Growing bioengineered teeth from single cells: Potential for dental regenerative medicine

Expert Opinion on Biological Therapy

Volumn 8, Issue 6, 2008, Pages 735-744

  Ikeda, Etsuko ^a   Tsuji, Takashi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Bioengineered tooth; Regenerative therapy; Stem cells; Tooth germ

Indexed keywords

BIOENGINEERING; CELL ACTIVITY; CELL AGGREGATION; CELL FUNCTION; CELL REGENERATION; DENTISTRY; GERM CELL; MORPHOLOGY; NONHUMAN; REGENERATIVE MEDICINE; REVIEW; TISSUE ENGINEERING; TOOTH; TOOTH DEVELOPMENT; TOOTH REGENERATION; TOOTH SIZE; TRANSPLANTATION;

ABSORBABLE IMPLANTS; ADULT STEM CELLS; AMELOBLASTS; ANIMALS; CELL AGGREGATION; CELL CULTURE TECHNIQUES; DENTAL IMPLANTS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INCISOR; MESODERM; MICE; MOLAR; ODONTOBLASTS; ODONTOGENESIS; REGENERATIVE MEDICINE; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TOOTH GERM;

EID: 45549084673     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.8.6.735     Document Type: Review

References (74)

1. Weiss S, Dunne C, Hewson J, et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J Neurosci 1996;16(23):7599-609
2. Brinster R. Male germline stem cells: from mice to men. Science 2007;316(5823):404-5
3. Autti T, Santavuoti P, Raininko R, et al. Bone-marrow transplantation in aspartylglucosaminuria. Lancet 1997;349(9062):1366-7
4. Bachoud-Levi AC, Gaura V, Brugières P, et al. Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study. Lancet Neurol 2006;5(4):303-9
5. Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;1282:1145-7 • This paper describes the establishment of the first human embryonic stem cell line.
6. Reubinoff BE, Pera MF, Fong CY, et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 2000;18:399-404
7. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-95
8. Lee JY, Qu-Petersen Z, Cao B, et al. Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol 2000;150:1085-100
9. Toma JG, Akhavan M, Fernandes KJ, et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001;3:778-84
10. Yen BL, Huang HI, Chien CC, et al. Isolation of multipotent cells from human term placenta. Stem Cells 2005;23:3-9
11. Kogler G, Sensken S, Airey JA, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 2004;200:123-35
12. Peggs KS, Hunter A, Chopra R, et al. Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation. Lancet 2005;365(9475):1934-41
13. Hehlmann R, Hochhaus A, Baccarani M. Chronic myeloid leukaemia. Lancet 2007;370(9584):342-50
14. Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med 2004;10(Suppl):S42-50
15. Sausa JE, Costa MA, Tuzcu EM, et al. New frontiers in interventional cardiology. Circulation 2005;111(5):671-81
16. Brenemark PI, Zarb GA, Albrektsson T. Tissue-integrated prostheses, osseointegration in clinical dentistry. Chicago: Quintessence; 1985
17. Rosenstiel MF, Land JF, Stephan F. Contemporary fixed prosthodontics. St Louis: Mosby; 1988
18. Tsukiboshi M. Autogenous tooth transplantation: a reevaluation. Int J Periodontics Restorative Dent 1993;13(2):120-49
19. Thesleff I. Epithelial-mesenchymal signaling regulating tooth morophogenesis. J Cell Sci 2003;116(9):1647-8
20. Tucker AS, Matthews KL, Sharp PT. Transformation of tooth type induced by inhibition of BMP signaling. Science 1998;282:1136-8
21. Mander M, Neubuser A. FGF signaling is necessary for the specification of the odontogenic mesenchyme. Dev Biol 2001;240:548-59
22. Griogoriou M, Tucker AS, Sharoe PT, Pachnis V. Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development 1998;125:2063-74
23. Bei M, Maas R. FGFs and BMP4 induce both Msx1-dependent signaling pathways in early tooth development. Development 1998;125:4325-33
