-
1
-
-
1642343326
-
Chemical genetic control of protein levels: Selective in vivo targeted degradation
-
Schneekloth, J. S., Fonseca, F. N., Koldobskiy, M., Mandal, A., Deshaies, R., Sakamoto, K., and Crews, C. M. (2004) Chemical genetic control of protein levels: Selective in vivo targeted degradation. J. Am. Chem. Soc. 126, 3748-3754.
-
(2004)
J. Am. Chem. Soc
, vol.126
, pp. 3748-3754
-
-
Schneekloth, J.S.1
Fonseca, F.N.2
Koldobskiy, M.3
Mandal, A.4
Deshaies, R.5
Sakamoto, K.6
Crews, C.M.7
-
2
-
-
1642285590
-
Development of protacs to target cancer-promoting proteins for ubiquitination and degradation
-
Sakamoto, K. M., Kim, K. B., Verma, R., Ransick, A., Stein, B., Crews, C. M., and Deshaies, R. J. (2003) Development of protacs to target cancer-promoting proteins for ubiquitination and degradation. Mol. Cell. Proteomics 2, 1350-1358.
-
(2003)
Mol. Cell. Proteomics
, vol.2
, pp. 1350-1358
-
-
Sakamoto, K.M.1
Kim, K.B.2
Verma, R.3
Ransick, A.4
Stein, B.5
Crews, C.M.6
Deshaies, R.J.7
-
3
-
-
20444464372
-
A potent transactivation domain mimic with activity in living cells
-
Liu, B., Alluri, P. G., Yu, P., and Kodadek, T. (2005) A potent transactivation domain mimic with activity in living cells. J. Am. Chem. Soc. 127, 8254-8255.
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 8254-8255
-
-
Liu, B.1
Alluri, P.G.2
Yu, P.3
Kodadek, T.4
-
4
-
-
0036711669
-
Estrogen receptor binding assay method for endocrine disruptors using fluorescence polarization
-
Ohno, K., Fukushima, T., Santa, T., Waizumi, N., Tokuyama, H., Maeda, M., and Imai, K. (2002) Estrogen receptor binding assay method for endocrine disruptors using fluorescence polarization. Anal. Chem. 74, 4391-4396.
-
(2002)
Anal. Chem
, vol.74
, pp. 4391-4396
-
-
Ohno, K.1
Fukushima, T.2
Santa, T.3
Waizumi, N.4
Tokuyama, H.5
Maeda, M.6
Imai, K.7
-
5
-
-
45749110419
-
Estrogen dendrimer conjugate reveals that estrogen-induced endothelial cell migration and proliferation are mediated by non-nuclear estrogen receptors that interact directly with G alpha i
-
Chambliss, K. I., Kumar, P., Yuhanna, I. S., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Chieko, M., and Shaul, P. W. (2006) Estrogen dendrimer conjugate reveals that estrogen-induced endothelial cell migration and proliferation are mediated by non-nuclear estrogen receptors that interact directly with G alpha i. Circulation 114, 157-157.
-
(2006)
Circulation
, vol.114
, pp. 157-157
-
-
Chambliss, K.I.1
Kumar, P.2
Yuhanna, I.S.3
Katzenellenbogen, B.S.4
Katzenellenbogen, J.A.5
Chieko, M.6
Shaul, P.W.7
-
6
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski, A. M., Pike, A. C., Dauter, Z., Hubbard, R. E., Bonn, T., Engstrom, O., Ohman, L., Greene, G. L., Gustafsson, J. A., and Carlquist, M. (1997) Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389, 753-758.
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
Pike, A.C.2
Dauter, Z.3
Hubbard, R.E.4
Bonn, T.5
Engstrom, O.6
Ohman, L.7
Greene, G.L.8
Gustafsson, J.A.9
Carlquist, M.10
-
7
-
-
0033198735
-
Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
-
Pike, A. C., Brzozowski, A. M., Hubbard, R. E., Bonn, T., Thorsell, A. G., Engstrom, O., Ljunggren, J., Gustafsson, J. A., and Carlquist, M. (1999) Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO J. 18, 4608-4618.
-
(1999)
EMBO J
, vol.18
, pp. 4608-4618
-
-
Pike, A.C.1
Brzozowski, A.M.2
Hubbard, R.E.3
Bonn, T.4
Thorsell, A.G.5
Engstrom, O.6
Ljunggren, J.7
Gustafsson, J.A.8
Carlquist, M.9
-
8
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., and Greene, G. L. (1998) The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95, 927-937.
