A numerical model of permeabilized skin with local transport regions

IEEE Transactions on Biomedical Engineering

Volumn 55, Issue 7, 2008, Pages 1927-1930

  Pavšelj, Nataša ^a   Miklavčič, Damijan ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Conductivity changes; Finite element method; Local transport regions; Numerical modeling; Skin electroporation

Indexed keywords

CAPILLARITY; CELL MEMBRANES; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; DRUG DELIVERY; DRUG DOSAGE; DRUG THERAPY; ELECTRIC PROPERTIES; ELECTROACUPUNCTURE; ELECTROPHYSIOLOGY; EXPERIMENTS; FLUIDS; GENE TRANSFER; LIPIDS; LIQUIDS; MATHEMATICAL MODELS; MEMBRANES; MOLECULAR STRUCTURE; MOLECULES; NUCLEIC ACIDS; NUMBER THEORY; NUMERICAL METHODS; ORGANIC ACIDS; SOLIDS;

(PL) PROPERTIES; BIOLOGICAL CELLS; DRUG MOLECULES; ELECTRIC PULSE (EP); ELECTROPERMEABILIZATION; ELECTROPORATION; GENE DELIVERY; IN VIVO EXPERIMENTS; LOCAL TRANSPORT REGIONS; LOW-PERMEABILITY (L-P); MOLECULAR TRANSPORT; NON-LINEAR PROCESSING; NUMERICAL MODELLING; PROTECTIVE FUNCTIONS; SKIN ELECTROPORATION; SKIN LAYERS; SKIN PERMEABILITY; STRATUM CORNEUM (SC); TISSUE CONDUCTIVITY; TRANSDERMAL DRUG DELIVERY (TDD);

SKIN;

LIPID;

ARTICLE; CELL MEMBRANE; COMPUTER MODEL; DRUG DELIVERY SYSTEM; ELECTRIC CONDUCTIVITY; ELECTRIC CURRENT; ELECTRIC FIELD; ELECTROPORATION; FINITE ELEMENT ANALYSIS; GENE TARGETING; GEOMETRY; IN VIVO STUDY; MATHEMATICAL MODEL; MEMBRANE TRANSPORT; NONLINEAR SYSTEM; SIMULATION; SKIN PERMEABILITY; STRATUM CORNEUM;

BIOLOGICAL TRANSPORT, ACTIVE; COMPUTER SIMULATION; ELECTRIC CONDUCTIVITY; ELECTROPORATION; HUMANS; MODELS, BIOLOGICAL; PERMEABILITY; SKIN ABSORPTION;

EID: 45749157624     PISSN: 00189294     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBME.2008.919730     Document Type: Article

References (19)

1. L. M. Mir, "Therapeutic perspectives of in vivo cell electropermeabilization," Bioelectrochemistry, vol. 53, pp. 1-10, 2000.
2. M. R. Prausnitz, "Reversible skin permeabilization for transdermal delivery of macromolecules," Crit. Rev. Ther. Drug Carrier Syst., vol. 14, no. 4, pp. 455-483, 1997.
3. M. R. Prausnitz, "A practical assessment of transdermal drug delivery by skin electroporation," Adv. Drug Deliv. Rev., vol. 35, pp. 61-76, 1999.
4. A.-R. Denet, R. Vanbever, and V. Préat, "Skin electroporation for transdermal and topical delivery," Adv. Drug Deliv. Rev., vol. 56, pp. 659-674, 2004.
5. E. Neumann, S. Kakorin, and K. Toensing, "Fundamentals of electroporative delivery of drugs and genes," Biochim. Biophys. Acta, vol. 48, pp. 3-16, 1999.
6. N. Pavšelj and V. Préat, "DNA electrotransfer into the skin using a combination of one high- and one low-voltage pulse," J. Control. Release, vol. 106, pp. 407-415, 2005.
7. T. Yamamoto and Y. Yamamoto, "Electrical properties of the epidermal stratum corneum," Med. Biol. Eng., vol. 14, no. 2, pp. 151-158, 1976.
8. T. Yamamoto and Y. Yamamoto, "Dielectric constant and resistivity of epidermal stratum corneum," Med. Biol. Eng., vol. 14, no. 5, pp. 494-500, 1976.
9. Y. A. Chizmadzhev, A. V. Indenbom, P. I. Kuzmin, S. V. Galichenko, J. C. Weaver, and R. O. Potts, "Electrical properties of skin at moderate voltages: Contribution of appendageal macropores," Biophys. J., vol. 74, pp. 843-856, 1998.
10. M. R. Prausnitz, V. G. Bose, R. Langer, and J. C. Weaver, "Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery," Proc. Natl. Acad. Sci. U.S.A., vol. 90, pp. 10504-10508, 1993.
11. U. Pliquett, R. Langer, and J. C. Weaver, "Changes in the passive electrical properties of human stratum corneum due to electroporation," Biochim. Biophys. Acta, vol. 1239, pp. 111-121, 1995.
12. U. Pliquett and J. C. Weaver, "Electroporation of human skin: Simultaneous measurement of changes in the transport of two fluorescent molecules and in the passive electrical properties," Bioelectrochem. Bioenerg., vol. 39, pp. 1-12, 1996.
13. U. F. Pliquett, R. Vanbever, V. Préat, and J. C. Weaver, "Local transport regions (LTRs) in human stratum corneum due to long and short 'high voltage' pulses," Bioelectrochem. Bioenerg., vol. 47, pp. 151-161, 1998.
14. R. Vanbever, U. F. Pliquett, V. Préat, and J. C. Weaver, "Comparison of the effects of short, high-voltage and long, medium-voltage pulses on skin electrical and transport properties," J. Control. Release, vol. 69, pp. 35-47, 1999.
15. J. C. Weaver, T. E. Vaughan, and Y. A. Chizmadzhev, "Theory of electrical creation of aqueous pathways across skin transport barriers," Adv. Drug Deliv. Rev., vol. 35, pp. 21-39, 1999.
16. U. Pliquett and C. Gusbeth, "Surface area involved in transdermal transport of charged species due to skin electroporation," Bioelectrochemistry, vol. 65, pp. 27-32, 2004.
17. U. Pliquett, S. Gallo, C. Gusbeth, E. Neumann, and S. W. Hui, "Local and transient perturbations in stratum corneum due to high voltage pulses: Contribution of local heating," Bioelectrochemistry, vol. 67, no. 1, pp. 37-46, 2005.
18. N. Pavšelj, Z. Bregar, D. Cukjati, D. Batiuskaite, L. M. Mir, and D. Miklavčič, "The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals," IEEE Trans. Biomed. Eng., vol. 52, no. 8, pp. 1373-1381, Aug. 2005.
19. N. Pavšelj, V. Préat, and D. Miklavčič, "A numerical model of skin electropermeabilization based on in vivo experiments," Ann. Biomed. Eng., vol. 35, no. 12, pp. 2138-2144, 2007.