24. Chen Y, Bei M, Woo I, et al. Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 1996;122:3035-44
25. Aberg T, Wozney J, Thesleff I. Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Dev Dyn 1997;210:383-96
26. MacKenzie A, Ferguson MW, Sharps PT. Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape. Development 1992;115(2):403-20
27. Vaahtokari A, Aberg T, Thesleff I. Apoptosis in the developing tooth: association with an embryonic signaling center and suppression by EGF and FGF-4. Development 1996;122:121-9
28. Tucker A, Headon DJ, Schneider P, et al. Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Development 2000;127(21):4691-700
29. Thesleff I. The genetic basis of tooth development and dental defect. Am J Med Gene Part A 2006;140:2530-5
30. Cao YL, Vacanti JP, Paige KT, et al. Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg 1997;100:297-302
31. Caplan AI, Brudar SP. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med 2000;7:259-64
32. Quarto R. Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 2001;1(344):385-6
33. Young CS, Terada S, Vacanti JP, et al. Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res 2002;81(10):695-700 •• This paper describes bioengineered tooth tissues produced using a cell-scaffold composite.
34. Honda MJ, Tsuchiya S, Sumita Y, et al. The sequential seeding of epithelial and mesenchymal cells for tissue-engineered tooth regeneration. Biomaterials 2007;28(4):680-9
35. Iwatsuki S, Honda MJ, Harada H, Ueda M. Cell proliferation in teeth reconstructed from dispersed cells of embryonic tooth germs in a three-dimensional scaffold. Eur J Oral Sci 2006;114(4):310-7
36. Yelick PC, Vacanti JP. Bioengineered teeth from tooth bud cells. Dent Clin North Am 2006;50(2):191-203
37. Duailibi MT, Duailibi SE, Young CS, et al. Bioengineered teeth from cultured rat tooth bud cells. J Dent Res 2004;83(7):523-8
38. Sumita Y, Honda MJ, Ohara T, et al. Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering. Biomaterials 2006;27(17):3238-48
39. Honda MJ, Sumita Y, Kagami H, Ueda M. Histological and immunohistochemical studies of tissue engineered odontogenesis. Arch Histol Cytol 2005;68(2):89-101
40. Honda M, Morikawa N, Hata K, et al. Rat costochondral cell characteristics on poly (L-lactide-co-ε-caprolactone) scaffolds. Biomaterials 2003;24(20):3511-9
41. Steinberg MS. Adhesion in development: an historical overview. Dev Biol 1996;180(2):377-88
42. Steinberg MS. The nature and origin of "ECM", a putative mediator of mutual cell adhesions. Am Zool 1962;2:561-2
43. Steinberg MS. On the mechanism of tissue reconstruction by dissociated cells. I. Population kinetics, differential adhesiveness, and the absence of directed migration. Proc Natl Acad Sci USA 1962;48:1577-82
44. Steinberg MS. Mechanism of tissue reconstruction by dissociated cells. II. Time course of events. Science 1962;137:762-3
45. Steinberg MS. On the mechanism of tissue reconstruction by dissociated cells. III. Free energy relations and the reorganization of fused heteronomic tissue fragments. Proc Natl Acad Sci USA 1962;48:1769-76
46. Layer PG, Robitzki A, Rothermel A, Willbold E. Of layers and spheres: the reaggregate approach in tissue engineering. Trends Neurosci 2002;25(3):131-4
47. Layer PG, Rothermel A, Willbold E. From stem cells towards neural layers: a lesson from re-aggregated embryonic retinal cells. Neuroreport 2001;12(7):A39-46
48. Tucker A, Sharpe P. The cutting-edge of mammalian development; how the embryo makes teeth. Nat Rev Genet 2004;5(7):499-508
49. Yamamoto H, Kim EJ, Cho SW, Jung HS. Analysis of tooth formation by reaggregated dental mesenchyme from mouse embryo. J Electron Microsc (Tokyo) 2003;52(6):559-66
