A numerical model of skin electropermeabilization based on in vivo experiments

Annals of Biomedical Engineering

Volumn 35, Issue 12, 2007, Pages 2138-2144

  Pavšelj, Nataša ^a   Préat, Veronique ^b   Miklavčič, Damijan ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Electro gene transfer; Electropermeabilization; Finite element method; Plate electrodes

Indexed keywords

CELL MEMBRANES; FINITE ELEMENT METHOD; GENE EXPRESSION; GENE TRANSFER; HEALTH RISKS; TISSUE;

ELECTRO GENE TRANSFER; ELECTRODE GEOMETRY; ELECTROPERMEABILIZATION; ELECTROPORATION;

SKIN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; ELECTROCHEMOTHERAPY; EVALUATION; GENETIC TRANSFECTION; METHODOLOGY; PHYSIOLOGY; PLASMID; RADIATION EXPOSURE; RAT; SKIN ABSORPTION; VALIDATION STUDY;

ANIMALS; COMPUTER SIMULATION; ELECTROCHEMOTHERAPY; MODELS, BIOLOGICAL; PLASMIDS; RATS; SKIN ABSORPTION; TRANSFECTION;

EID: 36448983948     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-007-9378-7     Document Type: Article

References (27)

1. Chizmadzhev Y. A., A. V. Indenbom, P. I. Kuzmin, S. V. Galichenko, J. C. Weaver, R. O. Potts. Electrical properties of skin at moderate voltages: contribution of appendageal macropores. Biophys. J. 74:843-856, 1998
2. Drabick J. J., J. Glasspool-Malone, A. King, R. W. Malone. Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization. Mol. Ther. 3(2):249-255, 2001
3. Ferber D. Gene therapy: safer and virus-free? Science 294:1638-1642, 2001
4. Gabriel C., S. Gabriel, E. Corthout. The dielectric properties of biological tissues: I. Literature survey. Phys. Med. Biol. 41:2231-2249, 1996
5. Gabriel S., R. W. Lau, C. Gabriel. The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. Phys. Med. Biol. 41:2251-2269, 1996
6. Gallo S. A., A. R. Oseroff, P. G. Johnson, S. W. Hui. Characterization of electric-pulse-induced permeabilization of porcine skin using surface electrodes. Biophys. J. 72:2805-2811, 1997
7. Jadoul A., J. Bouwstra, V. Préat. Effects of iontophoresis and electroporation on the stratum corneum; Review of the biophysical studies. Adv. Drug Deliv. Rev. 35:89-105, 1999
8. Mehier-Humbert S., R. H. Guy. Physical methods for gene transfer: improving the kinetic of gene delivery into cells. Adv. Drug Del. Rev. 57(5):733-753, 2005
9. Menon G. K. New insights into skin structure: scratching the surface. Adv. Drug Deliv. Rev. 54(Suppl.1):S3-S17, 2002
10. Mir L. M. Therapeutic perspectives of in vivo cell electropermeabilization. Review article. Bioelectrochemistry 53:1-10, 2000
11. Pavlin M., D. Miklavčič. Effective conductivity of a suspension of permeabilized cells: a theoretical analysis. Biophys. J. 85:719-729, 2003
12. Pavlin M., N. Pavšelj, D. Miklavčič. Dependence of induced transmembrane potential on cell density, arrangement and cell position inside a cell system. IEEE Trans. Biomed. Eng. 49(6):605-612, 2002
13. Pavšelj N., Z. Bregar, D. Cukjati, D. Batiuskaite, L. M. Mir, D. Miklavčič. The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals. IEEE Trans. Biomed. Eng. 52(8):1373-1381, 2005
14. Pavšelj N., V. Préat. DNA electrotransfer into the skin using a combination of one high- and one low-voltage pulse. J. Cont. Rel. 106:407-415, 2005
15. Pliquett U. Mechanistic studies of molecular transdermal transport due to skin electroporation. Adv. Drug. Deliv. Rev. 35:41-60, 1999
16. Pliquett U., R. Langer, J. C. Weaver. Changes in the passive electrical properties of human stratum corneum due to electroporation. Biochim. Biophys. Acta 1239:111-121, 1995
17. Pliquett U., J. C. Weaver. Electroporation of human skin: simultaneous measurement of changes in the transport of two fluorescent molecules and in the passive electrical properties. Bioelectrochem. Bioenerg. 39:1-12, 1996
18. Prausnitz M. R., V. G. Bose, R. Langer, Weaver J. C. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. USA 90:10504-10508, 1993
19. Prud'homme G. J., Y. Glinka, Khan A. S., Draghia-Akli R. Electroporation-enhanced nonviral gene transfer for the prevention of treatment of immunological, endocrine and neoplastic diseases. Curr. Gene Ther. 6:243-273, 2006
20. Susil R., D. Šemrov, D. Miklavčič. Electric field - induced transmembrane potential depends on cell density and organization Electro Magnetobiol. 17(3):391-399, 1998
21. Šel D., D. Cukjati, D. Batiuskaite, T. Slivnik, L. M. Mir, D. Miklavčič. Sequential finite element model of tissue electropermeabilization. IEEE Trans. Biomed. Eng. 52:816-827, 2005
22. Valič B., M. Golzio, M. Pavlin, A. Schatz, C. Faurie, B. Gabriel, J. Teissié, M. P. Rols, D. Miklavčič. Effect of electric field induced transmembrane potential on spheroidal cells: theory and experiment. Eur. Biophys. J. 32:519-528, 2003
23. Weaver J. C., T. E. Vaughan, Y. Chizmadzhev. Theory of electrical creation of aqueous pathways across skin transport barriers. Adv. Drug Del. Rev. 35:21-39, 1999
24. Wolf H., M. P. Rols, E. Boldt, E. Neumann, J. Teissié. Control by pulse parameters of electric field-mediated gene transfer in mammalian cells. Biophys. J. 66:524-531, 1994
25. Yamamoto T., Y. Yamamoto. Electrical properties of the epidermal stratum corneum. Med. Biol. Eng. 14(2):151-158, 1976
26. Yamamoto T., Y. Yamamoto. Dielectric constant and resistivity of epidermal stratum corneum. Med. Biol. Eng. 14(5):494-500, 1976
27. Zhang L., G. Widera, D. Rabussay. Enhancement of the effectiveness of electroporation-augmented cutaneous DNA vaccination by a particulate adjuvant. Bioelectrochemistry 63(1-2):369-373, 2004