Cytokeratins as targets for bile acid-induced toxicity

American Journal of Pathology

Volumn 160, Issue 2, 2002, Pages 491-499

  Fickert, Peter ^a   Trauner, Michael ^a   Fuchsbichler, Andrea ^a   Stumptner, Conny ^a   Zatloukal, Kurt ^a   Denk, Helmut ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHOLIC ACID; CYTOKERATIN 18; CYTOKERATIN 8; MESSENGER RNA; SULFUR 35; URSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CELL PROTECTION; CHOLESTASIS; CONTROLLED STUDY; CYTOSKELETON; HISTOPATHOLOGY; IMMUNOFLUORESCENCE MICROSCOPY; IN SITU HYBRIDIZATION; INTERMEDIATE FILAMENT; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 0036169056     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64868-7     Document Type: Article

References (39)

1. Molecular pathogenesis of cholestasis
2. Mechanisms of cholestasis
3. Cellular and molecular mechanisms of cholestasis
4. Impact of cholestasis on hepatic function: Retention of cholephiles and their potential targets
5. Cytokeratin intermediate filaments of rat hepatocytes: Different cytoskeletal domains and their three-dimensional structure
6. Intermediate filament protein of the liver. Emerging disease association and functions
7. Role of cytokeratin intermediate filaments in transhepatic transport and canalicular secretion
8. Pathologic changes in the cytokeratin pericanalicular sheath in experimental cholestasis and alcoholic fatty liver
9. Alterations of hepatocellular intermediate filaments during extrahepatic cholestasis in rat liver
10. Hepatocellular hyalin in cholestasis and cirrhosis: Its diagnostic significance
11. Mallory body revisited
12. Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant
13. Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant
14. Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice
15. Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at ser73 in tissues and cultured cells
16. Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies
17. Keratin 8 mutations in patients with cryptogenic liver disease
18. Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in Mallory bodies
19. Overexpression of keratin-8 and -18 mRNA associated with Mallory body formation in patients with alcoholic hepatitis
20. The rat canalicular conjugate export pump (Mrp2) is downregulated in intrahepatic and obstructive cholestasis
21. Effects of ursodeoxycholate and cholate feeding on liver diseases in FVB mice with disrupted mdr2 P-glycoprotein gene
22. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
23. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
24. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
25. Disturbance of keratin homeostasis in griseofulvin-intoxicated mouse liver
26. High molecular weight component of Mallory bodies detected by monoclonal antibody
27. A cytokeratin immunohistochemical study of cholestatic liver disease: Evidence that hepatocytes can express 'bile duct-type' cytokeratins
28. The role of kupffer cells on cytokeratin 8/18 expression in lipopolysaccharide or 3,5-diethoxycarbonyl-1,4-dihydrocollidine induced hepatic injury
29. Sequence of events in the assembly of Mallory body components in mouse liver: Clues to the pathogenesis and significance of Mallory body formation
30. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocytes couplets
31. Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane
32. The role of microfilaments and microtubules in taurocholate uptake by isolated rat liver cells
33. Actin filaments and microtubules are involved in different membrane traffic pathways that transport sphingolipids to the apical surface of polarized HepG2 cells
34. Effects of ursodeoxycholate and cholate feeding on liver disease in fvb mice with a disrupted mdr2 p-glycoprotein gene
35. Simple epithelium keratins are required for maintenance of hepatocyte integrity
36. Exocrine pancreatic disorders in transgenic mice expressing human keratin 8
37. Bilirubin binding activity of cytokeratin 18 isolated from the porcine liver
38. Mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver disease
39. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transport expression in mouse liver