50. Hu B, Nadiri A, Kuchler-Bopp S, et al. Tissue engineering of tooth crown, root, and periodontium. Tissue Eng 2006;12(8):2069-75
51. Hu B, Nadiri A, Bopp-Kuchler S, et al. Dental epithelial histo-morphogenesis in the mouse: positional information versus cell history. Arch Oral Biol 2005;50(2):131-6
52. Song Y, Zang Z, Yu X, et al. Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development. Dev Dyn 2006;235(5):1334-44
53. Nakao K, Morita R, Saji Y, et al. The development of a bioengineered organ germ method. Nat Methods 2007;4(3):227-30 •• This paper decribes the bioengineered organ germ method.
54. Ohazama A, Modino SA, Miletich I, Sharpe PT. Stem-cell-based tissue engineering of murine teeth. J Dent Res 2004;83(7):518-22 •• The first report, to our knowledge, that embryonic tooth primordia develop in the adult oral environment.
55. Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 2000;97(25):13625-30 •• This paper described the identification of stem cells in human dental pulp.
56. Gronthos S, Brahim J, Li W, et al. Stem cell properties of human dental pulp stem cells. J Dent Res 2002;81(8):531-5
57. Miura Y, Gronthos S, Zhao M, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 2003;100(10):5807-12
58. Iohara K, Zheng L, Ito M, et al. Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells 2006;24:2493-503
59. Seo BM, Miura M, Gronthos S, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364(9429):149-55
60. Sonoyama W, Liu Y, Fang D, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One 2006;1:e79. Published online 20 December 2006; doi:10.1371/journal.pone.0000079
61. Ikeda E, Yagi K, Kojima M, et al. Multipotent cells from the human third molar: feasibility of cell-based therapy for liver diseases. Differentiation 2007; In press. Published article online: 18-Dec-2007; doi: 10.1111/j.1432-0436. 2007.00245.x
62. Hu B, Unda F, Bopp-Kuchier S, et al. Bone marrow cells can give rise to ameloblast-like cells. J Dent Res 2006;85(5):416-21
63. Komine A, Suenaga M, Nakao K, et al. Tooth regeneration from newly established cell lines from a molar tooth germ epithelium. Biochem Biophys Res Commun 2007;355(3):758-63
64. Nickel JC. Human masticatory muscle forces during static biting. J Dent Res 2003;82:212-7
65. Lisi S, Peterkova R, Peterka M, et al. Tooth morphogenesis and pattern of odontoblast differentiation. Connect Tissue Res 2003;44:167-70
66. Kassai Y, Munne P, Hotta Y, et al. Regulation of mammalian tooth cusp patterning by ectodin. Science 2005;309:2067-70
67. Pispa JM, Mustonen T, Mikkola ML, et al. Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar. Dev Dyn 2004;231:432-40
68. Yamashiro T, Tummers M, Thesleff I. Expression of bone morphogenetic proteins and Msx gene during root formation. J Dent Res 2003;82:172-6
69. Yokohama-Tamaki T, Ohshima H, Fujiwara N, et al. Cessation of Fgf10 signaling, resulting in a defective dental epithelial stem cell compartment, leads to the transition from crown to root formation. Development 2006;133:1359-66
70. Nakatomi M, Morita K, Eto K, Ota MS. Sonic Hedgehog Signaling is important in tooth root development. J Dent Res 2006;85(5):427-31
71. Cai J, Cho SW, Kim JY, et al. Patterning the size and number of tooth and its cusps. Dev Biol 2007;304(2):499-507
72. Jernvall J, Thesleff I. Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev 2000;92(1):19-29
73. Nakashima M, Reddi A. The application of bone morphogenetic proteins to dental tissue engineering. Nat Biotechnol 2003;21(9):1025-32
74. Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. Cytokine Growth Factor Rev 2005;16:369-76