Ultrastructural and biochemical abnormalities in the liver of streptozotocin-diabetic rats: Protective effects of Murraya koenigii

Journal of Pharmacology and Toxicology

Volumn 3, Issue 3, 2008, Pages 190-202

  Arulselvan, P ^a   Subramanian, S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidants; Diabetes mellitus; Free radicals and streptozotocin; Murraya koenigii

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ALKALOID DERIVATIVE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CARBAZOLE DERIVATIVE; CATALASE; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GLYCOSIDE; GLYCOSYLATED HEMOGLOBIN; HYDROPEROXIDE; INSULIN; MURRAYA KOENIGII EXTRACT; PHENOL DERIVATIVE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRITERPENOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMISTRY; CELL STRUCTURE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID PEROXIDATION; LIVER CELL; LIVER DYSFUNCTION; LIVER PROTECTION; LIVER STRUCTURE; MALE; MITOCHONDRION SWELLING; MURRAYA; MURRAYA KOENIGII; NONHUMAN; PLANT LEAF; RAT; ROUGH ENDOPLASMIC RETICULUM; STREPTOZOCIN DIABETES; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT OUTCOME;

EID: 45449102684     PISSN: 1816496X     EISSN: None     Source Type: Journal    
DOI: 10.3923/jpt.2008.190.202     Document Type: Article

References (61)

