Cleavage of DNA by irradiation of substituted anthraquinones: Intercalation promotes electron transfer and efficent reaction at GG steps

Journal of the American Chemical Society

Volumn 118, Issue 36, 1996, Pages 8747-8748

  Ly, Danith ^a   Kan, Yongzhi ^a   Armitage, Bruce ^a   Schuster, Gary B ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE DERIVATIVE;

ARTICLE; DNA CLEAVAGE; IN VITRO STUDY; MOLECULAR DYNAMICS; PHOTOCHEMISTRY; REACTION ANALYSIS;

EID: 0029797028     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9615785     Document Type: Article

References (36)

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19. 7b
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21. -1. Under the conditions of the experiments reported here, essentially all of the quinone is bound to DNA.
22. The autoradiogram of this gel is included as supporting information to this paper.
23. 7b Cleavage was visualized by a high-resolution denaturing polyacrylamide gel (20%), electrophoresis, and autoradiography.
24. The samples were separated on Vydac Protein & Peptide C18 reverse-phase columns with water, acetonitrile, triethylammonium acetate (0.1 M), and NaCl (0.5 M) at 1 mL/min. Monitoring the eluent revealed peaks at 61 and 66 min, corresponding to 5′-AAA-3′ and 5′-GAAA-3′, respectively.
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36. i = 0.1 eV.