestos exposure release increased levels of leukotriene B4
    • Garcia JG, Griffith DE, Cohen AB, et al. Alveolar macrophages from patients with asbestos exposure release increased levels of leukotriene B4. Am Rev Respir Dis 1989; 139:1494-1501
    • (1989) Am Rev Respir Dis , vol.139 , pp. 1494-1501
    • Garcia, J.G.1    Griffith, D.E.2    Cohen, A.B.3
  • 45
    • 33645280326 scopus 로고    scopus 로고
    • Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade
    • Henderson WR Jr, Chiang GK, Tien YT, et al. Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. Am J Respir Crit Care Med 2006; 173:718-728
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 718-728
    • Henderson Jr, W.R.1    Chiang, G.K.2    Tien, Y.T.3
  • 46
    • 33748860064 scopus 로고    scopus 로고
    • Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge
    • Kelly MM, Chakir J, Vethanayagam D, et al. Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge. Chest 2006; 130:741-753
    • (2006) Chest , vol.130 , pp. 741-753
    • Kelly, M.M.1    Chakir, J.2    Vethanayagam, D.3
  • 47
    • 0037738455 scopus 로고    scopus 로고
    • Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma
    • Pierzchalska M, Szabo Z, Sanak M, et al. Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. J Allergy Clin Immunol 2003; 111:1041-1048
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1041-1048
    • Pierzchalska, M.1    Szabo, Z.2    Sanak, M.3
  • 48
    • 0036007547 scopus 로고    scopus 로고
    • Prostacyclin analogs as the brakes for pulmonary artery smooth muscle cell proliferation: Is it sufficient to treat severe pulmonary hypertension?
    • Tuder RM, Zaiman AL. Prostacyclin analogs as the brakes for pulmonary artery smooth muscle cell proliferation: is it sufficient to treat severe pulmonary hypertension? Am J Respir Cell Mol Biol 2002; 26:171-174
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 171-174
    • Tuder, R.M.1    Zaiman, A.L.2
  • 49
    • 0022474966 scopus 로고
    • Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguaiaretic acid: The role of alveolar macrophage activation and mediator production
    • Phan SH, Kunkel SL. Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguaiaretic acid: the role of alveolar macrophage activation and mediator production. Am J Pathol 1986; 124:343-352
    • (1986) Am J Pathol , vol.124 , pp. 343-352
    • Phan, S.H.1    Kunkel, S.L.2
  • 50
    • 34147097536 scopus 로고    scopus 로고
    • Cysteinyl-leukotriene 1 receptor antagonist attenuates bleomycin-induced pulmonary fibrosis in mice
    • Izumo T, Kondo M, Nagai A. Cysteinyl-leukotriene 1 receptor antagonist attenuates bleomycin-induced pulmonary fibrosis in mice. Life Sci 2007; 80:1882-1886
    • (2007) Life Sci , vol.80 , pp. 1882-1886
    • Izumo, T.1    Kondo, M.2    Nagai, A.3
  • 51
    • 0032903965 scopus 로고    scopus 로고
    • Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation
    • Gauvreau GM, Watson RM, O'Byrne PM. Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation. Am J Respir Crit Care Med 1999; 159:31-36
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 31-36
    • Gauvreau, G.M.1    Watson, R.M.2    O'Byrne, P.M.3
  • 52
    • 37849050983 scopus 로고    scopus 로고
    • Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia
    • Huang SK, Wettlaufer SH, Hogaboam CM, et al. Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia. Am J Respir Crit Care Med 2008; 177:66-74
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 66-74
    • Huang, S.K.1    Wettlaufer, S.H.2    Hogaboam, C.M.3
  • 53
    • 46149085232 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of iloprost inhalation in adults with abnormal pulmonary arterial pressure and exercise limitation associated with idiopathic pulmonary fibrosis [abstract]
    • Krowka MJ, Ahmad S, de Andrade JA, et al. A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of iloprost inhalation in adults with abnormal pulmonary arterial pressure and exercise limitation associated with idiopathic pulmonary fibrosis [abstract]. Chest 2007; 132:633a
    • (2007) Chest , vol.132
    • Krowka, M.J.1    Ahmad, S.2    de Andrade, J.A.3
  • 54
    • 0026662385 scopus 로고
    • Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene
    • Kujubu DA, Herschman HR. Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. J Biol Chem 1992; 267:7991-7994
    • (1992) J Biol Chem , vol.267 , pp. 7991-7994
    • Kujubu, D.A.1    Herschman, H.R.2
  • 55
    • 33745817789 scopus 로고    scopus 로고
    • Losartan attenuates bleomycin induced lung fibrosis by increasing prostaglandin E2 synthesis
    • Molina-Molina M, Serrano-Mollar A, Bulbena O, et al. Losartan attenuates bleomycin induced lung fibrosis by increasing prostaglandin E2 synthesis. Thorax 2006; 61:604-610
    • (2006) Thorax , vol.61 , pp. 604-610
    • Molina-Molina, M.1    Serrano-Mollar, A.2    Bulbena, O.3
  • 56
    • 11144258648 scopus 로고    scopus 로고
    • cAMP phosphodiesterase inhibitors potentiate effects of prostacyclin analogs in hypoxic pulmonary vascular remodeling
    • Phillips PG, Long L, Wilkins MR, et al. cAMP phosphodiesterase inhibitors potentiate effects of prostacyclin analogs in hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 2005; 288:L103-L115
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Phillips, P.G.1    Long, L.2    Wilkins, M.R.3


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