Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear

Plastic and Reconstructive Surgery

Volumn 100, Issue 2, 1997, Pages 297-304

  Cao, Yilin ^a   Vacanti, Joseph P ^b   Paige, Keith T ^b   Upton, Joseph ^b   Vacanti, Charles A ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

POLYGLYCOLIC ACID; POLYMER;

ARTICLE; BIODEGRADATION; CARTILAGE CELL; CELL ISOLATION; CELL TRANSPLANTATION; EAR RECONSTRUCTION; GENETIC ENGINEERING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; TECHNICAL AID;

ANIMALS; CATTLE; CELL CULTURE TECHNIQUES; CELL TRANSPLANTATION; CHILD, PRESCHOOL; EAR CARTILAGES; HUMANS; LACTIC ACID; MALE; MICE; MICE, NUDE; MODELS, ANATOMIC; ORGAN CULTURE TECHNIQUES; POLYGLYCOLIC ACID; POLYMERS;

EID: 0030726664     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-199708000-00001     Document Type: Article

References (10)

1. Tanzer, R. C. Total reconstruction of the external ear. Plast. Reconstr. Surg. 23: 1, 1959.
2. Brent, B. Auricular repair with autogenous rib cartilage grafts: Two decades of experience with 600 cases. Plast. Reconstr. Surg. 90: 355, 1992.
3. Paige, K. T., and Vacanti, C. A. Tissue-Engineered Cartilage and Bone. In C. Ricordi (Ed.), Methods in Cell Transplantation. Austin, Texas: R. G. Landes, 1993.
4. Klagsbrun, M. Large-scale preparation of chondrocytes. Methods Enzymol. 58: 560, 1979.
5. Wilkes, G. H., and Wolfaardt, J. F. Osseointegrafted alloplastic versus autogenous ear reconstruction: Criteria for treatment selection. Plast. Reconstr. Surg. 93: 967, 1994.
6. Wellisz, T. Reconstruction of the burned external ear using a Medpor porous polyethylene pivoting helix framework. Plast. Reconstr. Surg. 91: 811, 1993.
7. Vacanti, C. A., Langer, R., Schloo, B., and Vacanti, J. P. Synthetic biodegradable polymers seeded with chondrocytes provide a template for new cartilage formation. Plast. Reconstr. Surg. 88: 753, 1991.
8. Kim, W. S., Vacanti, J. P., Cima, L., et al. Cartilage engineered in predetermined shapes employing cell transplantation on synthetic biodegradable polymers. Plast. Reconstr. Surg. 94: 233, 1994.
9. Vacanti, J. P., Morse, M. A., Saltzman, W. M., and Domb, A. J. Selective cell transplantation using bioabsorbable artificial polymers as matrices. J. Pediatr. Surg. 23: 3, 1988.
10. Vacanti, C. A., Cima, L., Ratkowski, D., et al. Tissue engineering of new cartilage in the shape of a human ear employing specially configured synthetic polymers seeded with chondrocytes. Mater. Res. Soc. Symp. Proc. 52: 367, 1992.