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Volumn 49, Issue 32, 2008, Pages 4746-4749

Parallel solution phase synthesis of a library of amino acid derived 2-arylamino-[1,3,4]-oxadiazoles

Author keywords

[No Author keywords available]

Indexed keywords

2 ARYLAMINO [1,3,4]OXADIAZOLE; ALANINE; AMINO ACID; AMINO ACID DERIVATIVE; LEUCINE; PHENYLALANINE;

EID: 45649085010     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.05.110     Document Type: Article
Times cited : (14)

References (36)
  • 17
    • 0009174117 scopus 로고
    • For reviews on 1,3,4-oxadiazoles and leading references on their synthesis, see:. Weissberger A. (Ed), Wiley, New York
    • For reviews on 1,3,4-oxadiazoles and leading references on their synthesis, see:. Behr L.C. In: Weissberger A. (Ed). The Chemistry of Heterocyclic Compounds Vol. 17 (1962), Wiley, New York 263-282
    • (1962) The Chemistry of Heterocyclic Compounds , vol.17 , pp. 263-282
    • Behr, L.C.1
  • 20
    • 84943378537 scopus 로고
    • Potts K.T., Katritzky A.R., and Rees C.W. (Eds), Pergamon, Oxford
    • Hill J. In: Potts K.T., Katritzky A.R., and Rees C.W. (Eds). Comprehensive Heterocyclic Chemistry Vol. 6 (1984), Pergamon, Oxford 427-446
    • (1984) Comprehensive Heterocyclic Chemistry , vol.6 , pp. 427-446
    • Hill, J.1
  • 21
    • 84944041432 scopus 로고    scopus 로고
    • Katritzky A.R., Rees C.W., and Scriven E.F.V. (Eds), Pergamon, Oxford
    • Hill J. In: Katritzky A.R., Rees C.W., and Scriven E.F.V. (Eds). Comprehensive Heterocyclic Chemistry II Vol. 4 (1996), Pergamon, Oxford 267-287
    • (1996) Comprehensive Heterocyclic Chemistry II , vol.4 , pp. 267-287
    • Hill, J.1
  • 29
    • 45649083679 scopus 로고    scopus 로고
    • note
    • The Boc-thiosemicarbazides 2 did not require purification for use in the next step.
  • 30
    • 45649083749 scopus 로고    scopus 로고
    • note
    • 2 (108.6 mg, 0.4 mmol) and triethylamine (0.088 ml, 1.10 mmol). The reaction mixture was stirred at room temperature for 12 h. The reaction slurry was filtered through a short plug of Celite and the solvent was removed in vacuo. The crude products were purified using semi-automated flash chromatography (silica gel, EtOAc/hexanes 1:4) on a Biotage SP1 instrument.
  • 31
    • 45649084737 scopus 로고    scopus 로고
    • note
    • 3Br 459.1024, found 459.1026.
  • 32
    • 45649085731 scopus 로고    scopus 로고
    • note
    • Crystallographic data (excluding structure factors) for the structure of compound 4Ce have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 683066.
  • 33
    • 45649084205 scopus 로고    scopus 로고
    • note
    • Purities of 5 and 6 were determined by HPLC/LCMS with the UV absorption measured at 254 nm.
  • 34
    • 45649084318 scopus 로고    scopus 로고
    • note
    • {A figure is presented}.
  • 35
    • 10044264447 scopus 로고    scopus 로고
    • Polymer-supported CMPI equivalent 8 is prepared by treatment of Wang resin with excess of 2-chloropyridine and triflic anhydride, see:
    • Polymer-supported CMPI equivalent 8 is prepared by treatment of Wang resin with excess of 2-chloropyridine and triflic anhydride, see:. Crosignani S., Gonzalez J., and Swinnen D. Org. Lett. 6 (2004) 4579-4582
    • (2004) Org. Lett. , vol.6 , pp. 4579-4582
    • Crosignani, S.1    Gonzalez, J.2    Swinnen, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.