Biochemical evaluation of antidiabetogenic properties of some commonly used Indian plants on streptozotocin-induced diabetes in experimental rats

Clinical and Experimental Pharmacology and Physiology

Volumn 33, Issue 12, 2006, Pages 1150-1157

  Narendhirakannan, R T ^a   Subramanian, S ^a   Kandaswamy, M ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Aegle marmelos; Antidiabetic activity; Diabetes; Mentha piperitae; Murraya koenigii; Ocimum sanctum; Streptozotocin

Indexed keywords

AEGLE MARMELOS EXTRACT; C PEPTIDE; FRUCTOSE BISPHOSPHATASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN; HEXOKINASE; INSULIN; INSULIN RECEPTOR; IODINE 125; LACTATE DEHYDROGENASE; MENTHA PIPERITAE EXTRACT; MURRAYA KOENIGII EXTRACT; OCIMUM SANCTUM EXTRACT; PLANT EXTRACT; STREPTOZOCIN; UREA;

AEGLE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASIL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN BLOOD LEVEL; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; LIVER LEVEL; MALE; MENTHA; MURRAYA; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; STREPTOZOCIN DIABETES; UREA BLOOD LEVEL; WEIGHT CHANGE;

ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; BODY WEIGHT; C-PEPTIDE; CARBOHYDRATES; CREATININE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; HEMOGLOBIN A, GLYCOSYLATED; HEMOGLOBINS; HYPOGLYCEMIC AGENTS; INDIA; INSULIN; LIVER GLYCOGEN; MALE; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR;

EID: 33845526601     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2006.04507.x     Document Type: Article

References (58)

