Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 284, Issue 3 47-3, 2003, Pages

  Kamp, Elizabeth H ^a   Jones III, R Carter W ^a   Tillman, Shelly R ^a   Gebhart, G F ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Colon; Gender; Knockout mice; Strain; Visceral pain; opioid

Indexed keywords

IRRITANT AGENT; KAPPA OPIATE RECEPTOR AGONIST; MORPHINE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE;

ABDOMINAL WALL MUSCULATURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON DILATATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; FEMALE; HYPERALGESIA; MALE; MOUSE; MUSCLE CONTRACTILITY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSGENIC MOUSE; VISCERAL PAIN;

EID: 0037371103     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00324.2002     Document Type: Article

References (65)

1. Barber A, Bartoszyk GD, Bender HM, and Gottschlich R, Greiner HE, Harting J, Mauler F, Minck KO, Murray RD, Simon M. A pharmacological profile of the novel, peripherallyselective kappa-opioid receptor agonist, EMD 61753, Br J Pharmacol 113: 1317-1327, 1994.
2. Binder W, Carmody J, and Walker J. Effect of gender on anti-inflammatory and analgesic actions of two kappa-opioids. J Pharmacol Exp Ther 292: 303-309, 2000.
3. Black D and Trevethick M. The kappa opioid receptor is associated with the perception of visceral pain. Gut 43: 312-313, 1998.
4. Broadbear JH, Negus SS, Butelman ER, de Costa BR, and Woods JH. Differential effects of systemically administered nor-binaltorphimine (nor-BNI) on kappa-opioid agonists in the mouse writhing assay. Psychopharmacology (Berl) 115: 311-319, 1994.
5. Boku K, Ohno T, Saeki T, Hayashi H, Hayashi I, Katori M, Murata T, Narumiya S, Saigenji K, and Majima M. Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology 120: 134-143, 2001.
6. Burton MB and Gebhart GF. Effects of κ-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation. J Pharmacol Exp Ther 285: 707-715, 1999.
7. Cervero F. Sensory innervation of the viscera: peripheral basis of visceral pain. Physiol Rev 74: 95-138, 1994.
8. Cervero F and Laird J. Visceral pain. Lancet 353: 2145-2148, 1999.
9. Coutinho SV and Gebhart GF. A role for spinal nitric oxide in mediating visceral hyperalgesia in the rat. Gastroenterology 116: 1399-1408, 1999.
10. Coutinho SV, Meller ST, and Gebhart GF. Intracolonic zymosan produces visceral hyperalgesia in the rat that is mediated by spinal NMDA and non-NMDA receptors. Brain Res 736: 7-15, 1996.
11. Coutinho S, Su X, Sengupta JN, and Gebhart GF. Role of sensitized pelvic nerve afferents from the inflamed rat colon in the maintenance of visceral hyperalgesia. In: Progressive Brain Research: Nervous System Plasticity and Chronic Pain, edited by Sandkuhler J, Bromm B, and Gebhart GF, Amsterdam, The Netherlands: Elsevier, 2000, vol. 129, p. 375-387.
12. Davies NM, Sharkey KA, Asfaha S, Macnaughton WK, and Wallace JL. Aspirin causes rapid up-regulation of cyclo-oxygenase-2 expression in the stomach of rats. Aliment Pharmacol Ther 11: 1101-1108, 1997.
13. Elmer GI, Pieper JO, Negus SS, and Woods JH. Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests. Pain 75: 129-140, 1998.
14. Franco L and Doria D. Nitric oxide enhances prostaglandin production in ethanol-induced gastric mucosal injury in rats. Eur J Pharmacol 348: 247-256, 1998.
15. Friedrich AE and Gebhart GF. Effects of spinal CCK receptor antagonists on morphine antinociception in a model of visceral pain in the rat. J Pharmacol Exp Ther 292: 538-544, 2000.
16. Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH, and Levine JD. Kappa-opioids produce significantly greater analgesia in women than in men. Nat Med 2: 1248-1250, 1996.
17. Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH, and Levine JD. The kappa opioid nalbuphine produces genderand dose-dependent analgesia and antianalgesia in patients with postoperative pain. Pain 83: 339-345, 1999.
