Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar

Developmental Dynamics

Volumn 231, Issue 2, 2004, Pages 432-440

  Pispa, Johanna ^a   Mustonen, Tuija ^a   Mikkola, Marja L ^a   Kangas, Aapo T ^a   Koppinen, Petra ^a   Lukinmaa, Pirjo Liisa ^b,c   Jernvall, Jukka ^a   Thesleff, Irma ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Cusp; Enamel knot; Organogenesis; Patterning

Indexed keywords

KERATIN; PROTEIN EDAR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEVELOPMENTAL DISORDER; ECTODERM; EMBRYO; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TOOTH DEVELOPMENT; TRANSGENE; WESTERN BLOTTING;

AMELOGENESIS; ANIMALS; CELL DIFFERENTIATION; DENTAL ENAMEL; EDAR RECEPTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; KERATIN-14; KERATINS; MEMBRANE PROTEINS; MICE; PROMOTER REGIONS (GENETICS); RECEPTORS, ECTODYSPLASIN; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TOOTH; TRANSGENES;

EID: 4544379924     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.20138     Document Type: Article

References (28)

1. Dassule HR, Lewis P, Bei M, Maas R, McMahon AP. 2000. Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127:4775-4785.
2. Durmowicz MC, Cui CY, Schlessinger D. 2002. The EDA gene is a target of, but does not regulate Wnt signaling. Gene 285:203-211.
3. Gat U, DasGupta R, Degenstein L, Fuchs E. 1998. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95:605-614.
4. Grüneberg H. 1966. The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis. J Embryol Exp Morphol 15:223-244.
5. Jernvall J, Thesleff I. 2000. Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev 92:19-29.
6. Jernvall J, Keränen SV, Thesleff I. 2000. Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography. Proc Natl Acad Sci U S A 97:14444-14448.
7. Jung HS, Francis-West PH, Widelitz RB, Jiang TX, Ting-Berreth S, Tickle C, Wolpert L, Chuong CM. 1998. Local inhibitory action of BMPs and their relationships with activators in feather formation: implications for periodic patterning. Dev Biol 196:11-23.
8. Koppinen P, Pispa J, Laurikkala J, Thesleff I, Mikkola ML. 2001. Signalling and subcellular localization of the TNF receptor Edar. Exp Cell Res 269:180-192.
9. Kumar A, Eby MT, Sinha S, Jasmin A, Chaudhary PM. 2001. Ectodermal dysplasia receptor activates the nuclear factor kappa B, c-Jun N-terminal kinase and cell death pathways and binds to ectodysplasin A. J Biol Chem 276:2668-2677.
10. Lagerström M, Dahl N, Nakahori Y, Nakagome Y, Bäckman B, Landegren U, Pettersson U. 1991. A deletion in the amelogenin gene (AMG) causes X-linked amelogenesis imperfecta (AIH1). Genomics 10:971-975.
11. Laurikkala J, Mikkola M, Mustonen T, Åberg T, Koppinen P, Pispa J, Nieminen P, Galceran J, Grosschedl R, Thesleff I. 2001. TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Dev Biol 229:443-455.
12. Laurikkala J, Pispa J, Jung HS, Nieminen P, Mikkola M, Wang X, Saarialho-Kere U, Galceran J, Grosschedl R, Thesleff I. 2002. Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development 129:2541-2553.
13. Mikkola ML, Pispa J, Pekkanen M, Paulin L, Nieminen P, Kere J, Thesleff I. 1999. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev 88:133-146.
14. Millar SE, Koyama E, Reddy ST, Andl T, Gaddapara T, Piddington R, Gibson CW. 2003. Over- and ectopic expression of Wnt3 causes progressive loss of ameloblasts in postnatal mouse incisor teeth. Connect Tissue Res 44(Suppl 1): 124-129.
15. Mouse Genome Database (MGD), Mouse Genome Informatics Web Site, The Jackson Laboratory, Bar Harbor, Maine. Available at: http://www.informatics.jax. org (accessed March 2004.)
16. Mustonen T, Pispa J, Mikkola ML, Pummila M, Kangas AT, Jaatinen R, Thesleff I. 2003. Stimulation of ectodermal organ development by ectodysplasin-A1. Dev Biol 259:123-136.
17. Pispa J, Jung HS, Jernvall J, Kettunen P, Mustonen T, Tabata MJ, Kere J, Thesleff I. 1999. Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF. Dev Biol 216:521-534.
18. Pispa J, Mikkola ML, Mustonen T, Thesleff I. 2003. Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis. Gene Expr Patterns 3:675-679.
19. Ryan MC, Lee K, Miyashita Y, Carter WG. 1999. Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. J Cell Biol 145:1309-1323.
20. Salazar-Ciudad I, Jernvall J. 2002. A gene network model accounting for development and evolution of mammalian teeth. Proc Natl Acad Sci U S A 99:8116-8120.
21. Srinivas S, Wu Z, Chen CM, D'Agati V, Costantini F. 1999. Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development. Development 126:1375-1386.
22. Ten Gate AR. 1994. Oral histology. St Louis: Mosby-Year Book.
23. Thesleff I, Mikkola ML. 2002. Death receptor signaling giving life to ectodermal organs. Science's STKE http://stke.sciencemag.org/cgi/content/full/ OC_sigtrans;2002/131/pe22.
24. Timmer JR, Wang C, Niswander L. 2002. BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors. Development 129:2459-2472.
25. Tucker AS, Headon DJ, Schneider P, Ferguson BM, Overbeek P, Tschopp J, Sharpe PT. 2000. Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Development 127:4691-4700.
26. Wang X, Zinkel S, Polonsky K, Fuchs E. 1997. Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy. Proc Natl Acad Sci U S A 94:219-226.
27. Wilkinson D, Green J. 1990. In situ hybridization and the three-dimensional reconstruction of serial sections. In: Copp AJ, Cole DE, editors. Postimplantation mammalian embryos. London: Oxford University Press, p 155-171.
28. Yan MH, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM. 2000. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 290:523-527.