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
Cheng, L.4
Kushner, P.J.5
Agard, D.A.6
Greene, G.L.7
-
9
-
-
18244393501
-
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR alpha
-
Xu, H. E., Stanley, T. B., Montana, V. G., Lambert, M. H., Shearer, B. G., Cobb, J. E., McKee, D. D., Galardi, C. M., Plunket, K. D., Nolte, R. T., Parks, D. J., Moore, J. T., Kliewer, S. A., Willson, T. M., and Stimmel, J. B. (2002) Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR alpha. Nature 415, 813-817.
-
(2002)
Nature
, vol.415
, pp. 813-817
-
-
Xu, H.E.1
Stanley, T.B.2
Montana, V.G.3
Lambert, M.H.4
Shearer, B.G.5
Cobb, J.E.6
McKee, D.D.7
Galardi, C.M.8
Plunket, K.D.9
Nolte, R.T.10
Parks, D.J.11
Moore, J.T.12
Kliewer, S.A.13
Willson, T.M.14
Stimmel, J.B.15
-
10
-
-
0032867623
-
Nuclear-receptor ligands and ligand-binding domains
-
Weatherman, R. V., Fletterick, R. J., and Scanlan, T. S. (1999) Nuclear-receptor ligands and ligand-binding domains. Annu. Rev. Biochem. 68, 559-581.
-
(1999)
Annu. Rev. Biochem
, vol.68
, pp. 559-581
-
-
Weatherman, R.V.1
Fletterick, R.J.2
Scanlan, T.S.3
-
11
-
-
0037130243
-
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment
-
Nguyen, N. H., Apriletti, J. W., Lima, S. T. C., Webb, P., Baxter, J. D., and Scanlan, T. S. (2002) Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J. Med. Chem. 45, 3310-3320.
-
(2002)
J. Med. Chem
, vol.45
, pp. 3310-3320
-
-
Nguyen, N.H.1
Apriletti, J.W.2
Lima, S.T.C.3
Webb, P.4
Baxter, J.D.5
Scanlan, T.S.6
-
12
-
-
18244364644
-
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist
-
Baxter, J. D., Goede, P., Apriletti, J. W., West, B. L., Feng, W. J., Mellstrom, K., Fletterick, R. J., Wagner, R. L., Kushner, P. J., Ribeiro, R. C. J., Webb, P., Scanlan, T. S., and Nilsson, S. (2002) Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology 143, 517-524.
-
(2002)
Endocrinology
, vol.143
, pp. 517-524
-
-
Baxter, J.D.1
Goede, P.2
Apriletti, J.W.3
West, B.L.4
Feng, W.J.5
Mellstrom, K.6
Fletterick, R.J.7
Wagner, R.L.8
Kushner, P.J.9
Ribeiro, R.C.J.10
Webb, P.11
Scanlan, T.S.12
Nilsson, S.13
-
13
-
-
0034964207
-
Physiological and molecular basis of thyroid hormone action
-
Yen, P. M. (2001) Physiological and molecular basis of thyroid hormone action. Physiol. Rev. 81, 1097-1142.
-
(2001)
Physiol. Rev
, vol.81
, pp. 1097-1142
-
-
Yen, P.M.1
-
14
-
-
0344013153
-
Germline and somatic thyroid hormone receptor mutations in man
-
Yen, P. M., and Cheng, S. Y. (2003) Germline and somatic thyroid hormone receptor mutations in man. J. Endocrinol. Invest. 26, 780-787.
-
(2003)
J. Endocrinol. Invest
, vol.26
, pp. 780-787
-
-
Yen, P.M.1
Cheng, S.Y.2
-
15
-
-
1242341408
-
Thyroid hormone mutations in cancer
-
Cheng, S. Y. (2003) Thyroid hormone mutations in cancer. Mol. Cell. Endocrinol. 213, 23-30.
-
(2003)
Mol. Cell. Endocrinol
, vol.213
, pp. 23-30
-
-
Cheng, S.Y.1
-
16
-
-
0033678364
-
Thyroid hormones and their effects: A new perspective
-
Hulbert, A. J. (2000) Thyroid hormones and their effects: a new perspective. Biol. Rev. 75, 519-631.
-
(2000)
Biol. Rev
, vol.75
, pp. 519-631
-
-
Hulbert, A.J.1
-
17
-
-
0030060417
-
Syndrome of resistance to thyroid hormone: Insights into thyroid hormone action
-
Kopp, P., Kitajima, K., and Jameson, J. L. (1996) Syndrome of resistance to thyroid hormone: insights into thyroid hormone action. Proc. Soc. Exp. Biol. Med. 211, 49-61.