1. Acworth, I.N., D.R. McCabe and T. Maher, 1997. The Analysis of Free Radicals, Their Reaction Products and Antioxidants. In: Oxidants, Antioxidants and Free Radicals, Baskin, S.I. and H. Salem (Eds.). Taylor and Francis, Washington DC, Ch.2.
2. Adebajo, A.C., O.F. Ahoola, A.A. Iwalewa, A.A. Akindabunsi, N.O. Omisore, C.O. Adewunmi and T.K. Adenowo, 2006. Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigeria. Phytomedicine, 13: 246-254.
3. Al Yassin, D. and K. Ibrahim, 1981. A minor hemoglobin fraction and the level of fasting blood glucose. J. Fac. Med. Baghdad, 23: 373-380.
4. Anuradha, C.V. and R. Selvam, 1993. Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan-induced diabetic rats. J. Nutr. Biochem., 4: 212-217.
5. Anwer, T., M. Sharma, K.K. Pillai, S.E. Haque, M.M. Alam and M.S. Zaman, 2007. Protective effect of benzafibrate on streptozotocin-induced oxidative stress and toxicity in rats. Toxicology, 229: 165-172.
6. Arulselvan, P., G.P. Senthilkumar, D. Sathiskumar and S. Subramanian, 2006. Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats. Pharmazie, 61: 874-877.
7. Arulselvan, P. and S.P. Subramanian, 2007. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultrastructural changes of pancreatic β-cells in experimental diabetes in rats. Chem. Biol. Interact., 165: 155-164.
8. Baynes, J.W., 1991. Perspective in diabetes. Role of oxidative stress in development complications in diabetes. Diabetes, 40: 405-412.
9. Baynes, J.W. and S. Thorpe, 1999. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes, 48: 1-9.
10. Chakraborty, D.P., B.K. Barma and P.K. Bose, 1965. On the constitution of murrayanine, a carbazole derivative isolated from Murraya koenigii Spreng. Tetrahedron, 21: 681-685.
11. Del Maestro, R.F., 1980. An approach to free radicals in medicine and biology. Acta. Physiol. Scand., 492: 153-168.
12. Desai, I.D., 1984. Vitamin E analysis methods for animal tissues. Methods Enzymol., 105: 138-147.
13. El-Demerdash, F.M., M.I. Yousef and N.I. Abou El-Naga, 2005. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem. Toxicol., 43: 57-63.
14. Grover, J.K., V. Vats and S.S. Rathi, 2000. Anti-hyperglycemic effect of Eugenia jambolona and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J. Ethnopharmacol., 73: 461-470.
15. Grover, J.K. and V. Vats, 2001. Shifting paradigm from conventional to alternative medicine. An introduction on Traditional Indian Medicine. Asia Pacific Biotech News, 5: 28-32.
16. Gueeri, H., 1995. Influence on prolonged ethanol intake on the level and turnover of alcohol and aldehyde dehydrogenase and glutathione. Adv. Exp. Med. Biol., 23: 12-14.
17. Habig, W.H., M.J. Pabst and W.B. Jakoby, 1974. Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem., 249: 7130-7139.
18. Higuchi, Y., 1982. Lipid peroxides and alpha-tocopherol in rat streptozotocin induced diabetes mellitus. Acta. Med. Okayama., 36: 165-175.
19. Hunt J.V., 1996. Ascorbic acid and diabetes mellitus. Subcell. Biochem., 25: 369-465.
20. Illing, E.K.B., C.H. Gray and R.D. Lawrence, 1991. Blood glutathione and non glucose reducing substances in diabetes. Biochem. J., 48: 637.
21. Ji, X., P. Zhang, R.N. Armstrong and G.L. Gilliland, 1992. The three dimensional structure of a glutathione-S-tansferase from the Mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution Biochem., 31: 10169-10184.
22. Jiang, Z.Y., J.V. Hunt and S.D. Wolff, 1991. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein Anal. Biochem., 202: 384-389.
23. Kalender, Y., S. Kalender, A. Uzunhisarcikli, F. Ogutcu, F. Acikgcz and D. Durak, 2004. Effect of endosulfan on β-cells of Langerhans islets in rat pancreas. Toxicology, 200: 205-211.
24. Kasiviswanath, R., A. Ramesh and K.E. Kumar, 2005. Hypoglycemic and antihyperglycemic effect of Gmelina asiatica Linn. In normal and in alloxan induced diabetic rats. Biol. Pharm. Bull., 28: 729-732.
25. Khan, B.A., A. Abraham and S. Leelamma, 1995. Haematological and histological studies after curry leaf (Murraya koenigii) and mustard (Brassica juncea) feeding in rats. Ind. J. Med. Res., 102: 184-186.
26. Khan, B.A., A. Abraham and S. Leelamma, 1996a. Biochemical response in rats to the addition of curry leaf(Murraya koenigii) and mustard seeds (Brassic juncea) to the diet. Plant. Foods Hum. Nutr., 49: 295-299.
27. Khan, B.A., A. Abraham and S. Leelamma, 1996b. Murraya koenigii and Brassica juncea-alterations on lipid profile in 1-2 dimethyl hydrazine induced colon carcinogenesis. Invest. New Drugs, 14: 365-369.
28. King, J., 1965a. The Transaminases: Alanine and Asparate Transaminases. In: Practical Clinical Enzymology. Van, D. (Ed.). Nostran Co., London, pp: 363-395.
29. King, J., 1965b. The Hydrolases-acid and Alkaline Phosphatases. In: Practical Clinical Enzymology, Van, D. (Ed.). Nostran Co., London, pp: 199-208.
30. 1c in diabetes mellitus. New Eng. J. Med., 295: 417-420.
31. Kong, Y.C., K.H. Ng, P.P. But, Q. Li, S.X. Yu, H.T. Zhang and K.F. Cheng et al., 1986. Sources of the anti-implantation alkaloid yuehchukene in the genus Murraya J. Ethnopharmacol., 15: 195-200.
