Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 7, 2007, Pages 2018-2021

  Malm, Johan ^a   Gordon, Sandra ^a   Brandt, Peter ^a   Carlsson, Bo ^a   Agback, Peter ^a   Bäckbro Saeidi, Anna ^a   Sandberg, Johnny ^a  

^a Karo Bio   (Sweden)

Author keywords

Benzyloxyphenyl derivatives; Hyperthyroidism; Indirect antagonism; Thyroid hormone agonist; Thyroid hormone antagonist; Thyroid hormone receptor; Thyrotoxicosis

Indexed keywords

ANTITHYROID AGENT; THYROID HORMONE RECEPTOR;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL ASSAY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE;

BROMIDES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP; THYROID HORMONE RECEPTORS ALPHA; THYROID HORMONE RECEPTORS BETA; TRANS-ACTIVATION (GENETICS);

EID: 33847777160     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.009     Document Type: Article

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