1. Boyle JP, Honeycutt AA, Narayan KM et al. Projection of diabetes burden through 2050: Impact of changing demography and disease prevalence in the US. Diabetes Care 2001; 24: 1936-40.
2. King H, Aubert RE, Hermen WH. Global burden of diabetes 1995-2025 prevalence, numerical estimates and projections. Diabetes Care 1998; 21: 1414-31.
3. Grover JK, Vats V. Shifting paradigm from conventional to alternate medicine, an introduction on traditional Indian medicine. Asia Pac. Biotech. News 2001; 5: 28-32.
4. Charak S. The ancient textbook of Ayurveda. Shree Gulakunverba Ayurvedic Society, Jamnagar. 1949.
5. Narendhirakannan RT, Subramanian S, Kandaswamy M. Mineral contents of medicinal plants used in the treatment of diabetes mellitus. Biol. Trace Elem. Res. 2005; 103: 109-15.
6. Underwood EJ, Mertz W. Trace Elements in Human and Animal Nutrition. Academic Press, New York. 1986.
7. Rakieten N, Rakieten M, Nadkarni MV. Studies on the diabetogenic action of streptozotocin. Cancer Chemother. Rep. 1963; 29: 91-8.
8. Canepa ET, Llambias EBC, Grinstein M. Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from normal and experimental diabetic rats. Role of insulin. Biochem. Cell Biol. 1990; 68: 914-21.
9. Whittington KB, Solomon SS, Lu ZN. Islet allograft in the cryptochid testes of spontaneously diabetic BB/W or dp rats: Response to glucose, glipizide and arginine. Endocrinology 1991; 128: 2671-7.
10. Sasaki T, Matsy S, Sonae A. Effect of acetic acid concentration on the color reaction in O-toludine boric acid method for blood glucose estimation. Rinsho Kagaku 1972; 1: 346-53.
11. Drabkin DL, Austin JM. Spectrophotometric constants for common hemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem. 1932; 98: 719-33.
12. Nayak SS, Pattabiraman TN. A new colorimetric method for the estimation of glycosylated hemoglobin. Clin. Chem. Acta 1981; 109: 267-74.
13. Brod J, Sirota JH. Renal clearance of endogenous creatinine in man. J. Clin. Invest. 1948; 27: 645-54.
14. Natelson S, Scott ML, Begga E. A rapid method for the estimation of urea in biological fluids by means of the reaction between diacetyl and urea. Am. J. Clin. Pathol. 1951; 21: 275-81.
15. Lowry OH, Rosenbrough NJ, Farr AL, Randall R. Protein determination using Folin-Ciocalteu reagent. J. Biol. Chem. 1951; 193: 265-9.
16. Neville DM. Isolation of an organ specific protein antigen from cell surface membrane of rat liver. Biochim. Biophys. Acta 1968; 154: 540-52.
17. Hollenberg Cuatrecasas P. Insulin and epidermal growth factor: Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake. J. Biol. Chem. 1973; 250: 3485-853.
18. Cuatrecasas P. Properties of the insulin receptor of isolated cell membranes. J. Biol. Chem. 1971; 246: 7265-74.
19. Brandstrup N, Kirk JK, Bruni C. Determination of hexokinase in tissues. J. Gerontol. 1957; 12: 166-71.
20. King J. Colorimetric determination of serum lactate dehydrogenase. J. Med. Lab. Tech. 1959; 16: 265-9.
21. Koide H, Oda T. Pathological occurrence of glucose-6-phosphatase in serum in liver diseases. Clin. Chim. Acta 1959; 4: 554-61.
22. Ell HA, Kirkman HM. A colorimetric method for assay of erythrocytic glucose-6-phosphate dehydrogenase. Proc. Soc. Exp. Biol. Med. 1961; 106: 607-9.
23. Morales MA, Jabbagy AJ, Terenizi HR. Mutations affecting accumulation of Neurospora glycogen. News Lett. 1973; 20: 24-5.
24. Cornblath M, Randel PJ, Parmeggiani A, Morgan HE. Effects of glucagons and anoxia on lactate production, glycogen content, and phosphorylase activity in the perfused isolated rat heart. J. Biol. Chem. 1963; 238: 1592-7.
25. Leloir LF, Goldenberg SH. Glycogen synthetase from rat liver. In: Colowick SP, Kalpan, NO (eds). Methods of Enzymology. Academic Press, New York. 1979; 145-8.
26. Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous Drugs of India, 2nd edn. Dhar and Sons, Calcutta. 1958.
27. Shanie J, Goldschmied A, Joseph B, Ahronson Z, Sulman FG. Hypoglycemic effect of Trigonella foenum graceum and Lupinus terminis seeds and their major alkaloids in alloxan diabetic and normal rats. Arch. Int. Pharmacodyn. Ther. 1974; 210: 27-31.
28. Bach JF. Autoimmunity and type I diabetes. Trends Endocrinol. Metab. 1997; 8: 71-4.
29. Elsner M, Guldbakke B, Tiedge M, Nunday R, Lenzen S. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia 2000; 43: 1528-33.
30. Tomilson KC, Gardiner SM, Hebden RA, Bennett T. Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol. Rev. 1992; 44: 103-50.
