Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells

Bioscience, Biotechnology and Biochemistry

Volumn 72, Issue 6, 2008, Pages 1564-1570

  Kawauchi, Keiko ^a,b   Tobiume, Kei ^c   Iwashita, Kimi ^b   Inagaki, Hiroko ^b   Morikawa, Tetsunori ^b   Shibukawa, Yukinao ^b   Moriyama, Yoshinori ^d   Hirata, Hajime ^b   Kamata, Hideaki ^b  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b HYOGO UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

Author keywords

Akt; Apoptosis; PC12 cells; Prodigiosin; Ras

Indexed keywords

CELL DEATH;

INDUCED APOPTOSIS; PC12 CELLS; PRODIGIOSIN; PROTEIN SYNTHESIS INHIBITION;

COMPLEXATION;

ANDROSTANE DERIVATIVE; CASPASE 3; CYCLOHEXIMIDE; CYCLOPRODIGIOSIN; DACTINOMYCIN; INDOLE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYRROLE DERIVATIVE; RAS PROTEIN; WORTMANNIN;

ANIMAL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRAIN; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; APOPTOSIS; CASPASE 3; CYCLOHEXIMIDE; CYTOPROTECTION; DACTINOMYCIN; INDOLES; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; RAS PROTEINS; RATS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 45849124919     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80064     Document Type: Article

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