메뉴 건너뛰기




Volumn 229, Issue 1-2, 2007, Pages 165-172

Protective effect of bezafibrate on streptozotocin-induced oxidative stress and toxicity in rats

Author keywords

Bezafibrate; Diabetes mellitus; Lipid peroxidation; Oxidative stress; Streptozotocin

Indexed keywords

ANTIOXIDANT; BEZAFIBRATE; CATALASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; STREPTOZOCIN; SUPEROXIDE DISMUTASE;

EID: 33845305011     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.10.016     Document Type: Article
Times cited : (38)

References (45)
  • 2
    • 0028836708 scopus 로고
    • Insulin action and glucose metabolism are improved by gemfibrozil treatment in hypertriglyceridemic patients
    • Avogaro A., Beltramello P., and Marin R. Insulin action and glucose metabolism are improved by gemfibrozil treatment in hypertriglyceridemic patients. Atherosclerosis 113 1 (1995) 117-124
    • (1995) Atherosclerosis , vol.113 , Issue.1 , pp. 117-124
    • Avogaro, A.1    Beltramello, P.2    Marin, R.3
  • 3
    • 0025732948 scopus 로고
    • Role of oxidative stress in the development of complications in diabetes
    • Baynes J.W. Role of oxidative stress in the development of complications in diabetes. Diabetes 40 (1991) 405-412
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 4
    • 1842423094 scopus 로고    scopus 로고
    • The role of oxidative stress in diabetic complications
    • Baynes J.W., and Thorpe S.R. The role of oxidative stress in diabetic complications. Curr. Opin. Endocrinol. 3 (1997) 277-284
    • (1997) Curr. Opin. Endocrinol. , vol.3 , pp. 277-284
    • Baynes, J.W.1    Thorpe, S.R.2
  • 5
    • 0015297282 scopus 로고
    • An improved colour reaction for the determination of blood glucose by oxidase system
    • Braham D., and Trinder. An improved colour reaction for the determination of blood glucose by oxidase system. Analyst (1972) 142-144
    • (1972) Analyst , pp. 142-144
    • Braham, D.1    Trinder2
  • 6
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome prolifirator-activated receptor (PPARs): tissue distribution of PPAR-alpha, -beta, and gamma in the adult rat
    • Braissant O., Foufelle F., Scotto C., Dauca M., and Wahli W. Differential expression of peroxisome prolifirator-activated receptor (PPARs): tissue distribution of PPAR-alpha, -beta, and gamma in the adult rat. Endocrinology 137 (1996) 354-366
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 7
    • 0033107720 scopus 로고    scopus 로고
    • An evaluation of oxidative stress in diabetes mellitus during uncontrolled and controlled state and after vitamin E supplementation
    • Chugh S.N., Kakkar R., Kalra S., and Sharma A. An evaluation of oxidative stress in diabetes mellitus during uncontrolled and controlled state and after vitamin E supplementation. J. Assoc. Phys. Ind. 47 (1999) 380-383
    • (1999) J. Assoc. Phys. Ind. , vol.47 , pp. 380-383
    • Chugh, S.N.1    Kakkar, R.2    Kalra, S.3    Sharma, A.4
  • 9
    • 0037380305 scopus 로고    scopus 로고
    • Bezafibrate, a peroxisome proliferator-activated receptor (PPAR-α) activator, prevents pancreatic degeneration in obese and diabetic rats
    • Dongmei J., and Makoto O. Bezafibrate, a peroxisome proliferator-activated receptor (PPAR-α) activator, prevents pancreatic degeneration in obese and diabetic rats. Pancreas 24 3 (2003) 286-291
    • (2003) Pancreas , vol.24 , Issue.3 , pp. 286-291
    • Dongmei, J.1    Makoto, O.2
  • 10
    • 0022648879 scopus 로고
    • Conditions influencing the induction of peroxisomal b-oxidation in cultured rat hepatocytes
    • Foxworthy P.S., and Eacho P.I. Conditions influencing the induction of peroxisomal b-oxidation in cultured rat hepatocytes. Toxicol. Lett. 30 (1986) 189-196
    • (1986) Toxicol. Lett. , vol.30 , pp. 189-196
    • Foxworthy, P.S.1    Eacho, P.I.2
  • 11
    • 0025183341 scopus 로고
