Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B 1 receptor antagonist

European Journal of Pharmacology

Volumn 499, Issue 1-2, 2004, Pages 77-84

  Ransom, Richard W ^a   Harrell, Charles M ^a   Reiss, Duane R ^a   Murphy, Kathryn L ^a   Chang, Raymond S L ^a   Hess, J Fred ^a   Miller, Patricia J ^a   O'Malley, Stacey S ^a   Hey, Pat J ^a   Kunapuli, Priya ^a   Su, Dai Shi ^a   Markowitz, M Kristine ^a   Wallace, Michael A ^a   Raab, Conrad E ^a   Jones, Allen N ^a   Dean, Dennis C ^a   Pettibone, Douglas J ^a   Freidinger, Roger M ^a   Bock, Mark G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonist; Bradykinin B 1 receptor; Radioligand

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; BRADYKININ B2 RECEPTOR; BRADYKININ[1-8]; IMIDAZOLE DERIVATIVE; KALLIDIN DERIVATIVE; KALLIDIN[1-9]; KALLIDIN[10 DEARGININE 9 LEUCINE]; LIPOPOLYSACCHARIDE; N [2 [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ETHYL] 2 [1 (2 NAPHTHYLSULFONYL) 3 OXO 1,2,3,4 TETRAHYDROQUINOXALIN 2 YL]ACETAMIDE; N [2 [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ETHYL] 2 [1 (2 NAPHTHYLSULFONYL) 3 OXO 1,2,3,4 TETRAHYDROQUINOXALIN 2 YL]ACETAMIDE S 35; RADIOLIGAND; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING COMPETITION; BINDING SITE; CHO CELL; DOG; DRUG RECEPTOR BINDING; LIGAND BINDING; MALE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SIGNAL NOISE RATIO;

ANIMALS; AORTA, THORACIC; BINDING, COMPETITIVE; BLOOD PRESSURE; CHO CELLS; CRICETINAE; CRICETULUS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIDAZOLES; KALLIDIN; LIPOPOLYSACCHARIDES; MALE; QUINOXALINES; RABBITS; RADIOLIGAND ASSAY; RATS; RECEPTOR, BRADYKININ B1; TRANSFECTION; TRITIUM; VASOCONSTRICTION;

EID: 19344367480     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.07.104     Document Type: Article

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