18. Gebhart GF. Peripheral contributions to visceral hyperalgesia. Can J Gastroenterol 13, Suppl A: 37A-41A, 1999.
19. Gebhart GF and Ness TJ. Mechanisms of visceral pain. In: Proceedings of the VIth World Congress on Pain, edited by Bond MR, Charlton JE, and Woolf CJ. Amsterdam, The Netherlands: Elsevier, 1991, pp. 351-363.
20. Ikeda K, Ichikawa T, Kobayashi T, Kumanishi T, Oike S, and Yano R. Unique behavioural phenotypes of recombinantinbred CXBK mice: partial deficiency of sensitivity to mu- and kappa-agonists. Neurosci Res 34: 149-155, 1999.
21. Ji Y and Traub RJ. Spinal NMDA receptors contribute to neuronal processing of acute noxious and nonnoxious colorectal stimulation in the rat. J Neurophysiol 86: 1783-1791, 2001.
22. Julia V, Su X, Bueno L, and Gebhart GF. Role of NK3 receptors on viscerosensitive responses to noxious colorectal distension in the rat: electrophysiological and behavioral studies. Gastroenterology 116: 1124-1131, 1999.
23. Kamp EH, Beck DR, and Gebhart GF. Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia. J Pharmacol Exp Ther 299: 105-113, 2001.
24. Kamp EH and Gebhart GF. Characterization of a quantifiable model of visceral pain in the unanesthetized mouse (Abstract). Digestion 63: 275, 2001.
25. Kamp EH, Jones RCW, and Gebhart GF. A quantifiable model of visceral pain and hyperalgesia in the unanesthetized mouse (Abstract). Neurosci Abs 27: 817.3, 2001.
26. Kavaliers M and Choleris E. Sex differences in N-methyl-Daspartate involvement in kappa opioid and non-opioid predatorinduced analgesia in mice. Brain Res 768: 30-36, 1997.
27. Kest B, Wilson SG, and Mogil JS. Sex differences in supraspinal morphine analgesia are dependent on genotype. J Pharmacol Exp Ther 289: 1370-1375, 1999.
28. Kolhekar R and Gebhart GF. Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat. J Neurophysiol 75: 2344-2353, 1996.
29. Koster R, Anderson M, and de Beer EJ. Acetic acid for analgesic screening (Abstract). Fed Proc 18: 412, 1959.
30. Krawisz JE, Sharon P, and Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87: 1344-1350, 1984.
31. Laird JM, Olivar T, Lopez-Garcia JA, Maggi CA, and Cervero F. Responses of rat spinal neurons to distension of inflamed colon: role of tachykinin NK2 receptors. Neuropharmacology 40: 696-701, 2001.
32. Laird JM, Olivar T, Roza C, De Felipe C, Hunt SP, and Cervero F. Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene. Neuroscience 98: 345-352, 2000.
33. Laird JMA, Martinez-Caro L, Garcia-Nicas E, and Cervero F. A new model of visceral pain and referred hyperalgesia in the mouse. Pain 92: 335-342, 2001.
34. Lariviere WR, Chesler EJ, and Mogil JS. Transgenic studies of pain and analgesia: mutation or background genotype? J Pharmacol Exp Ther 297: 467-473, 2001.
35. Lautenbacher S and Rollman GB. Sex differences in responsiveness to painful and non-painful stimuli are dependent upon the stimulation method. Pain 53: 255-264, 1993.
36. Lautenbacher S and Strian F. Sex differences in pain and thermal sensitivity: the role of body size. Percept Psychophys 50: 179-183, 1991.
37. Lu G, Qian X, Berezin I, Telford GL, Huizinga JD, and Sarna SK. Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol 273: G1233-G1245, 1997.
38. Martinez V, Thakur S, Mogil JS, Tache Y, and Mayer EA. Differential effects of chemical and mechanical colonic irritation on behavioral pain response to intraperitoneal acetic acid in mice. Pain 81: 179-186, 1999.
39. Mayer EA and Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 107: 271-293, 1994.
40. Millan MJ and Colpaert FC. 5-hydroxytryptamine (HT) 1A receptors and the tail-flick response. III. Structurally diverse 5-HT1A partial agonists attenuate mu- but not kappa-opioid antinociception in mice and rats. J Pharmacol Exp Ther 256: 993-1001, 1991.