-
(1996)
Proc. Soc. Exp. Biol. Med
, vol.211
, pp. 49-61
-
-
Kopp, P.1
Kitajima, K.2
Jameson, J.L.3
-
18
-
-
0024553922
-
Selective thyromimetics-cardiac-sparing thyroid-hormone analogs containing 3′-arylmethyl substituents
-
Leeson, P. D., Emmett, J. C., Shah, V. P., Showell, G. A., Novelli, R., Prain, H. D., Benson, M. G., Ellis, D., Pearce, N. J., and Underwood, A. H. (1989) Selective thyromimetics-cardiac-sparing thyroid-hormone analogs containing 3′-arylmethyl substituents. J. Med. Chem. 32, 320-336.
-
(1989)
J. Med. Chem
, vol.32
, pp. 320-336
-
-
Leeson, P.D.1
Emmett, J.C.2
Shah, V.P.3
Showell, G.A.4
Novelli, R.5
Prain, H.D.6
Benson, M.G.7
Ellis, D.8
Pearce, N.J.9
Underwood, A.H.10
-
19
-
-
0029044699
-
Synthesis and structure-activity-relationships of oxamic acid and acetic-acid derivatives related to L-thyronine
-
Yokoyama, N., Walker, G. N., Main, A. J., Stanton, J. L., Morrissey, M. M., Boehm, C., Engle, A., Neubert, A. D., Wasvary, J. M., Stephan, Z. F., and Steele, R. E. (1995) Synthesis and structure-activity-relationships of oxamic acid and acetic-acid derivatives related to L-thyronine. J. Med. Chem. 38, 695-707.
-
(1995)
J. Med. Chem
, vol.38
, pp. 695-707
-
-
Yokoyama, N.1
Walker, G.N.2
Main, A.J.3
Stanton, J.L.4
Morrissey, M.M.5
Boehm, C.6
Engle, A.7
Neubert, A.D.8
Wasvary, J.M.9
Stephan, Z.F.10
Steele, R.E.11
-
20
-
-
0347364651
-
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor
-
Borngraeber, S., Budny, M. J., Chiellini, G., Cunha-Lima, S. T., Togashi, M., Webb, P., Baxter, J. D., Scanlan, T. S., and Fletterick, R. J. (2003) Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc. Natl. Acad. Sci. U.S.A. 100, 15358-15363.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 15358-15363
-
-
Borngraeber, S.1
Budny, M.J.2
Chiellini, G.3
Cunha-Lima, S.T.4
Togashi, M.5
Webb, P.6
Baxter, J.D.7
Scanlan, T.S.8
Fletterick, R.J.9
-
21
-
-
0034606444
-
Improved synthesis of the iodine-free thyromimetic GC-1
-
Chiellini, G., Nguyen, N. H., Yoshihara, H. A. I., and Scanlan, T. S. (2000) Improved synthesis of the iodine-free thyromimetic GC-1. Bioorg. Med. Chem. Lett. 10, 2607-2611.
-
(2000)
Bioorg. Med. Chem. Lett
, vol.10
, pp. 2607-2611
-
-
Chiellini, G.1
Nguyen, N.H.2
Yoshihara, H.A.I.3
Scanlan, T.S.4
-
22
-
-
15444367413
-
Mutant-selective thyromimetics for the chemical rescue of thyroid hormone mutants associated with resistance to thyroid hormone (RTH)
-
Shi, Y., Ye, H., Link, K. H., Putnam, M. C., Hubner, I., Dowdel, S., and Koh, J. T. (2005) Mutant-selective thyromimetics for the chemical rescue of thyroid hormone mutants associated with resistance to thyroid hormone (RTH). Biochem. J. 44, 4612-4626.
-
(2005)
Biochem. J
, vol.44
, pp. 4612-4626
-
-
Shi, Y.1
Ye, H.2
Link, K.H.3
Putnam, M.C.4
Hubner, I.5
Dowdel, S.6
Koh, J.T.7
-
23
-
-
0028832893
-
Two consecutive nucleotide substitutions resulting in the T3 receptor beta gene resulting in an 11-amino acid truncation in a patient with generalized resistance to thyroid hormone
-
Miyoshi, Y., Nakamura, H., Sasaki, S., Tagami, T., Misaki, T., Konishi, J., and Nakao, K. (1995) Two consecutive nucleotide substitutions resulting in the T3 receptor beta gene resulting in an 11-amino acid truncation in a patient with generalized resistance to thyroid hormone. Mol. Cell. Endocrinol. 114, 9-17.