31. Grover JK, Vat S, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cardifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J. Ethnopharmacol. 2000; 73: 461-70.
32. Kedar P, Chakrabarti CH. Effects of bitter gourd seed and glibenclamide in streptozotocin induced diabetes mellitus. Indian J. Exp. Biol. 1982; 20: 232-5.
33. Pari L, Latha M. Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats. Singapore Med. J. 2002; 43: 617-21.
34. Lee MK, Kim MJ, Cho SY et al. Hypoglycemic effect of Du-zhong (Eucommia ulmoides Oliv.) leaves in streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pract. 2005; 67: 22-8.
35. Sheela GC, Augusti KT. Antidiabetic effects of S-allyl cystein sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol. 1992; 30: 523-6.
36. 1C as an indicator of the degree of the glucose intolerance in diabetes. Diabetes 1976; 25: 230-40.
37. 1C like glycosylated proteins in kidneys of streptozotocin diabetes and controlled rats. Diabetes 1979; 28: 408-15.
38. Khan BA, Abraham A, Leelamma S. Hypoglycemic action of Murraya koenigii (curry leaf) and Brassica juncea (mustard): Mechanism of action. Indian J. Biochem. Biophys. 1995; 32: 106-8.
39. Peungvicha P, Temsiririrkul R, Prasain JK, Tezuka Y, Kedota S. Hydroxybenzoic acid: A hypoglycemic constituent of aqueous extract of Pandanus odorus root. J. Ethnopharmacol. 1998; 62: 79-84.
40. Ravi K, Ramachandran B, Subramanian S. Protective effect of Eugenia jambolana seed kernel on tissue anti-oxidants in streptozotocin induced rats. Biol. Pharm. Bull. 2004; 27: 1212-17.
41. Rajasekaran S, Sivagnanam K, Subramanian S. Modulatory effects of Aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin. J. Pharm. Pharmacol. 2005; 57: 241-6.
42. Rannels DE, Mokee DE, Morgan HE. Biochemical actions of hormones. In: Lit Wac G (ed.). Academic Press, New York. 1997; 135-95.
43. Dighe RR, Rojas FJ, Birnbanumer L. Glucagon stimulates adenylate cyclase in rat liver. The impact of STZ-induced diabetes mellitus. J. Clin. Invest. 1984; 73: 1013-24.
44. KatZ. RN, Nauck AM, Wilson TP. Induction of glucokinase by insulin under the permissive action of decamethasone in primary rat hepatocyte cultures. Biochem. Biophys. Res. Comm. 1979; 88: 23-9.
45. Pozzilli A, Signore A, Leslie RDG. Infections, immunity and diabetes. In: Alberti K, Zimmet P, De Fronzo R, Keen H (eds). International Text Book of Diabetes Mellitus, 2nd edn. 1997; 1231-41.
46. Minnassian C, Mitheux G. Differential time course of liver and kidney glucose-6-phosphatase activity during fasting in rats. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 1994; 109: 99-104.
47. Horecker BL, Melloni E, Pontremoli S. Fructose-1,6-bisphosphatases properties of the neutral enzyme and its modification by proteolytic enzymes. Adv. Enzymol. 1975; 42: 193-226.
48. Baquer NZ, Gupta D, Raju J. Regulation of metabolic pathways in liver and kidney during experimental diabetes. Effects of antidiabetic compounds. Indian J. Clin. Biochem. 1998; 13: 63-80.
49. Pugazhenthi S, Khandelwal RL, Angel JF. Insulin like effects of vanadate on malic enzyme and glucose -6-phosphate dehydrogenase activities in streptozotocin induced diabetic rat liver. Biochem. Biophys. Acta 1991; 1083: 310-12.
50. Shibib A, Khan LA, Rahman R. Hypoglycemic activity of Cocecinia indica and Momordica charantia in diabetic rats. Biochem. J. 1993; 292: 267-70.
51. Garvey WT. Glucose transport and NIDDM. Diabetes Care 1992; 15: 396-417.
52. Asayama K, Nakana T, Uchida N, Hayashibe H, Dobashi K, Nakazawa S. Serum anti-oxidant status in STZ-induced diabetic rat. Horm. Metab. Res. 1994; 26: 313-15.
53. Jensen PK, Chrisiansen JS, Steven K, Parving HH. Renal function in streptozotocin diabetic rats. Diabetologia 1981; 21: 409-14.
54. Gurnberger G, Qiang X, Li Z, Mathews ST, Sima AAF. Molecular basis for the insulinomimetic effects of C-peptide. Diabetologia 2001; 44: 1247-57.
55. Gurnberger G, Sima AAF. The C-peptide signaling. Exp. Diabetes Res. 2004; 5: 25-36.
56. Samnegard B, Jacobson SH, Jaremko G, Johansson BL, Sjoquist M. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 2001; 60: 1258-65.
57. Kasuga M, Akanuma Y, Iwamoto Y, Kosaka K. Insulin binding and glucose metabolism in adipocytes of streptozotocin-diabetic rats. Am. J. Physiol. 1978; 235: E175-82.
58. Kobayashi M, Olefsky JM. Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated adipocytes. Clin. Res. 1977; 25: 394A.