32. Larcan, A., H. Lambert, H. Laprevote and N. Delorme, 1979. Light and electron microscopic study of hepatic lesions in the course of hyperlactatemia in diabetic patients. Dia. Meta., 5. 103-112.
33. Liang, M.L., 2002. Effect of Tetramethylpyrazine on lipid peroxidation in screptozotocin-induced diabetic mice. Am. J. Chinese Med., 30: 601-608.
34. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265-275.
35. Matkovics, B., M. Kotorman, I.S. Varga, D.Q. Hai and C. Varga, 1998. Oxidative stress in experimental diabetes induced by streptozotocin. Acta. Physiol. Hung., 85: 29-38.
36. Misra, H.P. and I. Fridovich, 1972. The role of superoxide anion in the autoxidation of epinephrine and a simpie assay of superoxide dismutase. J. Biol. Chem., 247: 3170-3175.
37. Narendhirakannan, R.T., S. Subramanian and M. Kandaswamy, 2005. Mineral content of some medicinal plants used in the treatment of diabetic mellitus. Biol. Trace Elem. Res., 103: 109-115.
38. Narendhirakannan, R.T., S. Subramanian and M. Kandaswamy, 2006. Biochemical evaluation of antidiabetogenic properties of some commonly used Indian plants on streptozotocin-induced diabetes in experimental rats. Clin. Exp. Pharmacol. Physiol., 33: 1150-1157.
39. Nayak, S.S. and T.N. Pattabiraman, 1981. A new calorimetric method for the estimation of glycosylated hemoglobin. Chn. Chem. Acta., 109: 267-274.
40. Nedelco, A.M., O. Marco and R.E. Michod, 2004. Sex as a response to oxidative stress: A two-fold increase in cellular reactive oxygen species activates sex genes. Proc. R. Soc. London Ser B, 271: 1591-1590.
41. Nishigaki, J., M. Hagihara, H. Tsunekawa, M. Maseki and K. Yagi, 1981. Lipid peroxide levels of serum lipoprotein fractions of diabetic proteins. Biochem. Med., 25: 373-378.
42. Okhawa, H., N. Ohishi and K. Yagi, 1979. Assay for lipid peroxides in animal tissues by thiobarbituric reaction. Anal. Biochem., 95: 351-358.
43. Omaye, S.T., J.D. Turnbull and H.E. Sauberlich, 1979. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol., 62: 3-11.
44. Pickup, J.C. and G. Williams, 1997. Epidemiology of Diabetes Mellitus. In: Textbook of Diabetes. 2nd Edn., Vols.1-2, Blackwell, Oxford, pp: 3.1-3.28.
45. Prakasam, A., S. Sethupathy and K.V. Pugalendi, 2005. Antiperoxidative and antioxidant effects of Casearia esculenta root extract in streptozotocin-induced diabetic rats. Yale J. Biol. Med., 78:15-23.
46. Rakieten, N., M.L. Rakieten and M.V. Nadkarni, 1963. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother. Rep., 29: 91-98.
47. Ramachandran, B., K. Ravi, V. Narayanan, M. Kandaswamy and S. Subramanian, 2004. Effect of macrocyclic binuclear oxovanadium complex on tissue defense system in streptozotocin induced diabetic rats. Clin. Chim. Acta., 345: 141-150.
48. Ramsewak, R.S., M.G. Nair, G.M. Strasburg, D.L. DeWitt and J.L. Nitiss, 1999. Biologically active carbazoles alkaloids from Murraya koenigii. J. Agric. Food Chem., 47: 444-447.
49. Reaven, E., D. Wright, C.E. Mondon, R. Solomon, H. Ho and G.M. Reaven, 1983. Effect of age and diet on insulin secretion and insulin action in the rat. Diabetes, 32: 175-180.
50. Rotruck, J.T., A.L. Pope, H.E. Ganther, A.B. Swanson, D.G. Hafernan and W.G. Hoekstra, 1973. Selenium: Biochemical role as a component of glutathione peroxidase. Science, 179: 588-590.
51. Sasaki, T., S. Matsy and A. Sonae, 1972. Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for blood glucose estimation. Rinsh, Kagaku, 1: 346-353.
52. Sedlak, J. and R. H. Lindsay, 1969. Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem., 25: 293-305.
53. Sukalski, K.A., K.A. Piuto and J.L. Bernstein, 1981. Decreased susceptibility of liver mitochondria from diabetic rats to oxidative damage and associated increase in α-tocopherol. Free Radic. Biol. Med., 14: 57-65.
54. Sun, F., K. Iwaquchi, R. Shudo and Y. Nagaki et al., 1999. Change in tissue concentrations of lipid Hydroperoxides, vitamin C and vitamin E in rats with streptozotocin-induced diabetes. Clin. Sci., (Lond), 96: 185-190.
55. Tachibana, Y., H. Kikuzaki, N.H. Lajis and N. Nakatani, 2001. Antioxidative activity of carbazoles from Murraya koenigii leaves. J. Agric. Food Chem., 49: 5589-5594.
56. Tachibana, Y., H. Kikuzaki, N.H. Lajis and N. Nakatani, 2003. Comparison of antioxidative properties of carbazole alkaloids from Murraya koenigii leaves. J. Agric. Food Chem., 51: 6461-6467.
57. Takahara, S., B.H. Hamilton, J.V. Nell, Y. Ogura and E.T. Nishimura, 1960. Hypocatalasemia, a new genetic carrier gate. J. Clin. Invest., 29: 610-619.
58. Thakran, S., M.R. Siddiqui and N.Z. Baquer, 2004. Trigonella foenum graecum seed powder protects against histopathological abnormalities in tissues of diabetic rats. Mol. Cell. Biochem., 266: 151-159.
59. Vijayakumar, M., R. Govindarajan, G.M. Rao, Ch.V. Rao, A. Shirwaikar, S. Mehrotra and P. Pushpangadan, 2006. Action of Hygrophila auriculata against streptozotocin-induced oxidative stress. J. Ethnopharmacol., 104: 356-361.
60. Wang, H.X. and T.B. Ng, 1999. Natural products with hypoglycemic, hypotensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activities. Life Sci., 65: 2663-2677.
61. Wang, W., C.C. Pang, M.S. Rogers and A.M. Chang, 1996. Lipid peroxidation in cord blood at birth. Am. J. Obestet. Gynecol., 174: 62-65.