    • Effect of ciprofibrate, bezafibrate, and LY171883 on peroxisomal b-oxidation in cultured rat, dog, and rhesus monkey hepatocytes
    • Foxworthy P.S., White S.L., Hoover D.M., and Eacho P.I. Effect of ciprofibrate, bezafibrate, and LY171883 on peroxisomal b-oxidation in cultured rat, dog, and rhesus monkey hepatocytes. Toxicol. Appl. Pharmacol. 104 (1990) 386-394
    • (1990) Toxicol. Appl. Pharmacol. , vol.104 , pp. 386-394
    • Foxworthy, P.S.1    White, S.L.2    Hoover, D.M.3    Eacho, P.I.4
  • 12
    • 0029825461 scopus 로고    scopus 로고
    • Bezafibrate: an update of its pharmacology and use in the management of dyslipidemia
    • Goa K.L., Barradell L.B., and Plosker G.L. Bezafibrate: an update of its pharmacology and use in the management of dyslipidemia. Drugs 52 (1996) 725-753
    • (1996) Drugs , vol.52 , pp. 725-753
    • Goa, K.L.1    Barradell, L.B.2    Plosker, G.L.3
  • 13
    • 0000454838 scopus 로고
    • Insulin resistance: the fundamental trigger of type 2 diabetes
    • Groop L.C. Insulin resistance: the fundamental trigger of type 2 diabetes. Diabetes Obes. Metab. 1 Suppl 1 (1991) S1-S7
    • (1991) Diabetes Obes. Metab. , vol.1 , Issue.SUPPL. 1
    • Groop, L.C.1
  • 14
    • 0014269449 scopus 로고
    • Cellular mechanism of oxygen toxicity
    • Hauggard N. Cellular mechanism of oxygen toxicity. Physiol. Rev. 48 (1968) 311-373
    • (1968) Physiol. Rev. , vol.48 , pp. 311-373
    • Hauggard, N.1
  • 16
    • 0020324820 scopus 로고
    • Lipid peroxides and alpha-tocopherol in rat streptozotocin induced diabetes mellitus
    • Higuchi Y. Lipid peroxides and alpha-tocopherol in rat streptozotocin induced diabetes mellitus. Acta. Med. Okayama. 36 (1982) 165-175
    • (1982) Acta. Med. Okayama. , vol.36 , pp. 165-175
    • Higuchi, Y.1
  • 17
    • 0024244297 scopus 로고
    • Increased superoxide production by mononuclear cells of patients with hypertriglyceridemia and diabetes
    • Hiramatsu K., and Arimori S. Increased superoxide production by mononuclear cells of patients with hypertriglyceridemia and diabetes. Diabetes 37 (1988) 832-837
    • (1988) Diabetes , vol.37 , pp. 832-837
    • Hiramatsu, K.1    Arimori, S.2
  • 19
    • 0032750057 scopus 로고    scopus 로고
    • Bezafibrate may have a beneficial effect in pre-cirrhotic primary biliary cirrhosis
    • Iwasaki S., Tsuda K., and Ueta H. Bezafibrate may have a beneficial effect in pre-cirrhotic primary biliary cirrhosis. Hepatol. Res. 16 (1999) 12-18
    • (1999) Hepatol. Res. , vol.16 , pp. 12-18
    • Iwasaki, S.1    Tsuda, K.2    Ueta, H.3
  • 20
    • 0028858064 scopus 로고
    • Lipid peroxidation and activity of antioxidant enzymes in diabetic rats
    • Kakkar R., Kalra J., Manth S.V., and Parsad K. Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Mol. Cell. Biochem. 151 (1995) 113-119
    • (1995) Mol. Cell. Biochem. , vol.151 , pp. 113-119
    • Kakkar, R.1    Kalra, J.2    Manth, S.V.3    Parsad, K.4
  • 22
    • 12244297093 scopus 로고    scopus 로고
    • Protective effect of epicatechin against the toxic effects of STZ on rat pancreatic islets: in vivo and in vitro
    • Kim M.J., Ryu G.R., Chung J.S., Sim S.S., Min Dos Rhie D.J., Yoon S.H., Hahn S.J., Kim M.S., and Jo Y.M. Protective effect of epicatechin against the toxic effects of STZ on rat pancreatic islets: in vivo and in vitro. Pancreas 26 (2003) 292-299
    • (2003) Pancreas , vol.26 , pp. 292-299
    • Kim, M.J.1    Ryu, G.R.2    Chung, J.S.3    Sim, S.S.4    Min Dos Rhie, D.J.5    Yoon, S.H.6    Hahn, S.J.7    Kim, M.S.8    Jo, Y.M.9
  • 23
    • 0032517070 scopus 로고    scopus 로고
    • A study on the carotid artery intima-media thickness and its association with lipid peroxidation
    • Konukoglu D., Serin O., Kemerli D.G., Serin E., Hayiroglu A., and Oner B. A study on the carotid artery intima-media thickness and its association with lipid peroxidation. Clin. Chim. Acta 277 (1998) 91-98
