Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 2, 2005, Pages 425-432

  Kiuchi, Masatoshi ^a   Adachi, Kunitomo ^a   Tomatsu, Ayumi ^a   Chino, Masao ^a   Takeda, Shuzo ^a   Tanaka, Yoshihito ^a   Maeda, Yasuhiro ^a   Sato, Noriko ^a   Mitsutomi, Naoko ^a   Sugahara, Kunio ^a   Chiba, Kenji ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Asymmetric synthesis; Immunosuppressant; Lipase; Sphingosine 1 phosphate

Indexed keywords

2 (BENZYLOXYCARBONYL)AMINO 2 [2 (4 OCTYLPHENYL)ETHYL]PROPANE; 2 AMINO 2 (PHOSPHORYLOXY)METHYL 4 (4 OCTYLPHENYL)BUTANOL; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; N [1,1 BIS(HYDROXYMETHYL) 3 (4 OCTYLPHENYL)PROPYL]ACETAMIDE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VINYL ACETATE;

ACYLATION; ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASYMMETRIC SYNTHESIS; BINDING AFFINITY; BRADYCARDIA; CATALYSIS; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE MIGRATION; NONHUMAN; RAT;

ANIMALS; CELL LINE; CELL MOVEMENT; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTES; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PROPYLENE GLYCOLS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; STEREOISOMERISM;

EID: 20844443104     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.008     Document Type: Article

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25. Our pharmacokinetic study using the enantiomers of 2 will be reported in due course