One-electron oxidation of condensed DNA toroids: Injection-site dependent charge (radical cation) mobility

Bioconjugate Chemistry

Volumn 19, Issue 6, 2008, Pages 1235-1240

  Das, Prolay ^a   Schuster, Gary B ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETONES; OLIGOMERS; POSITIVE IONS;

% REDUCTIONS; CATION MOBILITY; CONDENSED DNA; DNA CONDENSATES; DNA TOROIDS; GUANINE; ONE-ELECTRON OXIDATION; RADICAL CATIONS; SPERMIDINE; UV-LIGHT;

DNA;

DNA; OLIGOMER; SPERMIDINE;

ARTICLE; GEL ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; MASS SPECTROMETRY; OXIDATION; PLASMID; REACTION ANALYSIS; SPIN TRAPPING; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET IRRADIATION;

EID: 45749097093     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc8000358     Document Type: Article

References (28)

1. Demple, B., and Harrison, L. (1994) Repair of oxidative damage to DNA: Enzymology and biology. Annu. Rev. Biochem. 63, 915-948.
2. Gasper, S. M., and Schuster, G. B. (1997) Intramolecular photoinduced electron transfer to anthraquinones linked to duplex DNA: The effect of gaps and traps on long-range radical cation migration. J. Am. Chem. Soc. 119, 12762-12771.
3. Nunez, M., Hall, D. B., and Barton, J. K. (1999) Long-range oxidative damage to DNA: Effects of distance and sequence. Chem. Biol. 6, 85-97.
4. Schuster, G. B., and Landman, U. (2004) The mechanism of long-distance radical cation transport in duplex DNA: Ion-gated hopping of polaron-like distortions. Top. Curr. Chem. 236, 139-162.
5. Liu, C.-S., Hernandez, R., and Schuster, G. B. (2004) Mechanism for radical cation transport in duplex DNA oligonucleotides. J. Am. Chem. Soc. 126, 2877-2884.
6. Joseph, J., and Schuster, G. B. (2006) Emergent functionality of nucleobase radical cations in duplex DNA: Prediction of reactivity using qualitative potential energy landscapes. J. Am. Chem. Soc. 128, 6070-6074.
7. Joy, A., Ghosh, A. K., and Schuster, G. B. (2006) One-electron oxidation of DNA oligomers that lack guanine: Reaction and strand cleavage at remote thymines by long-distance radical cation hopping. J. Am. Chem. Soc. 128, 5346-5347.
8. Boone, E., and Schuster, G. B. (2002) Long-range oxidative damage in duplex DNA: the effect of bulged G in a G-C tract and tandem G/A mispairs. Nucleic Acids Res. 30, 830-837.
9. Giese, B. (2000) Long-distance charge transport in DNA: The hopping mechanism. Acc. Chem. Res. 33, 631-636.
10. Giese, B. (2002) Long-distance electron transfer through DNA. Annu. Rev. Biochem. 71, 51-70.
11. Lewis, F. D., Liu, J., Weigel, W., Rettig, W., Kurnikov, I. V., and Beratan, D. N. (2002) Donor-bridge-acceptor energetics determine the distance dependence of electron tunneling in DNA. Proc. Natl. Acad. Sci. U.S.A. 99, 12536-12541.
12. Liu, C. S., and Schuster, G. B. (2003) Base sequence effects in radical cation migration in duplex DNA: Support for the polaron-like hopping model. J. Am. Chem. Soc. 125, 6098-6102.
13. Das, P., and Schuster, G. B. (2005) Effect of condensate formation on long-distance radical cation migration in DNA. Proc. Natl. Acad. Sci. U.S.A. 102, 4014227-14231.
14. Bloomfield, V. A. (1996) DNA condensation. Curr. Opin. Struct. Biol. 6, 334-341.
15. Bloomfield, V. A. (1997) DNA condensation by multivalent cations. Biopolymers 44, 269-282.
16. Chattoraj, D. K., Gosule, L. C., and Schellman, J. A. (1978) DNA condensation with polyamines: II. Electron microscopic studies. J. Mol. Biol. 121, 327-337.
17. 6. J. Mol. Biol. 144, 431-453.
18. Koltover, I., Wager, K., and Safinya, C. R. (2000) DNA condensation in two dimensions. Proc. Natl. Acad. Sci. U.S.A. 97, 14046-14051.
19. Gosule, L. C., and Schellman, J. A. (1976) Compact form of DNA induced by spermidine. Nature 259, 333-335.
20. Ly, D., Sanii, L., and Schuster, G. B. (1999) Mechanism of charge transport in DNA: Internally-linked anthraquinone conjugates support phonon-assisted polaron hopping. J. Am. Chem. Soc. 121, 9400-9410.
21. Robinson, D. H., and Lafleche, G. J. (2001) Nucleic acid electrophoresis in agarose gels. Essential molecular biology: A practical approach. Volume 1. (Brown, T. A., Ed.) pp. 94-111, Chapter 5, Oxford University Press, London.
22. Conwell, C. C., Vilfran, I. D., and Hud, N. V. (2003) Controlling the size of nanoscale toroidal DNA condensates with static curvature and ionic strength. Proc. Natl. Acad. Sci. U.S.A. 100, 9296-9301.
23. Ly, D., Kan, Y., Armitage, B., and Schuster, G. B. (1996) Cleavage of DNA by irradiation of substituted anthraquinones: Intercalation promotes electron transfer and efficient reaction at GG Steps. J. Am. Chem. Soc. 118, 8747-8748.
24. Schuster, G. B. (2000) Long-range charge transfer in DNA: Transient structural distortions control the distance dependence. Acc. Chem. Res. 33, 253-260.
25. Barnett, R. N., Cleveland, C. L., Joy, A., Landman, U., and Schuster, G. B. (2001) Charge migration in DNA: Ion-gated transport. Science 294, 5542567-571.
26. Schellman, J. A., and Parthasarathy, N. (1984) X-ray diffraction studies on cation-collapsed DNA. J. Mol. Biol. 175, 313-329.
27. Levin-Zaidman, S., Englander, J., Shimoni, E., Sharma, A. K., Minton, K. W., and Minsky, A. (2003) Ringlike structure of the Deinococcus radiodurans genome. A key to radioresistance? Science 229, 254-256.
28. Levin-Zaidman, S., Reich, Z., Wachtel, E. J., and Minsky, A. (1996) Flow of structural information between four DNA conformational levels. Biochemistry 35, 2985-2991.