    • (1998) Clin. Chim. Acta , vol.277 , pp. 91-98
    • Konukoglu, D.1    Serin, O.2    Kemerli, D.G.3    Serin, E.4    Hayiroglu, A.5    Oner, B.6
  • 24
    • 0034020079 scopus 로고    scopus 로고
    • Effect of bezafibrate in the treatment of primary biliary cirrhosis
    • Kurihara T., Furukawa M., and Tsuchiya M. Effect of bezafibrate in the treatment of primary biliary cirrhosis. Curr. Ther. Res. Clin. Exp. 61 (2000) 74-82
    • (2000) Curr. Ther. Res. Clin. Exp. , vol.61 , pp. 74-82
    • Kurihara, T.1    Furukawa, M.2    Tsuchiya, M.3
  • 26
    • 0037707713 scopus 로고    scopus 로고
    • Effects of α-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats
    • Maritim A.C., Sanders R.A., and Watkins J.B. Effects of α-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats. J. Nutr. Biochem. 14 (2003) 288-294
    • (2003) J. Nutr. Biochem. , vol.14 , pp. 288-294
    • Maritim, A.C.1    Sanders, R.A.2    Watkins, J.B.3
  • 27
    • 0016272750 scopus 로고
    • Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase
    • Marklund S., and Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47 (1974) 469-474
    • (1974) Eur. J. Biochem. , vol.47 , pp. 469-474
    • Marklund, S.1    Marklund, G.2
  • 28
    • 2442711384 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells
    • Marx N., Duez H., Fruchart J.C., and Stael B. Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells. Circ. Res. 94 (2004) 1168-1178
    • (2004) Circ. Res. , vol.94 , pp. 1168-1178
    • Marx, N.1    Duez, H.2    Fruchart, J.C.3    Stael, B.4
  • 29
    • 0021752183 scopus 로고
    • Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer
    • Mohandas J., Marshall J.J., Duggin G.G., Horvath J.S., and Tiller D.J. Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res. 44 (1984) 5086-5091
    • (1984) Cancer Res. , vol.44 , pp. 5086-5091
    • Mohandas, J.1    Marshall, J.J.2    Duggin, G.G.3    Horvath, J.S.4    Tiller, D.J.5
  • 30
    • 0019796887 scopus 로고
    • Lipid peroxide levels of serum lipoprotein fraction of diabetic proteins
    • Nishigaki J., Hagihara M., Tsunekawa H., Maseki M., and Yagi K. Lipid peroxide levels of serum lipoprotein fraction of diabetic proteins. Biochem. Med. 25 (1981) 373-378
    • (1981) Biochem. Med. , vol.25 , pp. 373-378
    • Nishigaki, J.1    Hagihara, M.2    Tsunekawa, H.3    Maseki, M.4    Yagi, K.5
  • 32
    • 0018384650 scopus 로고
    • Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H., Ohishi N., and Yagi K. Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
    • (1979) Anal. Biochem. , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 33
    • 0000548749 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPAR-α) in metabolic disease, inflammation, atherosclerosis and aging
    • Pineda, Torra, Gervois P., and Steals B. Peroxisome proliferator-activated receptor α (PPAR-α) in metabolic disease, inflammation, atherosclerosis and aging. Curr. Opin. Lipidol. 10 (1999) 151-159
    • (1999) Curr. Opin. Lipidol. , vol.10 , pp. 151-159
    • Pineda1    Torra2    Gervois, P.3    Steals, B.4
  • 34
    • 0035125001 scopus 로고    scopus 로고
    • β-Cell dysfunction and failure in type 2 diabetes: potential mechanism
    • Porta Jr. D., and Kahn S.E. β-Cell dysfunction and failure in type 2 diabetes: potential mechanism. Diabetes 50 Suppl. 1 (2001) S160-S163
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Porta Jr., D.1    Kahn, S.E.2
  • 35
    • 0024520373 scopus 로고
    • Effects of bezafibrate on insulin secretion and peripheral insulin sensitivity in hyperlipidemic patients with or without diabetes
    • Riccardi G., Genovese S., and Saladilamacchia G. Effects of bezafibrate on insulin secretion and peripheral insulin sensitivity in hyperlipidemic patients with or without diabetes. Atherosclerosis 75 (1989) 175-181
    • (1989) Atherosclerosis , vol.75 , pp. 175-181
