Disclosing new inhibitors by finding similarities in three-dimensional active-site architectures of polynuclear zinc phospholipases and aminopeptidases

Angewandte Chemie - International Edition

Volumn 43, Issue 7, 2004, Pages 862-865

  González Roura, Albert ^a   Navarro, Isabel ^a   Delgado, Antonio ^b   Llebaria, Amadeu ^a   Casas, Josefina ^a  

^a DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Hydrolases; Inhibitors; Metalloenzymes; Protein structures; Zinc

Indexed keywords

CONFORMATIONS; ENZYME INHIBITION; MOLECULAR STRUCTURE; STEREOCHEMISTRY;

ACTIVE SITES; AMINOPEPTIDASES; THREE DIMENSIONAL STRUCTURAL SIMILARITIES;

ENZYMES;

ALPHA AMINOHYDROXAMIC ACID; AMINOPEPTIDASE; HYDROXAMIC ACID DERIVATIVE; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ARTICLE; ENZYME INHIBITION; MOLECULAR DYNAMICS; PROTEIN FAMILY; PROTEIN HYDROLYSIS; PROTEIN TERTIARY STRUCTURE;

AMINOPEPTIDASES; BINDING SITES; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; KINETICS; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; PHOSPHOLIPASES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; ZINC;

EID: 4544353074     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352241     Document Type: Article

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