Surface area involved in transdermal transport of charged species due to skin electroporation

Bioelectrochemistry

Volumn 65, Issue 1, 2004, Pages 27-32

  Pliquett, U ^a   Gusbeth, C ^b  

^a BIELEFELD UNIVERSITY   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Electroporation; Fractional area; Molecular transport; Stratum corneum; Transdermal drug delivery

Indexed keywords

BIOLOGICAL MEMBRANES; ELECTRIC POTENTIAL; ELECTROCHEMISTRY; IONS; PHASE TRANSITIONS;

AQUEOUS PATHWAYS; ELECTROPORATIVE EFFECTS; HIGH VOLTAGE (HV) APPLICATIONS; LOCAL TRANSPORT REGIONS (LTR);

CHARGE TRANSFER;

SODIUM; SPHINGOLIPID;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROPORATION; HEATING; HUMAN; PERMEABILITY; PHASE TRANSITION; SKIN SURFACE; SURFACE PROPERTY;

BIOLOGICAL TRANSPORT; ELECTROPORATION; ELECTROSTATICS; HUMANS; IONS; MICROSCOPY, FLUORESCENCE; SILVER; SKIN ABSORPTION; SPHINGOLIPIDS; SURFACE PROPERTIES;

EID: 7544235176     PISSN: 15675394     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bioelechem.2004.05.005     Document Type: Article

References (20)

1. Johnson M.E., Berk D.A., Blankenstein D., Golan D.E., Jain R.K., Langer R. Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems. Biophys. J. 71:1996;2656-2668
2. Mitragotri S., Blankenstein D., Langer R. Ultrasound-mediated transdermal protein delivery. Science. 269:1995;850-853
3. Neumann E., Sowers A., Jordan C. Electroporation and Electrofusion in Cell Biology. 1989;Plenum Press, New York
4. Prausnitz M.R., Bose V.G., Langer R., Weaver J.C. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. U. S. A. 90:1993;10504-10508
5. Pliquett U., Weaver J.C. Electroporation of human skin: simultaneous measurement of changes in the transport of two fluorescent molecules and in the passive electrical properties. Bioelectrochem. Bioenerg. 39:1996;1-12
6. Pliquett U., Zewert T.E., Chen T., Langer R., Weaver J.C. Imaging of fluorescent molecule and small ion transport through human stratum corneum during high-voltage pulsing: localized transport regions are involved. Biophys. Chem. 58:1996;185-204
7. Prausnitz M.R., Gimm J.A., Guy R.H., Langer R., Weaver J.C., Cullander C. Imaging regions of transport across human stratum corneum during high voltage and low voltage exposures. J. Pharm. Sci. 85:1996;1363-1370
8. Pliquett U., Vanbever R., Weaver J.C. Local transport regions (LTRs) in human stratum corneum due to long and short high voltage pulses. Bioelectrochem. Bioenerg. 47:1998;151-161
9. Prausnitz M.R., Lee C.S., Liu C.H., Pang J.C., Singh T.P., Langer R., Weaver J.C. Transdermal transport efficiency during skin electroporation and iontophoresis. J. Control. Release. 38:1996;205-217
10. Prausnitz M.R., Pliquett U., Vanbever R. Mechanistic studies of skin electroporation using biophysical methods. Jaroszeski M., Gilbert R., Heller R. Electrically Mediated Delivery of Molecules to Cells: Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery by Electroporation. 1999;213-246 Humana Press, Totowa
11. Gummer C.L. The in vitro evaluation of transdermal delivery. Hadgraft J., Guy R.H. Transdermal Drug Delivery: Development Issues and Research Initiatives. 1989;177-186 Marcel Dekker, New York
12. Pliquett U., Langer R., Weaver J.C. Changes in the passive electrical properties of human stratum corneum due to electroporation. Biochim. Biophys. Acta. 1239:1995;111-121
13. Pliquett U., Prausnitz M.R. Electrical impedance spectroscopy for rapid and non-invasive analysis of skin electroporation. Jaroszeski M., Gilbert R., Heller R. Electrically Mediated Delivery of Molecules to Cells: Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery by Electroporation. 1999;377-406 Humana Press, Totowa
14. Chizmadzhev Y.A., Zarnitsin V.G., Weaver J.C., Potts R.O. Mechanism of electroinduced ionic species transport through a multilamellar lipid system. Biophys. J. 68:1995;749-765
15. Adam G., Lauger P., Stark G. Biophysikalische Chemie und Biophysik. 1995;Springer Verlag, Heidelberg
16. Pliquett U., Weaver J.C. Transport of a charged molecule across the human epidermis due to electroporation. J. Control. Release. 38:1996;1-10
17. Pliquett U., Gusbeth C. Perturbation of human skin due to application of high voltage. Bioelectrochem. Bioenerg. 51:2000;41-51
18. Pliquett U., Prausnitz M.R., Chizmadzhev Y.A., Weaver J.C. Measurement of rapid release kinetics for drug delivery. Pharm. Res. 12:1995;549-555
19. Glaser R.W., Leikin S.L., Chernomordik L.V., Pastuchenko V.F., Sokirko A.I. Reversible electrical breakdown of lipid layers: formation and evolution of pores. BBA. 940:1988;275-287
20. Gallo S.A., Sen A., Hensen M.L., Hui S.W. Temperature-dependent electrical and ultrastructural characterization of porcine skin upon electroporation. Biophys. J. 82:2002;109-119