-
(1995)
Mol. Cell. Endocrinol
, vol.114
, pp. 9-17
-
-
Miyoshi, Y.1
Nakamura, H.2
Sasaki, S.3
Tagami, T.4
Misaki, T.5
Konishi, J.6
Nakao, K.7
-
24
-
-
0029792155
-
Mild resistance to thyroid hormone with a truncated thyroid hormone receptor beta
-
Taniyama, M., Kusano, S., Miyoshi, Y., Nakamura, H., Kaihara, M., Tobe, T., Tomita, M., Katagiri, T., and Ban, Y. (1996) Mild resistance to thyroid hormone with a truncated thyroid hormone receptor beta. Exp. Clin. Endocrinol. Diabetes 104, 339-343.
-
(1996)
Exp. Clin. Endocrinol. Diabetes
, vol.104
, pp. 339-343
-
-
Taniyama, M.1
Kusano, S.2
Miyoshi, Y.3
Nakamura, H.4
Kaihara, M.5
Tobe, T.6
Tomita, M.7
Katagiri, T.8
Ban, Y.9
-
25
-
-
85123224606
-
-
i determined by nonlinear regression of single run ± 95% confidence interval.
-
i determined by nonlinear regression of single run ± 95% confidence interval.
-
-
-
-
26
-
-
16844371411
-
Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists
-
Nguyen, N. H., Apriletti, J. W., Baxter, J. D., and Scanlan, T. S. (2005) Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists. J. Am. Chem. Soc. 127, 4599-4608.
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 4599-4608
-
-
Nguyen, N.H.1
Apriletti, J.W.2
Baxter, J.D.3
Scanlan, T.S.4
-
27
-
-
33847777160
-
Thyroid receptor ligands
-
Malm, J., Gordon, S., Brandt, P., Carlsson, B., Agback, P., Saeidi, A. B., and Sandberg, J. (2007) Thyroid receptor ligands. Bioorg. Med. Chem. 17, 2018-2021.
-
(2007)
Bioorg. Med. Chem
, vol.17
, pp. 2018-2021
-
-
Malm, J.1
Gordon, S.2
Brandt, P.3
Carlsson, B.4
Agback, P.5
Saeidi, A.B.6
Sandberg, J.7
-
28
-
-
0037330393
-
-
Dow, R. L., Schneider, S. R., Paight, E. S., Hank, R. F., Chiang, P., Cornelius, P., Lee, E., Newsome, W. P., Swick, A. G., Spitzer, J., Hargrove, D. M., Patterson, T. A., Pandit, J., Chrunyk, B. A., LeMotte, P. K., Danley, D. E., Rosner, M. H., Ammirati, M. J., Simons, S. P., Schulte, G. K., Tate, B. F., and DaSilva-Jardine, P. (2003) Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: Potent, TR beta subtypeselective thyromimetics. Bioorg. Med. Chem. Lett. 13, 379-382.
-
Dow, R. L., Schneider, S. R., Paight, E. S., Hank, R. F., Chiang, P., Cornelius, P., Lee, E., Newsome, W. P., Swick, A. G., Spitzer, J., Hargrove, D. M., Patterson, T. A., Pandit, J., Chrunyk, B. A., LeMotte, P. K., Danley, D. E., Rosner, M. H., Ammirati, M. J., Simons, S. P., Schulte, G. K., Tate, B. F., and DaSilva-Jardine, P. (2003) Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: Potent, TR beta subtypeselective thyromimetics. Bioorg. Med. Chem. Lett. 13, 379-382.
-
-
-
-
29
-
-
33750970574
-
Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor
-
Koehler, K., Gordon, S., Brandt, P., Carlsson, B., Backsbro-Saeidi, A., Apelqvist, T., Agback, P., Grover, G. J., Nelson, W., Grynfarb, M., Farnegardh, M., Rehnmark, S., and Malm, J. (2006) Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J. Med. Chem. 49, 6635-6637.
-
(2006)
J. Med. Chem
, vol.49
, pp. 6635-6637
-
-
Koehler, K.1
Gordon, S.2
Brandt, P.3
Carlsson, B.4
Backsbro-Saeidi, A.5
Apelqvist, T.6
Agback, P.7
Grover, G.J.8
Nelson, W.9
Grynfarb, M.10
Farnegardh, M.11
Rehnmark, S.12
Malm, J.13
-
30
-
-
33947599307
-
Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton
-
Komatsu, T., Hirano, T., Songkram, C., Kawachi, E., and Kagechika, H. (2007) Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton. Bioorg. Med. Chem. 15, 3115-3126.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 3115-3126
-
-
Komatsu, T.1
Hirano, T.2
Songkram, C.3
Kawachi, E.4
Kagechika, H.5
|