    • Riccardi, G.1    Genovese, S.2    Saladilamacchia, G.3
  • 36
    • 0017684364 scopus 로고
    • Acute pancreatitis with hyperlipidemia studies with an isolated perfused canine pancreas
    • Saharia P., Margolis S., Zuidema G.D., and Cameron J.L. Acute pancreatitis with hyperlipidemia studies with an isolated perfused canine pancreas. Surgery 82 1 (1977) 60-67
    • (1977) Surgery , vol.82 , Issue.1 , pp. 60-67
    • Saharia, P.1    Margolis, S.2    Zuidema, G.D.3    Cameron, J.L.4
  • 37
    • 0014428865 scopus 로고
    • Estimation of total, protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent
    • Sedlak J., and Lindsay R.H. Estimation of total, protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25 (1968) 192-205
    • (1968) Anal. Biochem. , vol.25 , pp. 192-205
    • Sedlak, J.1    Lindsay, R.H.2
  • 38
    • 0023856329 scopus 로고
    • Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid b-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate
    • Sharma R., Lake B.G., and Gibson G.G. Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid b-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate. Biochem. Pharmacol. 37 (1988) 1203-1206
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 1203-1206
    • Sharma, R.1    Lake, B.G.2    Gibson, G.G.3
  • 39
    • 0346667197 scopus 로고    scopus 로고
    • The pyridoindole antioxidant stobadine attenuates histochemical changes in kidney of STZ-induced diabetic rats
    • Stefek M., Tribulova N., Gajdoski A., and Gajdosikova A. The pyridoindole antioxidant stobadine attenuates histochemical changes in kidney of STZ-induced diabetic rats. Acta Histochem. 104 (2002) 413-417
    • (2002) Acta Histochem. , vol.104 , pp. 413-417
    • Stefek, M.1    Tribulova, N.2    Gajdoski, A.3    Gajdosikova, A.4
  • 40
    • 0028963558 scopus 로고
    • The effect of lipid lowering drugs on metabolic control and lipoprotein composition in type 2 diabetic patients with mild hyperlipidemia
    • Stewart M.W., Dyer R.G., Alberti K.G., and Laker M.F. The effect of lipid lowering drugs on metabolic control and lipoprotein composition in type 2 diabetic patients with mild hyperlipidemia. Diabetes Med. 12 3 (1995) 250-257
    • (1995) Diabetes Med. , vol.12 , Issue.3 , pp. 250-257
    • Stewart, M.W.1    Dyer, R.G.2    Alberti, K.G.3    Laker, M.F.4
  • 41
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin action in β-cells of the rat pancreas
    • Szkudelski T. The mechanism of alloxan and streptozotocin action in β-cells of the rat pancreas. Physiol. Res. 50 (2001) 537-546
    • (2001) Physiol. Res. , vol.50 , pp. 537-546
    • Szkudelski, T.1
  • 43
    • 0021924359 scopus 로고
    • The effect of bezafibrate on hyperlipidemia in experimental nephrotic syndrome in rats
    • Williams A.J., and Baker F.E. The effect of bezafibrate on hyperlipidemia in experimental nephrotic syndrome in rats. J. Pharm. Pharmacol. 37 (1985) 741-743
    • (1985) J. Pharm. Pharmacol. , vol.37 , pp. 741-743
    • Williams, A.J.1    Baker, F.E.2
  • 44
    • 0025853670 scopus 로고
    • Protein glycation and oxidative stress in diabetes mellitus and ageing
    • Wolff S.P., Jang Z.Y., and Hunt V.J. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free. Radic. Biol. Med. 10 (1991) 339-352
    • (1991) Free. Radic. Biol. Med. , vol.10 , pp. 339-352
    • Wolff, S.P.1    Jang, Z.Y.2    Hunt, V.J.3
  • 45
    • 0035914213 scopus 로고    scopus 로고
    • Characteristic changes of stress protein expression in streptozotocin induced diabetic rats
    • Yamagishi N., Nakayama K., Wakatsuki T., and Hatayama T. Characteristic changes of stress protein expression in streptozotocin induced diabetic rats. Life Sci. 9 (2001) 2603-2609
    • (2001) Life Sci. , vol.9 , pp. 2603-2609
    • Yamagishi, N.1    Nakayama, K.2    Wakatsuki, T.3    Hatayama, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.