Synthesis and evaluation of the antitumor agent TMC-69-6H and a focused library of analogs

Tetrahedron

Volumn 60, Issue 43 SPEC. ISS., 2004, Pages 9543-9558

  Fürstner, Alois ^a   Feyen, Fabian ^a   Prinz, Heino ^b   Waldmann, Herbert ^b  

^a MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Heterocycles; Julia Kocienski olefination; N oxidation; Palladium; Phosphate inhibitors

Indexed keywords

3 (4 HYDROXY) 5 PHENYLPYRIDIN 2(1H) ONE; 3 (DODEC 2 ENYL) 4 HYDROXY 5 PHENYLPYRIDIN 2(1H) ONE; 3 (TETRAHYDRO 3 METHYL 5 PENTYL 2H PYRAN 2 YL) 1,4 DIHYDROXY 5 PHENYLPYRIDIN 2(1H) ONE; 3 (TETRAHYDRO 3 METHYL 5 PENTYL 2H PYRAN 2 YL) 4 HYDROXY 5 PHENYLPYRIDIN 2(1H) ONE; 3 (TETRAHYDRO 3 METHYL 5 TETRADECYL 2H PYRAN 2 YL) 1,4 DIHYDROXY 5 PHENYLPYRIDIN 2(1H) ONE; 3 (TETRAHYDRO 3 METHYL 5 TETRADECYL 2H PYRAN 2 YL) 4 HYDROXY 5 PHENYLPYRIDIN 2(1H) ONE; 3 DODECYL 1,4 DIHYDROXY 5 PHENYL 1H PYRIDIN 2 ONE; 3 DODECYL 4 HYDROXY 5 PHENYL 1H PYRIDIN 2 ONE; 3 [TETRAHDYRO 3 METHYL 5 (6 METHYLOCTYL) 2H PYRAN 2 YL] 4 HYDROXY 5 PHENYLPYRIDIN 2(1H) ONE; 3 [TETRAHYDRO 3 METHYL 5 (6 METHYLOCTYL) 2H PYRAN 2 YL] 1,4 DIHYDROXY 5 PHENYL 6 CHLOROPYRIDIN 2(1H) ONE; 3 [TETRAHYDRO 3 METHYL 5 (6 METHYLOCTYL) 2H PYRAN 2 YL] 1,4 DIHYDROXY 5 PHENYLPYRIDIN 2(1H) ONE; 3 [TETRAHYDRO 3 METHYL 5 (6 METHYLOCTYL) 2H PYRAN 2 YL] 4 HYDROXY 5 PHENYL 6 CHLOROPYRIDIN 2(1H) ONE; 4 HYDROXY 2 PYRIDONE; ANTINEOPLASTIC AGENT; HYDROXAMIC ACID; HYDROXYL GROUP; MOLYBDENUM COMPLEX; PALLADIUM; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PYRIDONE DERIVATIVE; SULFONE DERIVATIVE; TMC 69 6H; UNCLASSIFIED DRUG;

ADDITION REACTION; ANTINEOPLASTIC ACTIVITY; CATALYSIS; CHEMICAL MODIFICATION; CONFERENCE PAPER; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; OLEFINATION; OXIDATION KINETICS; PRIORITY JOURNAL; QUANTUM YIELD; X RAY CRYSTALLOGRAPHY;

DRYAS IULIA;

EID: 4544287532     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2004.06.139     Document Type: Conference Paper

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