41. Mogil JS and Wilson SG. Nociceptive and morphine antinociceptive sensitivity of 129 and C57BL/6 inbred mouse strains: implications for transgenic knock-out studies. Eur J Pain 1: 293-297, 1997.
42. Mogil JS, Wilson SG, Bon K, Lee SE, Chung K, Raber P, Pieper JO, Hain HS, Belknap JK, Hubert L, Elmer GI, Chung JM, and Devor M. Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80: 67-82, 1999.
43. Myers CP, Hogan D, Yao B, Koss M, Isenberg JI, and Barrett KE. Inhibition of rabbit duodenal bicarbonate secretion by ulcerogenic agents: histamine-dependent and -independent effects. Gastroenterology 114: 527-535, 1998.
44. Neri M and Agazzani E. Aging and right-left asymmetry in experimental pain measurement. Pain 19: 43-48, 1984.
45. Ness TJ and Gebhart GF. Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Brain Res 450: 153-169, 1988.
46. Ness TJ and Gebhart GF. Visceral pain: a review of experimental studies. Pain 41: 167-234, 1990.
47. Ramabadran K. Strain differences in the hyperalgesic effect of a novel κ receptor agonist, U-50488H in mice. Eur J Pharmacol 98: 425-427, 1994.
48. Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 14: 125-132, 1973.
49. Robin O, Vinard H, Vernet-Maury E, and Saumet JL. Influence of sex and anxiety on pain threshold and tolerance. Funct Neurol 2: 173-179, 1987.
50. Robinson DR, Humphrey PPA, and Hicks GA. Initial characterization of the primary spinal afferent innervation of the mouse colon using retrograde labeling. Digestion 63: 267, 2001.
51. Rollman GB and Lautenbacher S. Sex differences in musculoskeletal pain. Clin J Pain 17: 20-24, 2001.
52. Sengupta JN and Gebhart GF. Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. J Neurophysiol 71: 2046-2060, 1994.
53. Sengupta JN, Snider A, and Gebhart GF. Effects of kappa opioids in the inflamed rat colon. Pain 79: 175-185, 1999.
54. Sherrington CS. The Integrative Action of the Nervous System. New Haven, CT: Yale University Press, 1906.
55. Simonin F, Valverde O, Smadja C, Slowe S, Kitchen I, Dierich A, Le Meur M, Roques BP, Maldonado R, and Kieffer BL. Disruption of the κ-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488H and attenuates morphine withdrawal. EMBO J 17: 886-897, 1998.
56. Snape WJ, Matarazzo SA, and Cohen S. Abnormal gastrocolonic response in patients with ulcerative colitis. Gut 21: 392-396, 1980.
57. Spiggs EA, Code CF, Bargen JA, Curtiss RK, and Hightower NC Jr. Motility of the pelvic nerve colon and rectum of normal persons and patients with ulcerative colitis. Gastroenterology 19: 480-491, 1951.
58. Su X, Sengupta JN and Gebhart GF. Effects of kappa-opioid receptor agonists on mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. J Neurophysiol 78: 1003-1012, 1997.
59. Taber RI, Greenhouse DD, Rendell JK, and Irwin S. Agonist and antagonist interactions of opioids on acetic acid-induced abdominal stretching in mice. J Pharmacol Exp Ther 169: 29-38, 1969.
60. Tyers MB. A classification of opiate receptors that mediate antinociception in animals. Br J Pharmacol 69: 503-512, 1980.
61. Walker JS and Carmody JJ. Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen. Anesth Analg 86: 1257-1262, 1998.
62. Ward SJ and Takemori AE. Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice. J Pharmacol Exp Ther 224:525-530, 1983.
63. Wilson SG, Mitton BA, Haas JJ, Melton KA, and Mogil JS. The heritability of pain inhibition: pharmacogenetic mediation of multiple analgesic modalities (Abstract). Neurosci Abs 26: 2189, 2000.
64. Woodrow KM, Friedman GD, Siegelaub AB, and Collen MF. Pain tolerance: differences according to age, sex and race. Psychosom Med 34: 548-556, 1972.
65. Zhai QZ and Traub RJ. The NMDA receptor antagonist MD-801 attenuates c-Fos expression in the lumbosacral spinal cord following repetitive noxious and non-noxious colorectal distension. Pain 83: 321-329, 1999.